Not logged inTunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting
Hadjadj, Margot; Hassanzadeh, Malihe; Martel, Justin; Roy, Marie-Frederique; Giguere, Hugo; Murza, Alexandre; Holleran, Brian J.; Namkung, Yoon; Froehlich, Ulrike; Leduc, Richard; Auger-Messier, Mannix; Laporte, Stephane A.; Boudreault, Pierre-Luc .png)
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SaveShare Save Selective Azapeptide CD36 Ligand MPE-298 Regulates oxLDL-LOX-1-Mediated Inflammation and Mitochondrial Oxidative Stress in MacrophagesMulumba, Mukandila; Le, Catherine; Schelsohn, Emmanuelle; Namkung, Yoon; Laporte, Stephane A.; Febbraio, Maria; Servant, Marc J.; Chemtob, Sylvain; Lubell, William D.; Marleau, Sylvie; Ong, Huy Share Save Cannabis vaping elicits transcriptomic and metabolomic changes involved in inflammatory, oxidative stress, and cancer pathways in human bronchial epithelial cellsArlen, MT; Patterson, SJ; Page, MK; Liu, R; Caruana, V; Wilson, ET; Laporte, SA; Goniewicz, ML; Harris, CS; Eidelman, DH; Baglole, CJ Share Save Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 systemSarma, Parishmita; Carino, Carlo Marion C.; Seetharama, Deeksha; Pandey, Shubhi; Dwivedi-Agnihotri, Hemlata; Rui, Xue; Cao, Yubo; Kawakami, Kouki; Kumari, Poonam; Chen, Yu-Chih; Luker, Kathryn E.; Yadav, Prem N.; Luker, Gary D.; Laporte, Stephane A.; Chen, Xin; Inoue, Asuka; Shukla, Arun K. Share Save Unraveling allostery within the angiotensin II type 1 receptor for Gαq and β-arrestin couplingCao, Yubo; van der Velden, Wijnand J. C.; Namkung, Yoon; Nivedha, Anita K.; Cho, Aaron; Sedki, Dana; Holleran, Brian; Lee, Nicholas; Leduc, Richard; Muk, Sanychen; Le, Keith; Bhattacharya, Supriyo; Vaidehi, Nagarajan; Laporte, Stephane A. Share Save Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuitySandhu, Manbir; Cho, Aaron; Ma, Ning; Mukhaleva, Elizaveta; Namkung, Yoon; Lee, Sangbae; Ghosh, Soumadwip; Lee, John H.; Gloriam, David E.; Laporte, Stephane A.; Babu, M. Madan; Vaidehi, Nagarajan Share Save Share Save Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabodyBaidya, Mithu; Chaturvedi, Madhu; Dwivedi-Agnihotri, Hemlata; Ranjan, Ashutosh; Devost, Dominic; Namkung, Yoon; Stepniewski, Tomasz Maciej; Pandey, Shubhi; Baruah, Minakshi; Panigrahi, Bhanupriya; Sarma, Parishmita; Yadav, Manish K.; Maharana, Jagannath; Banerjee, Ramanuj; Kawakami, Kouki; Inoue, Asuka; Selent, Jana; Laporte, Stephane A.; Hebert, Terence E.; Shukla, Arun K. Share Save Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptorsPandey, Shubhi; Kumari, Punita; Baidya, Mithu; Kise, Ryoji; Cao, Yubo; Dwivedi-Agnihotri, Hemlata; Banerjee, Ramanuj; Li, Xaria X.; Cui, Cedric S.; Lee, John D.; Kawakami, Kouki; Maharana, Jagannath; Ranjan, Ashutosh; Chaturvedi, Madhu; Jhingan, Gagan Deep; Laporte, Stephane A.; Woodruff, Trent M.; Inoue, Asuka; Shukla, Arun K. Share Save Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine ReceptorFree, R. Benjamin; Cuoco, Caroline A.; Xie, Bing; Namkung, Yoon; Prabhu, Varun V.; Willette, Blair K. A.; Day, Marilyn M.; Sanchez-Soto, Marta; Lane, J. Robert; Laporte, Stephane A.; Shi, Lei; Allen, Joshua E.; Sibley, David R. Share Save Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screenGiubilaro, Jenna; Schuetz, Doris A.; Stepniewski, Tomasz M.; Namkung, Yoon; Khoury, Etienne; Lara-Marquez, Monica; Campbell, Shirley; Beautrait, Alexandre; Armando, Sylvain; Radresa, Olivier; Duchaine, Jean; Lamarche-Vane, Nathalie; Claing, Audrey; Selent, Jana; Bouvier, Michel; Marinier, Anne; Laporte, Stephane A. Share Save Share Save Key phosphorylation sites inGPCRs orchestrate the contribution of β-Arrestin 1 inERK1/2 activationBaidya, Mithu; Kumari, Punita; Dwivedi-Agnihotri, Hemlata; Pandey, Shubhi; Chaturvedi, Madhu; Maciej Stepniewski, Tomasz; Kawakami, Kouki; Cao, Yubo; Laporte, Stphane A.; Selent, Jana; Inoue, Asuka; Shukla, Arun K. Share Save Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2ARLukasheva, Viktoriya; Devost, Dominic; Le Gouill, Christian; Namkung, Yoon; Martin, Ryan D.; Longpre, Jean-Michel; Amraei, Mohammad; Shinjo, Yuji; Hogue, Mireille; Lagace, Monique; Breton, Billy; Aoki, Junken; Tanny, Jason C.; Laporte, Stephane A.; Pineyro, Graciela; Inoue, Asuka; Bouvier, Michel; Hebert, Terence E. Share Save Share Save Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensorsNamkung, Yoon; LeGouill, Christian; Kumar, Sahil; Cao, Yubo; Teixeira, Larissa B.; Lukasheva, Viktoriya; Giubilaro, Jenna; Simoes, Sarah C.; Longpre, Jean-Michel; Devost, Dominic; Hebert, Terence E.; Pineyro, Graciela; Leduc, Richard; Costa-Neto, Claudio M.; Bouvier, Michel; Laporte, Stephane A. Share Save FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRsWright, Shane C.; Canizal, Maria Consuelo Alonso; Benkel, Tobias; Simon, Katharina; Le Gouill, Christian; Matricon, Pierre; Namkung, Yoon; Lukasheva, Viktoria; Koenig, Gabriele M.; Laporte, Stephane A.; Carlsson, Jens; Kostenis, Evi; Bouvier, Michel; Schulte, Gunnar; Hoffmann, Carsten Share Save Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9Luttrell, Louis M.; Wang, Jialu; Plouffe, Bianca; Smith, Jeffrey S.; Yamani, Lama; Kaur, Suneet; Jean-Charles, Pierre-Yves; Gauthier, Christophe; Lee, Mi-Hye; Pani, Biswaranjan; Kim, Jihee; Ahn, Seungkirl; Rajagopal, Sudarshan; Reiter, Eric; Bouvier, Michel; Shenoy, Sudha K.; Laporte, Stephane A.; Rockman, Howard A.; Lefkowitz, Robert J. Share Save Share Save 
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