David E. Root - Publications, H-index & Citations

Back

David E. Root

Broad Institute of MIT and Harvard

106H-index

811Paper Count

7.0WCitation Count

Published Papers 183

Publication Date

A dependency map enhanced with next-generation 3D cancer models

Nature

IF48.5

2026-08-05

OAAI

James V. Neiswender; Samuel Maffa; Lisa Brenan; Dina ElHarouni; Yejie Yun; Isabella Boyle; Kirsty Wienand; Haider Inam; Tate Bertea; Ashley Anderson; Megan Wong; Matias Enriquez; Evan Lenz; Beatriz Villafranca; Nora Shanks; Mary Hager; Nia Lloyd; Hannah Shadmany; Sarah J. Wie; Harry Liang; Konnor Yunghans; Xiaomeng Zhang; Lauren Golden; Hannah Harris; Serena Day; Philip Montgomery; Samantha Stokes; Ross M. Giglio; Cynthia Hajal; James R. Whittle; Guadalupe Garcia; Caitlin E. Mills; Mehdi Touat; Kristine Pelton; Hongyu Li; Prem Sai Prabhakar; Sonja Herter; Zoe Hoffmann Kamrat; Dan Gui; Julien Dilly; Chen Khuan Wong; Jimmy A. Guo; Sangita Pal; Yossef Baidi; Ryan Johnston; Daniel D. Brown; Sonam Bhatia; Peter S. Winter; Srivatsan Raghavan; Rameen Beroukhim; Eva Colas; David L. Spector; Adam J. Bass; Peter K. Sorger; Yu Chen; Sarah J. Hill; Steffi Oesterreich; Adrian V. Lee; Himisha Beltran; Jesse S. Boehm; Yuen-Yi Tseng; David E. Root; William C. Hahn; Andrew J. Aguirre; Catarina D. Campbell; Keith L. Ligon; Joshua M. Dempster; Tsukasa Shibue; Francisca Vazquez

Save

A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction

Science Advances

IF12.5

2026-07-29

OAAI

Kannan V. Manian; Connor H. Ludwig; Yan Zhao; Nathan S. Abell; Robert Warneford-Thomson; Henry Chan; Zachary O. Casey; Xiaoping Yang; David E. Root; Matthew L. Albert; Jason Comander

Save

Expanding the human proteome with microproteins and peptideins

Nature

IF48.5

2026-05-01

PREAI

Deutsch, Eric W.; Kok, Leron W.; Mudge, Jonathan M.; Valls, Cristian F.; Jungreis, Irwin; Ruiz-Orera, Jorge; Sun, Zhi; Kusebauch, Ulrike; Fierro-Monti, Ivo; Abelin, Jennifer G.; Alba, M. Mar; Aspden, Julie L.; Bandyopadhyay, Sreejan; Banerjee, Kaushik; Baranov, Pavel V.; Bazzini, Ariel A.; Bourassa, Francis; Bruford, Elspeth A.; Calviello, Lorenzo; Carr, Steven A.; Carvunis, Anne-Ruxandra; Chothani, Sonia; Clauwaert, Jim; Dean, Kellie; Faridi, Pouya; Frankish, Adam; Goodale, Amy; Green, Thomas; Hubner, Norbert; Ingolia, Nicholas T.; Kellis, Manolis; Magrane, Michele; Martin, Maria Jesus; Martinez, Thomas F.; Menschaert, Gerben; Ohler, Uwe; Orchard, Sandra; Potter, Alisa; Rackham, Owen J. L.; Rees, Matthew G.; Root, David E.; Roth, Jennifer A.; Roucou, Xavier; Sialana, Fernando J.; Slavoff, Sarah A.; Swirski, Michal I.; Tierney, Jack A. S.; Trifiro, Felix-Antoine; Valen, Eivind; Vasylieva, Valeriia; Wacholder, Aaron; Wang, Shengbo; Wang, Li; Weissman, Jonathan S.; Wu, Wei; Choudhary, Jyoti S.; Bassani-Sternberg, Michal; Vizcaino, Juan Antonio; Ternette, Nicola; Brunet, Marie A.; Moritz, Robert L.; Prensner, John R.; van Heesch, Sebastiaan

Save

SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity

Nature Communications

IF15.7

2026-04-08

OAAI

Garrett W. Cooper; Benjamin P. Lee; Won Jun Kim; Yongdong Su; Victor Z. Chen; Eliseo Salas; Xiaoping Yang; Robert E. Lintner; Federica Piccioni; Andrew O. Giacomelli; Thomas P. Howard; Pritha Bagchi; Karen N. Conneely; David E. Root; Bo Liang; James C. Gumbart; William C. Hahn; David U. Gorkin; Jaclyn A. Biegel; Susan N. Chi; Andrew L. Hong

Save

TYK2 mediates neuroinflammation in Alzheimer’s disease brains with TDP-43 pathology

Nature Communications

IF15.7

2026-03-14

OAAI

Laura E. König; Steve Rodriguez; Clemens Hug; Shayda Daneshvari; Alexander Chung; Mark Appleman; Max Tsai; Gary A. Bradshaw; Asli Sahin; Yuyu Song; George Zhou; Robyn J. Eisert; Federica Piccioni; Christine Marques; Sharon Powley; James Yarmolinsky; Brian J. Wainger; Sudeshna Das; Marian Kalocsay; Abbas Dehghan; Ioanna Tzoulaki; Artem Sokolov; Peter Sorger; David E. Root; Mark W. Albers

Save

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis

Nature Communications

IF15.7

2025-12-21

OAAI

Jeffrey C. Hsiao; Douglas M. Warui; Jason J. Kwon; Margaret B. Dreishpoon; Nolan R. Bick; Tamra Blue-Lahom; David E. Root; Squire J. Booker; Peter Tsvetkov

Save

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

NATURE

IF48.5

2025-04-24

PREAI

Johannessen, Cory M.; Johnson, Laura A.; Piccioni, Federica; Townes, Aisha; Frederick, Dennie T.; Donahue, Melanie K.; Narayan, Rajiv; Flaherty, Keith T.; Wargo, Jennifer A.; Root, David E.; Garraway, Levi A.

Save

Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors

GENOME BIOLOGY

IF9.4

2024-12-02

OAAI

Merk, Daniel J.; Tsiami, Foteini; Hirsch, Sophie; Walter, Bianca; Haeusser, Lara A.; Maile, Jens D.; Stahl, Aaron; Jarboui, Mohamed A.; Lechado-Terradas, Anna; Klose, Franziska; Babaei, Sepideh; Admard, Jakob; Casadei, Nicolas; Roggia, Cristiana; Spohn, Michael; Schittenhelm, Jens; Singer, Stephan; Schueller, Ulrich; Piccioni, Federica; Persky, Nicole S.; Claassen, Manfred; Tatagiba, Marcos; Kahle, Philipp J.; Root, David E.; Templin, Markus; Tabatabai, Ghazaleh

Save

Posttranslational Changes in Histone Modification Driven By USP48 Loss Increase Sensitivity to Hypomethylating Agents in Acute Myeloid Leukemia

BLOOD

IF23.1

2024-11-05

PREAI

Schneider, Constanze; Alexe, Gabriela; Meyer, Ashleigh; Merickel, Lucy A.; Basanthakumar, Allen T.; Taillon, Audrey; Salhotra, Silvi; Rodriguez, Yara; Haeupl, Bjoern; Root, David E.; Oellerich, Thomas; Stegmaier, Kimberly

Save

Deciphering Drivers of Functional and Phenotypic Changes through Genome-Wide Screen (DRIVE-Genome) to Identify Genes Inducing Genomic Instability in Myeloma

BLOOD

IF23.1

2024-11-05

PREAI

Talluri, Srikanth; Buon, Leutz; Zhao, Jiangning; Meglino, Daniel; Chakraborty, Chandraditya; Liao, Chengcheng; Samur, Mehmet K.; Root, David E.; Shammas, Masood A.; Munshi, Nikhil C.

Save

Deep mutational scanning of SMARCB1 identifies missense mutants that destabilize SWI/SNF complex stability and diminish remodeling activity

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Cooper, Garrett; Lee, Benjamin; Kim, Won; Salas, Eliseo; Su, Yongdong; Chen, Victor; Yang, Xiaoping; Lintner, Robert; Piccioni, Federica; Giacomelli, Andrew; Howard, Thomas; Conneely, Karen; Root, David; Hahn, William; Gorkin, David; Liang, Bo; Biegel, Jaclyn; Chi, Susan; Hong, Andrew

Save

Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2024-08-07

OAAI

Tsiami, Foteini; Lago, Chiara; Pozza, Noemi; Piccioni, Federica; Zhao, Xuesong; Luelsberg, Fabienne; Root, David E.; Tiberi, Luca; Kool, Marcel; Schittenhelm, Jens; Bandopadhayay, Pratiti; Segal, Rosalind A.; Tabatabai, Ghazaleh; Merk, Daniel J.

Save

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

CANCER RESEARCH

IF16.6

2024-07-18

OAAI

Hillis, Alissandra L.; Martin, Timothy D.; Manchester, Haley E.; Hogstrom, Jenny; Zhang, Na; Lecky, Emmalyn; Kozlova, Nina; Lee, Jonah; Persky, Nicole S.; Root, David E.; Brown, Myles; Cichowski, Karen; Elledge, Stephen J.; Muranen, Taru; Fruman, David A.; Barry, Simon T.; Clohessy, John G.; Madsen, Ralitsa R.; Toker, Alex

Save

A ROLE FOR BRAF FUSION PARTNERS IN ONCOGENIC SIGNALING

NEURO-ONCOLOGY

IF13.4

2024-06-18

OAAI

Misek, Sean; Borgenvik, Anna; Fekade, Ruth; Zhang, Alexander; Ragnoni, Timothy; Fultineer, Aaron; Zhou, Kevin; Bondeson, Daniel; Novikov, Dana; Bahadur, Sher; Choi, Seung Hyun; Goodale, Amy; Condurat, Alexandra-Larisa; Cordero, Carolina; Persky, Nicole; Kiessling, Laura; Root, David; Eck, Michael; Boehm, Jesse; Jones, David; Beroukhim, Rameen; Bandopadhayay, Pratiti

Save

BEYOND MAPK SIGNALING - GENOME-SCALE CRISPR/CAS9 SCREENS REVEAL NEW TARGETS FOR TREATMENT OF KIAA1549::BRAF-DRIVEN PEDIATRIC LOW-GRADE GLIOMA

NEURO-ONCOLOGY

IF13.4

2024-06-18

OAAI

Borgenvik, Anna; Misek, Sean; Zhang, Alexander; Fekade, Ruth; Ragnoni, Timothy; Fultineer, Aaron; Zhou, Kevin; Bondeson, Daniel; Novikov, Dana; Bahadur, Sher; Choi, Seung (Riley) H.; Goodale, Amy; Condurat, Alexandra L.; Cordero, Carolina Ortiz; Persky, Nicole; Kiessling, Laura; Root, David; Eck, Michael; Boehm, Jesse; Jones, David; Beroukhim, Rameen; Bandopadahayay, Pratiti (Mimi)

Save

NQO1 AS A RESISTANCE DRIVER AND THERAPEUTIC TARGET IN DMG

NEURO-ONCOLOGY

IF13.4

2024-06-18

OAAI

Lupien, Leslie E.; Morin, Eric; Zhang, Daren F.; Novikov, Dana R.; Chacon, Madison S.; Khuu, Nicholas; Keshishian, Hasmik; Seidel, Olivia; Carr, Steven A.; Goodale, Amy; Persky, Nicole S.; Root, David E.; Cusick, Margaret; Ligon, Keith L.; Beroukhim, Rameen; Phoenix, Timothy M.; Rendo, Veronica; Bandopadhayay, Pratiti

Save

CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines

GENOME MEDICINE

IF11.2

2024-06-17

OAAI

Merk, Daniel J.; Paul, Linda; Tsiami, Foteini; Hohenthanner, Helen; Kouchesfahani, Ghazal Mohseni; Haeusser, Lara A.; Walter, Bianca; Brown, Adam; Persky, Nicole S.; Root, David E.; Tabatabai, Ghazaleh

Save

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

NATURE COMMUNICATIONS

IF15.7

2024-06-07

OAAI

Misek, Sean A.; Fultineer, Aaron; Kalfon, Jeremie; Noorbakhsh, Javad; Boyle, Isabella; Roy, Priyanka; Dempster, Joshua; Petronio, Lia; Huang, Katherine; Saadat, Alham; Green, Thomas; Brown, Adam; Doench, John G.; Root, David E.; McFarland, James M.; Beroukhim, Rameen; Boehm, Jesse S.

Save

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants (Vol 15, 2742, 2024)

NATURE COMMUNICATIONS

IF15.7

2024-04-16

OAAI

Hayes, Tikvah K.; Aquilanti, Elisa; Persky, Nicole S.; Yang, Xiaoping; Kim, Erica E.; Brenan, Lisa; Goodale, Amy B.; Alan, Douglas; Sharpe, Ted; Shue, Robert E.; Westlake, Lindsay; Golomb, Lior; Silverman, Brianna R.; Morris, Myshal D.; Fisher, Ty Running; Beyene, Eden; Li, Yvonne Y.; Cherniack, Andrew D.; Piccioni, Federica; Hicks, J. Kevin; Chi, Andrew S.; Cahill, Daniel P.; Dietrich, Jorg; Batchelor, Tracy T.; Root, David E.; Johannessen, Cory M.; Meyerson, Matthew

Save

Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

NATURE METHODS

IF32.1

2024-04-09

OAAI

Chandrasekaran, Srinivas Niranj; Cimini, Beth A.; Goodale, Amy; Miller, Lisa; Kost-Alimova, Maria; Jamali, Nasim; Doench, John G.; Fritchman, Briana; Skepner, Adam; Melanson, Michelle; Kalinin, Alexandr A.; Arevalo, John; Haghighi, Marzieh; Caicedo, Juan C.; Kuhn, Daniel; Hernandez, Desiree; Berstler, James; Shafqat-Abbasi, Hamdah; Root, David E.; Swalley, Susanne E.; Garg, Sakshi; Singh, Shantanu; Carpenter, Anne E.

Save

Research Directions