Rab K. Prinjha - Publications, H-index & Citations

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Rab K. Prinjha

glaxosmithkline r&d stevenage

64H-index

229Paper Count

1.9WCitation Count

Published Papers 116

Publication Date

Differential BET protein recruitment to IL6 and IL8 promoters and suppression of inflammatory and cell cycle genes by BET inhibitor in keratinocytes

Journal of Investigative Dermatology

IF5.7

2026-09-13

PREAI

Keith C.P. Wu; Nicola R. Harker; Simon J. Cockell; John Casement; Michael J. Donaldson; Erika Cule; Paul A. Wilson; Rab K. Prinjha; Mary A. Morse; Nick J. Reynolds

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SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry

Nature Genetics

IF29

2026-07-21

PREAI

Brian J. Liddicoat; Jesse J. Balic; Wendy Jia; Andrea Gillespie; Andrew B. Das; Laura Scolamiero; Naiara G. Bediaga; Yih-Chih Chan; Christa van der Maarel; Andrew A. Guirguis; Kelsy Prest; Oliver J. Sinclair; Laure Talarmain; Cassandra Litchfield; Enid Y. N. Lam; Sebastian Hollizeck; John R. Horton; Benjamin Kroeger; Tao Wang; Francesca Zappacosta; Roland S. Annan; Rab K. Prinjha; Melissa B. Pappalardi; Michael T. McCabe; Ching-Seng Ang; Matthew S. Graus; Mathias Francois; Kieran F. Harvey; Sarah-Jane Dawson; Xiaodong Cheng; Mark A. Dawson

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NLRP3 inflammasome–driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors

Science Advances

IF12.5

2025-07-09

PREAI

Farzaneh Shojaee; Esmaeel Azadian; Min Xian Wong; Xiuquan Ma; James Rickard; Jiyi Pang; Catherine Hall; Andrew J. Kueh; Seth L. Masters; Inmaculada Rioja; Rab K. Prinjha; Marcel Doerflinger; Kate E. Lawlor; Maryam Rashidi; James E. Vince

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Novel insights into the dynamic function of PRC2 in innate immunity

TRENDS IN IMMUNOLOGY

IF13.9

2024-12-01

OAAI

Kempkes, Rosalie W. M.; Prinjha, Rab K.; de Winther, Menno P. J.; Neele, Annette E.

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Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

BLOOD

IF23.1

2024-11-05

PREAI

Shah, Viral; Giotopoulos, George; Osaki, Hikari; Meyerhoefer, Markus; Meduri, Eshwar; Gallego-Crespo, Aaron; Behrendt, Malte Andreas; Saura-Panella, Maria; Schubert, Benedict; Yun, Haiyang; Horton, Sarah J.; Singh, Shuchi Agrawal; Haehnel, Patricia S.; Basheer, Faisal; Lugo, Dave; Kuehn, Michael; Guezguez, Borhane; Theobald, Matthias; Kindler, Thomas; Gallipoli, Paolo; Yeh, Paul; Dawson, Mark A.; Prinjha, Rab; Huntly, Brian J. P.; Sasca, Daniel

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Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages

CELL REPORTS

IF6.9

2024-09-01

OAAI

Chen, Hung-Jen; Sevin, Daniel C.; Griffith, Guillermo R.; Vappiani, Johanna; Booty, Lee M.; van Roomen, Cindy P. A. A.; Kuiper, Johan; den Dunnen, Jeroen; de Jonge, Wouter J.; Prinjha, Rab K.; Mander, Palwinder K.; Grandi, Paola; Wyspianska, Beata S.; de Winther, Menno P. J.

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CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders

BIOMEDICINES

IF3.9

2024-06-18

OAAI

Picavet, Lucas Wilhelmus; Samat, Anoushka A. K.; Calis, Jorg; Nijhuis, Lotte; Scholman, Rianne; Mokry, Michal; Tough, David F.; Prinjha, Rabinder K.; Vastert, Sebastiaan J.; van Loosdregt, Jorg

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Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-06-12

PREAI

Hirst, David J.; Bamborough, Paul; Al-Mahdi, Niam; Angell, Davina C.; Barnett, Heather A.; Baxter, Andrew; Bit, Rino A.; Brown, Jack A.; Chung, Chun-wa; Craggs, Peter D.; Davis, Robert P.; Demont, Emmanuel H.; Ferrie, Alan; Gordon, Laurie J.; Harada, Isobel; Ho, Tim C. T.; Holyer, Ian D.; Hooper-Greenhill, Edward; Jones, Katherine L.; Lindon, Matthew J.; Lovatt, Cerys; Lugo, David; Maller, Claire; Mcgonagle, Grant; Messenger, Cassie; Mitchell, Darren J.; Pascoe, David D.; Patel, Vipulkumar K.; Patten, Christopher; Poole, Darren L.; Shah, Rishi R.; Rioja, Inmaculada; Stafford, Kayleigh A. J.; Tape, Daniel; Taylor, Simon; Theodoulou, Natalie H.; Tomlinson, Laura; Wall, Ian D.; Wellaway, Christopher R.; White, Gemma; Prinjha, Rab K.; Humphreys, Philip G.

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Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-11-15

OAAI

Bradley, Erin; Fusani, Lucia; Chung, Chun-wa; Craggs, Peter D.; Demont, Emmanuel H.; Humphreys, Philip G.; Mitchell, Darren J.; Phillipou, Alex; Rioja, Inmaculada; Shah, Rishi R.; Wellaway, Christopher R.; Prinjha, Rab K.; Palmer, David S.; Kerr, William J.; Reid, Marc; Wall, Ian D.; Cookson, Rosa

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Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2023-08-14

PREAI

Bamborough, Paul; Chung, Chun-wa; Goodwin, Nicole C. C.; Mitchell, Darren J. J.; Neipp, Christopher E. E.; Phillipou, Alex; Preston, Alex; Prinjha, Rab K. K.; Soden, Peter E. E.; Watson, Robert J. J.; Demont, Emmanuel H. H.

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In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer

BRITISH JOURNAL OF CANCER

IF6.8

2023-04-29

OAAI

Quintela, Marcos; James, David W.; Garcia, Jetzabel; Edwards, Kadie; Margarit, Lavinia; Das, Nagindra; Lutchman-Singh, Kerryn; Beynon, Amy L.; Rioja, Inmaculada; Prinjha, Rab K.; Harker, Nicola R.; Gonzalez, Deyarina; Steven Conlan, R.; Francis, Lewis W.

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Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells

CLINICAL EPIGENETICS

IF4.4

2023-04-15

OAAI

Quintela, Marcos; James, David W.; Pociute, Agne; Powell, Lydia; Edwards, Kadie; Coombes, Zoe; Garcia, Jetzabel; Garton, Neil; Das, Nagindra; Lutchman-Singh, Kerryn; Margarit, Lavinia; Beynon, Amy L.; Rioja, Inmaculada; Prinjha, Rab K.; Harker, Nicola R.; Gonzalez, Deyarina; Conlan, R. Steven; Francis, Lewis W.

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Drug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c

SCIENTIFIC REPORTS

IF3.9

2023-04-06

OAAI

Dimond, Andrew; Van de Pette, Mathew; Taylor-Bateman, Victoria; Brown, Karen; Sardini, Alessandro; Whilding, Chad; Feytout, Amelie; Prinjha, Rab K.; Merkenschlager, Matthias; Fisher, Amanda G.

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Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition

COMMUNICATIONS BIOLOGY

IF5.1

2023-03-25

OAAI

Gleneadie, Hannah J. J.; Fernandez-Ruiz, Beatriz; Sardini, Alessandro; Van de Pette, Mathew; Dimond, Andrew; Prinjha, Rab K. K.; McGinty, James; French, Paul M. W.; Bagci, Hakan; Merkenschlager, Matthias; Fisher, Amanda G. G.

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Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-11-15

OAAI

Humphreys, Philip G.; Anderson, Niall A.; Bamborough, Paul; Baxter, Andrew; Chung, Chun-wa; Cookson, Rosa; Craggs, Peter D.; Dalton, Toryn; Fournier, Julie C. L.; Gordon, Laurie J.; Gray, Heather F.; Gray, Matthew W.; Gregory, Richard; Hirst, David J.; Jamieson, Craig; Jones, Katherine L.; Kessedjian, Hripsimee; Lugo, David; McGonagle, Grant; Patel, Vipulkumar K.; Patten, Christopher; Poole, Darren L.; Prinjha, Rab K.; Ramirez-Molina, Cesar; Rioja, Inmaculada; Seal, Gail; Stafford, Kayleigh A. J.; Shah, Rishi R.; Tape, Daniel; Theodoulou, Natalie H.; Tomlinson, Laura; Ukuser, Sabri; Wall, Ian D.; Wellaway, Natalie; White, Gemma

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N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2022-09-13

OAAI

Nord, Joshua A. A.; Wynia-Smith, Sarah L. L.; Gehant, Alyssa L. L.; Lipinski, Rachel A. Jones A.; Naatz, Aaron; Rioja, Inmaculada; Prinjha, Rab K. K.; Corbett, John A. A.; Smith, Brian C. C.

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A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn's Disease

CELLS

IF5.2

2022-09-12

OAAI

Elfiky, Ahmed M., I; Hageman, Ishtu L.; Becker, Marte A. J.; Verhoeff, Jan; Li Yim, Andrew Y. F.; Joustra, Vincent W.; Mulders, Lieven; Fung, Ivan; Rioja, Inmaculada; Prinjha, Rab K.; Smithers, Nicholas N.; Furze, Rebecca C.; Mander, Palwinder K.; Bell, Matthew J.; Buskens, Christianne J.; D'Haens, Geert R.; Wildenberg, Manon E.; de Jonge, Wouter J.

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Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters

NATURE COMMUNICATIONS

IF15.7

2022-07-27

OAAI

Robles-Rebollo, Irene; Cuartero, Sergi; Canellas-Socias, Adria; Wells, Sarah; Karimi, Mohammad M.; Mereu, Elisabetta; Chivu, Alexandra G.; Heyn, Holger; Whilding, Chad; Dormann, Dirk; Marguerat, Samuel; Rioja, Inmaculada; Prinjha, Rab K.; Stumpf, Michael P. H.; Fisher, Amanda G.; Merkenschlager, Matthias

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Bromodomain factor 5 is an essential regulator of transcription in Leishmania

NATURE COMMUNICATIONS

IF15.7

2022-07-13

OAAI

Jones, Nathaniel G.; Geoghegan, Vincent; Moore, Gareth; Carnielli, Juliana B. T.; Newling, Katherine; Calderon, Felix; Gabarro, Raquel; Martin, Julio; Prinjha, Rab K.; Rioja, Inmaculada; Wilkinson, Anthony J.; Mottram, Jeremy C.

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Phase 1 and preclinical profiling of ESM-HDAC391, a myeloid-targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2022-07-11

OAAI

Furze, Rebecca C.; Molnar, Judit; Parr, Nigel J.; Ahmad, Faiz; Henry, Yvette; Howe, David; Singh, Rajendra; Toal, Martin; Bassil, Anna K.; Bernard, Sharon G.; Davis, Robert P.; Gibson, Adele; Maller, N. Claire; Sharp, Catriona; Tough, David F.; Prinjha, Rab K.; Lewis, Huw D.

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Research Directions