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Alfred L. George

Northwestern University

100H-index
568Paper Count
3.5WCitation Count
Published Papers 278
Publication Date
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Epilepsy-Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
errAnnals of Clinical and Translational Neurology
IF3.9
err2026-02-01
err0
errOAAI
errLiebovitz, Lanie N.; Thompson, Christopher H.; Laux, Linda C.; George Jr, Alfred L.
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Characterization of the functional and clinical impacts of CACNA1A missense variants found in neurodevelopmental disorders
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2025-12-10
err0
PREAI
errKurganov, Erkin; Cui, Lei; Budnik, Nikita; Chen, Siwei; Olivares, Erick; Baez-Nieto, David; Asan, Ahmet S.; Lusk, Laina; Smith, Lacey; Jo, Sooyeon; Marques, Diogo; Nehme, Ralda; Mullegama, Sureni V.; Lindy, Amanda; George, Alfred L.; Poduri, Annapurna; Helbig, Ingo; Daly, Mark; Pan, Jen Q.
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Neurodevelopmental features in KCNQ2 developmental and epileptic encephalopathy may have limited associations with KV7.2 dysfunction
errEPILEPSIA OPEN
IF2.9
err2025-11-01
err0
errOAAI
errBidwell, Jessa S.; Vanoye, Carlos G.; Desai, Reshma R.; Berg, Anne T.; George Jr, Alfred L.
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errSave
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
errNature Neuroscience
IF20
err2025-10-31
err0
errOAAI
errBrian J. Joseph; Kelly A. Marshall; Peter Harley; Jacob R. Mann; Francesco Alessandrini; Carlos G. Vanoye; Wanhao Chi; Mercedes Prudencio; Dina Simkin; Tzu-Ting Kao; Reshma R. Desai; Matthew J. Keuss; Simone Barattucci; Matteo Zanovello; Puja R. Mehta; Jean-Marc DeKeyser; Francesco Limone; Jonathan Lee; Anna-Leigh Brown; Marcel F. Leyton-Jaimes; Leslie A. Nash; Irune Guerra San Juan; Eleonora Aronica; Brian J. Wainger; Mala Shah; Anand Goswami; Neil A. Shneider; Dennis W. Dickson; Juan Burrone; Chaolin Zhang; Hynek Wichterle; Leonard Petrucelli; Jonathan K. Watts; Alfred L. George; Pietro Fratta; Kevin Eggan; Evangelos Kiskinis
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In vivo prime editing rescues alternating hemiplegia of childhood in mice
errCell
IF42.5
err2025-07-21
err0
errOAAI
errAlexander A. Sousa; Markus Terrey; Holt A. Sakai; Christine Q. Simmons; Elena Arystarkhova; Natalia S. Morsci; Laura C. Anderson; Jun Xie; Fabian Suri-Payer; Linda C. Laux; Emmanuel Roze; Sylvie Forlani; Guangping Gao; Simon Frost; Nina Frost; Kathleen J. Sweadner; Alfred L. George; Cathleen M. Lutz; David R. Liu
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Changes in S-Citalopram Plasma Concentrations Across Pregnancy and Postpartum
errClinical Pharmacology & Therapeutics
IF5.5
err2025-03-18
err0
PREAI
errCatherine S. Stika; Michael J. Avram; Alfred L. George Jr.; Amy Yang; Jody D. Ciolino; Hyunyoung Jeong; Raman Venkataramanan; Steve N. Caritis
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errSave
Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-02-19
err0
errOAAI
errBrewer, Kathryn R.; Vanoye, Carlos G.; Huang, Hui; Moster, Katherine R. Clowes; Desai, Reshma R.; Hayes, James B.; Burnette, Dylan T.; George, Alfred L.; Sanders, Charles R.
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Genotype-function-phenotype correlations for SCN1A variants identified by clinical genetic testing
errANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
IF3.9
err2025-01-21
err0
errOAAI
errKnox, Andrew T.; Thompson, Christopher H.; Scott, Dillon; Abramova, Tatiana V.; Stieve, Bethany; Freeman, Abigail; George, Alfred L.
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errSave
Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
errELIFE
IF0
err2025-01-06
err0
errOAAI
errAbreo, Timothy J.; Thompson, Emma C.; Madabushi, Anuraag; Park, Kristen L.; Soh, Heun; Varghese, Nissi; Vanoye, Carlos G.; Springer, Kristen; Johnson, Jim; Sims, Scotty; Ji, Zhigang; Chavez, Ana G.; Jankovic, Miranda J.; Habte, Bereket; Zuberi, Aamir R.; Lutz, Cathleen M.; Wang, Zhao; Krishnan, Vaishnav; Dudler, Lisa; Einsele-Scholz, Stephanie; Noebels, Jeffrey L.; George, Alfred L.; Maheshwari, Atul; Tzingounis, Anastasios; Cooper, Edward C.
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errSave
Rare dysfunctional SCN2A variants are associated with malformation of cortical development
errEPILEPSIA
IF6.6
err2024-12-21
err0
errOAAI
errClatot, Jerome; Thompson, Christopher H.; Sotardi, Susan; Jiang, Jinan; Trivisano, Marina; Balestrini, Simona; Ward, D. Isum; Ginn, Natalie; Guaragni, Brunetta; Malerba, Laura; Vakrinou, Angeliki; Sherer, Mia; Helbig, Ingo; Somarowthu, Ala; Sisodiya, Sanjay M.; Ben-Shalom, Roy; Guerrini, Renzo; Specchio, Nicola; George Jr, Alfred L.; Goldberg, Ethan M.
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errSave
Novel mouse model of alternating hemiplegia of childhood exhibits prominent motor and seizure phenotypes
errNEUROBIOLOGY OF DISEASE
IF5.6
err2024-12-01
err0
errOAAI
errHawkins, Nicole A.; Dekeyser, Jean-Marc; Kearney, Jennifer A.; George Jr, Alfred L.
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errSave
The Need for Speed; Investigating Channelopathy-Associated Epilepsy Using High Throughput Electrophysiological Approaches
errEPILEPSY CURRENTS
IF6.3
err2024-10-16
err0
errOAAI
errGeorge Jr, Alfred L.; Kiskinis, Evangelos
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errSave
Scanning mutagenesis of the voltage-gated sodium channel Na V 1.2 using base editing (Vol 42, 112563, 2023)
errCELL REPORTS
IF6.9
err2024-06-01
err1
errOAAI
errPablo, Juan Lorenzo B.; Cornett, Savannah L.; Wang, Lei A.; Jo, Sooyeon; Brunger, Tobias; Budnik, Nikita; Hegde, Mudra; Dekeyser, Jean -Marc; Thompson, Christopher H.; Doench, John G.; Lal, Dennis; George Jr, Alfred L.; Pan, Jen Q.
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errSave
Molecular and cellular context influences SCN8A variant function
errJCI INSIGHT
IF6.1
err2024-05-21
err2
errOAAI
errVanoye, Carlos G.; Abramova, Tatiana V.; DeKeyser, Jean -Marc; Ghabra, Nora F.; Oudin, Madeleine J.; Burge, Christopher B.; Helbig, Ingo; Thompson, Christopher H.; George, Alfred L.
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Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias
errJOURNAL OF THE AMERICAN HEART ASSOCIATION
IF5.3
err2024-05-21
err1
errOAAI
errOhiri, Joyce C.; Dellefave-Castillo, Lisa; Tomar, Garima; Wilsbacher, Lisa; Choudhury, Lubna; Barefield, David Y.; Fullenkamp, Dominic; Gacita, Anthony M.; Monroe, Tanner O.; Pesce, Lorenzo; Blancard, Malorie; Vaught, Lauren; George Jr, Alfred L.; Demonbreun, Alexis R.; Puckelwartz, Megan J.; McNally, Elizabeth M.
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errSave
Susceptibility to innate immune activation in genetically mediated myocarditis
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2024-05-16
err1
errOAAI
errSelgrade, Daniel F.; Fullenkamp, Dominic E.; Chychula, Ivana A.; Li, Binjie; Dellefave-Castillo, Lisa; Dubash, Adi D.; Ohiri, Joyce; Monroe, Tanner O.; Blancard, Malorie; Tomar, Garima; Holgren, Cory; Burridge, Paul W.; George Jr, Alfred L.; Demonbreun, Alexis R.; Puckelwartz, Megan J.; George, Sharon A.; Efimov, Igor R.; Green, Kathleen J.; McNally, Elizabeth M.
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In Memoriam Arthur J. Atkinson, Jr. (1938-2024)
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2024-05-13
err0
PREAI
errLertora, Juan J. L.; Huang, Shiew-Mei; George Jr, Alfred L.
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errSave
Late Sodium Current Promotes Ventricular Arrhythmia in Epilepsy-Related Sudden Death
errJACC-CLINICAL ELECTROPHYSIOLOGY
IF7.7
err2024-05-01
err0
PREAI
errGeorge Jr, Alfred L.
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errSave
Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
errNEUROBIOLOGY OF DISEASE
IF5.6
err2024-05-01
err1
errOAAI
errKang, Seok Kyu; Hawkins, Nicole A.; Thompson, Christopher H.; Baker, Erin M.; Echevarria-Cooper, Dennis M.; Barse, Levi; Thenstedt, Tyler; Dixon, Conor J.; Speakes, Nathan; George Jr, Alfred L.; Kearney, Jennifer A.
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errSave
Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders
errBRAIN
IF11.7
err2024-04-23
err4
errOAAI
errBerg, Anne T.; Thompson, Christopher H.; Myers, Leah Schust; Anderson, Erica; Evans, Lindsey; Kaiser, Ariela J. E.; Paltell, Katherine; Nili, Amanda N.; Dekeyser, Jean-Marc L.; Abramova, Tatiana, V; Nesbitt, Gerry; Egan, Shawn M.; Vanoye, Carlos G.; George Jr, Alfred L.
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Research Directions

No research directions
Co-authors
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Arthur A.M. Wilde
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