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Christian C. Felder

national institute of food & drug safety evaluation

72H-index
206Paper Count
1.8WCitation Count
Published Papers 84
Publication Date
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
err2023-09-06
err10
errOAAI
errBurger, Wessel A. C.; Pham, Vi; Vuckovic, Ziva; Powers, Alexander S.; Mobbs, Jesse I.; Laloudakis, Yianni; Glukhova, Alisa; Wootten, Denise; Tobin, Andrew B.; Sexton, Patrick M.; Paul, Steven M.; Felder, Christian C.; Danev, Radostin; Dror, Ron O.; Christopoulos, Arthur; Valant, Celine; Thal, David M.
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Structural basis of efficacy-driven ligand selectivity at GPCRs (Feb, 10.1038/s41589-022-01247-5, 2023)
err2023-03-06
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errOAAI
errPowers, Alexander S.; Pham, Vi; Burger, Wessel A. C.; Thompson, Geoff; Laloudakis, Yianni; Barnes, Nicholas W.; Sexton, Patrick M.; Paul, Steven M.; Christopoulos, Arthur; Thal, David M.; Felder, Christian C.; Valant, Celine; Dror, Ron O.
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Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic
err2022-12-01
err41
errOAAI
errYohn, Samantha E.; Weiden, Peter J.; Felder, Christian C.; Stahl, Stephen M.
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Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia
err2022-09-01
err53
PREAI
errPaul, Steven M.; Yohn, Samantha E.; Popiolek, Michael; Miller, Andrew C.; Felder, Christian C.
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Biased Profile of Xanomeline at the Recombinant Human M4Muscarinic Acetylcholine Receptor
err2022-04-05
err10
PREAI
errMcDonald, Jack K.; van der Westhuizen, Emma T.; Pham, Vi; Thompson, Geoff; Felder, Christian C.; Paul, Steven M.; Thal, David M.; Christopoulos, Arthur; Valant, Celine
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The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain
err2020-12-20
err34
errOAAI
errMontani, Caterina; Canella, Carola; Schwarz, Adam J.; Li, Jennifer; Gilmour, Gary; Galbusera, Alberto; Wafford, Keith; Gutierrez-Barragan, Daniel; McCarthy, Andrew; Shaw, David; Knitowski, Karen; McKinzie, David; Gozzi, Alessandro; Felder, Christian
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The Opioid Crisis and the Future of Addiction and Pain Therapeutics
err2019-11-01
err78
errOAAI
errCoussens, Nathan P.; Sittampalam, G. Sitta; Jonson, Samantha G.; Hall, Matthew D.; Gorby, Heather E.; Tamiz, Amir P.; McManus, Owen B.; Felder, Christian C.; Rasmussen, Kurt
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Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
err2019-07-23
err52
errOAAI
errHollingsworth, Scott A.; Kelly, Brendan; Valant, Celine; Michaelis, Jordan Arthur; Mastromihalis, Olivia; Thompson, Geoff; Venkatakrishnan, A. J.; Hertig, Samuel; Scammells, Peter J.; Sexton, Patrick M.; Felder, Christian C.; Christopoulos, Arthur; Dror, Ron O.
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Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pains
err2019-06-01
err19
errOAAI
errKnopp, Kelly L.; Simmons, Rosa Maria A.; Guo, Wenhong; Adams, Benjamin L.; Gardinier, Kevin M.; Gernert, Douglas L.; Ornstein, Paul L.; Porter, Warren; Reel, Jon; Ding, Chunjin; Wang, He; Qian, Yuewei; Burris, Kevin D.; Need, Anne; Barth, Vanessa; Swanson, Steven; Catlow, John; Witkin, Jeffrey M.; Zwart, Ruud; Sher, Emanuele; Choong, Kar-Chan; Wall, Theron M.; Schober, Douglas; Felder, Christian C.; Kato, Akihiko S.; Bredt, David S.; Nisenbaum, Eric S.
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KARXT: A M1/M4 PREFERRING MUSCARINIC AGONIST FOR THE TREATMENT OF SCHIZOPHRENIA
err2019-04-09
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errOAAI
errBrannan, Stephen; Miller, Andrew; Felder, Christian; Paul, Steven; Breier, Alan
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Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors
err2018-11-16
err6
errOAAI
errBroad, Lisa M.; Sanger, Helen E.; Mogg, Adrian J.; Colvin, Ellen M.; Zwart, Ruud; Evans, David A.; Pasqui, Francesca; Sher, Emanuele; Wishart, Graham N.; Barth, Vanessa N.; Felder, Christian C.; Goldsmith, Paul J.
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Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
err2018-06-01
err25
errOAAI
errBradley, Sophie J.; Molloy, Colin; Bundgaard, Christoffer; Mogg, Adrian J.; Thompson, Karen J.; Dwomoh, Louis; Sanger, Helen E.; Crabtree, Michael D.; Brooke, Simon M.; Sexton, Patrick M.; Felder, Christian C.; Christopoulos, Arthur; Broad, Lisa M.; Tobin, Andrew B.; Langmead, Christopher J.
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In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography
err2018-06-01
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errOAAI
errMogg, Adrian J.; Eessalu, Thomas; Johnson, Megan; Wright, Rebecca; Sanger, Helen E.; Xiao, Hongling; Crabtree, Michael G.; Smith, Alex; Colvin, Ellen M.; Schober, Douglas; Gehlert, Donald; Jesudason, Cynthia; Goldsmith, Paul J.; Johnson, Michael P.; Felder, Christian C.; Barth, Vanessa N.; Broad, Lisa M.
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Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide
err2017-04-19
err20
errOAAI
errUdawela, M.; Scarr, E.; Boer, S.; Um, J. Y.; Hannan, A. J.; McOmish, C.; Felder, C. C.; Thomas, E. A.; Dean, B.
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Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain
err2017-04-01
err7
errOAAI
errFelder, Christian C.; Schober, Douglas A.; Tu, Yuan; Quets, Anne; Xiao, Hongling; Watt, Marla; Siuda, Ed; Nisenbaum, Eric; Xiang, Chuanxi; Heinz, Beverly; Prieto, Lourdes; McKinzie, David L.; Monn, James A.
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M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
err2016-12-19
err66
errOAAI
errBradley, Sophie J.; Bourgognon, Julie-Myrtille; Sanger, Helen E.; Verity, Nicholas; Mogg, Adrian J.; White, David J.; Butcher, Adrian J.; Moreno, Julie A.; Molloy, Colin; Macedo-Hatch, Timothy; Edwards, Jennifer M.; Wess, Jurgen; Pawlak, Robert; Read, David J.; Sexton, Patrick M.; Broad, Lisa M.; Steinert, Joern R.; Mallucci, Giovanna R.; Christopoulos, Arthur; Felder, Christian C.; Tobin, Andrew B.
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Characterization of PCS1055, a novel muscarinic M4 receptor antagonist
err2016-07-01
err24
PREAI
errCroy, Carrie H.; Chan, Wai Y.; Castetter, Andrea M.; Watt, Marla L.; Quets, Anne T.; Felder, Christian C.
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An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory
err2016-04-01
err31
errOAAI
errButcher, Adrian J.; Bradley, Sophie J.; Prihandoko, Rudi; Brooke, Simon M.; Mogg, Adrian; Bourgognon, Julie-Myrtille; Macedo-Hatch, Timothy; Edwards, Jennifer M.; Bottrill, Andrew R.; Challiss, R. A. John; Broad, Lisa M.; Felder, Christian C.; Tobin, Andrew B.
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