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John H. Brumell

Hospital for Sick Children

75H-index
218Paper Count
3.1WCitation Count
Published Papers 95
Publication Date
A pore-forming toxin initiates ABI1 complex switching to promote bacterial cell-to-cell spread
err2026-04-13
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errHe Sun; Arlon Wizzard; John H. Brumell; Darren E. Higgins
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Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission (vol 21, e1013507, 2025)
err2025-12-30
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errWaldmann, Anna K.; Ammendolia, Dustin A.; Sydor, Andrew M.; Li, Ren; St-Germain, Jonathan; Raught, Brian; Brumell, John H.
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The primate-specific Nedd4-1(NE) localizes to late endosomes in response to amino acids to suppress autophagy
err2025-03-18
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errKefalas, G.; Priya, A.; Astori, A.; Persaud, A.; Jing, L.; Sydor, A. M.; Yao, H. H. Y.; Warner, N.; Zhang, Y.; Brumell, J. H.; Muise, A. M.; Sari, S.; Su, H. C.; Lenardo, M. J.; Kahr, W. H. A.; Raught, B.; Rotin, D.
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IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a
err2024-09-01
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PREAI
errJang, Erika; Ho, Tse Wing Winnie; Brumell, John H.; Lefebvre, Francois; Wang, Changsen; Lee, Warren L.
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Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy
err2024-06-11
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errHerrera, Alfa; Packer, Megan M.; Lemus, Monica Rosas-; Minasov, George; Chen, Jiexi; Brumell, John H.; Satchell, Karla J. F.
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Salmonella exploits membrane reservoirs for invasion of host cells
err2024-04-10
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errZhu, Hongxian; Sydor, Andrew M.; Boddy, Kirsten C.; Coyaud, Etienne; Laurent, Estelle M. N.; Au, Aaron; Tan, Joel M. J.; Yan, Bing-Ru; Moffat, Jason; Muise, Aleixo M.; Yip, Christopher M.; Grinstein, Sergio; Raught, Brian; Brumell, John H.
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Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function
err2023-06-20
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errChi, Lijun; Lee, Dorothy; Leung, Sharon; Hu, Guanlan; Wen, Bijun; Delgado-Olguin, Paul; Vissa, Miluska; Li, Ren; Brumell, John H.; Kim, Peter K.; Bandsma, Robert H. J.
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SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing
err2023-06-13
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errBhosle, Vikrant K.; Tan, Joel M. J.; Li, Taoyingnan; Hua, Rong; Kwon, Hyunwoo; Li, Zhubing; Patel, Sajedabanu; Tessier-Lavigne, Marc; Robinson, Lisa A.; Kim, Peter K.; Brumell, John H.
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The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils
err2023-03-28
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errKiefer, F; Brumell, J; Al-Alawi, N; Latour, S; Cheng, A; Veillette, A; Grinstein, S; Pawson, T
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Dynamic glucose uptake, storage, and release by human microvascular endothelial cells
err2022-10-01
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errYazdani, Samaneh; Bilan, Philip J.; Jaldin-Fincati, Javier R.; Pang, Janice; Ceban, Felicia; Saran, Ekambir; Brumell, John H.; Freeman, Spencer A.; Klip, Amira
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Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
err2022-08-15
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errZou, Angela; Nadeau, Kerry; Xiong, Xuejian; Wang, Pauline W.; Copeland, Julia K.; Lee, Jee Yeon; St Pierre, James; Ty, Maxine; Taj, Billy; Brumell, John H.; Guttman, David S.; Sharif, Shayan; Korver, Doug; Parkinson, John
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The MCF Toxin of the Extracellular Pathogen Vibrio vulnificus is Activated by and Targets Host GTPases
err2022-05-13
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PREAI
errHerrera, Alfa; Packer, Megan M.; Brumell, John; Satchell, Karla
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V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy
err2022-05-05
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errHooper, Kirsty M.; Jacquin, Elise; Li, Taoyingnan; Goodwin, Jonathan M.; Brumell, John H.; Durgan, Joanne; Florey, Oliver
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Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase
err2022-04-28
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errWalpole, Glenn F. W.; Pacheco, Jonathan; Chauhan, Neha; Clark, Jonathan; Anderson, Karen E.; Abbas, Yazan M.; Brabant-Kirwan, Danielle; Montano-Rendon, Fernando; Liu, Zetao; Zhu, Hongxian; Brumell, John H.; Deiters, Alexander; Stephens, Len R.; Hawkins, Phillip T.; Hammond, Gerald R., V; Grinstein, Sergio; Fairn, Gregory D.
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Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn's disease
err2021-11-05
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errHaq, Sabah; Wang, Huaqing; Grondin, Jensine; Banskota, Suhrid; Marshall, John K.; Khan, Irfan I.; Chauhan, Usha; Cote, Francine; Kwon, Yun Han; Philpott, Dana; Brumell, John H.; Surette, Michael; Steinberg, Gregory R.; Khan, Waliul, I
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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis
err2021-10-01
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errGoodwin, Jonathan M.; Walkup, Ward G.; Hooper, Kirsty; Li, Taoyingnan; Kishi-Itakura, Chieko; Ng, Aylwin; Lehmberg, Timothy; Jha, Archana; Kommineni, Sravya; Fletcher, Katherine; Garcia-Fortanet, Jorge; Fan, Yaya; Tang, Qing; Wei, Menghao; Agrawal, Asmita; Budhe, Sagar R.; Rouduri, Sreekanth R.; Baird, Dan; Saunders, Jeff; Kiselar, Janna; Chance, Mark R.; Ballabio, Andrea; Appleton, Brent A.; Brumell, John H.; Florey, Oliver; Murphy, Leon O.
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Global Proximity Interactome of the Human Macroautophagy Pathway
errAUTOPHAGY
IF14.3
err2021-09-15
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errTu, Yi Xin (Iris); Sydor, Andrew M.; Coyaud, Etienne; Laurent, Estelle M. N.; Dyer, Diana; Mellouk, Nora; St-Germain, Jonathan; Vernon, Robert M.; Forman-Kay, Julie D.; Li, Taoyingnan; Hua, Rong; Zhao, Kexin; Ridgway, Neale D.; Kim, Peter K.; Raught, Brian; Brumell, John H.
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C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy
errAUTOPHAGY
IF14.3
err2021-08-25
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errYan, Bing-Ru; Li, Taoyingnan; Coyaud, Etienne; Laurent, Estelle M. N.; St-Germain, Jonathan; Zhou, Yuhuan; Kim, Peter K.; Raught, Brian; Brumell, John H.
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Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
err2021-08-17
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errTan, Joel M. J.; Garner, Monica E.; Regeimbal, James M.; Greene, Catherine J.; Marquez, Jorge D. Rojas; Ammendolia, Dustin A.; McCluggage, Adam R. R.; Li, Taoyingnan; Wu, Katherine J.; Cemma, Marija; Ostrowski, Philip P.; Raught, Brian; Diamond, Michael S.; Grinstein, Sergio; Yates, Robin M.; Higgins, Darren E.; Brumell, John H.
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Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10
err2021-08-04
err11
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errBoddy, Kirsten C.; Zhu, Hongxian; D'Costa, Vanessa M.; Xu, Caishuang; Beyrakhova, Ksenia; Cygler, Miroslaw; Grinstein, Sergio; Coyaud, Etienne; Laurent, Estelle M. N.; St-Germain, Jonathan; Raught, Brian; Brumell, John H.
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