Not logged in Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium Schoofs, Hans; Daubel, Nina; Schnabellehner, Sarah; Gronloh, Max L. B.; Martinez, Sebastian Palacios; Halme, Aleksi; Marks, Amanda M.; Jeansson, Marie; Barcos, Sara; Brakebusch, Cord; Benedito, Rui; Engelhardt, Britta; Vestweber, Dietmar; Gaengel, Konstantin; Linsenmeier, Fabian; Schurmann, Sebastian; Saharinen, Pipsa; van Buul, Jaap D.; Friedrich, Oliver; Smith, Richard S. Share Save
Endothelial Pim3 kinase protects the vascular barrier during lung metastasis Santio, Niina M.; Ganesh, Keerthana; Kaipainen, Pihla P.; Halme, Aleksi; Seyednasrollah, Fatemeh; Arbash, Emad; Hanninen, Satu; Kivela, Riikka; Carpen, Olli; Saharinen, Pipsa Share Save
Ex vivo modeling of precision immuno-oncology responses in lung cancer Alsaed, Bassel; Smolander, Johannes; Laitinen, Hanna; Lin, Linh; Bobik, Nina; Lahtinen, Lilja; Rasanen, Mikko; Jansouz, Shadi; Peltonen, Karita; Jokinen, Emmi; Klievink, Jay; Ganesh, Keerthana; Ainola, Mari; Sutinen, Eva; Ronty, Mikko; Narvi, Elli; Thotakura, Anil; Saharinen, Pipsa; Mustjoki, Satu; Ilonen, Ilkka; Haikala, Heidi M. Share Save
Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy Sultan, Ibrahim; Ramste, Markus; Peletier, Pim; Hemanthakumar, Karthik Amudhala; Ramanujam, Deepak; Tirronen, Annakaisa; von Wright, Ylva; Antila, Salli; Saharinen, Pipsa; Eklund, Lauri; Mervaala, Eero; Yla-Herttuala, Seppo; Engelhardt, Stefan; Kivelae, Riikka; Alitalo, Kari Share Save
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Comparison of trastuzumab emtansine, trastuzumab deruxtecan, and disitamab vedotin in a multiresistant HER2-positive breast cancer lung metastasis model Pourjamal, Negar; Yazdi, Narjes; Halme, Aleksi; Le Joncour, Vadim; Laakkonen, Pirjo; Saharinen, Pipsa; Joensuu, Heikki; Barok, Mark Share Save
DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells Alve, Sanni; Gramolelli, Silvia; Jukonen, Joonas; Juteau, Susanna; Pink, Anne; Manninen, Atte A.; Hanninen, Satu; Monto, Elisa; Lackman, Madeleine H.; Carpen, Olli; Saharinen, Pipsa; Karaman, Sinem; Vaahtomeri, Kari; Ojala, Paeivi M. Share Save
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Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a Jak1-dependent pathway Stancato, LF; Sakatsume, M; David, M; Dent, P; Dong, F; Petricoin, EF; Krolewski, JJ; Silvennoinen, O; Saharinen, P; Pierce, J; Marshall, CJ; Sturgill, T; Finbloom, DS; Larner, AC Share Save
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Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression Korhonen, Emilia A.; Murtomaki, Aino; Jha, Sawan Kumar; Anisimov, Andrey; Pink, Anne; Zhang, Yan; Stritt, Simon; Liaqat, Inam; Stanczuk, Lukas; Alderfer, Laura; Sun, Zhiliang; Kapiainen, Emmi; Singh, Abhishek; Sultan, Ibrahim; Lantta, Anni; Leppanen, Veli-Matti; Eklund, Lauri; He, Yulong; Augustin, Hellmut G.; Vaahtomeri, Kari; Saharinen, Pipsa; Makinen, Taija; Alitalo, Kari Share Save
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Characterization of ANGPT2 mutations associated with primary lymphedema Leppanen, Veli-Matti; Brouillard, Pascal; Korhonen, Emilia A.; Sipila, Tuomas; Jha, Sawan Kumar; Revencu, Nicole; Labarque, Veerle; Fastre, Elodie; Schlogel, Matthieu; Ravoet, Marie; Singer, Amihood; Luzzatto, Claudia; Angelone, Donatella; Crichiutti, Giovanni; D'Elia, Angela; Kuurne, Jaakko; Elamaa, Harri; Koh, Gou Young; Saharinen, Pipsa; Vikkula, Miikka; Alitalo, Kari Share Save
Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers Talwelkar, Sarang S.; Nagaraj, Ashwini S.; Devlin, Jennifer R.; Hemmes, Annabrita; Potdar, Swapnil; Kiss, Elina A.; Saharinen, Pipsa; Salmenkivi, Kaisa; Mayranpaa, Mikko, I; Wennerberg, Krister; Verschuren, Emmy W. Share Save
b1-Integrin promotes inflammatory cytokine-induced vascular leakage Kiss, Elina A.; Hakanpaa, Laura; Jacquemet, Guillaume; Miinalainen, Ilkka; Lerche, Martina; Guzman, Camilo; Mervaala, Eero; Eklund, Lauri; Ivaska, Johanna; Saharinen, Pipsa Share Save
Targeting β1-integrin inhibits vascular leakage in endotoxemia Hakanpaa, Laura; Kiss, Elina A.; Jacquemet, Guillaume; Miinalainen, Ilkka; Lerche, Martina; Guzman, Camilo; Mervaala, Eero; Eklund, Lauri; Ivaska, Johanna; Saharinen, Pipsa Share Save
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation Pekkonen, Pirita; Alve, Sanni; Balistreri, Giuseppe; Gramolelli, Silvia; Tatti-Bugaeva, Olga; Paatero, Ilkka; Niiranen, Otso; Tuohinto, Krista; Perala, Nina; Taiwo, Adewale; Zinovkina, Nadezhda; Repo, Pauliina; Icay, Katherine; Ivaska, Joanna; Saharinen, Pipsa; Hautaniemi, Sampsa; Lehti, Kaisa; Ojala, Paivi M. Share Save
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