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T

Timothy A. Springer

Harvard University

165H-index
734Paper Count
11.0WCitation Count
Published Papers 249
Publication Date
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A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
errNature Biotechnology
IF41.7
err2025-10-28
err0
errOAAI
errWim B. M. de Lau; Joost J. A. P. M. Wijnakker; Gijs J. F. van Son; Daniel Krueger; Daisong Wang; Matthijs S. Abendroth; Robin Schreurs; Claudia Y. Janda; Fenna L. H. van Rijt; Benjamin J. P. Chalopin; Emma Bokobza; Johan H. van Es; Timothy A. Springer; Arnoud Sonnenberg; Hans Clevers
errShare
errSave
Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations
errJournal of Biological Chemistry
IF3.9
err2025-06-12
err0
errOAAI
errSean M. Watson; Edward P. Harvey; Novalia Pishesha; Hidde L. Ploegh; Timothy A. Springer
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errSave
De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties
errAdvanced Materials
IF26.8
err2025-06-09
err0
errOAAI
errXinru Wang; Jordi Guillem-Marti; Saurav Kumar; David S. Lee; Daniel Cabrerizo-Aguado; Rachel Werther; Kevin Alexander Estrada Alamo; Yan Ting Zhao; Adam Nguyen; Irina Kopyeva; Buwei Huang; Jing Li; Yuxin Hao; Xinting Li; Aritza Brizuela-Velasco; Analisa Murray; Stacey Gerben; Anindya Roy; Cole A. DeForest; Timothy Springer; Hannele Ruohola-Baker; Jonathan A. Cooper; Melody G. Campbell; Jose Maria Manero; Maria-Pau Ginebra; David Baker
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errSave
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits
errMABS
IF7.3
err2024-06-18
err0
errOAAI
errHao, Yuxin; Yan, Jiabin; Fraser, Courtney; Jiang, Aiping; Anuganti, Murali; Zhang, Roushu; Lloyd, Kenneth; Jardine, Joseph; Coppola, Jessica; Meijers, Rob; Li, Jing; Springer, Timothy A.
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errSave
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8
errNATURE COMMUNICATIONS
IF15.7
err2023-09-13
err7
errOAAI
errRoy, Anindya; Shi, Lei; Chang, Ashley; Dong, Xianchi; Fernandez, Andres; Kraft, John C.; Li, Jing; Le, Viet Q.; Winegar, Rebecca Viazzo; Cherf, Gerald Maxwell; Slocum, Dean; Poulson, P. Daniel; Casper, Garrett E.; Vallecillo-Zuniga, Mary L.; Valdoz, Jonard Corpuz; Miranda, Marcos C.; Bai, Hua; Kipnis, Yakov; Olshefsky, Audrey; Priya, Tanu; Carter, Lauren; Ravichandran, Rashmi; Chow, Cameron M.; Johnson, Max R.; Cheng, Suna; Smith, McKaela; Overed-Sayer, Catherine; Finch, Donna K.; Lowe, David; Bera, Asim K.; Matute-Bello, Gustavo; Birkland, Timothy P.; DiMaio, Frank; Raghu, Ganesh; Cochran, Jennifer R.; Stewart, Lance J.; Campbell, Melody G.; Van Ry, Pam M.; Springer, Timothy; Baker, David
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errSave
Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii
errCOMMUNICATIONS BIOLOGY
IF5.1
err2023-08-31
err4
errOAAI
errZhang, Su; Wang, Fangfang; Zhang, Dujuan; Liu, Dongsheng; Ding, Wei; Springer, Timothy A.; Song, Gaojie
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errSave
A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-07-01
err2
errOAAI
errBoudko, Sergei P.; Konopka, Elizabeth H.; Kim, Woojin; Taga, Yuki; Mizuno, Kazunori; Springer, Timothy A.; Hudson, Billy G.; Moy, Terence I.; Lin, Fu-Yang
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errSave
Conformational change of Plasmodium TRAP is essential for sporozoite migration and transmission
errEMBO REPORTS
IF6.2
err2023-06-12
err2
errOAAI
errBraumann, Friedrich; Klug, Dennis; Kehrer, Jessica; Song, Gaojie; Feng, Juan; Springer, Timothy A.; Frischknecht, Friedrich
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errSave
A specialized integrin-binding motif enables proTGF- β2 activation by integrin αVβ6 but not αVβ8
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-06-06
err8
errOAAI
errLe, Viet Q.; Zhao, Bo; Ramesh, Siddanth; Toohey, Cameron; DeCosta, Adam; Mintseris, Julian; Liu, Xinyue; Gygi, Steven; Springer, Timothy A.
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errSave
Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err190
errOAAI
errLu, Chafen; Mi, Li-Zhi; Grey, Michael J.; Zhu, Jieqing; Graef, Elizabeth; Yokoyama, Shigeyuki; Springer, Timothy A.
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errSave
Single-molecule characterization of subtype-specific β1 integrin mechanics
errNATURE COMMUNICATIONS
IF15.7
err2022-12-03
err16
errOAAI
errJo, Myung Hyun; Li, Jing; Jaumouille, Valentin; Hao, Yuxin; Coppola, Jessica; Yan, Jiabin; Waterman, Clare M.; Springer, Timothy A.; Ha, Taekjip
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errSave
Reflections on Integrins-Past, Present, and Future The Albert Lasker Basic Medical Research Award
errJAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
IF55
err2022-10-04
err17
errOAAI
errHynes, Richard O.; Ruoslahti, Erkki; Springer, Timothy A.
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errSave
Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-09-01
err12
errOAAI
errSu, Yang; Iacob, Roxana E.; Li, Jing; Engen, John R.; Springer, Timothy A.
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errSave
Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state
errNATURE COMMUNICATIONS
IF15.7
err2022-07-13
err3
errOAAI
errFeng, Juan; Dong, Xianchi; Su, Yang; Lu, Chafen; Springer, Timothy A.
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errSave
Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker
errELIFE
IF0
err2022-05-09
err3
errOAAI
errBonazza, Klaus; Iacob, Roxana E.; Hudson, Nathan E.; Li, Jing; Lu, Chafen; Engen, John R.; Springer, Timothy A.
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errSave
Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2
errELIFE
IF0
err2021-12-23
err10
errOAAI
errFeng, Juan; Dong, Xianchi; DeCosta, Adam; Su, Yang; Angrisano, Fiona; Sala, Katarzyna A.; Blagborough, Andrew M.; Lu, Chafen; Springer, Timothy A.
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errSave
Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state
errELIFE
IF0
err2021-12-02
err24
errOAAI
errLi, Jing; Yan, Jiabin; Springer, Timothy A.
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errSave
Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6
errAMERICAN JOURNAL OF HEMATOLOGY
IF9.9
err2021-11-03
err2
errOAAI
errRenella, Raffaele; Gagne, Katelyn; Beauchamp, Ellen; Fogel, Jonathan; Perlov, Aleksej; Sola, Mireia; Schlaeger, Thorsten; Hofmann, Inga; Shimamura, Akiko; Ebert, Benjamin L.; Schmitz-Abe, Klaus; Markianos, Kyriacos; Murphy, Kristi; Sun, Liang; Rockowitz, Shira; Sliz, Piotr; Campagna, Dean R.; Springer, Timothy A.; Bahl, Christopher; Agarwal, Suneet; Fleming, Mark D.; Williams, David A.
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errSave
Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b
errJOURNAL OF IMMUNOLOGY
IF3.4
err2021-06-15
err21
errOAAI
errJensen, Rasmus K.; Bajic, Goran; Sen, Mehmet; Springer, Timothy A.; Vorup-Jensen, Thomas; Andersen, Gregers R.
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errSave
CD11c regulates hematopoietic stem and progenitor cells under stress
errBLOOD ADVANCES
IF7.1
err2020-12-09
err14
errOAAI
errHou, Lifei; Voit, Richard A.; Sankaran, Vijay G.; Springer, Timothy A.; Yuki, Koichi
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errSave

Research Directions

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Co-authors
Cooperation Journals
H
Hans Clevers
H-index: 236 · Papers: 1.3K
P
Peer Bork
H-index: 233 · Papers: 948
G
Gordon J. Freeman
H-index: 174 · Papers: 1.1K
T
Tadamitsu Kishimoto
H-index: 161 · Papers: 852
C
Christian Weber
H-index: 160 · Papers: 1.8K
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