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Michael Houghton

university of alberta

92H-index
327Paper Count
4.2WCitation Count
Published Papers 102
Publication Date
Discovery of Novel Pyrido[2,3-b]Pyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition
err2024-12-27
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PREAI
errBai, Bing; Kandadai, Appan Srinivas; Hena, Mostofa; Belovodskiy, Alexandr; Shen, John; Houghton, Michael; Nieman, James A.
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Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone
err2024-12-01
err1
errOAAI
errKundu, Juthika; Le, Hoa T.; Logan, Michael; Hockman, Darren; Landi, Abdolamir; Crawford, Kevin; Wininger, Mark; Johnson, Janelle; Kundu, Joydeb K.; Tiffney, E. Alana; Urbanowicz, Richard A.; Ball, Jonathan K.; Bailey, Justin R.; Bukh, Jens; Law, Mansun; Foung, Steven; Tyrrell, D. Lorne; Houghton, Michael; Law, John Lokman
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Small molecules targeting GRP78 mitigate anti-GRP78 autoantibody-mediated tissue factor procoagulant activity in cultured endothelial cells
err2024-11-01
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errOAAI
errChen, Jack; Lynn, Edward G.; Sharma, Hitesh; Byun, Jae H.; Kenyon, Victor A.; Sahu, Kamlesh K.; Tyrrell, D. Lorne; Houghton, Michael; Gross, Peter L.; Trigatti, Bernardo L.; Shayegan, Bobby; Austin, Richard C.
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Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
err2023-08-14
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errOAAI
errLiang, T. Jake; Law, John L. M.; Pietschmann, Thomas; Ray, Stuart C.; Bukh, Jens; Bull, Rowena; Chung, Raymond T.; Tyrrell, D. Lorne; Houghton, Michael; Rice, Charles M.
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Bovine Serum Albumin-Protected Gold Nanoclusters for Sensing of SARS-CoV-2 Antibodies and Virus
err2023-06-14
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PREAI
errShen, Qiming; Hossain, Faisal; Fang, Changhao; Shu, Tong; Zhang, Xueji; Law, John Lok Man; Logan, Michael; Houghton, Michael; Tyrrell, D. Lorne; Joyce, Michael A.; Serpe, Michael J.
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Utilization of a Glucometer Test Strip and Enzymatic Reactions to Quantify Anti-SARS-CoV-2 Spike RBD IgG Antibody and SARS-CoV-2 Virus in Saliva and Serum
err2023-05-08
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PREAI
errHossain, Faisal; Shen, Qinling; Balasuriya, Nicholas; Law, John Lok Man; Logan, Michael; Houghton, Michael; Tyrrell, D. Lorne; Joyce, Michael A.; Serpe, Michael J.
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Three-Dimensional Reconstruction of the Hepatitis C Virus Envelope Glycoprotein E1E2 Heterodimer by Electron Microscopic Analysis
err2023-01-31
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errOAAI
errKanai, Tapan; Hu, Zongyi; Yang, Renbin; Wu, Weimin; Wang, Ziqiu; Ma, Christopher D.; Sanchez-Meza, Jaime; Law, Mansun; Houghton, Michael; Law, John Lokman; Logan, Michael; de Val, Natalia; Liang, T. Jake
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Same-day emergency care
err2023-01-01
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errOAAI
errHoughton, Michael
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A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis
err2021-02-28
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errOAAI
errGindin, Yevgeniy; Chung, Chuhan; Jiang, Zhaoshi; Zhou, Jing Zhu; Xu, Jun; Billin, Andrew N.; Myers, Robert P.; Goodman, Zachary; Landi, Abdolamir; Houghton, Michael; Green, Richard M.; Levy, Cynthia; Kowdley, Kris V.; Bowlus, Christopher L.; Muir, Andrew J.; Trauner, Michael
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Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase
err2020-12-01
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errOAAI
errFreedman, Holly; Kundu, Juthika; Tchesnokov, Egor Petrovitch; Law, John Lok Man; Nieman, James A.; Schinazi, Raymond F.; Tyrrell, D. Lorne; Gotte, Matthias; Houghton, Michael
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A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
err2020-10-01
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errOAAI
errKalyaanamoorthy, Subha; Lamothe, Shawn M.; Hou, Xiaoqing; Moon, Tae Chul; Kurata, Harley T.; Houghton, Michael; Barakat, Khaled H.
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Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1
err2020-07-01
err19
errOAAI
errHu, Zongyi; Rolt, Adam; Hu, Xin; Ma, Christopher D.; Le, Derek J.; Park, Seung Bum; Houghton, Michael; Southall, Noel; Anderson, D. Eric; Talley, Daniel C.; Lloyd, John R.; Marugan, Juan C.; Liang, T. Jake
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Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
err2020-04-30
err52
errOAAI
errSanter, Deanna M.; Minty, Gillian E. S.; Golec, Dominic P.; Lu, Julia; May, Julia; Namdar, Afshin; Shah, Juhi; Elahi, Shokrollah; Proud, David; Joyce, Michael; Tyrrell, D. Lorne; Houghton, Michael
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Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins
err2019-12-03
err25
errOAAI
errAkache, Bassel; Deschatelets, Lise; Harrison, Blair A.; Dudani, Renu; Stark, Felicity C.; Jia, Yimei; Landi, Amir; Law, John L. M.; Logan, Michael; Hockman, Darren; Kundu, Juthika; Tyrrell, D. Lorne; Krishnan, Lakshmi; Houghton, Michael; McCluskie, Michael J.
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A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1
err2019-11-15
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errOAAI
errJohnson, Janelle; Freedman, Holly; Logan, Michael; Wong, Jason Alexander Ji-Xhin; Hockman, Darren; Chen, Chao; He, Jianqi; Beard, Michael R.; Eyre, Nicholas S.; Baumert, Thomas F.; Tyrrell, D. Lorne; Law, John L. M.; Houghton, Michael
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Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
err2019-08-27
err104
errOAAI
errGanesan, Aravindhan; Ahmed, Marawan; Okoye, Isobel; Arutyunova, Elena; Babu, Dinesh; Turnbull, William L.; Kundu, Joydeb Kumar; Shields, Justin; Agopsowicz, Katharine Cheryl; Xu, Lai; Tabana, Yasser; Srivastava, Nutan; Zhang, Guangzhi; Moon, Tae Chul; Belovodskiy, Alexandr; Hena, Mostofa; Kandadai, Appan Srinivas; Hosseini, Seyedeh N. Argess; Hitt, Mary; Walker, John; Smylie, Michael; West, Frederick G.; Siraki, Arno G.; Lemieux, M. Joanne; Elahi, Shokrollah; Nieman, James A.; Tyrrell, D. Lorne; Houghton, Michael; Barakat, Khaled
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A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors
err2019-06-01
err14
errOAAI
errBanda, Dominic H.; Perin, Paula M.; Brown, Richard J. P.; Todt, Daniel; Solodenko, Wladimir; Hoffmeyer, Patrick; Sahu, Kamlesh Kumar; Houghton, Michael; Meuleman, Philip; Mueller, Rolf; Kirschning, Andreas; Pietschmann, Thomas
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Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants
err2019-04-01
err21
errOAAI
errKhera, Tanvi; Behrendt, Patrick; Bankwitz, Dorothea; Brown, Richard J. P.; Todt, Daniel; Doepke, Mandy; Khan, Abdul Ghafoor; Schulze, Kai; Law, John; Logan, Michael; Hockman, Darren; Wong, Jason Alexander Ji-Xhin; Dold, Leona; Gonzalez-Motos, Victor; Spengler, Ulrich; Viejo-Borbolla, Abel; Stroeh, Luisa J.; Krey, Thomas; Tarr, Alexander W.; Steinmann, Eike; Manns, Michael P.; Klein, Florian; Guzman, Carlos A.; Marcotrigiano, Joseph; Houghton, Michael; Pietschmann, Thomas
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