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Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells Oikonomidi, Ioanna; Kameswaran, Vasumathi; Pham, Victoria C.; Zuazo-Gaztelu, Iratxe; Gutgesell, Lauren M.; Marsters, Scot; Daniel, Bence; Lill, Jennie R.; Modrusan, Zora; Ashkenazi, Avi Share Save
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Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model Braun, Marie-Gabrielle; Ashkenazi, Avi; Beveridge, Ramsay E.; Castanedo, Georgette; Wallweber, Heidi Ackerly; Beresini, Maureen H.; Clark, Kevin R.; De Bruyn, Tom; Fu, Liqiang; Gibbons, Paul; Jiang, Fan; Kaufman, Susan; Kan, David; Kiefer, James R.; Leclerc, Jean-Philippe; Lemire, Alexandre; Ly, Cuong; Segal, Ehud; Sims, Jessica; Wang, Weiru; Wei, Wentao; Zhao, Liang; Schwarz, Jacob B.; Rudolph, Joachim Share Save
APRIL-deficient mice have normal immune system development Varfolomeev, E; Kischkel, F; Martin, F; Seshasayee, D; Wang, H; Lawrence, D; Olsson, C; Tom, L; Erickson, S; French, D; Schow, P; Grewal, QS; Ashkenazi, A Share Save
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Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation Guttman, Ofer; Le Thomas, Adrien; Marsters, Scot; Lawrence, David A.; Gutgesell, Lauren; Zuazo-Gaztelu, Iratxe; Harnoss, Jonathan M.; Haag, Simone M.; Murthy, Aditya; Strasser, Geraldine; Modrusan, Zora; Wu, Thomas; Mellman, Ira; Ashkenazi, Avi Share Save
Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma Guidi, Riccardo; Xu, Daqi; Choy, David F.; Ramalingam, Thirumalai R.; Lee, Wyne P.; Modrusan, Zora; Liang, Yuxin; Marsters, Scot; Ashkenazi, Avi; Huynh, Alison; Mills, Jessica; Flanagan, Sean; Hambro, Shannon; Nunez, Victor; Leong, Laurie; Cook, Ashley; Tran, Tiffany Hao; Austin, Cary D.; Cao, Yi; Clarke, Christine; Panettieri, Reynold A., Jr.; Koziol-White, Cynthia; Jester, William F., Jr.; Wang, Fen; Wilson, Mark S. Share Save
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Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α Le Thomas, Adrien; Ferri, Elena; Marsters, Scot; Harnoss, Jonathan M.; Lawrence, David A.; Zuazo-Gaztelu, Iratxe; Modrusan, Zora; Chan, Sara; Solon, Margaret; Chalouni, Cecile; Li, Weihan; Koeppen, Hartmut; Rudolph, Joachim; Wang, Weiru; Wu, Thomas D.; Walter, Peter; Ashkenazi, Avi Share Save
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Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands Ferri, Elena; Le Thomas, Adrien; Wallweber, Heidi Ackerly; Day, Eric S.; Walters, Benjamin T.; Kaufman, Susan E.; Braun, Marie-Gabrielle; Clark, Kevin R.; Beresini, Maureen H.; Mortara, Kyle; Chen, Yung-Chia A.; Canter, Breanna; Phung, Wilson; Liu, Peter S.; Lammens, Alfred; Ashkenazi, Avi; Rudolph, Joachim; Wang, Weiru Share Save
Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity Beveridge, Ramsay E.; Wallweber, Heidi Ackerly; Ashkenazi, Avi; Beresini, Maureen; Clark, Kevin R.; Gibbons, Paul; Ghiro, Elise; Kaufman, Susan; Larivee, Alexandre; Leblanc, Melissa; Leclerc, Jean-Philippe; Lemire, Alexandre; Ly, Cuong; Rudolph, Joachim; Schwarz, Jacob B.; Srivastava, Sanjay; Wang, Weiru; Zhao, Liang; Braun, Marie-Gabrielle Share Save
IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment Harnoss, Jonathan M.; Le Thomas, Adrien; Reichelt, Mike; Guttman, Ofer; Wu, Thomas D.; Marsters, Scot A.; Shemorry, Anna; Lawrence, David A.; Kan, David; Segal, Ehud; Merchant, Mark; Totpal, Klara; Crocker, Lisa M.; Mesh, Kathryn; Dohse, Monika; Solon, Margaret; Modrusan, Zora; Rudolph, Joachim; Koeppen, Hartmut; Walter, Peter; Ashkenazi, Avi Share Save
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Disruption of IRE1α through its kinase domain attenuates multiple myeloma Harnoss, Jonathan M.; Le Thomas, Adrien; Shemorry, Anna; Marsters, Scot A.; Lawrence, David A.; Lu, Min; Chen, Yung-Chia Ariel; Qing, Jing; Totpal, Klara; Kan, David; Segal, Ehud; Merchant, Mark; Reichelt, Mike; Wallweber, Heidi Ackerly; Wang, Weiru; Clark, Kevin; Kaufman, Susan; Beresini, Maureen H.; Laing, Steven T.; Sandoval, Wendy; Lorenzo, Maria; Wu, Jiansheng; Lyh, Justin; De Bruyn, Tom; Heidersbach, Amy; Haley, Benjamin; Gogineni, Alvin; Weimer, Robby M.; Lee, Dong; Braun, Marie-Gabrielle; Rudolph, Joachim; VanWyngarden, Michael J.; Sherbenou, Daniel W.; Gomez-Bougie, Patricia; Amiot, Martine; Acosta-Alvear, Diego; Walter, Peter; Ashkenazi, Avi Share Save
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members Yang, Yanli; Yeh, Sherry H.; Madireddi, Shravan; Matochko, Wadim L.; Gu, Chen; Sanchez, Patricia Pacheco; Ultsch, Mark; Boenig, Gladys De Leon; Harris, Seth F.; Leonard, Brandon; Scales, Suzie J.; Zhu, Jing W.; Christensen, Erin; Hang, Julie Q.; Brezski, Randall J.; Marsters, Scot; Ashkenazi, Avi; Sukumaran, Siddharth; Chiu, Henry; Cubas, Rafael; Kim, Jeong M.; Lazar, Greg A. Share Save
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate Chang, Tsun-Kai; Lawrence, David A.; Lu, Min; Tan, Jenille; Harnoss, Jonathan M.; Marsters, Scot A.; Liu, Peter; Sandoval, Wendy; Martin, Scott E.; Ashkenazi, Avi Share Save
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