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Stanley T. Crooke

n-lorem foundation

94H-index
534Paper Count
3.2WCitation Count
Published Papers 121
Publication Date
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Individualized antisense oligonucleotides for SCN2A-related developmental epileptic encephalopathy
errNature Medicine
IF50
err2026-07-21
err0
errOAAI
errOlivia Kim-McManus; Laurence Mignon; Julie Douville; He Pu; Catherine Parisien; Sarah Glass; C. Frank Bennett; Janelle Celso; Kendall Robbins; Hoameng Ung; Heather Olson; Stephen F. Kingsmore; Steven Petrou; Stanley T. Crooke; Joseph G. Gleeson; Elizabeth Berry-Kravis
errShare
errSave
Phosphorothioate antisense oligonucleotide induced innate immune activation is attenuated by tryptophan oxidation products
errNucleic Acids Research
IF13.1
err2026-04-13
err0
errOAAI
errJulia Pytte; Lesley Saldana; Wei Zhang; Konstantina Skourti-Stathaki; Stanley T Crooke
errShare
errSave
Establishing a commercial solution for extremely rare genetic diseases
errNature Biotechnology
IF41.7
err2026-03-02
err0
PREAI
errStanley T. Crooke; Andrew W. Lo
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errSave
Letter: Correspondence on Damle, SS, et al. (2025) A Workflow for Transcriptome-Wide Assessment of Antisense Oligonucleotide Selectivity. Nucleic Acid Therapeutics
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2025-12-01
err0
PREAI
errCrooke, Stanley T.
errShare
errSave
Splice-modulating antisense oligonucleotides targeting a pathogenic intronic variant in adult polyglucosan body disease correct mis-splicing and restore enzyme activity in patient cells
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-07-22
err0
errOAAI
errThomas, Ria; Miyoshi, Emily; Akman, Hasan O.; Storz, Sophie H. R.; Goffena, Joy; Pytte, Julia; Miller, Danny E.; Skourti-Stathaki, Konstantina; Crooke, Stanley T.
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errSave
Addressing the Needs of Nano-Rare Patients
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2025-01-29
err0
PREAI
errCrooke, Stanley T.
errShare
errSave
Addressing the Challenges of Treating Patients with Heterozygous Gain of Function Mutations
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2024-12-01
err0
PREAI
errCrooke, Stanley T.
errShare
errSave
Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder
errNATURE MEDICINE
IF50
err2024-08-09
err1
PREAI
errZiegler, Alban; Carroll, Joanne; Bain, Jennifer M.; Sands, Tristan T.; Fee, Robert J.; Uher, David; Kanner, Cara H.; Montes, Jacqueline; Glass, Sarah; Douville, Julie; Mignon, Laurence; Gleeson, Joseph G.; Crooke, Stanley T.; Chung, Wendy K.
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errSave
Safety and Tolerability of GalNAc3-Conjugated Antisense Drugs Compared to the Same-Sequence 2′-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2024-02-01
err4
errOAAI
errBaker, Brenda F.; Xia, Shuting; Partridge, Wesley; Engelhardt, Jeffery A.; Tsimikas, Sotirios; Crooke, Stanley T.; Bhanot, Sanjay; Geary, Richard S.
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errSave
Characterization of cooperative PS-oligo activation of human TLR9
errMOLECULAR THERAPY-NUCLEIC ACIDS
IF0
err2023-09-01
err2
errOAAI
errPollak, Adam J.; Zhao, Luyi; Crooke, Stanley T.
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errSave
A way forward for diagnosis of patients with extremely rare genetic mutations
errNATURE BIOTECHNOLOGY
IF41.7
err2023-07-17
err1
PREAI
errCrooke, Stanley T.; Kim-McManus, Olivia S.; Dalby, Kelley
errShare
errSave
Personalized antisense oligonucleotides 'for free, for life' - the n-Lorem Foundation
errNATURE MEDICINE
IF50
err2023-05-11
err10
PREAI
errGleeson, Joseph G. G.; Bennett, C. Frank; Carroll, Jeffrey B. B.; Cole, Tracy; Douville, Julie; Glass, Sarah; Tekendo-Ngongang, Cedrik; Williford, Amy C. C.; Crooke, Stanley T. T.
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errSave
Systematic Analysis of Chemical Modifications of Phosphorothioate Antisense Oligonucleotides that Modulate Their Innate Immune Response
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2023-04-01
err9
PREAI
errPollak, Adam J.; Zhao, Luyi; Crooke, Stanley T.
errShare
errSave
SIDT2 Inhibits Phosphorothioate Antisense Oligonucleotide Activity by Regulating Cellular Localization of Lysosomes
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2023-04-01
err2
PREAI
errZhao, Jing Crystal; Saleh, Aurian; Crooke, Stanley T.
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errSave
The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2022-10-01
err12
errOAAI
errZhang, Lingdi; Liang, Xue-hai; De Hoyos, Cheryl Li; Migawa, Michael; Nichols, Joshua G.; Freestone, Graeme; Tian, Jun; Seth, Punit P.; Crooke, Stanley T.
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errSave
NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2022-08-01
err5
errOAAI
errZhang, Lingdi; Bernardo, Karla D.; Vickers, Timothy A.; Tian, Jun; Liang, Xue-hai; Crooke, Stanley T.
errShare
errSave
Insights into innate immune activation via PS-ASO-protein-TLR9 interactions
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-07-15
err15
errOAAI
errPollak, Adam J.; Zhao, Luyi; Vickers, Timothy A.; Huggins, Ian J.; Liang, Xue-Hai; Crooke, Stanley T.
errShare
errSave
Establishing an environment in which rigorous scientific inquiry is practiced: a personal journey
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-07-08
err0
errOAAI
errCrooke, Stanley T.
errShare
errSave
RNA modifications can affect RNase H1-mediated PS-ASO activity
errMOLECULAR THERAPY-NUCLEIC ACIDS
IF0
err2022-06-01
err13
errOAAI
errLacy, Katelyn A. Doxtader; Liang, Xue-hai; Zhang, Lingdi; Crooke, Stanley T.
errShare
errSave
Addressing the Needs of Patients with Ultra-Rare Mutations One Patient at a Time: The n-Lorem Approach
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2022-04-01
err17
PREAI
errCrooke, Stanley T.
errShare
errSave

Research Directions

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Co-authors
Cooperation Journals
J
Joseph L. Witztum
H-index: 157 · Papers: 605
C
Colin Hill
H-index: 131 · Papers: 829
W
Wendy K. Chung
H-index: 127 · Papers: 1.3K
E
Erik S.G. Stroes
H-index: 120 · Papers: 758
S
Sotirios Tsimikas
H-index: 111 · Papers: 617
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