Dietrich Keppler - Publications, H-index & Citations

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Dietrich Keppler

German Cancer Research Center (DKFZ)

94H-index

338Paper Count

3.1WCitation Count

Published Papers 65

Publication Date

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2013-04-10

231

OAAI

Brouwer, K. L. R.; Keppler, D.; Hoffmaster, K. A.; Bow, D. A. J.; Cheng, Y.; Lai, Y.; Palm, J. E.; Stieger, B.; Evers, R.

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Emerging Transporters of Clinical Importance: An Update From the International Transporter Consortium

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2013-04-08

326

OAAI

Hillgren, K. M.; Keppler, D.; Zur, A. A.; Giacomini, K. M.; Stieger, B.; Cass, C. E.; Zhang, L.

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Promoting drug discovery by collaborative innovation: a novel risk- and reward-sharing partnership between the German Cancer Research Center and Bayer HealthCare

DRUG DISCOVERY TODAY

IF7.5

2012-11-01

PREAI

Wellenreuther, Ruth; Keppler, Dietrich; Mumberg, Dominik; Ziegelbauer, Karl; Lessl, Monika

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Membrane transporters in drug development

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2010-03-01

2.9K

OAAI

Giacomini, Kathleen M.; Huang, Shiew-Mei; Tweedie, Donald J.; Benet, Leslie Z.; Brouwer, Kim L. R.; Chu, Xiaoyan; Dahlin, Amber; Evers, Raymond; Fischer, Volker; Hillgren, Kathleen M.; Hoffmaster, Keith A.; Ishikawa, Toshihisa; Keppler, Dietrich; Kim, Richard B.; Lee, Caroline A.; Niemi, Mikko; Polli, Joseph W.; Sugiyama, Yuicchi; Swaan, Peter W.; Ware, Joseph A.; Wright, Stephen H.; Yee, Sook Wah; Zamek-Gliszczynski, Maciej J.; Zhang, Lei

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Expression of Organic Cation Transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) Is Affected by Genetic Factors and Cholestasis in Human Liver

HEPATOLOGY

IF15.8

2009-10-01

343

OAAI

Nies, Anne T.; Koepsell, Hermann; Winter, Stefan; Burk, Oliver; Klein, Kathrin; Kerb, Reinhold; Zanger, Ulrich M.; Keppler, Dietrich; Schwab, Matthias; Schaeffeler, Elke

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Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation

MOLECULAR CANCER THERAPEUTICS

IF5.5

2009-01-12

PREAI

Rius, Maria; Stresemann, Carlo; Keller, Daniela; Brom, Manuela; Schirrmacher, Esther; Keppler, Dietrich; Lyko, Frank

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Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY

IF3.4

2008-05-18

PREAI

Nies, Anne T.; Schwab, Matthias; Keppler, Dietrich

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ATP-dependent transport of Leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4)

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2008-01-01

123

PREAI

Rius, Maria; Hummel-Eisenbeiss, Johanna; Keppler, Dietrich

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Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IF3.1

2007-12-19

110

PREAI

Nies, Anne T.; Herrmann, Elke; Brom, Manuela; Keppler, Dietrich

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Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3

TOXICOLOGICAL SCIENCES

IF4.1

2007-01-18

141

OAAI

Komatsu, Masaharu; Furukawa, Tatsuhiko; Ikeda, Ryuji; Takumi, Shota; Nong, Qingqing; Aoyama, Kohji; Akiyama, Shin-ichi; Keppler, Dietrich; Takeuchi, Toru

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Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2006-07-01

100

PREAI

Liu, Lichuan; Cui, Yunhai; Chung, Alfred Y.; Shitara, Yoshihisa; Sugiyama, Yuichi; Keppler, Dietrich; Pang, K. Sandy

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Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IF3.3