Not logged in.png)
Share.png)
SaveShare Save HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics
Chitre, Avantika S.; Wu, Ping; Walters, Benjamin T.; Wang, Xiangdan; Bouyssou, Alexandre; Du, Xiangnan; Lehoux, Isabelle; Fong, Rina; Arata, Alisa; Chan, Joyce; Wang, Die; Franke, Yvonne; Grogan, Jane L.; Mellman, Ira; Comps-Agrar, Laetitia; Wang, Weiru Share Save The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated anti-tumor immunityLim, Junghyun; Rodriguez, Ryan; Williams, Katherine; Silva, John; Gutierrez, Alan; Tyler, Paul; Baharom, Faezzah; Sun, Tao; Lin, Eva; Martin, Scott; Kayser, Brandon; Johnston, Robert J.; Mellman, Ira; Delamarre, Lelia; West, Nathaniel; Mueller, Soren; Qu, Yan; Heger, Klaus Share Save Harnessing the gp70 endogenous retrovirus envelope protein as a universal tumor antigen for T cell therapy in miceLehar, Sophie M.; Roy, Srirupa; Liao, Lisa; Chen, Haiyin; Chen, Yongmei; Tleugabulova, Mayra Cruz; Janezic, Eric; Madjidi, Azadeh; Jones, Tamaki; Javinal, Vincent; Ziai, James; Mellman, Ira; Schartner, Jill; Shaw, Andrey Share Save Enhancing TCR T cell function in solid tumors through in vivo combinatorial screens and single-cell analysisPolyak, Dina; Fuhriman, Jessica; Susanto, Josephine; Merrell, Allyson; Simon, Mandi; Oh, Catherine; Cordazo, Andrew; DeTomasso, David; Tocchini, Carla; Sail, Vibhavari; Cui, Eric; Milush, Jeff; Gray-Rupp, Levi; Galvin, Brendan; Murriel, Christopher; Zheng, Grace; Boroughs, Angela C.; Thakore, Pratiksha; Oh, Soyoung; Freimer, Jake; Chen, Bob; Eidenschenk, Celine; Wheeler, Emily; Levine, Jacob; Huetter, Jan-Christian; Schartner, Jill; Geiger-Schuller, Katie; Rozenblatt-Rosen, Orit; Rutz, Sascha; Mellman, Ira; Haining, W. Nicholas Share Save Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulationJoshi, Sahil; Wozniak, Glenn; Gagnon, John; Vucci, Kristina; Merrell, Allyson; Simon, Mandi; Oh, Catherine; Cardozo, Andrew; DeTomaso, David; Chow, Julie; Zheng, Grace; Boroughs, Angela; Joho, Keith; Thakore, Pratiksha; Oh, Soyoung; Freimer, Jake; Cass, Ashley; Sail, Vibhavari; Tocchini, Carla; Sandoval, Marian; Liu, Andrea; Cui, Eric; Drever, Matt; Galvin, Brendan; Milush, Jeff; Gray-Rupp, Levi; Wheeler, Emily; Chen, Bob; Levine, Jacob; Eidenschenk, Celine; Schartner, Jill; Geiger-Schuller, Katie; Huetter, Jan-Christian; Rutz, Sascha; Rozenblatt-Rosen, Orit; Mellman, Ira; Haining, W. Nicholas Share Save Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancerGalsky, Matthew D.; Guan, Xiangnan; Rishipathak, Deepali; Rapaport, Aaron S.; Shehata, Hesham M.; Banchereau, Romain; Yuen, Kobe; Varfolomeev, Eugene; Hu, Ruozhen; Han, Chia -Jung; Li, Haocheng; Liang, Yuxin; Vucic, Domagoj; Wang, Li; Zhu, Jun; Yu, Haocheng; Herbst, Rebecca H.; Hajaj, Emma; Kiner, Evgeny; Bamias, Aristotelis; De Santis, Maria; Davis, Ian D.; Arranz, Jose Angel; Kikuchi, Eiji; Bernhard, Sandrine; Williams, Patrick; Lee, Chooi; Mellman, Ira; Sanjabi, Shomyseh; Johnston, Robert; Black, Peter C.; Grande, Enrique; Mariathasan, Sanjeev Share Save Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavageTong, Ann-Jay; Leylek, Rebecca; Herzner, Anna-Maria; Rigas, Diamanda; Wichner, Sara; Blanchette, Craig; Tahtinen, Siri; Kemball, Christopher C.; Mellman, Ira; Haley, Benjamin; Freund, Emily C.; Delamarre, Lelia Share Save Share Save Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumorsCastiglioni, Alessandra; Yang, Yagai; Williams, Katherine; Gogineni, Alvin; Lane, Ryan S.; Wang, Amber W.; Shyer, Justin A.; Zhang, Zhe; Mittman, Stephanie; Gutierrez, Alan; Astarita, Jillian L.; Thai, Minh; Hung, Jeffrey; Yang, Yeqing Angela; Pourmohamad, Tony; Himmels, Patricia; De Simone, Marco; Elstrott, Justin; Capietto, Aude-Helene; Cubas, Rafael; Modrusan, Zora; Sandoval, Wendy; Ziai, James; Gould, Stephen E.; Fu, Wenxian; Wang, Yulei; Koerber, James T.; Sanjabi, Shomyseh; Mellman, Ira; Turley, Shannon J.; Mueller, Soeren Share Save Share Save Anti-TIGIT antibody tiragolumab leverages myeloid cells and regulatory T cells to improve PD-L1 checkpoint blockadePatil, Namrata S.; Srivats, Shyam; Choi, Yoonha; Guan, Xiangnan; Nabet, Barzin; McGinnis, Lisa; Chiang, Eugene; Dunkle, Alexis; O'Gorman, Bill; Chang, Patrick S.; Hu, Ruozhen; Silva, John; Han, Joy; Au-Yeung, Amelia; Takahashi, Chikara; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Meng, Raymond; Mariathasan, Sanjeev; Johnston, Robert; Shames, David S. Share Save CD8+T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapyHuseni, Mahrukh A.; Wang, Lifen; Klementowicz, Joanna E.; Yuen, Kobe; Breart, Beatrice; Orr, Christine; Liu, Li-fen; Li, Yijin; Gupta, Vinita; Li, Congfen; Rishipathak, Deepali; Peng, Jing; Senbabaoglu, Yasin; Modrusan, Zora; Keerthivasan, Shilpa; Madireddi, Shravan; Chen, Ying-Jiun; Fraser, Eleanor J.; Leng, Ning; Hamidi, Habib; Koeppen, Hartmut; Ziai, James; Hashimoto, Kenji; Fasso, Marcella; Williams, Patrick; McDermott, David F.; Rosenberg, Jonathan E.; Powles, Thomas; Emens, Leisha A.; Hegde, Priti S.; Mellman, Ira; Turley, Shannon J.; Wilson, Mark S.; Mariathasan, Sanjeev; Molinero, Luciana; Merchant, Mark; West, Nathaniel R. Share Save Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentationGuttman, Ofer; Le Thomas, Adrien; Marsters, Scot; Lawrence, David A.; Gutgesell, Lauren; Zuazo-Gaztelu, Iratxe; Harnoss, Jonathan M.; Haag, Simone M.; Murthy, Aditya; Strasser, Geraldine; Modrusan, Zora; Wu, Thomas; Mellman, Ira; Ashkenazi, Avi Share Save Share Save Share Save IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccinesTahtinen, Siri; Tong, Ann-Jay; Himmels, Patricia; Oh, Jaehak; Paler-Martinez, Andres; Kim, Leesun; Wichner, Sara; Oei, Yoko; McCarron, Mark J.; Freund, Emily C.; Amir, Zhainib Adel; de la Cruz, Cecile C.; Haley, Benjamin; Blanchette, Craig; Schartner, Jill M.; Ye, Weilan; Yadav, Mahesh; Sahin, Ugur; Delamarre, Lelia; Mellman, Ira Share Save Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunityda Silva, Rosa Barreira; Leitao, Ricardo M.; Pechuan-Jorge, Ximo; Werneke, Scott; Oeh, Jason; Javinal, Vincent; Wang, Yingyun; Phung, Wilson; Everett, Christine; Nonomiya, Jim; Arnott, David; Lu, Cheng; Hsiao, Yi-Chun; Koerber, James T.; Hotzel, Isidro; Ziai, James; Modrusan, Zora; Pillow, Thomas H.; Roose-Girma, Merone; Schartner, Jill M.; Merchant, Mark; Rutz, Sascha; Eidenschenk, Celine; Mellman, Ira; Albert, Matthew L. Share Save Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responsesBanta, Karl L.; Xu, Xiaozheng; Chitre, Avantika S.; Au-Yeung, Amelia; Takahashi, Chikara; O'Gorman, William E.; Wu, Thomas D.; Mittman, Stephanie; Cubas, Rafael; Comps-Agrar, Laetitia; Fulzele, Amit; Bennett, Eric J.; Grogan, Jane L.; Hui, Enfu; Chiang, Eugene Y.; Mellman, Ira Share Save 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}