Not logged inPARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation (vol 43, pg 2929,2024)
Kar, Pulak; Chatrin, Chatrin; Dukic, Nina; Suyari, Osamu; Schuller, Marion; Zhu, Kang; Prokhorova, Evgeniia; Bigot, Nicolas; Baretic, Domagoj; Ahel, Juraj; Elsborg, Jonas Damgaard; Nielsen, Michael L.; Clausen, Tim; Huet, Sebastien; Niepel, Mario; Sanyal, Sumana; Ahel, Dragana; Smith, Rebecca; Ahel, Ivan .png)
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SaveThe PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical modelsNiepel, M.; Vasbinder, M.; Molina, J.; Gui, B.; Kunii, K.; Blackwell, D.; Mateer, E.; Mo, J.; Coutts, C.; Perl, N.; Kuplast-Barr, K.; Church, W.; Majer, C.; Schenkel, L. B.; Swinger, K.; Abo, R.; Bamberg, E.; Ren, Y.; Utley, L.; Wigle, T.; Reik, C.; Lu, A.; Cheung, A.; Minissale, E.; Mceachern, K.; Richon, V.; Parasuraman, S.; Kuntz, K.; Keilhack, H. Share Save Multiplexed and reproducible high content screening of live and fixed cells using Dye DropMills, Caitlin E.; Subramanian, Kartik; Hafner, Marc; Niepel, Mario; Gerosa, Luca; Chung, Mirra; Victor, Chiara; Gaudio, Benjamin; Yapp, Clarence; Nirmal, Ajit J.; Clark, Nicholas; Sorger, Peter K. Share Save ADP-ribosyltransferases, an update on function and nomenclatureLuscher, Bernhard; Ahel, Ivan; Altmeyer, Matthias; Ashworth, Alan; Bai, Peter; Chang, Paul; Cohen, Michael; Corda, Daniela; Dantzer, Francoise; Daugherty, Matthew D.; Dawson, Ted M.; Dawson, Valina L.; Deindl, Sebastian; Fehr, Anthony R.; Feijs, Karla L. H.; Filippov, Dmitri V.; Gagne, Jean-Philippe; Grimaldi, Giovanna; Guettler, Sebastian; Hoch, Nicolas C.; Hottiger, Michael O.; Korn, Patricia; Kraus, W. Lee; Ladurner, Andreas; Lehtio, Lari; Leung, Anthony K. L.; Lord, Christopher J.; Mangerich, Aswin; Matic, Ivan; Matthews, Jason; Moldovan, George-Lucian; Moss, Joel; Natoli, Gioacchino; Nielsen, Michael L.; Niepel, Mario; Nolte, Friedrich; Pascal, John; Paschal, Bryce M.; Pawlowski, Krzysztof; Poirier, Guy G.; Smith, Susan; Timinszky, Gyula; Wang, Zhao-Qi; Yelamos, Jose; Yu, Xiaochun; Zaja, Roko; Ziegler, Mathias Share Save A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explantsSchenkel, Laurie B.; Molina, Jennifer R.; Swinger, Kerren K.; Abo, Ryan; Blackwell, Danielle J.; Lu, Alvin Z.; Cheung, Anne E.; Church, W. David; Kunii, Kaiko; Kuplast-Barr, Kristy G.; Majer, Christina R.; Minissale, Elena; Mo, Jan-Rung; Niepel, Mario; Reik, Christopher; Ren, Yue; Vasbinder, Melissa M.; Wigle, Tim J.; Richon, Victoria M.; Keilhack, Heike; Kuntz, Kevin W. Share Save A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explantsSchenkel, Laurie; Molina, Jennifer; Swinger, Kerren; Abo, Ryan; Blackwell, Danielle; Cheung, Anne; Church, William; Kuplast-Barr, Kristy; Lu, Alvin; Minissale, Elena; Niepel, Mario; Vasbinder, Melissa; Wigle, Tim; Richon, Victoria; Keilhack, Heike; Kuntz, Kevin Share Save PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition leads to tumor regressionGozgit, Joseph M.; Vasbinder, Melissa M.; Abo, Ryan P.; Kunii, Kaiko; Kuplast-Barr, Kristy G.; Gui, Bin; Lu, Alvin Z.; Swinger, Kerren K.; Wigle, Tim J.; Blackwell, Danielle J.; Majer, Christina R.; Ren, Yue; Niepel, Mario; Varsamis, Zacharenia A.; Nayak, Sunaina P.; Bamberg, Ellen; Mo, Jan-Rung; Church, William; Song, Jeff; Utley, Luke; Rao, Patricia E.; Mitchison, Timothy J.; Kuntz, Kevin W.; Richon, Victoria M.; Keilhack, Heike Share Save A bespoke screening platform to study mono(ADP-ribosylation)Wigle, Tim J.; Blackwell, Danielle J.; Schenkel, Laurie B.; Ren, Yue; Church, William D.; Desai, Hetvi J.; Swinger, Kerren K.; Santospago, Andrew G.; Majer, Christina R.; Lu, Alvin Z.; Niepel, Mario; Perl, Nicholas R.; Vasbinder, Melissa M.; Keilhack, Heike; Kuntz, Kevin W. Share Save RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathwaysVasbinder, Melissa M.; Gozgit, Joseph M.; Abo, Ryan P.; Kunii, Kaiko; Kuplast-Barr, Kristy G.; Gui, Bin; Lu, Alvin Z.; Swinger, Kerren K.; Wigle, Tim J.; Blackwell, Danielle J.; Majer, Christina R.; Ren, Yue; Niepel, Mario; Varsamis, Zacharenia A.; Nayak, Sunaina P.; Bamberg, Ellen; Mo, Jan-Rung; Church, W. David; Song, Jeff; Utley, Luke; Rao, Patricia E.; Mitchison, Timothy J.; Kuntz, Kevin W.; Richon, Victoria M.; Keilhack, Heike Share Save Share Save In Vitro and Cellular Probes to Study PARP Enzyme Target EngagementWigle, Tim J.; Blackwell, Danielle J.; Schenkel, Laurie B.; Ren, Yue; Church, W. David; Desai, Hetvi J.; Swinger, Kerren K.; Santospago, Andrew G.; Majer, Christina R.; Lu, Alvin Z.; Niepel, Mario; Perl, Nicholas R.; Vasbinder, Melissa M.; Keilhack, Heike; Kuntz, Kevin W. Share Save Share Save Share Save Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer CellsChopra, Sameer S.; Jenney, Anne; Palmer, Adam; Niepel, Mario; Chung, Mirra; Mills, Caitlin; Sivakumaren, Sindhu Carmen; Liu, Qingsong; Chen, Jia-Yun; Yapp, Clarence; Asara, John M.; Gray, Nathanael S.; Sorger, Peter K. Share Save Torin2 and related analogs exploit replicative and checkpoint vulnerabilities to induce death of triple negative breast cancer cellsChopra, Sameer S.; Jenney, Annie; Palmer, Adam; Niepel, Mario; Chung, Mirra; Mills, Caitlin; Sivakumaren, Sindhu Carmen; Liu, Qingsong; Chen, Jia-Yun; Yapp, Clarence; Gray, Nathanael S.; Sorger, Peter K. Share Save Share Save A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell LinesNiepel, Mario; Hafner, Marc; Mills, Caitlin E.; Subramanian, Kartik; Williams, Elizabeth H.; Chung, Mirra; Gaudio, Benjamin; Barrette, Anne Marie; Stern, Alan D.; Hu, Bin; Korkola, James E.; Gray, Joe W.; Birtwistle, Marc R.; Heiser, Laura M.; Sorger, Peter K.; Shamu, Caroline E.; Jayaraman, Gomathi; Azeloglu, Evren U.; Iyengar, Ravi; Sobie, Eric A.; Mills, Gordon B.; Liby, Tiera; Jaffe, Jacob D.; Alimova, Maria; Davison, Desiree; Lu, Xiaodong; Golub, Todd R.; Subramanian, Aravind; Shelley, Brandon; Svendsen, Clive N.; Ma'ayan, Avi; Medvedovic, Mario Share Save Share Save The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to PerturbationsKeenan, Alexandra B.; Jenkins, Sherry L.; Jagodnik, Kathleen M.; Koplev, Simon; He, Edward; Torre, Denis; Wang, Zichen; Dohlman, Anders B.; Silverstein, Moshe C.; Lachmann, Alexander; Kuleshov, Maxim V.; Ma'ayan, Avi; Stathias, Vasileios; Terryn, Raymond; Cooper, Daniel; Forlin, Michele; Koleti, Amar; Vidovic, Dusica; Chung, Caty; Schurer, Stephan C.; Vasiliauskas, Jouzas; Pilarczyk, Marcin; Shamsaei, Behrouz; Fazel, Mehdi; Ren, Yan; Niu, Wen; Clark, Nicholas A.; White, Shana; Mahi, Naim; Zhang, Lixia; Kouril, Michal; Reichard, John F.; Sivaganesan, Siva; Medvedovic, Mario; Meller, Jaroslaw; Koch, Rick J.; Birtwistle, Marc R.; Iyengar, Ravi; Sobie, Eric A.; Azeloglu, Evren U.; Kaye, Julia; Osterloh, Jeannette; Haston, Kelly; Kalra, Jaslin; Finkbiener, Steve; Li, Jonathan; Milani, Pamela; Adam, Miriam; Escalante-Chong, Renan; Sachs, Karen; Lenail, Alex; Ramamoorthy, Divya; Fraenkel, Ernest; Daigle, Gavin; Hussain, Uzma; Coye, Alyssa; Rothstein, Jeffrey; Sareen, Dhruv; Ornelas, Loren; Banuelos, Maria; Mandefro, Berhan; Ho, Ritchie; Svendsen, Clive N.; Lim, Ryan G.; Casale, Malcolm S.; Thompson, Terri G.; Wu, Jie; Thompson, Leslie M.; Dardov, Victoria; Venkatraman, Vidya; Matlock, Andrea; Van Eyk, Jennifer E.; Jaffe, Jacob D.; Papanastasiou, Malvina; Subramanian, Aravind; Golub, Todd R.; Erickson, Sean D.; Fallahi-Sichani, Mohammad; Hafner, Marc; Gray, Nathanael S.; Lin, Jia-Ren; Mills, Caitlin E.; Muhlich, Jeremy L.; Niepel, Mario; Shamu, Caroline E.; Williams, Elizabeth H.; Wrobel, David; Sorger, Peter K.; Heiser, Laura M.; Gray, Joe W.; Korkola, James E.; Mills, Gordon B.; LaBarge, Mark; Feiler, Heidi S.; Dane, Mark A.; Bucher, Elmar; Nederlof, Michel; Sudar, Damir; Gross, Sean; Kilburn, David F.; Smith, Rebecca; Devlin, Kaylyn; Margolis, Ron; Derr, Leslie; Lee, Albert; Pillai, Ajay Share Save Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profilingNiepel, Mario; Hafner, Marc; Duan, Qiaonan; Wang, Zichen; Paull, Evan O.; Chung, Mirra; Lu, Xiaodong; Stuart, Joshua M.; Golub, Todd R.; Subramanian, Aravind; Ma'ayan, Avi; Sorger, Peter K. 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