Not logged inArticle γ-Secretase exosites as targets for substrate-selective lowering of Aβ generation
Maruyama, Riki; Fukumori, Akio; Funamoto, Satoru; Okada, Ken; Akamine, Shoshin; Yanagida, Kanta; Shinohara, Mitsuru; Sato, Naoyuki; Okochi, Masayasu; Kudo, Takashi; Steiner, Harald .png)
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Saveγ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds (vol 17, 49, 2025)Trambauer, J; Sarmiento, RMR; Garringer, HJ; Salbaum, K; Pedro, LD; Crusius, D; Vidal, R; Ghetti, B; Paquet, D; Baumann, K; Lindemann, L; Steiner, H Share Save γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compoundsTrambauer, Johannes; Sarmiento, Rosa Maria Rodriguez; Garringer, Holly J.; Salbaum, Katja; Pedro, Liliana D.; Crusius, Dennis; Vidal, Ruben; Ghetti, Bernardino; Paquet, Dominik; Baumann, Karlheinz; Lindemann, Lothar; Steiner, Harald Share Save Share Save Share Save Share Save Membrane lipid remodeling modulates γ-secretase processivityDawkins, Edgar; Derks, Rico J. E.; Schifferer, Martina; Trambauer, Johannes; Winkler, Edith; Simons, Mikael; Paquet, Dominik; Giera, Martin; Kamp, Frits; Steiner, Harald Share Save Share Save Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activityGuener, Goekhan; Assfalg, Marlene; Zhao, Kai; Dreyer, Tobias; Lahiri, Shibojyoti; Lo, Yun; Slivinschi, Bianca Ionela; Imhof, Axel; Jocher, Georg; Strohm, Laura; Behrends, Christian; Langosch, Dieter; Bronger, Holger; Nimsky, Christopher; Bartsch, Joerg W.; Riddell, Stanley R.; Steiner, Harald; Lichtenthaler, Stefan F. Share Save Share Save Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen AnalogueSaretz, Stefan; Basset, Gabriele; Useini, Liridona; Laube, Markus; Pietzsch, Jens; Draca, Dijana; Maksimovic-Ivanic, Danijela; Trambauer, Johannes; Steiner, Harald; Hey-Hawkins, Evamarie Share Save Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque depositionColombo, Alessio Vittorio; Sadler, Rebecca Katie; Llovera, Gemma; Singh, Vikramjeet; Roth, Stefan; Heindl, Steffanie; Monasor, Laura Sebastian; Verhoeven, Aswin; Peters, Finn; Parhizkar, Samira; Kamp, Frits; de Aguero, Mercedes Gomez; MacPherson, Andrew J.; Winkler, Edith; Herms, Jochen; Benakis, Corinne; Dichgans, Martin; Steiner, Harald; Giera, Martin; Haass, Christian; Tahirovic, Sabina; Liesz, Arthur Share Save Share Save Share Save Share Save Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effectsVoeglein, Jonathan; Willem, Michael; Trambauer, Johannes; Schoenecker, Sonja; Dieterich, Marianne; Biskup, Saskia; Giudici, Camilla; Utz, Kathrin; Oberstein, Timo; Brendel, Matthias; Rominger, Axel; Danek, Adrian; Steiner, Harald; Haass, Christian; Levin, Johannes Share Save Share Save Share Save Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase CleavageGoetz, Alexander; Mylonas, Nadine; Hoegel, Philipp; Silber, Mara; Heinel, Hannes; Menig, Simon; Vogel, Alexander; Feyrer, Hannes; Huster, Daniel; Luy, Burkhard; Langosch, Dieter; Scharnagl, Christina; Muhle-Goll, Claudia; Kamp, Frits; Steiner, Harald Share Save Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's diseaseVoeglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M.; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R.; Masters, Colin L.; Goate, Alison; Buckles, Virginia; Fox, Nick; Rossor, Martin; Chrem, Patricio; Allegri, Ricardo; Ringman, John M.; Hoeglinger, Guenter; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C.; Bateman, Randall J.; Danek, Adrian; Levin, Johannes Share Save 
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