James C. Whisstock - Publications, H-index & Citations

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James C. Whisstock

monash university

78H-index

396Paper Count

2.2WCitation Count

Published Papers 166

Publication Date

Helicobacter pylori induces the production of interleukin-37 to promote broad immunosuppression and enhance colonization

Gut Microbes

IF11

2026-02-14

OAAI

Rishi Pathirana; Nagaja Capitani; Christopher McCrory; Chiara Della Bella; Isabella Stuart; William Gilmore; Natalie J. Bitto; Michelle D. Tate; Ella L. Johnston; Lauren Zavan; Steven Batinovic; John Pedersen; Sam Norden; Hassan Chaudhry; Richard L. Ferrero; Tony M. Korman; David Greening; Neil O’Brien-Simpson; Andrew M. Ellisdon; James C. Whisstock; Steve Petrovski; Renea A. Taylor; Mario M. D’Elios; Claudia A. Nold-Petry; Marcel F. Nold; Maria Kaparakis-Liaskos

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Characteristics of T-Cells Expressing IL-37 and Its Receptors in Inflammatory Bowel Disease

International Journal of Molecular Sciences

IF4.9

2026-02-05

OAAI

Indiana Zorkau; Peter J. Eggenhuizen; Marie Lee; Steven X. Cho; Kylie R. James; Andrew M. Ellisdon; James C. Whisstock; Joshua D. Ooi; Marcel F. Nold; Claudia A. Nold-Petry; Rimma Goldberg

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Structural basis for uPAR binding to an antibody developed for targeted cancer therapy. Mechanistic insights into flexibility, ligand recognition, and molecular imaging

Protein Science

IF5.2

2026-01-23

OAAI

Rex F. Anane; Anni Kumari; Hari Venugopal; Sylvain Trépout; James C. Whisstock; Lars H. Engelholm; Ruby H. P. Law; Michael Ploug

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Patients with Waldenström macroglobulinemia have impaired platelet and coagulation function

BLOOD ADVANCES

IF7.1

2024-10-25

OAAI

Brysland, Simone A.; Talaulikar, Dipti; Hicks, Sarah M.; Hearn, James I.; Ali, Sidra A.; Maqbool, Muhammad Gohar; Mokoonlall, Mridula; Bhoopalan, Vijay; Kaur, Amandeep; Thong, Yee Lin; Andrews, Robert K.; Whisstock, James C.; Crispin, Philip J.; Gardiner, Elizabeth E.

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Macrocyclic Inhibitors Targeting the Prime Site of the Fibrinolytic Serine Protease Plasmin

CHEMMEDCHEM

IF3.4

2024-09-30

OAAI

Wiedemeyer, Simon J. A.; Wu, Guojie; Lang-Henkel, Heike; Whisstock, James C.; Law, Ruby H. P.; Steinmetzer, Torsten

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Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2024-01-01

OAAI

Cramer, Dario A. T.; Yin, Victor; Caval, Tomislav; Franc, Vojtech; Yu, Dingyi; Wu, Guojie; Lloyd, Gordon; Langendorf, Christopher; Whisstock, James C.; Law, Ruby H. P.; Heck, Albert J. R.

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Fragment-based and structure-guided discovery of perforin inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-12-01

OAAI

Jose, Jiney; Law, Ruby H. P.; Leung, Eleanor W. W.; Wai, Dorothy C. C.; Akhlaghi, Hedieh; Chandrashekaran, Indu R.; Caradoc-Davies, Tom T.; Voskoboinik, Ilia; Feutrill, John; Middlemiss, David; Jeevarajah, Devadharshini; Bashtannyk-Puhalovich, Tanya; Giddens, Anna C.; Lee, Tet Woo; Jamieson, Stephen M. F.; Trapani, Joseph A.; Whisstock, James C.; Spicer, Julie A.; Norton, Raymond S.

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OpenFIBSEM: A universal API for FIBSEM control

JOURNAL OF STRUCTURAL BIOLOGY

IF5.1

2023-09-01

OAAI

Cleeve, Patrick; Dierickx, David; Naegele, Lucile; Kannachel, Rohit; Burne, Lachlan; Buckley, Genevieve; Gorelick, Sergey; Whisstock, James C.; de Marco, Alex

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Design of Polarity-Dependent Immunosensors Based on the Structural Analysis of Engineered Antibodies

ACS CHEMICAL BIOLOGY

IF3.8

2023-07-13

PREAI

Islam, Jiaul; Conroy, Paul; Fercher, Christian; Kim, Mijin; Yaari, Zvi; Jones, Martina; Bell, Toby D. M.; Caradoc-Davies, Tom; Law, Ruby; Whisstock, James; Heller, Daniel; Mahler, Stephen; Corrie, Simon

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Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Bird, CH; Sun, J; Ung, K; Karambalis, D; Whisstock, JC; Trapani, JA; Bird, PI

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Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors

CHEMMEDCHEM

IF3.4

2023-02-07

OAAI

Wiedemeyer, Simon J. A.; Wu, Guojie; Pham, T. L. Phuong; Lang-Henkel, Heike; Perez Urzua, Benjamin; Whisstock, James C.; Law, Ruby H. P.; Steinmetzer, Torsten

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The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

COMMUNICATIONS BIOLOGY

IF5.1

2023-01-13

OAAI

Bayly-Jones, Charles; Ho, Bill H. T.; Lau, Corinna; Leung, Eleanor W. W.; D'Andrea, Laura; Lupton, Christopher J. J.; Ekkel, Susan M. M.; Venugopal, Hariprasad; Whisstock, James C. C.; Mollnes, Tom E. E.; Spicer, Bradley A. A.; Dunstone, Michelle A. A.

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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

NATURE COMMUNICATIONS

IF15.7

2022-10-19

OAAI

Bayly-Jones, Charles; Lupton, Christopher J.; Fritz, Claudia; Venugopal, Hariprasad; Ramsbeck, Daniel; Wermann, Michael; Jaeger, Christian; de Marco, Alex; Schilling, Stephan; Schlenzig, Dagmar; Whisstock, James C.

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Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-07-21

OAAI

Chang, Yong-Gang; Lupton, Christopher J.; Bayly-Jones, Charles; Keen, Alastair C.; D'Andrea, Laura; Lucato, Christina M.; Steele, Joel R.; Venugopal, Hari; Schittenhelm, Ralf B.; Whisstock, James C.; Halls, Michelle L.; Ellisdon, Andrew M.

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Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation

IMMUNOLOGY AND CELL BIOLOGY

IF3

2022-05-12

OAAI

Ebrahimnezhaddarzi, Salimeh; Bird, Catherina H.; Allison, Cody C.; Tuipulotu, Daniel E.; Kostoulias, Xenia; Macri, Christophe; Stutz, Michael D.; Abraham, Gilu; Kaiserman, Dion; Pang, Siew Siew; Man, Si Ming; Mintern, Justine D.; Naderer, Thomas; Peleg, Anton Y.; Pellegrini, Marc; Whisstock, James C.; Bird, Phillip, I

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Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential

CELL CHEMICAL BIOLOGY

IF7.2

2022-04-01

OAAI

Bujotzek, Alexander; Tiefenthaler, Georg; Lariviere, Laurent; D'Andrea, Laura; Marquez, Elsa A.; Rudloff, Ina; Cho, Steven X.; Deen, Nadia S.; Richter, Wolfgang; Regenass-Lechner, Franziska; Poehler, Alexander; Whisstock, James C.; Sydow-Andersen, Jasmin; Reiser, Xaver; Schuster, Sabine; Neubauer, Jeannette; Hoepfl, Sebastian; Richter, Kirsten; Nold, Marcel F.; Nold-Petry, Claudia A.; Schumacher, Felix; Ellisdon, Andrew M.

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Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2

FEBS JOURNAL

IF4.2

2022-02-01

OAAI

Bakopoulos, Daniel; Whisstock, James C.; Warr, Coral G.; Johnson, Travis K.

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The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2021-12-09

PREAI

Lupton, Christopher J.; Bayly-Jones, Charles; D'Andrea, Laura; Huang, Cheng; Schittenhelm, Ralf B.; Venugopal, Hari; Whisstock, James C.; Halls, Michelle L.; Ellisdon, Andrew M.

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Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1

SCIENCE SIGNALING

IF6.6

2021-05-04

OAAI

D'Andrea, Laura; Lucato, Christina M.; Marquez, Elsa A.; Chang, Yong-Gang; Civciristov, Srgjan; Mastos, Chantel; Lupton, Christopher J.; Huang, Cheng; Elmlund, Hans; Schittenhelm, Ralf B.; Mitchell, Christina A.; Whisstock, James C.; Halls, Michelle L.; Ellisdon, Andrew M.

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Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

NATURE COMMUNICATIONS

IF15.7

2020-11-13

OAAI

Cho, Steven X.; Rudloff, Ina; Lao, Jason C.; Pang, Merrin A.; Goldberg, Rimma; Bui, Christine B.; McLean, Catriona A.; Stock, Magdalena; Klassert, Tilman E.; Slevogt, Hortense; Mangan, Niamh E.; Cheng, Wei; Fischer, Doris; Gfroerer, Stefan; Sandhu, Manjeet K.; Ngo, Devi; Bujotzek, Alexander; Lariviere, Laurent; Schumacher, Felix; Tiefenthaler, Georg; Beker, Friederike; Collins, Clare; Kamlin, C. Omar F.; Konig, Kai; Malhotra, Atul; Tan, Kenneth; Theda, Christiane; Veldman, Alex; Ellisdon, Andrew M.; Whisstock, James C.; Berger, Philip J.; Nold-Petry, Claudia A.; Nold, Marcel F.

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Research Directions