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Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis Clausen, Thomas Mandel; Weiss, Ryan J.; Tremblay, Jacob R.; Kellman, Benjamin P.; Coker, Joanna; Dworkin, Leo A.; Rodriguez, Jessica P.; Chang, Ivy M.; Chen, Timothy; Padala, Vikram; Karlsson, Richard; Song, Hyemin; Peck, Kristina L.; Ogawa, Satoshi; Sandoval, Daniel R.; Joshi, Hiren J.; Wang, Gaowei; Ferguson, L. Paige; Bhalerao, Nikita; Moores, Allison; Reya, Tannishtha; Sander, Maike; Caffrey, Thomas C.; Grem, Jean L.; Aicher, Alexandra; Heeschen, Christopher; Le, Dzung; Lewis, Nathan E.; Hollingsworth, Michael A.; Grandgenett, Paul M.; Bellis, Susan L.; Miller, Rebecca L.; Fuster, Mark M.; Dawson, David W.; Engle, Dannielle D.; Esko, Jeffrey D. Share Save
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Gasdermin C promotes Stemness and Immune Evasion in Pancreatic Cancer via Pyroptosis-Independent Mechanism Wu, Renfei; Li, Jingwei; Aicher, Alexandra; Jiang, Ke; Tondi, Serena; Dong, Shuang; Zheng, Quan; Tang, Siqi; Chen, Minchun; Guo, Zhenyang; Sabanovic, Berina; Ananthanarayanan, Preeta; Jiang, Lingxi; Sapino, Anna; Wen, Chenlei; Fu, Da; Shen, Baiyong; Heeschen, Christopher Share Save
CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches Tang, Jiajia; Zheng, Quan; Wang, Qi; Zhao, Yaru; Ananthanarayanan, Preeta; Reina, Chiara; Sabanovic, Berina; Jiang, Ke; Yang, Ming-Hsin; Meny, Clara Csilla; Wang, Huimin; Agerbaek, Mette O.; Clausen, Thomas Mandel; Gustavsson, Tobias; Wen, Chenlei; Borghi, Felice; Mellano, Alfredo; Fenocchio, Elisabetta; Gregorc, Vanesa; Sapino, Anna; Theander, Thor G.; Fu, Da; Aicher, Alexandra; Salanti, Ali; Shen, Baiyong; Heeschen, Christopher Share Save
Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells Mascaraque, Marta; Courtois, Sarah; Royo-Garcia, Alba; Barneda, David; Stoian, Andrei M.; Villaoslada, Isabel; Espiau-Romera, Pilar; Bokil, Ansooya; Cano-Galiano, Andres; Jagust, Petra; Heeschen, Christopher; Sancho, Patricia Share Save
A Self-Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer Liu, Ying; Okesola, Babatunde O.; de la Pena, David Osuna; Li, Weiqi; Lin, Meng-Lay; Trabulo, Sara; Tatari, Marianthi; Lawlor, Rita T.; Scarpa, Aldo; Wang, Wen; Knight, Martin; Loessner, Daniela; Heeschen, Christopher; Mata, Alvaro; Pearce, Oliver M. T. Share Save
Disulfiram and its metal complexes reversed hypoxia induced stemness and synergized with first line drugs in primary patient derived pancreatic ductal adenocarcinoma cells Small, Benjamin J.; Nkeonye, Ogechi; Kannappan, Vinodh; Kumarasamy, Shalini; Butcher, Kate; Azar, Karim; Rajendran, Gowtham; Lakshmanan, Yoshitha Lakshmanan; Morris, Mark; Heeschen, Christopher; Wang, Yaohe; Wang, Weiguang Share Save
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity Zheng, Quan; Tang, Jiajia; Aicher, Alexandra; Bou Kheir, Tony; Sabanovic, Berina; Ananthanarayanan, Preeta; Reina, Chiara; Chen, Minchun; Gu, Jian-Min; He, Bin; Alcala, Sonia; Behrens, Diana; Lawlo, Rita T.; Scarpa, Aldo; Hidalgo, Manuel; Sainz Jr, Bruno; Sancho, Patricia; Heeschen, Christopher Share Save
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Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice Skeltved, Nanna; Nordmaj, Mie A. A.; Berendtsen, Nicolai T. T.; Dagil, Robert; Stormer, Emilie M. R.; Al-Nakouzi, Nader; Jiang, Ke; Aicher, Alexandra; Heeschen, Christopher; Gustavsson, Tobias; Choudhary, Swati; Gogenur, Ismail; Christensen, Jan P. P.; Theander, Thor G. G.; Daugaard, Mads; Salanti, Ali; Nielsen, Morten A. A. Share Save
Identification of membrane-expressed CAPRIN-1 as a novel and universal cancer target and generation of a therapeutic anti-CAPRIN-1 antibody TRK-950 Okano, Fumiyoshi; Saito, Takanori; Minamida, Yoshitaka; Kobayashi, Shinichi; Ido, Takayoshi; Miyauchi, Yasushi; Wasai, Ukei; Ke, Jiang; Aicher, Alexandra; Heeschen, Christopher; Yonehara, Tetsu Share Save
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