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SaveShare Save Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results
Crespo-Garcia, Sergio; Fournier, Frederik; Diaz-Marin, Roberto; Klier, Sharon; Ragusa, Derek; Masaki, Lauren; Cagnone, Gael; Blot, Guillaume; Hafiane, Ikhlas; Dejda, Agnieszka; Rizk, Rana; Juneau, Rachel; Buscarlet, Manuel; Chorfi, Sarah; Patel, Priyanka; Beltran, Pedro J.; Joyal, Jean-Sebastien; Rezende, Flavio A.; Hata, Masayuki; Nguyen, Alex; Sullivan, Lynne; Damiano, Jason; Wilson, Ariel M.; Mallette, Frederick A.; David, Nathaniel E.; Ghosh, Anirvan; Tsuruda, Pamela R.; Dananberg, Jamie; Sapieha, Przemyslaw Share Save HIF1α-dependent hypoxia response in myeloid cells requires IRE1αMawambo, Gaelle; Oubaha, Malika; Ichiyama, Yusuke; Blot, Guillaume; Crespo-Garcia, Sergio; Dejda, Agnieszka; Binet, Francois; Diaz-Marin, Roberto; Sawchyn, Christina; Sergeev, Mikhail; Juneau, Rachel; Kaufman, Randal J.; Affar, El Bachir; Mallette, Frederick A.; Wilson, Ariel M.; Sapieha, Przemyslaw Share Save Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later lifeHata, Masayuki; Hata, Maki; Andriessen, Elisabeth M. M. A.; Juneau, Rachel; Pilon, Frederique; Crespo-Garcia, Sergio; Diaz-Marin, Roberto; Guber, Vera; Binet, Francois; Fournier, Frederik; Buscarlet, Manuel; Grou, Caroline; Calderon, Virginie; Heckel, Emilie; Melichar, Heather J.; Joyal, Jean-Sebastien; Wilson, Ariel M.; Sapieha, Przemyslaw Share Save Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysisFournier, Frederik; Diaz-Marin, Roberto; Pilon, Frederique; Neault, Mathieu; Juneau, Rachel; Girouard, Gabrielle; Wilson, Ariel M.; Larrivee, Bruno; Mallette, Frederick A.; Crespo-Garcia, Sergio; Sapieha, Przemyslaw Share Save Share Save The Succinate Receptor SUCNR1 Resides at the Endoplasmic Reticulum and Relocates to the Plasma Membrane in Hypoxic ConditionsSanchez, Melanie; Hamel, David; Bajon, Emmanuel; Duhamel, Francois; Bhosle, Vikrant K.; Zhu, Tang; Rivera, Jose Carlos; Dabouz, Rabah; Nadeau-Vallee, Mathieu; Sitaras, Nicholas; Tremblay, David-Etienne; Omri, Samy; Habelrih, Tiffany; Rouget, Raphael; Hou, Xin; Gobeil, Fernand; Joyal, Jean-Sebastien; Sapieha, Przemyslaw; Mitchell, Grant; Ribeiro-Da-Silva, Alfredo; Nezhady, Mohammad Ali Mohammad; Chemtob, Sylvain Share Save Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferationHeckel, Emilie; Cagnone, Gael; Agnihotri, Tapan; Cakir, Bertan; Das, Ashim; Kim, Jin Sung; Kim, Nicholas; Lavoie, Genevieve; Situ, Anu; Pundir, Sheetal; Sun, Ye; Wunnemann, Florian; Pierce, Kerry A.; Dennis, Courtney; Mitchell, Grant A.; Chemtob, Sylvain; Rezende, Flavio A.; Andelfinger, Gregor; Clish, Clary B.; Roux, Philippe P.; Sapieha, Przemyslaw; Smith, Lois Eh; Joyal, Jean-Sebastien Share Save eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polaritySmith, Tracy L.; Oubaha, Malika; Cagnone, Gael; Boscher, Cecile; Kim, Jin Sung; El Bakkouri, Yassine; Zhang, Ying; Chidiac, Rony; Corriveau, Jeanne; Delisle, Chantal; Andelfinger, Gregor U.; Sapieha, Przemyslaw; Joyal, Jean-Sebastien; Gratton, Jean-Philippe Share Save Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosisUriarte, Maxime; Sen Nkwe, Nadine; Tremblay, Roch; Ahmed, Oumaima; Messmer, Clemence; Mashtalir, Nazar; Barbour, Haithem; Masclef, Louis; Voide, Marion; Viallard, Claire; Daou, Salima; Abdelhadi, Djaileb; Ronato, Daryl; Paydar, Mohammadjavad; Darracq, Anais; Boulay, Karine; Desjardins-Lecavalier, Nicolas; Sapieha, Przemyslaw; Masson, Jean-Yves; Sergeev, Mikhail; Kwok, Benjamin H.; Hulea, Laura; Mallette, Frederick A.; Milot, Eric; Larrivee, Bruno; Wurtele, Hugo; Affar, El Bachir Share Save Share Save Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammationAndriessen, Elisabeth M. M. A.; Binet, Francois; Fournier, Frederik; Hata, Masayuki; Dejda, Agnieszka; Mawambo, Gaelle; Crespo-Garcia, Sergio; Pilon, Frederique; Buscarlet, Manuel; Beauchemin, Karine; Bougie, Veronique; Cumberlidge, Garth; Wilson, Ariel M.; Bourgault, Steve; Rezende, Flavio A.; Beaulieu, Normand; Delisle, Jean-Sebastien; Sapieha, Przemyslaw Share Save Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibitionCrespo-Garcia, Sergio; Tsuruda, Pamela R.; Dejda, Agnieszka; Ryan, Rathi D.; Fournier, Frederik; Chaney, Shawnta Y.; Pilon, Frederique; Dogan, Taner; Cagnone, Gael; Patel, Priyanka; Buscarlet, Manuel; Dasgupta, Sonali; Girouard, Gabrielle; Rao, Surabhi R.; Wilson, Ariel M.; O'Brien, Robert; Juneau, Rachel; Guber, Vera; Dubrac, Alexandre; Beausejour, Christian; Armstrong, Scott; Mallette, Frederick A.; Yohn, Christopher B.; Joyal, Jean-Sebastien; Marquess, Dan; Beltran, Pedro J.; Sapieha, Przemyslaw Share Save The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte EliminationBeguier, Fanny; Housset, Michael; Roubeix, Christophe; Augustin, Sebastien; Zagar, Yvrick; Nous, Caroline; Mathis, Thibaud; Eandi, Chiara; Benchaboune, Mustapha; Drame-Maigne, Adele; Carpentier, Wassila; Chardonnet, Solenne; Touhami, Sara; Blot, Guillaume; Conart, Jean Baptiste; Charles-Messance, Hugo; Potey, Anais; Girmens, Jean-Francois; Paques, Michel; Blond, Frederic; Leveillard, Thierry; Koertvely, Elod; Roger, Jerome E.; Sahel, Jose-Alain; Sapieha, Przemyslaw; Delarasse, Cecile; Guillonneau, Xavier; Sennlaub, Florian Share Save Share Save Share Save NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathyMiloudi, Khalil; Oubaha, Malika; Menard, Catherine; Dejda, Agnieszka; Guber, Vera; Cagnone, Gael; Wilson, Ariel M.; Tetreault, Nicolas; Mawambo, Gaelle; Binet, Francois; Chidiac, Rony; Delisle, Chantal; Buscarlet, Manuel; Cerani, Agustin; Crespo-Garcia, Sergio; Bentley, Katie; Rezende, Flavio; Joyal, Jean-Sebastien; Mallette, Frederick A.; Gratton, Jean-Philippe; Larrivee, Bruno; Sapieha, Przemyslaw Share Save Share Save Share Save 
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