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TNG456 is a next-generation, brain-penetrant, MTA-cooperative PRMT5 inhibitor for the treatment of solid tumors, including glioblastoma, with MTAP loss Briggs, Kimberly; Tsai, Alice; Zhang, Minjie; Zhang, Wenhai; Huang, Alan; Andersen, Jannik; Cottrell, Kevin Share Save
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Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L.; Gong, Shanzhong; Gotur, Deepali; Gu, Lina; Huang, Alan; Lazarides, Katherine; Maxwell, John P.; McCarren, Patrick; McMillan, Brian J.; Pham, Truc, V; Simoneau, Antoine; Tsai, Alice; Whittington, Douglas A.; Wilker, Erik; Zhang, Minjie; Zhang, Wenhai Share Save
Genome-wide drug anchor screens identify CAAP1 and AKAP17A as regulators of PRMT5 inhibitor sensitivity Yoda, Satoshi; Tonini, Matthew R.; Nicolson, Hilary E.; Poleretzky, Samuel; Fenoglio, Silvia; Lombardo, Steven; Grove, Lauren; Meier, Samuel R.; Choi, Ashley; Yu, Yi; Cottrell, Kevin M.; Maxwell, John P.; Teng; Andersen, Jannik N.; Briggs, Kimberly J. Share Save
Stearoyl-CoA desaturase is a synthetic lethal target in SMAD4-deficient cancers Lu, Alvin; Fenoglio, Silvia; Wu, Hsin-Jung; Zhang, Minjie; Tsai, Alice; Ferdinez, Maria L.; Grove, Lauren; Liu, Shangtao; Wu, Edward; Choi, Ashley; Throner, Scott; Meier, Samuel; Yu, Yi; Zhang, Wenhai; Maxwell, John; Andersen, Jannik N.; Teng, Teng; Haines, Brian B.; Chen, Yingnan P. Share Save
TNG348 is synergistic with PARP inhibitors in tumor models with elevated replication stress Simoneau, Antoine; Wu, Hsin-Jung; Pratt, Charlotte; Comer, Grace; Liu, Shangtao; Meier, Samuel; Khendu, Tenzing; Choi, Ashley; Zhang, Hongxiang; Shen, Binzhang; Whittington, Douglas; Sudsakorn, Sirimas; Zhang, Wenhai; Yu, Yi; Chen, Yingnan; Haines, Brian; Crystal, Adam; Andersen, Jannik N.; Maxwell, John; Throner, Scott Share Save
LIG1 inactivation selectively inhibits growth of BRCA1 mutant cells in vitro and in vivo Martires, Lauren; Ahronian, Leanne G.; Pratt, Charlotte; Das, Nikitha; Zhang, Xiaobin; Whittington, Douglas A.; Zhang, Hongxiang; Shen, Binzhang; Come, Jon; McCarren, Patrick; Liu, Mu-Sen; Min, Chengyin; Feng, Tianshu; Jahic, Haris; Brophy, Eric; Aird, Daniel; Andersen, Jannik N.; Huang, Alan; Li, Fang; Mallender, William D.; Nicholson, Hilary E. Share Save
TNG260, a small molecule CoREST inhibitor, sensitizes STK11-mutant NSCLC to anti-PD1 immunotherapy Patel, Ayushi; Sahu, Soumyadip; Geng, Ke; Punekar, Salman; Stephens, Janaye; Deng, Jiehui; Chen, Ting; Ahronian, Leanne; Zhang, Minjie; Andersen, Jannik; Haines, Brian; Wong, Kwok-Kin Share Save
Unbiased in vitro and in vivo drug anchor screens identify mechanisms of resistance and sensitization for MTA-cooperative PRMT5 inhibitors in MTAP-deleted cancer models Lombardo, Steven; Tonini, Matthew R.; Grove, Lauren; Fenoglio, Silvia; Tepper, James; Shen, Binzhang; Stowe, Hannah; Liu, Shangtao; Meier, Samuel R.; Choi, Ashley H.; Khendu, Tenzing; Yu, Yi; Cottrell, Kevin M.; Maxwell, John P.; Andersen, Jannik N.; Huang, Alan; Briggs, Kimberly J.; Teng, Teng Share Save
Inducible activation of sgRNA libraries in tumor xenografts empowers large-scale in vivo target discovery screens Fenoglio, Silvia; Tepper, James; Grove, Lauren; Uijttewaal, Esther C. H.; Bejnood, Alborz; Yu, Yi; Wu, Hsin-Jung; Devault, Annabel; Liu, Shangtao; Shen, Binzhang; Meier, Samuel R.; Choi, Ashley H.; Khendu, Tenzing; Stowe, Hannah; Zhang, Minjie; Haines, Brian B.; Huang, Alan; Andersen, Jannik N.; Pan, Xuewen; Elling, Ulrich; Teng, Teng Share Save
TNG348, a selective USP1 inhibitor, shows strong preclinical combination activity with PARP inhibitors and other agents targeting DNA repair Simoneau, Antoine; Pratt, Charlotte; Corner, Grace; Wu, Hsin-Jung; Choi, Ashley; Khendu, Tenzing; Meier, Samuel; Yu, Yi; Liu, Shangtao; Zhang, Wenhai; Whittington, Douglas; Mallender, William; Sudsakorn, Sirimas; Chen, Yingnan; Haines, Brian; Throner, Scott; Crystal, Adam; Huang, Alan; Maxwell, John; Andersen, Jannik Share Save
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Characterization of the clinical development candidate TNG348 as a potent and selective inhibitor of USP1 for the treatment of BRCA1/2mut cancers Simoneau, Antoine; Wu, Hsin-Jung; Bandi, Madhavi; Lazarides, Katherine; Sun, Sining; Liu, Shangtao; Meier, Samuel; Choi, Ashley; Zhang, Hongxiang; Shen, Binzhang; Whittington, Douglas; Sudsakorn, Sirimas; Zhang, Wenhai; Yu, Yi; Liu, Yong; Liang, Colin; Palmieri, Michael; Chen, Yingnan; Haines, Brian; Tsai, Alice; Zhang, Minjie; Huang, Alan; Andersen, Jannik; Feng, Tianshu; Throner, Scott; Maxwell, John Share Save
Structural and evolutionary relationships among protein tyrosine phosphatase domains Andersen, JN; Mortensen, OH; Peters, GH; Drake, PG; Iversen, LF; Olsen, OH; Jansen, PG; Andersen, HS; Tonks, NK; Moller, NPH Share Save
Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer Simoneau, Antoine; Engel, Justin L.; Bandi, Madhavi; Lazarides, Katherine; Liu, Shangtao; Meier, Samuel R.; Choi, Ashley H.; Zhang, Hongxiang; Shen, Binzhang; Martires, Lauren; Gotur, Deepali; Pham, Truc, V; Li, Fang; Gu, Lina; Gong, Shanzhong; Zhang, Minjie; Wilker, Erik; Pan, Xuewen; Whittington, Douglas A.; Throner, Scott; Maxwell, John P.; Chen, Yingnan; Yu, Yi; Huang, Alan; Andersen, Jannik N.; Feng, Tianshu Share Save
VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma Shields, Julie A.; Meier, Samuel R.; Bandi, Madhavi; Mulkearns-Hubert, Erin E.; Hajdari, Nicole; Ferdinez, Maria Dam; Engel, Justin L.; Silver, Daniel J.; Shen, Binzhang; Zhang, Wenhai; Hubert, Christopher G.; Mitchell, Kelly; Shakya, Sajina; Zhao, Shan-Chuan; Bejnood, Alborz; Zhang, Minjie; Sjin, Robert Tjin Tham; Wilker, Erik; Lathia, Justin D.; Andersen, Jannik N.; Chen, Yingnan; Li, Fang; Weber, Barbara; Huang, Alan; Emmanuel, Natasha Share Save
CRISPR screens identify sensitizers to trametinib in KRAS mutant cancer cell lines Fenoglio, Silvia; Cristo, Aileen M.; Tepper, James; Teng, Teng; Meier, Samuel R.; Choi, Ashley; Zhang, Hongxiang; Zhao, Shan-Chuan; Liu, Shangtao; Ahronian, Leanne G.; Aird, Daniel; Das, Nikitha M.; Yu, Yi; Sjin, Robert Tjin Tham; Andersen, Jannik N.; Huang, Alan; Li, Fang; Pan, Xuewen Share Save
Loss of HS2ST1 cooperates with MAPK inhibition to impair growth of mesenchymal KRAS mutant NSCLC Ahronian, Leanne G.; Fenoglio, Silvia; Das, Nikitha; Aird, Daniel; Guerin, David; Whittington, Douglas; Jahic, Haris; Brophy, Erin; McCarren, Patrick; McMillan, Brian; Tepper, James; Mentzer, Michaela; Li, Fang; Zhang, Hongxiang; Pan, Xuewen; Maxwell, John; Andersen, Jannik; Huang, Alan; Sjin, Robert Tjin Tham Share Save
Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities Vohidov, Farrukh; Andersen, Jannik N.; Economides, Kyriakos D.; Shipitsin, Michail, V; Burenkova, Olga; Ackley, James C.; Vangamudi, Bhavatarini; Nguyen, Hung V-T; Gallagher, Nolan M.; Shieh, Peyton; Golder, Matthew R.; Liu, Jenny; Dahlberg, William K.; Ehrlich, Deborah J. C.; Kim, Julie; Kristufek, Samantha L.; Huh, Sung Jin; Neenan, Allison M.; Baddour, Joelle; Paramasivan, Sattanathan; de Stanchina, Elisa; Kc, Gaurab; Turnquist, David J.; Saucier-Sawyer, Jennifer K.; Kopesky, Paul W.; Brady, Samantha W.; Jessel, Michael J.; Reiter, Lawrence A.; Chickering, Donald E.; Johnson, Jeremiah A.; Blume-Jensen, Peter Share Save
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