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J

Jon C. Aster

brigham and women’s hospital

119H-index
546Paper Count
5.3WCitation Count
Published Papers 166
Publication Date
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A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma
errCell
IF42.5
err2025-07-10
err0
PREAI
errEryn Blass; Derin B. Keskin; Chloe R. Tu; Cleo Forman; Allison Vanasse; Haley E. Sax; Bohoon Shim; Vipheaviny Chea; Nawoo Kim; Isabel Carulli; Jackson Southard; Haoxiang Lyu; Wesley Lu; Micah Rickles-Young; Alexander B. Afeyan; Oriol Olive; Ambica Mehndiratta; Haley Greenslade; Keerthi Shetty; Joanna Baginska; Ilana Gomez Diaz; Allison Nau; Kathleen L. Pfaff; Andrew Gans; Srinika Ranasinghe; Elizabeth I. Buchbinder; Tamara A. Sussman; Megan L. Insco; Charles H. Yoon; Scott J. Rodig; Sachet A. Shukla; Shuqiang Li; Jon C. Aster; David A. Braun; Carrie Cibulskis; Nir Hacohen; Donna S. Neuberg; Anita Giobbie-Hurder; Kenneth J. Livak; Edward F. Fritsch; Giacomo Oliveira; Jeremy M. Simon; Catherine J. Wu; Patrick A. Ott
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Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment
errBlood
IF23.1
err2025-06-16
err0
PREAI
errNicolas A. Gort-Freitas; Maria Moscvin; Matteo C. Da Vià; Francesca Lazzaroni; Alice Nevone; Sam Sadigh; Samuel Boullt; Benjamin Evans; Tianzeng Chen; Tanya Karagiannis; Albert Tai; Sean Rowell; Srinidhi Raghav; Antonia F. Chen; Jacob P. Laubach; Caitlin Edwards; Jon C. Aster; Zizhang Sheng; Joao A. Paulo; Chi N. Chan; Mario Nuvolone; Niccolò Bolli; Raymond L. Comenzo; Allon M. Klein; Giada Bianchi
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errSave
Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5
errCELL CHEMICAL BIOLOGY
IF7.2
err2025-04-01
err0
PREAI
errCao, Ruili; Jones, Daniel T. D.; Pan, Li; Yang, Annie; Wang, Shumei; Padi, Sathish K. R.; Rawson, Shaun; Aster, Jon C.; Blacklow, Stephen C.
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errSave
Integrative cytogenetic and molecular studies unmask chromosomal mimicry in hematologic malignancies
errBLOOD ADVANCES
IF7.1
err2025-03-11
err1
errOAAI
errZhao, Melissa; Ryall, Scott; Brody, Samuel J.; Harris, Amyah C.; Cabral, Kristin; Brownstein, Catherine; Kim, Jaeseung C.; Smith, Adam C.; Dal Cin, Paola; Narayan, Rupa; Sikkink, Kristin; Schmitt, Anthony; Griffin, Gabriel K.; Hobbs, Gabriela S.; Fathi, Amir T.; Sait, Sheila N. J.; Iafrate, Anthony J.; Aster, Jon C.; Graubert, Timothy A.; Nardi, Valentina; Dubuc, Adrian M.
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errSave
The Clinical Impact of Isolated Trisomy 15 in Myelodysplastic Syndrome Is Governed By Its Clonality
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errRyall, Scott; Tsai, Harrison K.; Nardi, Valentina; Aster, Jon C.; Hasserjian, Robert P.; Dal Cin, Paola
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errSave
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia (vol 21, pg 547, 2017)
errCELL STEM CELL
IF20.4
err2024-10-01
err0
PREAI
errTothova, Zuzana; Krill-Burger, John M.; Popova, Katerina D.; Landers, Catherine C.; Sievers, Quinlan L.; Yudovich, David; Belizaire, Roger; Aster, Jon C.; Morgan, Elizabeth A.; Tsherniak, Aviad; Ebert, Benjamin L.
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Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain
errDEVELOPMENTAL CELL
IF8.7
err2024-06-01
err0
PREAI
errTveriakhina, Lena; Scanavachi, Gustavo; Egan, Emily D.; Correia, Ricardo Bango Da Cunha; Martin, Alexandre P.; Rogers, Julia M.; Yodh, Jeremy S.; Aster, Jon C.; Kirchhausen, Tom; Blacklow, Stephen C.
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errSave
Spatial single-cell deconvolution of the bone marrow microenvironment to define predictive biomarker for response to immunotherapy in patients treated with a check point inhibitor in smoldering multiple myeloma, phase II trial of nivolumab in combination with lenalidomide and low dose dexamethasone
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errKonishi, Yoshinobu; Tarantino, Giuseppe; He, Yiwen; Sklavenitis-Pistofidis, Romanos; Shah, Sujal I.; Towle, Katherine; Cea-Curry, Christian J.; Zavidij, Oksana; Carrasco, Ruben D.; Rodig, Scott J.; Aster, Jon C.; Liu, David; Getz, Gad; Ghobrial, Irene M.
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errSave
Gene expression patterns in adenoid cystic carcinoma with and without diffuse NOTCH1 intracellular domain (NICD1) immunohistochemistry staining
errORAL ONCOLOGY
IF3.9
err2023-11-01
err0
PREAI
errPatel, Karan; Manzo, Massimiliano; Hapuarachi, Brindley; Rack, Samuel; Jermann, Philip; Feeney, Laura; Heathcote, Emily; Betts, Guy; Aster, Jon C.; Murone, Maximilien; Bobadilla, Maria; Lehal, Rajwinder; Vogl, Florian D.; Harrington, Kevin; Metcalf, Robert
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errSave
Tumor-specific immunity generated by a personalized neoantigen vaccination incorporating locally delivered ipilimumab in renal cell carcinoma.
errCANCER RESEARCH
IF16.6
err2023-08-15
err1
PREAI
errBraun, David A.; Keskin, Derin B.; Shukla, Sachet A.; McGregor, Bradley A.; Schindler, Nicholas R.; Blass, Eryn; Klaeger, Susan; Pomerance, Lucas; Sarkizova, Siranush; Li, Shuqiang; Southard, Jackson; Moranzoni, Giorgia; Pedersen, Christina B.; Liu, Yiwen; Chang, Steven L.; Hirsch, Michelle S.; LeBoeuf, Nicole R.; Mossanen, Matthew; Chea, Vipheaviny; Carulli, Isabel; Olive, Oriol; Mehndiratta, Ambica; Greenslade, Haley; Oliveira, Giacomo; Iorgulescu, J. Bryan; Signoretti, Sabina; Aster, Jon C.; Elagina, Liudmila; Leshchiner, Ignaty; Getz, Gad; Harden, Maegan; Gabriel, Stacey; Olsen, Lars R.; Neuberg, Donna S.; Fritsch, Edward F.; Hacohen, Nir; Livak, Kenneth J.; Carr, Steven; Ott, Patrick A.; Wu, Catherine J.; Choueiri, Toni K.
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errSave
A spatiotemporal Notch interaction map from plasma membrane to nucleus
errSCIENCE SIGNALING
IF6.6
err2023-08-01
err3
errOAAI
errMartin, Alexandre P. P.; Bradshaw, Gary A. A.; Eisert, Robyn J. J.; Egan, Emily D. D.; Tveriakhina, Lena; Rogers, Julia M. M.; Dates, Andrew N. N.; Scanavachi, Gustavo; Aster, Jon C. C.; Kirchhausen, Tom; Kalocsay, Marian; Blacklow, Stephen C. C.
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errSave
Targeting CCR7-PI3K? overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2023-06-28
err6
PREAI
errMastini, Cristina; Campisi, Marco; Patrucco, Enrico; Mura, Giulia; Ferreira, Antonio; Costa, Carlotta; Ambrogio, Chiara; Germena, Giulia; Martinengo, Cinzia; Peola, Silvia; Mota, Ines; Vissio, Elena; Molinaro, Luca; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele; Prokoph, Nina; Tabbo, Fabrizio; Shoji, Brent; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D.; Cuesta-Mateos, Carlos; D'Aliberti, Deborah; Mologni, Luca; Piazza, Rocco; Gambacorti-Passerini, Carlo; Inghirami, Giorgio G.; Chiono, Valeria; Kamm, Roger D.; Hirsch, Emilio; Koch, Raphael; Weinstock, David M.; Aster, Jon C.; Voena, Claudia; Chiarle, Roberto
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errSave
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err211
errOAAI
errLuo, B; Aster, JC; Hasserjian, RP; Kuo, F; Sklar, J
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errSave
Calcium depletion dissociates and activates heterodimeric notch receptors
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err440
errOAAI
errRand, MD; Grimm, LM; Artavanis-Tsakonas, S; Patriub, V; Blacklow, SC; Sklar, J; Aster, JC
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errSave
Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err292
errOAAI
errAster, JC; Xu, LW; Karnell, FG; Patriub, V; Pui, JC; Pear, WS
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errSave
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err94
errOAAI
errChiang, Mark Y.; Xu, Mina L.; Histen, Gavin; Shestova, Olga; Roy, Monideepa; Nam, Yunsun; Blacklow, Stephen C.; Sacks, David B.; Pear, Warren S.; Aster, Jon C.
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errSave
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err415
errOAAI
errWeng, AP; Nam, Y; Wolfe, MS; Pear, WNS; Griffin, JD; Blacklow, SC; Aster, JC
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errSave
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err269
errOAAI
errMalecki, Michael J.; Sanchez-Irizarry, Cheryll; Mitchell, Jennifer L.; Histen, Gavin; Xu, Mina L.; Aster, Jon C.; Blacklow, Stephen C.
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errSave
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err235
errOAAI
errSanchez-Irizarry, C; Carpenter, AC; Weng, AP; Pear, WS; Aster, JC; Blacklow, SC
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errSave
MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-03
err7
errOAAI
errRogers, Julia M.; Guo, Bingqian; Egan, Emily D.; Aster, Jon C.; Adelman, Karen; Blacklow, Stephen C.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Gad Getz
H-index: 248 · Papers: 1.8K
S
Stacey Gabriel
H-index: 220 · Papers: 938
D
David Baltimore
H-index: 209 · Papers: 1.1K
S
Stuart H. Orkin
H-index: 179 · Papers: 795
T
Todd R. Golub
H-index: 176 · Papers: 749
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