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S

Stuart H. Orkin

Harvard Medical School

179H-index
795Paper Count
10.6WCitation Count
Published Papers 220
Publication Date
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Silencing of BCL11A by Disrupting Enhancer-Dependent Epigenetic Insulation
errBlood
IF23.1
err2025-11-07
err0
errOAAI
errKaili Wang; Juan Wang; Ruopeng Feng; Kseniia Dudnyk; Yoon Jung Kim; Jun Yi Stanley Lim; Michael Lee; Yuannyu Zhang; Xiaofei Gao; Yong Cheng; Stuart H. Orkin; Jian Zhou; Mitchell J. Weiss; Feng Yue; Jian Xu
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errSave
Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-01-01
err0
errOAAI
errYang, Huan; Zheng, Ge; Li, Grace Y.; Alshaye, Alia; Orkin, Stuart H.
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errSave
A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing
errSCIENCE
IF45.8
err2024-11-29
err2
PREAI
errZheng, Ge; Yin, Maolu; Mehta, Stuti; Chu, I-Te; Wang, Stacy; Alshaye, Alia; Drainville, Kirstin; Buyanbat, Altantsetseg; Bienfait, Frederique; Tenglin, Karin; Zhu, Qian; Orkin, Stuart H.
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errSave
The epigenetic state of the cell of origin defines mechanisms of leukemogenesis
errLEUKEMIA
IF13.4
err2024-10-01
err0
PREAI
errLi, Zhiheng; Fierstein, Sara; Tanaka-Yano, Mayuri; Frenis, Katie; Chen, Chun-Chin; Wang, Dahai; Falchetti, Marcelo; Cote, Parker; Curran, Christina; Lu, Kate; Liu, Tianxin; Orkin, Stuart; Li, Hojun; da Rocha, Edroaldo Lummertz; Hu, Shaoyan; Zhu, Qian; Rowe, R. Grant
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errSave
Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions
errNATURE COMMUNICATIONS
IF15.7
err2024-02-10
err5
errOAAI
errLiu, Tianxin; Zhu, Qian; Kai, Yan; Bingham, Trevor; Wang, Stacy; Cha, Hye Ji; Mehta, Stuti; Schlaeger, Thorsten M.; Yuan, Guo-Cheng; Orkin, Stuart H.
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errSave
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche
errNATURE COMMUNICATIONS
IF15.7
err2023-12-02
err6
errOAAI
errManieri, Elisa; Tie, Guodong; Malagola, Ermanno; Seruggia, Davide; Madha, Shariq; Maglieri, Adrianna; Huang, Kun; Fujiwara, Yuko; Zhang, Kevin; Orkin, Stuart H.; Wang, Timothy C.; He, Ruiyang; Mccarthy, Neil; Shivdasani, Ramesh A.
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errSave
Identifying quantitatively differential chromosomal compartmentalization changes and their biological significance from Hi-C data using DARIC
errBMC GENOMICS
IF3.7
err2023-10-13
err1
errOAAI
errKai, Yan; Liu, Nan; Orkin, Stuart H.; Yuan, Guo-Cheng
errShare
errSave
In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice
errBLOOD ADVANCES
IF7.1
err2023-09-14
err2
errOAAI
errLi, Bin E.; Li, Grace Y.; Cai, Wenqing; Zhu, Qian; Seruggia, Davide; Fujiwara, Yuko; Vakoc, Christopher R.; Orkin, Stuart H.
errShare
errSave
Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis
errNATURE GENETICS
IF31.8
err2023-06-29
err7
errOAAI
errTenney, Alan P.; Di Gioia, Silvio Alessandro; Webb, Bryn D.; Chan, Wai-Man; de Boer, Elke; Garnai, Sarah J.; Barry, Brenda J.; Ray, Tammy; Kosicki, Michael; Robson, Caroline D.; Zhang, Zhongyang; Collins, Thomas E.; Gelber, Alon; Pratt, Brandon M.; Fujiwara, Yuko; Varshney, Arushi; Lek, Monkol; Warburton, Peter E.; Van Ryzin, Carol; Lehky, Tanya J.; Zalewski, Christopher; King, Kelly A.; Brewer, Carmen C.; Thurm, Audrey; Snow, Joseph; Facio, Flavia M.; Narisu, Narisu; Bonnycastle, Lori L.; Swift, Amy; Chines, Peter S.; Bell, Jessica L.; Mohan, Suresh; Whitman, Mary C.; Staffieri, Sandra E.; Elder, James E.; Demer, Joseph L.; Torres, Alcy; Rachid, Elza; Al-Haddad, Christiane; Boustany, Rose-Mary; Mackey, David A.; Brady, Angela F.; Fenollar-Cortes, Maria; Fradin, Melanie; Kleefstra, Tjitske; Padberg, George W.; Raskin, Salmo; Sato, Mario Teruo; Orkin, Stuart H.; Parker, Stephen C. J.; Hadlock, Tessa A.; Vissers, Lisenka E. L. M.; van Bokhoven, Hans; Jabs, Ethylin Wang; Collins, Francis S.; Pennacchio, Len A.; Manoli, Irini; Engle, Elizabeth C.
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errSave
Core transcriptional regulatory circuitry in AML
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errHarada, Taku; Perez, Monika; Kalfon, Jeremie; Eagle, Kenneth; Braes, Flora Dievenich; Batley, Rashad; Stegmaier, Kimberly; Orkin, Stuart; Pimkin, Maxim
errShare
errSave
Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err108
errOAAI
errBlobel, GA; Orkin, SH
errShare
errSave
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err167
errOAAI
errQu, CK; Shi, ZQ; Shen, R; Tsai, FY; Orkin, SH; Feng, GS
errShare
errSave
Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: Suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err29
errOAAI
errLien, LL; Lee, YS; Orkin, SH
errShare
errSave
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err369
errOAAI
errWeiss, MJ; Yu, CN; Orkin, SH
errShare
errSave
Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err67
errOAAI
errKadri, Z; Maouche-Chretien, L; Rooke, HM; Orkin, SH; Romeo, PH; Mayeux, P; Leboulch, P; Chretien, S
errShare
errSave
Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err63
errOAAI
errKatz, SG; Cantor, AB; Orkin, SH
errShare
errSave
E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err104
errOAAI
errZhu, JW; Field, SJ; Gore, L; Thompson, M; Yang, HD; Fujiwara, Y; Cardiff, RD; Greenberg, M; Orkin, SH; DeGregori, J
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errSave
Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner deaf-1
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err133
errOAAI
errHahm, KM; Sum, EYM; Fujiwara, Y; Lindeman, GJ; Visvader, JE; Orkin, SH
errShare
errSave
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err40
errOAAI
errSchlaeger, TM; Schuh, A; Flitter, S; Fisher, A; Mikkola, H; Orkin, SH; Vyas, P; Porcher, C
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errSave
Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err190
errOAAI
errSue, Nancy; Jack, Briony H. A.; Eaton, Sally A.; Pearson, Richard C. M.; Funnell, Alister P. W.; Turner, Jeremy; Czolij, Robert; Denyer, Gareth; Bao, Shisan; Molero-Navajas, Juan Carlos; Perkins, Andrew; Fujiwara, Yuko; Orkin, Stuart H.; Bell-Anderson, Kim; Crossley, Merlin
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Research Directions

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Co-authors
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A
Aviv Regev
H-index: 208 · Papers: 965
T
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H-index: 176 · Papers: 749
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