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Adam Kieżun

Harvard University
H-index:37
Citation Count:2.6万
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Case-control analysis identifies shared properties of rare germline variation in cancer predisposing genes
EUROPEAN JOURNAL OF HUMAN GENETICS
IF4.6
2019-02-045
OAAI
Artomov, Mykyta; Joseph, Vijai; Tiao, Grace; Thomas, Tinu; Schrader, Kasmintan; Klein, Robert J.; Kiezun, Adam; Gupta, Namrata; Margolin, Lauren; Stratigos, Alexander J.; Kim, Ivana; Shannon, Kristen; Ellisen, Leif W.; Haber, Daniel; Getz, Gad; Tsao, Hensin; Lipkin, Steven M.; Altshuler, David; Offit, Kenneth; Daly, Mark J.
Rare germline variants in ATM are associated with chronic lymphocytic leukemia
LEUKEMIA
IF13.4
2017-06-2729
OAAI
Tiao, G.; Improgo, M. R.; Kasar, S.; Poh, W.; Kamburov, A.; Landau, D-A; Tausch, E.; Taylor-Weiner, A.; Cibulskis, C.; Bahl, S.; Fernandes, S. M.; Hoang, K.; Rheinbay, E.; Kim, H. T.; Bahlo, J.; Robrecht, S.; Fischer, K.; Hallek, M.; Gabriel, S.; Lander, E. S.; Stilgenbauer, S.; Wu, C. J.; Kiezun, A.; Getz, G.; Brown, J. R.
Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution
NATURE COMMUNICATIONS
IF15.7
2015-12-07210
OAAI
Kasar, S.; Kim, J.; Improgo, R.; Tiao, G.; Polak, P.; Haradhvala, N.; Lawrence, M. S.; Kiezun, A.; Fernandes, S. M.; Bahl, S.; Sougnez, C.; Gabriel, S.; Lander, E. S.; Kim, H. T.; Getz, G.; Brown, J. R.
Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes
NATURE BIOTECHNOLOGY
IF41.7
2015-09-15541
OAAI
Shukla, Sachet A.; Rooney, Michael S.; Rajasagi, Mohini; Tiao, Grace; Dixon, Philip M.; Lawrence, Michael S.; Stevens, Jonathan; Lane, William J.; Dellagatta, Jamie L.; Steelman, Scott; Sougnez, Carrie; Cibulskis, Kristian; Kiezun, Adam; Hacohen, Nir; Brusic, Vladimir; Wu, Catherine J.; Getz, Gad
Sensitive detection of somatic mutations in class I HLA genes reveals enrichment for functional events in cancer
CANCER RESEARCH
IF16.6
2015-08-011
PRE
Shukla, Sachet A.; Rajasagi, Mohini; Dixon, Philip; Tiao, Grace; Lawrence, Michael S.; Sougnez, Carrie; Brusic, Vladimir; Cibulskis, Kristian; Kiezun, Adam; Wu, Catherine J.; Getz, Gad
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

互补的基因组方法强调PI3K/mTOR途径是骨肉瘤的常见脆弱性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2014-12-15355
OAAI
Perry, Jennifer A.; Kiezun, Adam; Tonzi, Peter; Van Allen, Eliezer M.; Carter, Scott L.; Baca, Sylvan C.; Cowley, Glenn S.; Bhatt, Ami S.; Rheinbay, Esther; Pedamallu, Chandra Sekhar; Helman, Elena; Taylor-Weiner, Amaro; McKenna, Aaron; DeLuca, David S.; Lawrence, Michael S.; Ambrogio, Lauren; Sougnez, Carrie; Sivachenko, Andrey; Walensky, Loren D.; Wagle, Nikhil; Mora, Jaume; de Torres, Carmen; Lavarino, Cinzia; Aguiar, Simone Dos Santos; Yunes, Jose Andres; Brandalise, Silvia Regina; Mercado-Celis, Gabriela Elisa; Melendez-Zajgla, Jorge; Cardenas-Cardos, Roco; Velasco-Hidalgo, Liliana; Roberts, Charles W. M.; Garraway, Levi A.; Rodriguez-Galindo, Carlos; Gabriel, Stacey B.; Lander, Eric S.; Golub, Todd R.; Orkin, Stuart H.; Getz, Gad; Janeway, Katherine A.
The Genomic Landscape of Pediatric Ewing Sarcoma
CANCER DISCOVERY
IF33.3
2014-11-02398
OAAI
Crompton, Brian D.; Stewart, Chip; Taylor-Weiner, Amaro; Alexe, Gabriela; Kurek, Kyle C.; Calicchio, Monica L.; Kiezun, Adam; Carter, Scott L.; Shukla, Sachet A.; Mehta, Swapnil S.; Thorner, Aaron R.; de Torres, Carmen; Lavarino, Cinzia; Sunol, Mariona; McKenna, Aaron; Sivachenko, Andrey; Cibulskis, Kristian; Lawrence, Michael S.; Stojanov, Petar; Rosenberg, Mara; Ambrogio, Lauren; Auclair, Daniel; Seepo, Sara; Blumenstiel, Brendan; DeFelice, Matthew; Imaz-Rosshandler, Ivan; Schwarz-Cruz y Celis, Angela; Rivera, Miguel N.; Rodriguez-Galindo, Carlos; Fleming, Mark D.; Golub, Todd R.; Getz, Gad; Mora, Jaume; Stegmaier, Kimberly
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
CANCER RESEARCH
IF16.6
2014-10-092
PRE
Kiezun, Adam; Perry, Jennifer; Tonzi, Peter; Van Allen, Eliezer; Carter, Scott L.; Baca, Sylvan; Bhatt, Ami; Lawrence, Michael; Walensky, Loren; Wagle, Nikhil; Mora, Jaume; de Torres, Carmen; Lavarino, Cinzia; Velasco-Hidalgo, Liliana; Cardenas-Cardos, Rocio; Aguiar, Simone dos Santos; Yunes, Jose A.; Mercado, Gabriela; Melendez-Zajgla, Jorge; Roberts, Charles; Garraway, Levi; Rodriguez-Galindo, Carlos; Golub, Todd; Orkin, Stuart; Getz, Gad; Janeway, Katherine
MutationValidator: A computational method for variant cross-validation in next-generation sequencing data
CANCER RESEARCH
IF16.6
2014-10-010
PRE
Rosenberg, Mara; Getz, Gad; Kiezun, Adam; Sivachenko, Andrey
The genomic landscape of pediatric Ewing sarcoma
CANCER RESEARCH
IF16.6
2014-10-010
PRE
Crompton, Brian; Stewart, Chip; Taylor-Weiner, Amaro; Alexa, Gabriela; Kurek, Kyle; Calicchio, Monica; Kiezun, Adam; Carter, Scott; Shukla, Sachet; Mehta, Swapnil; Thorner, Aaron; De Torres, Carmen; Lavarino, Cinzia; Sunol, Mariona; McKenna, Aaron; Sivachenko, Andrey; Cibulskis, Kristian; Lawrence, Michael; Ambrogio, Lauren; Auclair, Daniel; Rosshandler, Ivan; Celis, Angela Schwarz-Cruz Y.; Rivera, Miguel; Rodriguez-Galindo, Carlos; Fleming, Mark; Golub, Todd; Getz, Gad; Mora, Jaume; Stegmaier, Kimberly
Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences
ONCOGENE
IF7.3
2014-06-09131
OAAI
Pugh, T. J.; Yu, W.; Yang, J.; Field, A. L.; Ambrogio, L.; Carter, S. L.; Cibulskis, K.; Giannikopoulos, P.; Kiezun, A.; Kim, J.; McKenna, A.; Nickerson, E.; Getz, G.; Hoffher, S.; Messinger, Y. H.; Dehner, L. P.; Roberts, C. W. M.; Rodriguez-Galindo, C.; Williams, G. M.; Rossi, C. T.; Meyerson, M.; Hill, D. A.
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

福尔马林固定石蜡包埋肿瘤标本全外显子组测序及临床解读指导精准肿瘤医学

NATURE MEDICINE
IF50
2014-05-18455
OAAI
Van Allen, Eliezer M.; Wagle, Nikhil; Stojanov, Petar; Perrin, Danielle L.; Cibulskis, Kristian; Marlow, Sara; Jane-Valbuena, Judit; Friedrich, Dennis C.; Kryukov, Gregory; Carter, Scott L.; McKenna, Aaron; Sivachenko, Andrey; Rosenberg, Mara; Kiezun, Adam; Voet, Douglas; Lawrence, Michael; Lichtenstein, Lee T.; Gentry, Jeff G.; Huang, Franklin W.; Fostel, Jennifer; Farlow, Deborah; Barbie, David; Gandhi, Leena; Lander, Eric S.; Gray, Stacy W.; Joffe, Steven; Janne, Pasi; Garber, Judy; MacConaill, Laura; Lindeman, Neal; Rollins, Barrett; Kantoff, Philip; Fisher, Sheila A.; Gabriel, Stacey; Getz, Gad; Garraway, Levi A.
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

APOBEC胞苷脱氨酶诱变模式在人类癌症中广泛存在

NATURE GENETICS
IF31.8
2013-07-141.0K
OA
Roberts, Steven A.; Lawrence, Michael S.; Klimczak, Leszek J.; Grimm, Sara A.; Fargo, David; Stojanov, Petar; Kiezun, Adam; Kryukov, Gregory V.; Carter, Scott L.; Saksena, Gordon; Harris, Shawn; Shah, Ruchir R.; Resnick, Michael A.; Getz, Gad; Gordenin, Dmitry A.
Progressive biallelic loss of TP53 is associated with progression of pleuropulmonary blastoma initiated by germline loss and somatic mutation of DICER1
CANCER RESEARCH
IF16.6
2013-04-010
PRE
Pugh, Trevor J.; Yu, Weiying; Yang, Jiandong; Ambrogio, Lauren; Carter, Scott L.; Kiezun, Adam; McKenna, Aaron; Giannikopoulos, Petros; Getz, Gad; Messinger, Yoav; Meyerson, Matthew; Hill, D. Ashley
Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency

人类基因组中的有害等位基因平均比相同频率的中性等位基因年轻

PLOS GENETICS
IF3.7
2013-02-2854
OAAI
Kiezun, Adam; Pulit, Sara L.; Francioli, Laurent C.; van Dijk, Freerk; Swertz, Morris; Boomsma, Dorret I.; van Duijn, Cornelia M.; Slagboom, P. Eline; van Ommen, G. J. B.; Wijmenga, Cisca; de Bakker, Paul I. W.; Sunyaev, Shamil R.
HAMPI: A Solver for Word Equations over Strings, Regular Expressions, and Context-Free Grammars
ACM TRANSACTIONS ON SOFTWARE ENGINEERING AND METHODOLOGY
IF6.2
2013-02-0753
PREAI
Kiezun, Adam; Ganesh, Vijay; Artzi, Shay; Guo, Philip J.; Hooimeijer, Pieter; Ernst, Michael D.
Exome sequencing and the genetic basis of complex traits

外显子组测序与复杂性状的遗传基础

NATURE GENETICS
IF31.8
2012-05-29343
OAAI
Kiezun, Adam; Garimella, Kiran; Do, Ron; Stitziel, Nathan O.; Neale, Benjamin M.; McLaren, Paul J.; Gupta, Namrata; Sklar, Pamela; Sullivan, Patrick F.; Moran, Jennifer L.; Hultman, Christina M.; Lichtenstein, Paul; Magnusson, Patrik; Lehner, Thomas; Shugart, Yin Yao; Price, Alkes L.; de Bakker, Paul I. W.; Purcell, Shaun M.; Sunyaev, Shamil R.
Development and Validation of a Computational Method for Assessment of Missense Variants in Hypertrophic Cardiomyopathy
AMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
2011-02-0168
OAAI
Jordan, Daniel M.; Kiezun, Adam; Baxter, Samantha M.; Agarwala, Vineeta; Green, Robert C.; Murray, Michael F.; Pugh, Trevor; Lebo, Matthew S.; Rehm, Heidi L.; Funke, Birgit H.; Sunyaev, Shamil R.
Computational and statistical approaches to analyzing variants identified by exome sequencing
GENOME BIOLOGY
IF9.4
2011-01-01148
OAAI
Stitziel, Nathan O.; Kiezun, Adam; Sunyaev, Shamil
Finding Bugs in Web Applications Using Dynamic Test Generation and Explicit-State Model Checking
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
IF5.6
2010-07-0194
OAAI
Artzi, Shay; Kiezun, Adam; Dolby, Julian; Tip, Frank; Dig, Danny; Paradkar, Amit; Ernst, Michael D.

Research Directions

The data has not been retrieved yet.
G
Gad Getz
H-index:248Papers:1,846Citations:35.1万
M
Michael S. Lawrence
H-index:145Papers:648Citations:18.8万
S
Scott L. Carter
H-index:83Papers:548Citations:8.6万
K
Kristian Cibulskis
H-index:99Papers:289Citations:16.1万
A
Aaron McKenna
H-index:43Papers:169Citations:7.7万
C
Carlos Rodríguez‐Galindo
H-index:87Papers:728Citations:2.7万
G
Grace Tiao
H-index:47Papers:113Citations:3.8万
A
Andrey Sivachenko
H-index:43Papers:203Citations:9.3万
L
Lauren Ambrogio
H-index:19Papers:84Citations:1.6万
J
Jaume Mora
H-index:59Papers:688Citations:2.5万