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Michael S. Lawrence

massachusetts general hospital cancer center
H-index:145
Citation Count:18.8万
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Gene clustering drives the transcriptional coherence of disparate biological processes in eukaryotes

基因聚类驱动真核生物中不同生物过程的转录一致性

iScience
IF4.1
2026-07-250
OAAI
Richard I. Joh; Michael S. Lawrence; Martin J. Aryee; Mo Motamedi
RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions

RB loss调节染色质组织，通过调控cohesin依赖性环和增强子-启动子相互作用。

Nature Communications
IF15.7
2026-04-080
OAAI
Hanjun Lee; Ioanna-Maria Gkotinakou; Connor G. McGrath; Badri Krishnan; Sambhavi Animesh; Isabella Salinas; Robert Morris; Moshe Sade-Feldman; Wilhelm Hass; Michael S. Lawrence; Ioannis Sanidas
Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity

可遗传的染色质接触变化与跨代对饮食诱导的胰岛素失调和肥胖的易感性相关

Nature Communications
IF15.7
2026-02-120
OAAI
Richard C. Chang; Riann J. Egusquiza; Angélica Amorim Amato; Zhuorui Li; Alivia L. Dougherty; Kaitlin T. To; Michelle Avila; Erika M. Joloya; Hailey B. Wheeler; Angela Nguyen; Keiko Shioda; Junko Odajima; Michael S. Lawrence; Toshi Shioda; Bruce Blumberg
Circulating tumor human papillomavirus DNA whole genome sequencing enables human papillomavirus-associated oropharynx cancer early detection
JNCI-Journal of the National Cancer Institute
IF7.2
2025-11-014
PRE
Das, Dipon; Hirayama, Shun; Aye, Ling; Bryan, Michael E.; Naegele, Saskia; Zhao, Brian; Efthymiou, Vasileios; Mendel, Julia; Fisch, Adam S.; Guan, Zoe; Kroller, Lea; Michels, Birgitta E.; Waterboer, Tim; Richmon, Jeremy D.; Adalsteinsson, Viktor; Lawrence, Michael S.; Crowson, Matthew G.; Iafrate, A. John; Faden, Daniel L.
Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma
BLOOD CANCER JOURNAL
IF11.6
2024-08-272
OAAI
Bai, Baoyan; Wise, Jillian F.; Vodak, Daniel; Nakken, Sigve; Sharma, Ankush; Blaker, Yngvild Nuvin; Brodtkorb, Marianne; Hilden, Vera; Troen, Gunhild; Ren, Weicheng; Lorenz, Susanne; Lawrence, Michael S.; Myklebost, Ola; Kimby, Eva; Pan-Hammarstrom, Qiang; Steen, Chloe B.; Meza-Zepeda, Leonardo A.; Beiske, Klaus; Smeland, Erlend B.; Hovig, Eivind; Lingjaerde, Ole Christian; Holte, Harald; Myklebust, June Helen
Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy (vol 82, pg 773, 2022)
CANCER RESEARCH
IF16.6
2024-05-020
OA
Zhang, Songfa; Yan, Chuan; Millar, David G.; Yang, Qiqi; Heather, James M.; Langenbucher, Adam; Morton, Laura T.; Sepulveda, Sean; Alpert, Eric; Whelton, Lauren R.; Zarrella, Dominique T.; Guo, Mei; Minogue, Eleanor; Lawrence, Michael S.; Rueda, Bo R.; Spriggs, David R.; Lu, Weiguo; Langenau, David M.; Cobbold, Mark
Patterns in the tapestry of chromatin-bound RB
TRENDS IN CELL BIOLOGY
IF18.1
2024-04-014
OA
Sanidas, Ioannis; Lawrence, Michael S.; Dyson, Nicholas J.
RB represses cohesin-dependent loop formation and activates E2Findependent transcription
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Lee, Hanjun; Gkotinakou, Ioanna-Maria; Krishnan, Badri; Dyson, Nicholas J.; Lawrence, Michael S.; Sanidas, Ioannis
APOBEC3A drives tumor evolution through activation of ERVs in non small cell lung cancer
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Isozaki, Hideko; Sakhtemani, Ramin; Nikpour, Naveed; Monroe, Susanna; Lawrence, Michael; Hata, Aaron
Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations
NATURE COMMUNICATIONS
IF15.7
2024-03-184
OAAI
Butt, Yasha; Sakhtemani, Ramin; Mohamad-Ramshan, Rukshana; Lawrence, Michael S.; Bhagwat, Ashok S.
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
NATURE COMMUNICATIONS
IF15.7
2024-03-185
OAAI
Sanchez, Ambrocio; Ortega, Pedro; Sakhtemani, Ramin; Manjunath, Lavanya; Oh, Sunwoo; Bournique, Elodie; Becker, Alexandrea; Kim, Kyumin; Durfee, Cameron; Temiz, Nuri Alpay; Chen, Xiaojiang S.; Harris, Reuben S.; Lawrence, Michael S.; Buisson, Remi
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs
CANCER DISCOVERY
IF33.3
2024-02-217
OAAI
Choudhuri, Shreoshi Pal; Girard, Luc; Lim, Jun Yi Stanley; Wise, Jillian F.; Freitas, Braeden; Yang, Di; Wong, Edmond; Hamilton, Seth; Chien, Victor D.; Kim, Yoon Jung; Gilbreath, Collin; Zhong, Jun; Phat, Sarah; Myers, David T.; Christensen, Camilla L.; Mazloom-Farsibaf, Hanieh; Stanzione, Marcello; Wong, Kwok-Kin; Hung, Yin P.; Farago, Anna F.; Meador, Catherine B.; Dyson, Nicholas J.; Lawrence, Michael S.; Wu, Sihan; Drapkin, Benjamin J.
APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability

APOBEC3A通过PRIMPOL诱导DNA缺口并赋予缺口相关的治疗脆弱性

SCIENCE ADVANCES
IF12.5
2024-01-1914
OAAI
Kawale, Ajinkya S.; Ran, Xiaojuan; Patel, Parasvi S.; Saxena, Sneha; Lawrence, Michael S.; Zou, Lee
Revisiting the use of structural similarity index in Hi-C
NATURE GENETICS
IF31.8
2023-12-051
OA
Lee, Hanjun; Blumberg, Bruce; Lawrence, Michael S.; Shioda, Toshihiro
Therapy-induced APOBEC3A drives evolution of persistent cancer cells

治疗诱导的APOBEC3A驱动持续性癌细胞的进化

Nature
IF48.5
2023-07-050
PRE
Hideko Isozaki; Ramin Sakhtemani; Ammal Abbasi; Naveed Nikpour; Marcello Stanzione; Sunwoo Oh; Adam Langenbucher; Susanna Monroe; Wenjia Su; Heidie Frisco Cabanos; Faria M. Siddiqui; Nicole Phan; Pégah Jalili; Daria Timonina; Samantha Bilton; Maria Gomez-Caraballo; Hannah L. Archibald; Varuna Nangia; Kristin Dionne; Amanda Riley; Matthew Lawlor; Mandeep Kaur Banwait; Rosemary G. Cobb; Lee Zou; Nicholas J. Dyson; Christopher J. Ott; Cyril Benes; Gad Getz; Chang S. Chan; Alice T. Shaw; Justin F. Gainor; Jessica J. Lin; Lecia V. Sequist; Zofia Piotrowska; Beow Y. Yeap; Jeffrey A. Engelman; Jake June-Koo Lee; Yosef E. Maruvka; Rémi Buisson; Michael S. Lawrence; Aaron N. Hata
Epigenetic regulation of APOBEC3A mutagenesis and tumor evolution during targeted therapy in non-small cell lung cancer
CANCER RESEARCH
IF16.6
2023-04-041
PRE
Isozaki, Hideko; Sakhtemani, Ramin; Nikpour, Naveed; Monroe, Susanna; Lin, Jessica; Sequist, Lecia; Piotrowska, Zofia; Gainor, Justin; Buisson, Remi; Lawrence, Michael; Hata, Aaron
Genomics and transcriptomics profiling of BRCA mutation carriers revealed the landscape of early pathogenesis of BRCA1/2-associated breast cancer
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Ren, Zuen; Lin, Po-Han; Koh, Siang Boon; Stewart, Kai; Haradhvala, Nick; Dedeoglu, Aylin S.; Smidt, Ilze; Suzuki, Akiko; Li, David; Thant, Win; Mueller, Sarah; Joseph, Taisha; Bossuyt, Veerle; Lawrence, Michael; Getz, Gad; Ellisen, Leif W.
The non-canonical role of Rb in enhancers and insulators
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Lee, Hanjun; Gkotinakou, Ioanna M.; Sanidas, Ioannis; Lawrence, Michael S.; Dyson, Nicholas J.
TGF β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
CELL REPORTS
IF6.9
2023-03-0123
OAAI
Matsuda, Satoru; Revandkar, Ajinkya; Dubash, Taronish D.; Ravi, Arvind; Wittner, Ben S.; Lin, Maoxuan; Morris, Robert; Burr, Risa; Guo, Hongshan; Seeger, Karsen; Szabolcs, Annamaria; Che, Dante; Nieman, Linda; Getz, Gad A.; Ting, David T.; Lawrence, Michael S.; Gainor, Justin; Haber, Daniel A.; Maheswaran, Shyamala
Hypomethylation of immune-related loci contribute to prostate tumorigenesis
CANCER RESEARCH
IF16.6
2023-01-150
PRE
Haber, Daniel A.; Guo, Hongshan; Wittner, Ben S.; Vuille, Joanna A.; Lawrence, Michael S.; Wu, Chin-Lee; Toner, Mehmet; Miyamoto, David T.; Maheswaran, Shyamala

Research Directions

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