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An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy Koliesnik, Ievgen; Totagrande, Michael; Jayaraman, Bhargavi; Burgess, Ryan; Tran, Kim Quyen; Bauer, Michele; Balasubrahmanyam, Priyanka; Ali, Mohammed; Rosas, Henry; Emmerich, Jan; Chaturvedi, Deepti; Rokkam, Deepti; Singh, Somya; Chang, Woei; Buffone, Cindy; Mehta-Damani, Anita; Malefyt, Rene de Waal; Greb, Heiko; Ratti, Navneet; Rosen, David B.; Zuniga, Luis; Kastelein, Robert A.; Aspuria, Paul-Joseph; Vivona, Sandro; Oft, Martin; Lupardus, PatrickJ. Share Save
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Novel IL-12 Partial Agonist For Cancer Immunotherapy Avoids NK-cell Mediated Toxicity Koliesnik, Ievgen; Emmerich, Jan; Tran, Kim Q.; Bauer, Michele; Totagrande, Michael; Jayaraman, Bhargavi; Buffone, Cindy; Balasubrahmanyam, Priyanka; Rokkam, Deepti; Malefyt, Rene de Waal; Zuniga, Luis; Greb, Heiko; Ratti, Navneet; Vivona, Sandro; Oft, Martin; Lupardus, Patrick J.; Kastelein, Robert A. Share Save
: STK-012, an a/b-selective IL-2 activates tumor antigen specific CD25+CD8 T cells to reject tumors without acute vascular toxicity Oft, Martin; Ratti, Navneet; Vivona, Sandro; Emmerich, Jan; Riener, Romina; Koliesnik, Ievgen O.; McCauley, Scott; Bauer, Michele; Semana, Marie; Rokkam, Deepti; Jayaraman, Bhargavi; Malefyt, Rene de Waal; Aspuria, Paul-Joseph; Totagrande, Michael; Mehta-Damani, Anita; Lupardus, Patrick J.; Kastelein, Rob A. Share Save
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PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection Perry, Joseph A.; Shallberg, Lindsey; Clark, Joseph T.; Gullicksrud, Jodi A.; DeLong, Jonathan H.; Douglas, Bonnie B.; Hart, Andrew P.; Lanzar, Zachary; O'Dea, Keenan; Konradt, Christoph; Park, Jeongho; Kuchroo, Juhi R.; Grubaugh, Daniel; Zaretsky, Arielle Glatman; Brodsky, Igor E.; Malefyt, Rene de Waal; Christian, David A.; Sharpe, Arlene H.; Hunter, Christopher A. Share Save
An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CART cells and clearance of bulky lymphoma Aspuria, Paul-Joseph; Vivona, Sandro; Bauer, Michele; Semana, Marie; Ratti, Navneet; McCauley, Scott; Riener, Romina; Malefyt, Rene de Waal; Rokkam, Deepti; Emmerich, Jan; Kastelein, Rob A.; Lupardus, Patrick J.; Oft, Martin Share Save
Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy Raghavan, Sukanya; Tovbis-Shifrin, Nataliya; Kochel, Christina; Sawant, Anandi; Mello, Marielle; Sathe, Manjiri; Blumenschein, Wendy; Muise, Eric S.; Chackerian, Alissa; Pinheiro, Elaine M.; Rosahl, Thomas W.; Luche, Herve; de Waal Malefyt, Rene Share Save
Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab Hutchins, Beth; Starling, Gary C.; McCoy, Mark A.; Herzyk, Danuta; Poulet, Frederique M.; Dulos, John; Liu, Liming; Kang, Soonmo Peter; Fayadat-Dilman, Laurence; Hsieh, Mark; Andrews, Christine L.; Ayanoglu, Gulesi; Cullen, Constance; Malefyt, Rene de Waal; Kastelein, Robert A.; Le Saux, Sabine; Lee, Julie; Li, Sophie; Malashock, Dan; Sadekova, Svetlana; Soder, George; van Eenennaam, Hans; Willingham, Aarron; Yu, Ying; Streuli, Michel; Carven, Gregory J.; van Elsas, Andrea Share Save
LAG3+ Regulatory T Cells Restrain Interleukin-23 Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis Bauche, David; Joyce-Shaikh, Barbara; Jain, Renu; Grein, Jeff; Ku, Karin S.; Blumenschein, Wendy M.; Ganal-Vonarburg, Stephanie C.; Wilson, Douglas C.; McClanahan, Terrill K.; Malefyt, Rene de Waal; Macpherson, Andrew J.; Annamalai, Lakshmanan; Yearley, Jennifer H.; Cua, Daniel J. Share Save
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Blockade of LAG-3 amplifies immune activation signatures and augments curative antitumor responses to anti-PD-1 therapy in immune competent mouse models of cancer Haines, Brian B.; Javaid, Sarah; Cui, Long; Hirsch, Heather; Cemerski, Saso; McClanahan, Terri; Sathe, Manjiri; Zhang, Shuli; Rosenzweig, Michael; Long, Brian; Malefyt, Rene de Waal Share Save
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization Yoon, Juhan; Leyva-Castillo, Juan Manuel; Wang, Guoxing; Galand, Claire; Oyoshi, Michiko K.; Kumar, Lalit; Hoff, Sabine; He, Rui; Chervonsky, Alexander; Oppenheim, Joost J.; Kuchroo, Vijay K.; van den Brink, Marcel R. M.; Malefyt, Rene De Waal; Tessier, Philippe A.; Fuhlbrigge, Robert; Rosenstiel, Philip; Terhorst, Cox; Murphy, George; Geha, Raif S. Share Save
IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis Adamopoulos, Iannis E.; Suzuki, Erika; Chao, Cheng-Chi; Gorman, Dan; Adda, Sarvesh; Maverakis, Emanual; Zarbalis, Konstantinos; Geissler, Richard; Asio, Agelio; Blumenschein, Wendy M.; Mcclanahan, Terrill; Malefyt, Rene De Waal; Gershwin, M. Eric; Bowman, Edward P. Share Save
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