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ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways Xu, JX; Dong, XQ; Peng, Y; Yan, J; Xu, PP; Li, FY; Zhang, SW; Chen, LX; Meng, XJ; Wang, KN; Xing, MY; Li, WY; Huang, DCS; Zhao, Q; Chen, B Share Save
Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins Gong, Jia-Nan; Djajawi, Tirta M.; Moujalled, Donia M.; Pomilio, Giovanna; Khong, Tiffany; Zhang, Li-Ping; Fedele, Pasquale L.; Low, Michael S.; Anderson, Mary Ann; Riffkin, Christopher D.; White, Christine A.; Lan, Ping; Lessene, Guillaume; Herold, Marco J.; Strasser, Andreas; Spencer, Andrew; Grigoriadis, George; Wei, Andrew H.; van Delft, Mark F.; Roberts, Andrew W.; Huang, David C. S. Share Save
NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis Li, Qixiang; Ci, Hongfei; Zhao, Pengpeng; Yang, Dongjun; Zou, Yi; Chen, Panhai; Wu, Dongliang; Shangguan, Wenbing; Li, Wenyang; Meng, Xingjun; Xing, Mengying; Chen, Yuzhong; Zhang, Ming; Chen, Bing; Kong, Lingdong; Zen, Ke; Huang, David C. S.; Jiang, Zhi-Wei; Zhao, Quan Share Save
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules Li, Kaiming; Yap, Yu Q.; Moujalled, Donia M.; Sumardy, Fransisca; Khakham, Yelena; Georgiou, Angela; Jahja, Michelle; Lew, Thomas E.; De Silva, Melanie; Luo, Meng-Xiao; Gong, Jia-nan; Yuan, Zheng; Birkinshaw, Richard W.; Czabotar, Peter E.; Lowes, Kym; Huang, David C. S.; Kile, Benjamin T.; Wei, Andrew H.; Dewson, Grant; van Delft, Mark F. Share Save
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Leveraging synthetic lethality across EP300-mutant solid cancers through selective CBP degradation Sappal, Darshan; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudi; Elliott, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, David; La Bonte, Laura; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Wilson, Molly M.; Zhou, Qianhe; Zimmerman, Mark Share Save
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Identification of selective CBP degraders with robust preclinical PK, PD, efficacy and safety across solid tumor indications Sappal, Darshan; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudia; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Zhou, Qianhe; Zimmerman, Mark; La Bonte, Laura Share Save
Discovery of potent and selective EP300 degraders with anti-cancer activity Zimmerman, Mark; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudia; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Sappal, Darshan; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Zhou, Qianhe; La Bonte, Laura Share Save
FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma Yang, Dongjun; Li, Qixiang; Lu, Peifen; Wu, Dongliang; Li, Wenyang; Meng, Xingjun; Xing, Mengying; Shangguan, Wenbing; Chen, Bing; Yang, Jie; Zhang, Zhihong; Wang, Zengjun; Huang, David C. S.; Zhao, Quan Share Save
Discovery of potent and selective EP300 degraders with anti-cancer activity Zimmerman, Mark; Sappal, Darshan; Adam, Ammar; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; DiBernardo, Julie; Dixon, Thomas; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; LaBonte, Laura; Daniels, Danette Share Save
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells Wang, Zilu; Burigotto, Matteo; Ghetti, Sabrina; Vaillant, Francois; Tan, Tao; Capaldo, Bianca D.; Palmieri, Michelle; Hirokawa, Yumiko; Tai, Lin; Simpson, Daniel S.; Chang, Catherine; Huang, Allan Shuai; Lieschke, Elizabeth; Diepstraten, Sarah T.; Kaloni, Deeksha; Riffkin, Chris; Huang, David C. S.; Li Wai Suen, Connie S. N.; Garnham, Alexandra L.; Gibbs, Peter; Visvader, Jane E.; Sieber, Oliver M.; Herold, Marco J.; Fava, Luca L.; Kelly, Gemma L.; Strasser, Andreas Share Save
Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells Teh, Charis E.; Peng, Hongke; Luo, Meng-Xiao; Tan, Tania; Trussart, Marie; Howson, Lauren J.; Chua, Chong Chyn; Muttiah, Christine; Brown, Fiona; Ritchie, Matthew E.; Wei, Andrew H.; Roberts, Andrew W.; Bryant, Vanessa L.; Anderson, Mary Ann; Lindeman, Geoffrey J.; Huang, David C. S.; Thijssen, Rachel; Gray, Daniel H. D. Share Save
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase Pierotti, Catia L.; Jacobsen, Annette V.; Grohmann, Christoph; Dempsey, Ruby K.; Etemadi, Nima; Hildebrand, Joanne M.; Fitzgibbon, Cheree; Young, Samuel N.; Davies, Katherine A.; Kersten, Wilhelmus J. A.; Silke, John; Lowes, Kym N.; Huang, David C. S.; van Delft, Mark F.; Murphy, James M.; Lessene, Guillaume Share Save
The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer Zeng, Xiangwei; Yao, Bing; Liu, Jianpeng; Gong, Guan-Wen; Liu, Ming; Li, Jiahuang; Pan, Hua-Feng; Li, Qixiang; Yang, Dongjun; Lu, Peifen; Wu, Dongliang; Xu, Peipei; Chen, Bing; Chen, Panhai; Zhang, Ming; Zen, Ke; Jing, Jian; Huang, David C. S.; Chen, Dijun; Jiang, Zhi-Wei; Zhao, Quan Share Save
Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins Huang, Allan Shuai; San Chin, Hui; Reljic, Boris; Djajawi, Tirta M.; Tan, Iris K. L.; Gong, Jia-Nan; Stroud, David A.; Huang, David C. S.; van Delft, Mark F.; Dewson, Grant Share Save
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL Jacobsen, Annette, V; Pierotti, Catia L.; Lowes, Kym N.; Au, Amanda E.; Zhang, Ying; Etemadi, Nima; Fitzgibbon, Cheree; Kersten, Wilhelmus J. A.; Samson, Andre L.; van Delft, Mark F.; Huang, David C. S.; Sabroux, Helene Jousset; Lessene, Guillaume; Silke, John; Murphy, James M. Share Save
Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death Garciaz, Sylvain; Guirguis, Andrew A.; Muller, Sebastian; Brown, Fiona C.; Chan, Yih-Chih; Motazediani, Ali; Rowe, Caitlin L.; Kuzich, James A.; Chan, Kah Lok; Tran, Kevin; Smith, Lorey; MacPherson, Laura; Liddicoat, Brian; Lam, Enid Y. N.; Caneque, Tatiana; Burr, Marian L.; Litalien, Veronique; Pomilio, Giovanna; Poplineau, Mathilde; Duprez, Estelle; Dawson, Sarah-Jane; Ramm, Georg; Cox, Andrew G.; Brown, Kristin K.; Huang, David C. S.; Wei, Andrew H.; McArthur, Kate; Rodriguez, Raphael; Dawson, Mark A. Share Save
Mesenchymal stromal cell apoptosis is required for their therapeutic function Pang, Swee Heng Milon; D'Rozario, Joshua; Mendonca, Senora; Bhuvan, Tejasvini; Payne, Natalie L.; Zheng, Di; Hisana, Assifa; Wallis, Georgia; Barugahare, Adele; Powell, David; Rautela, Jai; Huntington, Nicholas D.; Dewson, Grant; Huang, David C. S.; Gray, Daniel H. D.; Heng, Tracy S. P. Share Save
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