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D

David C.S. Huang

walter & eliza hall institute

101H-index
575Paper Count
4.5WCitation Count
Published Papers 173
Publication Date
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ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways
errADVANCED SCIENCE
IF14.1
err2025-05-10
err0
errOAAI
errXu, JX; Dong, XQ; Peng, Y; Yan, J; Xu, PP; Li, FY; Zhang, SW; Chen, LX; Meng, XJ; Wang, KN; Xing, MY; Li, WY; Huang, DCS; Zhao, Q; Chen, B
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Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins
errCELL DEATH AND DIFFERENTIATION
IF15.4
err2025-04-09
err0
errOAAI
errGong, Jia-Nan; Djajawi, Tirta M.; Moujalled, Donia M.; Pomilio, Giovanna; Khong, Tiffany; Zhang, Li-Ping; Fedele, Pasquale L.; Low, Michael S.; Anderson, Mary Ann; Riffkin, Christopher D.; White, Christine A.; Lan, Ping; Lessene, Guillaume; Herold, Marco J.; Strasser, Andreas; Spencer, Andrew; Grigoriadis, George; Wei, Andrew H.; van Delft, Mark F.; Roberts, Andrew W.; Huang, David C. S.
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NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis
errJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
err2025-03-10
err0
errOAAI
errLi, Qixiang; Ci, Hongfei; Zhao, Pengpeng; Yang, Dongjun; Zou, Yi; Chen, Panhai; Wu, Dongliang; Shangguan, Wenbing; Li, Wenyang; Meng, Xingjun; Xing, Mengying; Chen, Yuzhong; Zhang, Ming; Chen, Bing; Kong, Lingdong; Zen, Ke; Huang, David C. S.; Jiang, Zhi-Wei; Zhao, Quan
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Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
errSCIENCE ADVANCES
IF12.5
err2025-03-07
err0
errOAAI
errLi, Kaiming; Yap, Yu Q.; Moujalled, Donia M.; Sumardy, Fransisca; Khakham, Yelena; Georgiou, Angela; Jahja, Michelle; Lew, Thomas E.; De Silva, Melanie; Luo, Meng-Xiao; Gong, Jia-nan; Yuan, Zheng; Birkinshaw, Richard W.; Czabotar, Peter E.; Lowes, Kym; Huang, David C. S.; Kile, Benjamin T.; Wei, Andrew H.; Dewson, Grant; van Delft, Mark F.
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CENTRAL NERVOUS SYSTEM METASTASES ARE GENOMICALLY DIVERGENT FROM THEIR RESPECTIVE EXTRACRANIAL SITES
errNEURO-ONCOLOGY
IF13.4
err2024-11-11
err0
PREAI
errHuang, David; Bergagnini, Isabella; Hajiyeva, Sabina; Akerman, Meredith; Wong, Tamika; D'Amico, Randy; Boockvar, John; Vojnic, Morana
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Leveraging synthetic lethality across EP300-mutant solid cancers through selective CBP degradation
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-06-10
err0
PREAI
errSappal, Darshan; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudi; Elliott, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, David; La Bonte, Laura; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Wilson, Molly M.; Zhou, Qianhe; Zimmerman, Mark
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Co-operation of MCL-1 and BCL-XL anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity
errFRONTIERS IN ONCOLOGY
IF3.3
err2024-04-08
err1
errOAAI
errGalas-Filipowicz, Daria; Chavda, Selina J.; Gong, Jia-Nan; Huang, David C. S.; Khwaja, Asim; Yong, Kwee
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errSave
Identification of selective CBP degraders with robust preclinical PK, PD, efficacy and safety across solid tumor indications
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errSappal, Darshan; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudia; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Zhou, Qianhe; Zimmerman, Mark; La Bonte, Laura
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errSave
Discovery of potent and selective EP300 degraders with anti-cancer activity
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errZimmerman, Mark; Adam, Ammar; Ahmad, Hafiz; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; Di Bernardo, Julie; Dixon, Thomas; Daniels, Danette; Dominici, Claudia; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Sappal, Darshan; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; Zhou, Qianhe; La Bonte, Laura
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FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-01-01
err0
errOAAI
errYang, Dongjun; Li, Qixiang; Lu, Peifen; Wu, Dongliang; Li, Wenyang; Meng, Xingjun; Xing, Mengying; Shangguan, Wenbing; Chen, Bing; Yang, Jie; Zhang, Zhihong; Wang, Zengjun; Huang, David C. S.; Zhao, Quan
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errSave
Discovery of potent and selective EP300 degraders with anti-cancer activity
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errZimmerman, Mark; Sappal, Darshan; Adam, Ammar; Adams, Benjamin; Adhikari, Ketaki; Austin, Wesley; Bullock, Breanna; DiBernardo, Julie; Dixon, Thomas; Elliot, GiNell; Ethell, Brian; Gervais, Anais; Hossain, Md Imran; Huang, David; Lahr, Dave; Lin, Mei Yun; Mayhew, David; Mizeracka, Karolina; Negretti, Solymar; Nguyen, Tyler; Prifti, Olga; Schiller, Shawn; Sherbanee, Brenna; Terry, David; Ucisik, Nihan; Wittenborn, Elizabeth; LaBonte, Laura; Daniels, Danette
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errSave
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells
errCANCER DISCOVERY
IF33.3
err2023-10-24
err22
errOAAI
errWang, Zilu; Burigotto, Matteo; Ghetti, Sabrina; Vaillant, Francois; Tan, Tao; Capaldo, Bianca D.; Palmieri, Michelle; Hirokawa, Yumiko; Tai, Lin; Simpson, Daniel S.; Chang, Catherine; Huang, Allan Shuai; Lieschke, Elizabeth; Diepstraten, Sarah T.; Kaloni, Deeksha; Riffkin, Chris; Huang, David C. S.; Li Wai Suen, Connie S. N.; Garnham, Alexandra L.; Gibbs, Peter; Visvader, Jane E.; Sieber, Oliver M.; Herold, Marco J.; Fava, Luca L.; Kelly, Gemma L.; Strasser, Andreas
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Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells
errBLOOD ADVANCES
IF7.1
err2023-06-15
err12
errOAAI
errTeh, Charis E.; Peng, Hongke; Luo, Meng-Xiao; Tan, Tania; Trussart, Marie; Howson, Lauren J.; Chua, Chong Chyn; Muttiah, Christine; Brown, Fiona; Ritchie, Matthew E.; Wei, Andrew H.; Roberts, Andrew W.; Bryant, Vanessa L.; Anderson, Mary Ann; Lindeman, Geoffrey J.; Huang, David C. S.; Thijssen, Rachel; Gray, Daniel H. D.
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The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase
errBIOCHEMICAL JOURNAL
IF4.3
err2023-05-12
err8
errOAAI
errPierotti, Catia L.; Jacobsen, Annette V.; Grohmann, Christoph; Dempsey, Ruby K.; Etemadi, Nima; Hildebrand, Joanne M.; Fitzgibbon, Cheree; Young, Samuel N.; Davies, Katherine A.; Kersten, Wilhelmus J. A.; Silke, John; Lowes, Kym N.; Huang, David C. S.; van Delft, Mark F.; Murphy, James M.; Lessene, Guillaume
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The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer
errNPJ PRECISION ONCOLOGY
IF8
err2023-03-15
err14
errOAAI
errZeng, Xiangwei; Yao, Bing; Liu, Jianpeng; Gong, Guan-Wen; Liu, Ming; Li, Jiahuang; Pan, Hua-Feng; Li, Qixiang; Yang, Dongjun; Lu, Peifen; Wu, Dongliang; Xu, Peipei; Chen, Bing; Chen, Panhai; Zhang, Ming; Zen, Ke; Jing, Jian; Huang, David C. S.; Chen, Dijun; Jiang, Zhi-Wei; Zhao, Quan
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Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins
errCELL DEATH AND DIFFERENTIATION
IF15.4
err2022-09-28
err6
PREAI
errHuang, Allan Shuai; San Chin, Hui; Reljic, Boris; Djajawi, Tirta M.; Tan, Iris K. L.; Gong, Jia-Nan; Stroud, David A.; Huang, David C. S.; van Delft, Mark F.; Dewson, Grant
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errSave
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
errCELL DEATH & DISEASE
IF9.6
err2022-04-01
err15
errOAAI
errJacobsen, Annette, V; Pierotti, Catia L.; Lowes, Kym N.; Au, Amanda E.; Zhang, Ying; Etemadi, Nima; Fitzgibbon, Cheree; Kersten, Wilhelmus J. A.; Samson, Andre L.; van Delft, Mark F.; Huang, David C. S.; Sabroux, Helene Jousset; Lessene, Guillaume; Silke, John; Murphy, James M.
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Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death
errCANCER DISCOVERY
IF33.3
err2022-03-08
err17
errOAAI
errGarciaz, Sylvain; Guirguis, Andrew A.; Muller, Sebastian; Brown, Fiona C.; Chan, Yih-Chih; Motazediani, Ali; Rowe, Caitlin L.; Kuzich, James A.; Chan, Kah Lok; Tran, Kevin; Smith, Lorey; MacPherson, Laura; Liddicoat, Brian; Lam, Enid Y. N.; Caneque, Tatiana; Burr, Marian L.; Litalien, Veronique; Pomilio, Giovanna; Poplineau, Mathilde; Duprez, Estelle; Dawson, Sarah-Jane; Ramm, Georg; Cox, Andrew G.; Brown, Kristin K.; Huang, David C. S.; Wei, Andrew H.; McArthur, Kate; Rodriguez, Raphael; Dawson, Mark A.
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Mesenchymal stromal cell apoptosis is required for their therapeutic function
errNATURE COMMUNICATIONS
IF15.7
err2021-11-11
err121
errOAAI
errPang, Swee Heng Milon; D'Rozario, Joshua; Mendonca, Senora; Bhuvan, Tejasvini; Payne, Natalie L.; Zheng, Di; Hisana, Assifa; Wallis, Georgia; Barugahare, Adele; Powell, David; Rautela, Jai; Huntington, Nicholas D.; Dewson, Grant; Huang, David C. S.; Gray, Daniel H. D.; Heng, Tracy S. P.
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Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing
errGENOME BIOLOGY
IF9.4
err2021-11-11
err85
errOAAI
errTian, Luyi; Jabbari, Jafar S.; Thijssen, Rachel; Gouil, Quentin; Amarasinghe, Shanika L.; Voogd, Oliver; Kariyawasam, Hasaru; Du, Mei R. M.; Schuster, Jakob; Wang, Changqing; Su, Shian; Dong, Xueyi; Law, Charity W.; Lucattini, Alexis; Prawer, Yair David Joseph; Collar-Fernandez, Coralina; Chung, Jin D.; Naim, Timur; Chan, Audrey; Ly, Chi Hai; Lynch, Gordon S.; Ryall, James G.; Anttila, Casey J. A.; Peng, Hongke; Anderson, Mary Ann; Flensburg, Christoffer; Majewski, Ian; Roberts, Andrew W.; Huang, David C. S.; Clark, Michael B.; Ritchie, Matthew E.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Shizuo Akira
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Scott W. Lowe
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Kiyoshi Takeda
H-index: 135 · Papers: 669
B
Brian Druker
H-index: 135 · Papers: 2.6K
A
Andreas Strasser
H-index: 135 · Papers: 815
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