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J

Jeffrey R. Holt

Boston Children's Hospital

51H-index
151Paper Count
1.0WCitation Count
Published Papers 48
Publication Date
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Assessment of auditory and vestibular function and gene therapy in the Snell’s waltzer mouse model of human deafness and balance dysfunction
errMammalian Genome
IF2.7
err2026-08-28
err0
errOAAI
errEyal Marton; Roni Hahn; Lior Bikovski; Gwenaëlle S. G. Géléoc; Jeffrey R. Holt; Matti Mintz; Karen B. Avraham
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errSave
AAV-Mediated Exon Skipping Therapy for Usher Syndrome, Type 2A.
errMolecular Therapy
IF12
err2025-09-23
err0
PREAI
errStephanie A. Mauriac; Jiyoon Lee; Jingyuan Zhang; Jiahe Jin; Carl Nist-Lund; Camille T. Martin; Cristobal R. Von Muhlenbrock; Sydney O’Malley; Mary G. Chaves; Margot A. Madison; Kate Foster; Shinong Long; Chris Jacobs; Sripriya Ravindra Kumar; Silvia Ramirez; Justin Ichida; Karl R. Koehler; Jeffrey R. Holt; Gwenaëlle S.G. Géléoc
errShare
errSave
Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-09-16
err1
errOAAI
errShearer, A. Eliot; Chen, Yuan-Siao; Rouse, Stephanie L.; Wang, Xiaohan; Fermin, Janmaris Marin; Booth, Kevin T. A.; Moawad, Jasmine; Libiran, Nicole Bianca; Li, Jinan; Kim, Hae-Young; Hoa, Michael; Olszewski, Rafal; Lei, Jing-Yu; Cabrera, Ernesto; Totten, Douglas J.; Zhao, Bo; Holt, Jeffrey R.; Nelson, Rick F.
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errSave
A contemporary view of mechanosensory transduction in auditory hair cells
errBiophysical Journal
IF3.1
err2025-06-16
err0
PREAI
errMatthew Mun; Jeffrey R. Holt
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errSave
Structural and functional basis of mechanosensitive TMEM63 channelopathies
errNeuron
IF15
err2025-06-05
err0
PREAI
errWang Zheng; Augustus J. Lowry; Harper E. Smith; Jiale Xie; Shaun Rawson; Chen Wang; Jin Ou; Marcos Sotomayor; Tian-Min Fu; Huanghe Yang; Jeffrey R. Holt
errShare
errSave
Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells
errHEARING RESEARCH
IF2.5
err2025-05-01
err0
PREAI
errPeineau, Thibault; Marcovich, Irina; Rodriguez, Cristobal von Muhlenbrock; O'Malley, Sydney; Cui, Runjia; Ballesteros, Angela; Holt, Jeffrey R.
errShare
errSave
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels
errELIFE
IF0
err2025-01-08
err2
errOAAI
errGiese, Arnaud P. J.; Weng, Wei-Hsiang; Kindt, Katie S.; Chang, Hui Ho Vanessa; Montgomery, Jonathan S.; Ratzan, Evan M.; Beirl, Alisha J.; Aponte Rivera, Roberto; Lotthammer, Jeffrey M.; Walujkar, Sanket; Foster, Mark P.; Zobeiri, Omid A.; Holt, Jeffrey R.; Riazuddin, Saima; Cullen, Kathleen E.; Sotomayor, Marcos; Ahmed, Zubair M.
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errSave
Sensory transduction in auditory hair cells-PIEZOs can't touch this
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-05-10
err1
errOAAI
errHolt, Jeffrey R.; Fettiplace, Robert; Muller, Ulrich
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errSave
TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels
errNEURON
IF15
err2023-10-01
err32
PREAI
errZheng, Wang; Rawson, Shaun; Shen, Zhangfei; Tamilselvan, Elakkiya; Smith, Harper E.; Halford, Julia; Shen, Chen; Murthy, Swetha E.; Ulbrich, Maximilian H.; Sotomayor, Marcos; Fu, Tian-Min; Holt, Jeffrey R.
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errSave
Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2023-06-28
err15
PREAI
errMathiesen, Barbara K.; Miyakoshi, Leo M.; Cederroth, Christopher R.; Tserga, Evangelia; Versteegh, Corstiaen; Bork, Peter A. R.; Hauglund, Natalie L.; Gomolka, Ryszard Stefan; Mori, Yuki; Edvall, Niklas K.; Rouse, Stephanie; Mollgard, Kjeld; Holt, Jeffrey R.; Nedergaard, Maiken; Canlon, Barbara
errShare
errSave
pH regulates potassium conductance and drives a constitutive proton current in human TMEM175
errSCIENCE ADVANCES
IF12.5
err2022-03-25
err27
errOAAI
errZheng, Wang; Shen, Chen; Wang, Longfei; Rawson, Shaun; Xie, Wen Jun; Nist-Lund, Carl; Wu, Jason; Shen, Zhangfei; Xia, Shiyu; Holt, Jeffrey R.; Wu, Hao; Fu, Tian-Min
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errSave
Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss
errSCIENCE ADVANCES
IF12.5
err2021-12-17
err33
errOAAI
errShubina-Oleinik, Olga; Nist-Lund, Carl; French, Courtney; Rockowitz, Shira; Shearer, A. Eliot; Holt, Jeffrey R.
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errSave
Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses
errELIFE
IF0
err2021-11-04
err9
PREAI
errLee, John; Kawai, Kosuke; Holt, Jeffrey R.; Geleoc, Gwenaelle Sg
errShare
errSave
Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice
errMOLECULAR THERAPY
IF12
err2021-03-01
err42
errOAAI
errWu, Jason; Solanes, Paola; Nist-Lund, Carl; Spataro, Sofia; Shubina-Oleinik, Olga; Marcovich, Irina; Goldberg, Hannah; Schneider, Bernard L.; Holt, Jeffrey R.
errShare
errSave
Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness
errEMBO MOLECULAR MEDICINE
IF8.3
err2020-12-22
err40
errOAAI
errTaiber, Shahar; Cohen, Roie; Yizhar-Barnea, Ofer; Sprinzak, David; Holt, Jeffrey R.; Avraham, Karen B.
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errSave
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2020-06-03
err128
errOAAI
errYeh, Wei-Hsi; Shubina-Oleinik, Olga; Levy, Jonathan M.; Pan, Bifeng; Newby, Gregory A.; Wornow, Michael; Burt, Rachel; Chen, Jonathan C.; Holt, Jeffrey R.; Liu, David R.
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errSave
Continuous evolution of base editors with expanded target compatibility and improved activity (vol 37, pg 1070, 2019)
errNATURE BIOTECHNOLOGY
IF41.7
err2019-08-12
err7
errOAAI
errThuronyi, Benjamin W.; Koblan, Luke W.; Levy, Jonathan M.; Yeh, Wei-Hsi; Zheng, Christine; Newby, Gregory A.; Wilson, Christopher; Bhaumik, Mantu; Shubina-Oleinik, Olga; Holt, Jeffrey R.; Liu, David R.
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errSave
Continuous evolution of base editors with expanded target compatibility and improved activity
errNATURE BIOTECHNOLOGY
IF41.7
err2019-07-22
err269
errOAAI
errThuronyi, Benjamin W.; Koblan, Luke W.; Levy, Jonathan M.; Yeh, Wei-Hsi; Zheng, Christine; Newby, Gregory A.; Wilson, Christopher; Bhaumik, Mantu; Shubina-Oleinik, Olga; Holt, Jeffrey R.; Liu, David R.
errShare
errSave
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
errNATURE MEDICINE
IF50
err2019-07-03
err154
errOAAI
errGyorgy, Bence; Nist-Lund, Carl; Pan, Bifeng; Asai, Yukako; Karavitaki, K. Domenica; Kleinstiver, Benjamin P.; Garcia, Sara P.; Zaborowski, Mikolaj P.; Solanes, Paola; Spataro, Sofia; Schneider, Bernard L.; Joung, J. Keith; Geleoc, Gwenaelle S. G.; Holt, Jeffrey R.; Corey, David P.
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errSave
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders (vol 10, 236, 2019)
errNATURE COMMUNICATIONS
IF15.7
err2019-02-08
err3
errOAAI
errNist-Lund, Carl A.; Pan, Bifeng; Patterson, Amy; Asai, Yukako; Chen, Tianwen; Zhou, Wu; Zhu, Hong; Romero, Sandra; Resnik, Jennifer; Polley, Daniel B.; Geleoc, Gwenaelle S.; Holt, Jeffrey R.
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Research Directions

The data has not been retrieved yet.
Co-authors
Cooperation Journals
M
Maiken Nedergaard
H-index: 157 · Papers: 583
D
David R. Liu
H-index: 124 · Papers: 380
K
Kausik K. Ray
H-index: 120 · Papers: 842
R
Richard J. Smith
H-index: 118 · Papers: 1.5K
P
Patrick Aebischer
H-index: 103 · Papers: 460
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