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Discovery of a Chiral 2,4-Substituted Pyrrolo[2,3-d]pyrimidine as a Potent, Selective, and Orally Bioavailable LRRK2 Inhibitor Moukha-Chafiq, Omar; Malankhanova, Tuyana; Valiyaveettil, Jacob; Gupta, Vandana; Kezar, Hollis; Zhang, Sixue; Nguyen, Theresa H.; Karyakarte, Shuklendu; Zhang, Wei; Bhakat, Soumendranath; Galemmo, Robert A.; Ananthan, Subramaniam; Manuvakhova, Anna; Ross, Larry I.; Maddry, Joseph A.; Bostwick, Robert; Suto, Mark J.; West, Andrew; Augelli-Szafran, Corinne E. Share Save
Bioaccumulation of microplastics in decedent human brains (feb, 10.1038/s41591-024-03453-1, 2025) Nihart, Alexander J.; Garcia, Marcus A.; El Hayek, Eliane; Liu, Rui; Olewine, Marian; Kingston, Josiah D.; Castillo, Eliseo F.; Gullapalli, Rama R.; Howard, Tamara; Bleske, Barry; Scott, Justin; Gonzalez-Estrella, Jorge; Gross, Jessica M.; Spilde, Michael; Adolphi, Natalie L.; Gallego, Daniel F.; Jarrell, Heather S.; Dvorscak, Gabrielle; Zuluaga-Ruiz, Maria E.; West, Andrew B.; Campen, Matthew J. Share Save
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases Sokratian, Arpine; Zhou, Ye; Tatli, Meltem; Burbidge, Kevin J.; Xu, Enquan; Viverette, Elizabeth; Donzelli, Sonia; Duda, Addison M.; Yuan, Yuan; Li, Huizhong; Strader, Samuel; Patel, Nirali; Shiell, Lauren; Malankhanova, Tuyana; Chen, Olivia; Mazzulli, Joseph R.; Perera, Lalith; Stahlberg, Henning; Borgnia, Mario; Bartesaghi, Alberto; Lashuel, Hilal A.; West, Andrew B. Share Save
Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation Yuan, Yuan; Li, Huizhong; Sreeram, Kashyap; Malankhanova, Tuyana; Boddu, Ravindra; Strader, Samuel; Chang, Allison; Bryant, Nicole; Yacoubian, Talene A.; Standaert, David G.; Erb, Madalynn; Moore, Darren J.; Sanders, Laurie H.; Lutz, Michael W.; Velmeshev, Dmitry; West, Andrew B. Share Save
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Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation Liu, Zhiyong; Sokratian, Arpine; Duda, Addison M.; Xu, Enquan; Stanhope, Christina; Fu, Amber; Strader, Samuel; Li, Huizhong; Yuan, Yuan; Bobay, Benjamin G.; Sipe, Joana; Bai, Ketty; Lundgaard, Iben; Liu, Na; Hernandez, Belinda; Rickman, Catherine Bowes; Miller, Sara E.; West, Andrew B. Share Save
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Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson's-like pathology burden Delic, Vedad; Karp, Joshua H.; Guzman, Maynard; Arismendi, Gabriel R.; Stalnaker, Katherine J.; Burton, Julia A.; Murray, Kathleen E.; Stamos, Joshua P.; Beck, Kevin D.; Sokratian, Arpine; West, Andrew B.; Citron, Bruce A. Share Save
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Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity Fernandez, Belen; Chittoor-Vinod, Vinita G.; Kluss, Jillian H.; Kelly, Kaela; Bryant, Nicole; Nguyen, An Phu Tran; Bukhari, Syed A.; Smith, Nathan; Ordonez, Antonio Jesus Lara; Fdez, Elena; Chartier-Harlin, Marie-Christine; Montine, Thomas J.; Wilson, Mark A.; Moore, Darren J.; West, Andrew B.; Cookson, Mark R.; Nichols, R. Jeremy; Hilfiker, Sabine Share Save
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