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S

Stephen H. Leppla

national institutes of health (nih) - usa

89H-index
385Paper Count
2.3WCitation Count
Published Papers 133
Publication Date
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Structural basis of double-stranded RNA recognition by the J2 monoclonal antibody
errNature Communications
IF15.7
err2025-12-13
err0
errOAAI
errCharles Bou-Nader; Kevin M. Juma; Ankur Bothra; Andrew J. Brasington; Rodolfo Ghirlando; Motoshi Suzuki; David N. Garboczi; Stephen H. Leppla; Jinwei Zhang
errShare
errSave
Environmental regulation of toxin production in Bacillus anthracis
errPLOS PATHOGENS
IF4.9
err2025-12-01
err1
PREAI
errBothra, Ankur; Pomerantsev, Andrei; Schwarz, Benjamin; Mondal, Anupam; Bohrnsen, Eric; Sangwan, Nitika; Stromberg, Kaitlin A.; Moayeri, Mahtab; Ma, Qian; Fattah, Rasem; Ganesan, Sundar; Bosio, Catharine M.; Leppla, Stephen H.
errShare
errSave
Anthrax ET activates Rac1 and RTK signaling to induce F-actin reorganization and endothelial permeability
erriScience
IF4.1
err2025-10-03
err0
errOAAI
errPrashant Jain; Annabel Guichard; Mahtab Moayeri; Saluja Kaduwal; Margot Mel de Fontenay; Ian Rousseau; Stephen H. Leppla; Ethan Bier
errShare
errSave
Targeting virulence to disarm the pathogen: Enzyme-activated-substrate inhibition of Anthrax edema factor
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2025-09-02
err0
PREAI
errSeongjin Kim; Lynne Cregar-Hernandez; Mahtab Moayeri; Stephen H. Leppla; Alan T. Johnson
errShare
errSave
ERK pathway reactivation prevents anthrax toxin lethality in mice
errNATURE MICROBIOLOGY
IF19.4
err2025-03-28
err1
PREAI
errLiu, Jie; Zuo, Zehua; Ewing, Michael; Cao, Qing; Cao, Liu; Li, Qi; Finkel, Toren; Leppla, Stephen H.
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errSave
Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system
errMBIO
IF4.7
err2024-12-11
err0
errOAAI
errLiu, Jie; Zuo, Zehua; Fattah, Rasem; Finkel, Toren; Leppla, Stephen H.; Liu, Shihui
errShare
errSave
Environmental Regulation of Toxin Production in Bacillus Anthracis
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-03-01
err0
errOAAI
errBothra, Ankur; Schwarz, Benjamin; Pomerantsev, Andrei; Fattah, Rasem; Moayeri, Mahtab; Bosio, Catharine; Leppla, Stephen
errShare
errSave
S9.6-based hybrid capture immunoassay for pathogen detection
errSCIENTIFIC REPORTS
IF3.9
err2023-12-19
err1
errOAAI
errBothra, Ankur; Perry, Megan L.; Wei, Elena; Moayeri, Mahtab; Ma, Qian; Biamonte, Marco A.; Siirin, Marina; Leppla, Stephen H.
errShare
errSave
S9.6 Antibody-Enzyme Conjugates for the Detection of DNA-RNA Hybrids
errBIOCONJUGATE CHEMISTRY
IF3.9
err2023-04-17
err5
errOAAI
errWei, Elena; Bou-Nader, Charles; Perry, Megan L.; Fattah, Rasem; Zhang, Jinwei; Leppla, Stephen H.; Bothra, Ankur
errShare
errSave
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err159
errOAAI
errLiu, SH; Milne, GT; Kuremsky, JG; Fink, GR; Leppla, SH
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errSave
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err65
errOAAI
errLiu, Shihui; Wiggins, Jason F.; Sreenath, Taduru; Kulkarni, Ashok B.; Ward, Jerrold M.; Leppla, Stephen H.
errShare
errSave
ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2022-12-27
err16
errOAAI
errZuo, Zehua; Liu, Jie; Sun, Zhihao; Cheng, Yu-Wei; Ewing, Michael; Bugge, Thomas H.; Finkel, Toren; Leppla, Stephen H.; Liu, Shihui
errShare
errSave
Role of serine/threonine protein phosphatase PrpN in the life cycle of Bacillus anthracis
errPLOS PATHOGENS
IF4.9
err2022-08-01
err3
errOAAI
errGangwal, Aakriti; Sangwan, Nitika K.; Dhasmana, Neha P.; Kumar, Nishant H.; Keshavam, Chetkar Chandra; Singh, Lalit M.; Bothra, Ankur; Goel, Ajay M.; Pomerantsev, Andrei; Leppla, Stephen M.; Singh, Yogendra
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errSave
Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2022-07-08
err3
errOAAI
errDuru, Nadire; Pawar, Nisha R.; Martin, Erik W.; Buzza, Marguerite S.; Conway, Gregory D.; Lapidus, Rena G.; Liu, Shihui; Reader, Jocelyn; Rao, Gautam G.; Roque, Dana M.; Leppla, Stephen H.; Antalis, Toni M.
errShare
errSave
A potent tumor-selective ERK pathway inactivator with high therapeutic index
errPNAS NEXUS
IF3.8
err2022-07-01
err5
errOAAI
errZuo, Zehua; Liu, Jie; Sun, Zhihao; Silverstein, Rachel; Zou, Meijuan; Finkel, Toren; Bugge, Thomas H.; Leppla, Stephen H.; Liu, Shihui
errShare
errSave
Structural basis of R-loop recognition by the S9.6 monoclonal antibody
errNATURE COMMUNICATIONS
IF15.7
err2022-03-28
err41
errOAAI
errBou-Nader, Charles; Bothra, Ankur; Garboczi, David N.; Leppla, Stephen H.; Zhang, Jinwei
errShare
errSave
Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-01-01
err4
errOAAI
errMerritt, Carly; Chun, Elizabeth M.; Fattah, Rasem J.; Silva, Lakmali M.; Ma, Quinn Q.; Moayeri, Mahtab; Paliga, Dennis; Neumann, Sebastian; Heumann, Rolf; Leppla, Stephen H.; Bugge, Thomas H.
errShare
errSave
The Crystal Structure of Bacillus cereus HblL1
errTOXINS
IF4
err2021-03-31
err7
errOAAI
errWorthy, Harley L.; Williamson, Lainey J.; Auhim, Husam Sabah; Leppla, Stephen H.; Sastalla, Inka; Jones, D. Dafydd; Rizkallah, Pierre J.; Berry, Colin
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errSave
A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models
errTOXINS
IF4
err2021-01-13
err2
errOAAI
errCouse, Zoe; Cui, Xizhong; Li, Yan; Moayeri, Mahtab; Leppla, Stephen; Eichacker, Peter Q.
errShare
errSave
Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells
errTOXINS
IF4
err2020-09-24
err1
errOAAI
errda Fonseca, Jonathan Mackowiak; Mackowiak da Fonseca, Ivone Izabel; Nagamine, Marcia Kazumi; Massoco, Cristina de Oliveira; Nishiya, Adriana Tomoko; Ward, Jerrold Michael; Liu, Shihui; Leppla, Stephen Howard; Bugge, Thomas Henrik; Zaidan Dagli, Maria Lucia
errShare
errSave

Research Directions

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Co-authors
Cooperation Journals
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Lewis C. Cantley
H-index: 214 · Papers: 1.4K
T
Tien Yin Wong
H-index: 208 · Papers: 3.1K
S
Steven M. Holland
H-index: 155 · Papers: 1.9K
R
Robert G. Parton
H-index: 149 · Papers: 705
G
GutkindJ.Silvio (J. Silvio Gutkind)
H-index: 140 · Papers: 1.3K
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