David J. Lefer - Publications, H-index & Citations

Back

David J. Lefer

louisiana state university system

92H-index

513Paper Count

3.1WCitation Count

Published Papers 208

Publication Date

Obesity and Heart Failure With Preserved Ejection Fraction: A Clinical Nexus for Exercise Intolerance

Obesity

IF4.7

2026-03-01

PREAI

Pandit, Abhishek; Gupta, Mahima; Arabie, Daniel A.; Milton, Payton; Elbatreek, Mahmoud; Goodchild, Traci; Lefer, David J.; Francis, Joseph; Moll, David; Allerton, Timothy D.

Save

Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF

jacc basic to translational science

IF0

2025-08-15

PREAI

Andrew A. Gibb; Kyle LaPenna; Ryan B. Gaspar; Nadina R. Latchman; Yinfei Tan; Carmen Choya-Foces; Jake E. Doiron; Zhen Li; Huijing Xia; Michael P. Lazaropoulos; Mariell Conwell; Thomas E. Sharp; Traci T. Goodchild; David J. Lefer; John W. Elrod

Save

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF

jacc basic to translational science

IF0

2025-08-06

OAAI

Jake E. Doiron; Mahmoud H. Elbatreek; Huijing Xia; Xiaoman Yu; Natalie D. Gehred; Tatiana Gromova; Jingshu Chen; Ian H. Driver; Naoto Muraoka; Martin Jensen; Smitha Shambhu; W.H. Wilson Tang; Kyle B. LaPenna; Thomas E. Sharp; Traci T. Goodchild; Ming Xian; Shi Xu; Heather Quiriarte; Timothy D. Allerton; Alexia Zagouras; Jennifer Wilcox; Sanjiv J. Shah; Josef Pfeilschifter; Karl-Friedrich Beck; Thomas M. Vondriska; Zhen Li; David J. Lefer

Save

Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study

Clinical and Translational Science

IF2.8

2025-07-31

OAAI

Thomas E. Sharp III; Amy L. Scarborough; Amelia G. Haydel; J. Stephen Jenkins; Marloe Prince; Aashish Gupta; Florian Rader; Zhen Li; David J. Lefer; Traci T. Goodchild

Save

Impact of Voluntary Exercise on Systemic Inflammation in a 2? Hit Model of Heart Failure With Preserved Ejection Fraction

JOURNAL OF THE AMERICAN HEART ASSOCIATION

IF5.3

2025-02-18

OAAI

Quiriarte, Heather; Cho, Eunhan; Kim, Youyoung; Doiron, Jake E.; Davis, Gregory; Stampley, James; Noland, Robert C.; Li, Zhen; Shah, Sanjiv J.; Irving, Brian A.; Spielmann, Guillaume; Lefer, David J.; Allerton, Timothy D.

Save

Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation

PHARMACOLOGICAL RESEARCH

IF10.5

2025-01-01

OAAI

Zampas, Paraskevas; Li, Zhen; Katsouda, Antonia; Varela, Aimilia; Psarras, Stelios; Davos, Constantinos H.; Lefer, David J.; Papapetropoulos, Andreas

Save

Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2024-12-01

PREAI

Jani, Vivek P.; Koleini, Navid; Fenwick, Axel J.; Sharp, Thomas E.; Goodchild, Traci T.; Hill, Joseph A.; Lefer, David J.; Cammarato, Anthony; Kass, David A.

Save

A Bifunctional Sulfide Donor Approach for Ischemic Stroke: Leveraging Butylphthalide as a Carrier for Sulfide Prodrug

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-11-20

PREAI

Peng, Wen; Liu, Jianru; Li, Zhen; Wang, Yuanan; Sun, Yangqian; Chen, Yanzhao; Lefer, David J.; Guo, Weiwei; Zheng, Yueqin

Save

Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model

SCIENTIFIC REPORTS

IF3.9

2024-10-30

PREAI

Allerton, Timothy D.; Stampley, James E.; Li, Zhen; Yu, Xiaoman; Quiariate, Heather; Doiron, Jake E.; White, Ginger; Wigger, Zach; Gartia, Manas Ranjan; Lefer, David J.; Soto, Paul; Irving, Brian A.

Save

A Highly Atom-Efficient Prodrug Approach to Generate Synergy between H2S and Nonsteroidal Anti-inflammatory Drugs and Improve Safety

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-09-24

PREAI

Peng, Wen; Qin, Lixiao; Wang, Tianci; Sun, Yangqian; Li, Zhen; Lefer, David J.; Luo, Cheng; Ye, Fei; Wang, Binghe; Guo, Weiwei; Zheng, Yueqin

Save

Circulating Inflammation and the Plasma Proteome in Heart Failure With Preserved Ejection Fraction

JACC-BASIC TO TRANSLATIONAL SCIENCE

IF7.2

2024-09-01

OAAI

Vondriska, Thomas M.; Lefer, David J.

Save

Gut Microbial Metabolite Phenylacetylglutamine Leads to Cardiomyocyte Hypercontractility and Vascular Endothelial Cell Activation

CIRCULATION RESEARCH

IF16.2

2024-08-02

PREAI

Li, Zhen; Zaparte, Aline; Fu, Xiaoming; Li, Xinmin; Wong, David; Gibson, Aaron; Gorse, Kiersten; Wong, Zeneng; Hazen, Stanley; Lefer, David; Quijada, Pearl; Makarewich, Cat; Sharp, Thomas

Save

Mitochondrial Hydrogen Sulfide Regulates Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF

CIRCULATION RESEARCH

IF16.2

2024-08-02

PREAI

Allerton, Timothy; Doiron, Jake; Elbatreek, Mahmoud; Li, Zhen; Stampley, James; Davis, Gregory, III; Noland, Robert; Irving, Brian; Sharp, Thomas; Xia, Huijing; Shah, Sanjiv; Lefer, David

Save

3-Mercaptopyruvate Sulfurtransferase is a Critical Regulator of Branched-Chain Amino Acid Catabolism in Cardiometabolic HFpEF

CIRCULATION RESEARCH

IF16.2

2024-08-02

PREAI

Li, Zhen; Doiron, Jake; Xia, Huijing; LaPenna, Kyle; Sharp, Thomas; Yu, Xiaoman; Nagahara, Noriyuki; Goodchild, Traci; Lefer, David

Save

Aberrant Trans- and De- Nitrosylation Underpins Nitrosative Stress in Cardiometabolic HFpEF

CIRCULATION RESEARCH

IF16.2

2024-08-02

PREAI

Li, Zhen; Gehred, Natalie; Gromova, Tatiana; LaPenna, Kyle; Sharp, Thomas; Chen, Jingshu; Shambhu, Smitha; Yu, Xiaoman; Goodchild, Traci; Jensen, Martin Borch; Vondriska, Thomas; Lefer, David

Save

Improved Skeletal Muscle Metabolism and Exercise Capacity Following Hydrogen Sulfide Therapy in Cardiometabolic HFpEF

CIRCULATION RESEARCH

IF16.2

2024-08-02

PREAI

Allerton, Timothy; Quiriarte, Heather; Li, Zhen; Stampley, James; Davis, Gregory, III; Noland, Robert; Doiron, Jake; Sharp, Thomas; Xia, Huijing; Shah, Sanjiv; Irving, Brian; Lefer, David

Save

Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2024-07-09

OAAI

Doiron, Jake E.; Xia, Huijing; Yu, Xiaoman; Nevins, Alexandra R.; LaPenna, Kyle B.; Sharp III, Thomas E.; Goodchild, Traci T.; Allerton, Timothy D.; Elgazzaz, Mona; Lazartigues, Eric; Shah, Sanjiv J.; Li, Zhen; Lefer, David J.

Save

Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction

JOURNAL OF THE AMERICAN HEART ASSOCIATION

IF5.3

2024-02-20

OAAI

Doiron, Jake E.; Li, Zhen; Yu, Xiaoman; LaPenna, Kyle B.; Quiriarte, Heather; Allerton, Timothy D.; Koul, Kashyap; Malek, Andrew; Shah, Sanjiv J.; Sharp, Thomas E.; Goodchild, Traci T.; Kapusta, Daniel R.; Lefer, David J.

Save

Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics

JOURNAL OF THE AMERICAN HEART ASSOCIATION

IF5.3

2024-01-16

OAAI

Fenwick, Axel J.; Jani, Vivek P.; Foster, D. Brian; Sharp, Thomas E.; Goodchild, Traci T.; LaPenna, Kyle; Doiron, Jake E.; Lefer, David J.; Hill, Joseph A.; Kass, David A.; Cammarato, Anthony

Save

Cardiomyocyte Mechanics In Animal Models Of Heart Failure With Preserved Ejection Fraction

CIRCULATION RESEARCH

IF16.2

2023-08-04

PREAI

Jani, Vivek; Fenwick, Axel; Mishra, Sumita; Sharp, Thomas E.; Doiron, Jake; LaPenna, Kyle B.; Goodchild, Traci T.; Jiang, Nan; Gillette, Thomas G.; Hill, Joseph A.; Lefer, David J.; Kass, David A.

Save

Research Directions