Not logged in Afadin loss induces breast cancer metastasis through destabilisation of E-cadherin to F-actin linkage Ratze, Max A. K.; Enserink, Lotte N. F. L.; Ishiyama, Noboru; Veltman, Christina H. J.; Nijman, Isaac J.; Haakma, Wisse E.; Caldas, Carlos; van Diest, Paul J.; Christgen, Matthias; Koorman, Thijs; Derksen, Patrick W. B. Share Save
α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure Wang, Yuou; Yemelyanov, Alex; Go, Christopher D.; Kim, Sun K.; Quinn, Jeanne M.; Flozak, Annette S.; Le, Phuong M.; Liang, Shannon; Gingras, Anne-Claude; Ikura, Mitsu; Ishiyama, Noboru; Gottardi, Cara J. Share Save
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Preclinical characterization of a brain penetrant RAF inhibitor, BDTX-4933, targeting oncogenic BRAF Class I/II/III and RAS mutations Han, Yoon-Chi; Ng, Pui-Yee; Ogawa, Luisa Shin; Yang, Shao Ning; Chen, Miao; Ishiyama, Noboru; Lin, Tai-An; Buck, Elizabeth Share Save
Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects Ishiyama, Noboru; O'Connor, Matthew; Salomatov, Andrei; Romashko, Darlene; Thakur, Shalabh; Mentes, Ahmet; Hopkins, Julia F.; Frampton, Garrett M.; Albacker, Lee A.; Kohlmann, Anna; Roberts, Christopher; Buck, Elizabeth Share Save
Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin Duong, Cao Nguyen; Brueckner, Randy; Schmitt, Martina; Nottebaum, Astrid F.; Braun, Laura J.; Zu Brickwedde, Marika Meyer; Ipe, Ute; Vom Bruch, Hermann; Schoeler, Hans R.; Trapani, Giuseppe; Trappmann, Britta; Ebrahimkutty, Mirsana P.; Huveneers, Stephan; de Rooij, Johan; Ishiyama, Noboru; Ikura, Mitsuhiko; Vestweber, Dietmar Share Save
Pre-clinical evaluation of next-generation inhibitor targeting a wide spectrum of oncogenic BRAF dimers Han, Yoon-Chi; Ng, Pui Yee; Schulz, Ryan; Yang, Shao Ning; Lelo, Alana; Shin, Luisa; O'Connor, Matthew; Jewett, Ivan; Ishiyama, Noboru; Romashko, Darlene; Thakur, Shalabh; Salomatov, Andrei; Smith, Sherri; Buck, Elizabeth; Roberts, Christopher; Lucas, Matthew; Lin, Tai-An Share Save
Pre-clinical evaluation of potent and orally bioavailable next-generation inhibitors targeting the family of mutants that drive oncogenic BRAF dimer formation Han, Y-C.; Ng, P. Y.; Schulz, R.; Yang, S. N.; Lelo, A.; Ogawa, L. S.; O'Connor, M.; Ishiyama, N.; Jewett, I.; Romashko, D.; Salomatov, A.; Thakur, S.; Smith, S.; Buck, E.; Roberts, C.; Lucas, M.; Lin, T-A. Share Save
Discovery and characterization of selective, FGFR1-sparing, inhibitors of FGFR2/3 oncogenic mutations for the treatment of cancers Dardenne, E.; Padilla, F.; Rasmussen, S.; Yang, S. N.; Mentes, A.; Ogawa, L. S.; Fiorenza, R.; Trombino, A.; Smith, S.; Romashko, D.; Ishiyama, N.; Chevtsova, M.; Thakur, S.; Rosfjord, E.; Buck, E.; Roberts, C.; Lucas, M.; Lin, T-A. Share Save
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Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions Ishiyama, Noboru; Sarpal, Ritu; Wood, Megan N.; Barrick, Samantha K.; Nishikawa, Tadateru; Hayashi, Hanako; Kobb, Anna B.; Flozak, Annette S.; Yemelyanov, Alex; Fernandez-Gonzalez, Rodrigo; Yonemura, Shigenobu; Leckband, Deborah E.; Gottardi, Cara J.; Tepass, Ulrich; Ikura, Mitsuhiko Share Save
MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity Sandi, Maroa-Jose; Marshall, Christopher B.; Balan, Marc; Coyaud, Etienne; Zhou, Ming; Monson, Daniel M.; Ishiyama, Noboru; Chandrakumar, Arun A.; La Rose, Jose; Couzens, Amber L.; Gingras, Anne-Claude; Raught, Brian; Xu, Wei; Ikura, Mitsuhiko; Morrison, Deborah K.; Rottapel, Robert Share Save
Evolution of AF6-RAS association and its implications in mixed-lineage leukemia Smith, Matthew J.; Ottoni, Elizabeth; Ishiyama, Noboru; Goudreault, Marilyn; Haman, Andre; Meyer, Claus; Tucholska, Monika; Gasmi-Seabrook, Genevieve; Menezes, Serena; Laister, Rob C.; Minden, Mark D.; Marschalek, Rolf; Gingras, Anne-Claude; Trang Hoang; Ikura, Mitsuhiko Share Save
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An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function Zheng, Weiyue; Umitsu, Masataka; Jagan, Ishaan; Tran, Charles W.; Ishiyama, Noboru; BeGora, Michael; Araki, Kiyomi; Ohashi, Pamela S.; Ikura, Mitsuhiko; Muthuswamy, Senthil K. Share Save
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α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism Escobar, David J.; Desai, Ridhdhi; Ishiyama, Noboru; Folmsbee, Stephen S.; Novak, Megan N.; Flozak, Annette S.; Daugherty, Rebecca L.; Mo, Rigen; Nanavati, Dhaval; Sarpal, Ritu; Leckband, Deborah; Ikura, Mitsu; Tepass, Ulrich; Gottardi, Cara J. Share Save
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An Autoinhibited Structure of α-Catenin and Its Implications for Vinculin Recruitment to Adherens Junctions Ishiyama, Noboru; Tanaka, Nobutoshi; Abe, Kentaro; Yang, Yoo Jeong; Abbas, Yazan M.; Umitsu, Masataka; Nagar, Bhushan; Bueler, Stephanie A.; Rubinstein, John L.; Takeichi, Masatoshi; Ikura, Mitsuhiko Share Save
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