Merck Kgaa

学者数3.3K

论文数2.0K

被引数11

关联论文 (1938)

发表时间

A Supply Chain Digital Twin for Adaptive Master Planning under Multi-Source Disruptions: Evidence from a Dual-Channel Manufacturing Case 多源中断下用于适应性主计划的供应链数字孪生：来自双渠道制造案例的证据

International Journal of Production Economics

IF10

2026-08-28

PREAI

Ali Rouzkhosh; S. Ali Torabi; Ali Beiki Ashkezari; Amir Ghasemi

A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability 一项基于实验亲和力与可开发性的模拟抗体发现的盲法前瞻性基准研究

Nature Biotechnology

IF41.7

2026-08-19

OAAI

M. Frank Erasmus; Daniel Bedinger; Elizabeth Hopkins; Ginger Ferguson; Justine Strickler; Christilyn P. Graff; Samantha R. Summers; Stacy L. Capehart; Joshua D. Slocum; Crystal Richardson; Sumit Kumar; Zhifei Sun; Yujie Shang; Jixian Zhang; Ming Gu; Lixia Yi; Alon Wellner; Shuangjia Zheng; Wei Lu; Pietro Sormanni; Matthew Greenig; Haiping Zhang; Brendan T. Mann; Mahdi Baghbanzadeh; Ali Rahnavard; Gregory L. Moore; Huaiyu Sun; Ying Ding; Alex Nisthal; Jitendra Kanodia; Matthew J. Bernett; Aurélien Pélissier; Yanjun Shao; Maria Rodriguez Martinez; Karthik Ramesh; Horacio Nastri; Andreas Evers; Anhar Abdelatif; Andrew J. Bordner; Mykola Bordyuh; Lim Heo; Brian A. Kidd; H. Serhat Tetikol; Shuai Wei; Jung-Eun Shin; Ryan Peckner; Leigh Manley; Ajitesh Lunge; Yashas Devasurmutt; Bora Guloglu; Liviu Copoiu; Miles McGibbon; Monica L. Fernandez-Quintero; Nitesh Mishra; Sean M. Callaghan; Olivia M. Swanson; Daniel L. V. Bader; James A. Ferguson; Sai S. R. Raghavan; Benjamin Nemoz; Colleen A. Maillie; Charles Bowman; Bryan Briney; Andrew B. Ward; Paolo Marcatili; Rahmad Akbar; Bing He; Fandi Wu; Jianhua Yao; Bin Hu; Michal Kucer; Kaetlyn Rose Gibson; Rahul Somasundaram; Li-Wei Hung; Tomasz Kaszuba; Daved H. Fremont; Hyeongsun Jeong; Vinodh Babu Kurella; Shipra Malhotra; Satyendra Kumar; Yanyun Liu; Lingling Xu; Joshua Misa; Alexander Nicholas St. John; Jeff Vogt; Fátima A. Dávila-Hernández; Da Xu; Michael Chungyoun; Zyaja D. Huggan; Jeffrey J. Gray; Jonathan Parkinson; Young Su Ko; Wei Wang; Franziska Geiger; Jonathon D. Ziegler; Nikhil Haas; Chance Challacombe; Ahmad Qamar; Akshita Singh; Yi-Ching Tang; Zhiqiang An; Xiaoqian Jiang; Yejin Kim; Xinyan Zhao; Erik Swanson; Jürgen Klattig; Karsten Winkler; Tschimegma Bataa; Volker Sandig; Lilian Denzler; Chunan Liu; Randall J. Brezski; Laura Spector; Katheryn Perea-Schmittle; Sara D’Angelo; Fortunato Ferrara; Andrew R. M. Bradbury

Structure Elucidation and Initial Characterization of a N-glucuronide Metabolite (M1) of Tuvusertib Tuvusertib的N-葡糖醛酸苷代谢物（M1）的结构解析与初步表征

European Journal of Drug Metabolism and Pharmacokinetics

IF2.4

2026-07-01

PREAI

Lang, Benedikt; Schieferstein, Hanno; Thede, Kai; Bader, Matthias; Ren, Tianjing; Mukker, Jatinder Kaur; Scheible, Holger

RiboScreenTM Technology Delivers Small-Molecule Ribodrugs to Convert Ribosomal Proteins into Molecular Valves for Tailored Protein Production Levels in Rare and Prevalent Disease RiboScreenTM技术将小分子核糖体药物递送至细胞，将核糖体蛋白转化为分子阀门，以调节罕见病和常见病中定制化的蛋白质生产水平

Biomedicines

IF3.9

2026-06-24

OAAI

Genevieve Edobor; Ronald Huber; Christoph Reiter; Hanna Gercke; Niklas Kaefer; Elli Kronsteiner; Bjoern Wimmer; Marlies Wimmer; Thomas Karl; Mark Rinnerthaler; Jan Krauß; Heinrich Krobath; Thomas Mohr; Christopher Gerner; Joerg von Hagen; Norbert Müller; Helmut Hintner; Bernadette Liemberger; Ulrich Koller; Johann W. Bauer; Gazmend Temaj; Hannelore Breitenbach-Koller

Cytosine base editor-DNA binding domain fusions for editing window modulation in the RNP format 胞嘧啶碱基编辑器-DNA结合结构域融合用于核糖核蛋白格式中的编辑窗口调节

BMC Biotechnology

IF3.4

2026-06-23

OAAI

Erin Brettmann; Fuqiang Chen; Stephen Beishir; Graeme Garvey

Osmolality-Independent Impact of Sodium on Glycosylation of an Fc-Fusion Protein and the Hexosamine Biosynthesis Pathway in a Chinese Hamster Ovary Cell Line 渗透压无关的钠离子对Fc融合蛋白糖基化及六碳糖胺合成通路在中国仓鼠卵巢细胞系中的影响

Biotechnology Journal

IF3.1

2026-06-17

OAAI

Jason Reiniger; Adrian Pöttner; Lara Rosenberger; Aline Zimmer

Author Correction: 3D bio-screen printing for high-throughput production of scaffolds for meat alternatives 作者更正：3D生物筛网印刷用于肉替代品高通量支架生产

npj Science of Food

IF7.8

2026-06-11

OAAI

Robin Maatz; Philipp Karnop; Ryan Sylvia; Thomas Herget; Andreas Blaeser

OrgLine: A versatile pipeline for organoid morphometry using detector-guided prompts OrgLine：一种使用探测器引导提示的类器官形态测量通用管道

Cell Reports Methods

IF4.5

2026-06-08

OAAI

Xun Deng; Xinyu Hao; Thomas Herget; Mei Gao; Mathias Winkel; Feng Tan; Lun Hu; Pengwei Hu

Progression to Wheelchair in Secondary Progressive Multiple Sclerosis and Impact of Siponimod: Post Hoc Analyses From the EXPAND Study 继发性进展型多发性硬化中轮椅进展及Siponimod的影响：EXPAND研究的事后分析

European Journal of Neurology

IF3.9

2026-06-08

OAAI

Patrick Vermersch; Sophie Arnould; Ralf Gold; Ludwig Kappos; Robert Fox; Amit Bar-Or; Bruce A. C. Cree; Soudeh Ansari; Daniela Piani Meier; Goeril Karlsson; Nicolas Rouyrre; Gavin Giovannoni

Theoretical and Experimental Assessment of Nitrosamine Risk in Industrial Solvent Recovery 工业溶剂回收中硝基亚胺风险的理论及实验评估

ACS Sustainable Chemistry & Engineering

IF0

2026-05-21

OAAI

Peter Ritzler; Holger Bauer; Michael Burns; Brunhilde Guessregen; Andrés González de Castilla; Stephanie Peper; Naiffer Romero; Joerg Schlingemann; Jonathan Stanway; Simone Tomasi

Large-Scale Collaborative Assessment of Binding Free Energy Calculations for Drug Discovery Using OpenFE 利用OpenFE进行药物发现中结合自由能计算的大规模协作评估

Journal of Chemical Information and Modeling

IF5.3

2026-05-21

PREAI

Hannah M. Baumann; Joshua T. Horton; Michael M. Henry; Alyssa Travitz; Benjamin Ries; Richard J. Gowers; David W. H. Swenson; Iván Pulido; Dominic Rufa; David L. Dotson; Nupur Bansal; Joseph P. Bluck; Howard Broughton; Kira A. Campbell; Lili Cao; Benedikt Frieg; Vytautas Gapsys; Hendrik Göddeke; Marco Klähn; Sirish Kaushik Lakkaraju; Stephanie M. Linker; Thomas Löhr; Aniket Magarkar; Sergio Pérez-Conesa; Hans E. Purkey; Hayk Saribekyan; Jenke Scheen; Christina E. M. Schindler; Thomas Steinbrecher; Chaya D. Stern; Patricia Suriana; William C. Swope; Gary Tresadern; Lev Tsidilkovski; Binqing Wei; Alexander H. Williams; Yao Wu; Ivy Zhang; John D. Chodera; James R. B. Eastwood; David L. Mobley; Irfan Alibay

Optimising patient centred drug development to realise impact 优化以患者为中心的药物开发以实现影响

Communications Medicine

IF6.3

2026-05-19

OAAI

Melanie Calvert; Paul Kamudoni; Christina Yap; Claire Snyder; Roger Wilson; Olalekan Lee Aiyegbusi

Verbal Expressions of Probability in Pharmacovigilance: Most Likely Too Ambiguous 药物警戒中概率的言语表达：极有可能过于模糊

Clinical Therapeutics

IF3.6

2026-05-15

PREAI

Manfred Hauben; Nayanika Rivankar

3D bio-screen printing for high-throughput production of scaffolds for meat alternatives 3D生物打印技术在肉制品替代品支架高通量生产中的应用

npj Science of Food

IF7.8

2026-05-13

PREAI

Maatz, Robin; Karnop, Philipp; Sylvia, Ryan; Herget, Thomas; Blaeser, Andreas

Efficacy and safety of enpatoran, a Toll-like receptor 7/8 inhibitor, in patients with skin manifestations of cutaneous lupus erythematosus or systemic lupus erythematosus: findings from Cohort A of a multicentre, international, double-blind, placebo-controlled, dose-finding phase 2 trial 恩帕托兰（一种Toll样受体7/8抑制剂）在具有皮肤表现的皮肤狼疮或系统性红斑狼疮患者中的疗效与安全性：一项多中心、国际性、双盲、安慰剂对照、剂量探索性2期试验中Cohort A的结果

The Lancet Rheumatology

IF0

2026-05-07

PREAI

Eric F Morand; Victoria P Werth; Joerg Wenzel; Richard Furie; Maria Dall’Era; Jorge Sanchez-Guerrero; Sanjeev Roy; Summer G Goodson; Flavie Moreau; Hans Gühring; Evridiki Sgouroudi; Lena Klopp-Schulze; David R Pearson

Comparative assessment of treatment switching in patients with multiple sclerosis receiving cladribine tablets versus fingolimod, dimethyl fumarate, and teriflunomide 多发性硬化症患者接受克拉屈滨片剂、 fingolimod、二甲基富马酸和 teriflunomide 治疗切换的对比评估

Multiple Sclerosis and Related Disorders

IF2.9

2026-05-01

PREAI

Lobo, Carroline; Rey, Gabriel Gomez; Zhao, Xin; Anderson, Jeffrey; Kim, Sonia; Kozma, Chris; Cai, Chao; Evans, Emily; Phillips, Amy L.; Chen, Xiaoxue

Frontal chromatography purification of monoclonal antibodies with high loadings using a cation exchange hydrogel membrane 采用阳离子交换水凝胶膜的 frontal 色谱法高载量纯化单克隆抗体

Journal of Chromatography Open

IF3.2

2026-05-01

PREAI

Dutta, Amit K.; Ly, Ariana; Elbakri, Amro M.; Pham, Vivian; Schroyer, Brett S.; Foley, Sean L.; Goddard, Philip M.; Rautio, Kevin S.; Stone, Matthew T.

Development and validation of a semi-automated hybrid immunocapture liquid chromatography-mass spectrometry method to quantify LALA-mutated biotherapeutics in mouse plasma 半自动化杂交免疫捕获液相色谱-质谱法在鼠血浆中定量检测LALA突变生物治疗药物的研制与验证

European Journal of Pharmaceutical Sciences

IF4.7

2026-04-30

OAAI

Vittoria Papa; Ilse De Salve; Francesco Molinaro; Andrea Di Ianni; Stefania Monge; Rita Mastroianni; Alessandra Ariaudo; Patrizia Tavano; Valeria Castagna; Kyra Cowan; Federico Riccardi Sirtori

Development and First-in-Human Translation of Hyperpolarized [1-13C]Alpha-Ketoglutarate MR Spectroscopy in the Brain 脑内高极化[1-13C]α-酮戊二酸磁共振波谱的开发与首次人体转化研究

Sensors

IF3.5

2026-04-29

OAAI

Yaewon Kim; Duy Dang; James Slater; Andrew Riselli; Donghyun Hong; Jeremy W. Gordon; Susan M. Chang; Yan Li; Javier E. Villanueva-Meyer; Adam W. Autry; Evelyn Escobar; Stacy Andosca; Hsin-Yu Chen; Chou T. Tan; Chris Suszczynski; Sri Maddali; Robert A. Bok; Daniel B. Vigneron

The immunoregulatory role of progesterone during embryo implantation and pregnancy 孕酮在胚胎着床和妊娠过程中的免疫调节作用

trends in endocrinology & metabolism

IF0

2026-04-01

PREAI

Alessandra Colamatteo; Fortunata Carbone; Clorinda Fusco; Claudia Russo; Teresa Micillo; Debora Carluccio; Claudia La Rocca; Wenjing Zheng; Salvatore Longobardi; Giuseppe Matarese