未登录 Structural basis for CCR6 modulation by allosteric antagonists Wasilko, David Jonathan; Gerstenberger, Brian S.; Farley, Kathleen A.; Li, Wei; Alley, Jennifer; Schnute, Mark E.; Unwalla, Ray J.; Victorino, Jorge; Crouse, Kimberly K.; Ding, Ru; Sahasrabudhe, Parag V.; Vincent, Fabien; Frisbie, Richard K.; Dermenci, Alpay; Flick, Andrew; Choi, Chulho; Chinigo, Gary; Mousseau, James J.; Trujillo, John I.; Nuhant, Philippe; Mondal, Prolay; Lombardo, Vincent; Lamb, Daniel; Hogan, Barbara J.; Minhas, Gurdeep Singh; Segala, Elena; Oswald, Christine; Windsor, Ian W.; Han, Seungil; Rappas, Mathieu; Cooke, Robert M.; Calabrese, Matthew F.; Berstein, Gabriel; Thorarensen, Atli; Wu, Huixian 分享 收藏
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Non-Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece Young, Graeme C.; Spracklin, Douglas K.; James, Alexander D.; Hvenegaard, Mette G.; Pedersen, Mette L.; Wagner, David S.; Georgi, Katrin; Schieferstein, Hanno; Bjornsdottir, Inga; Romeo, Andrea A.; Cassidy, Kenneth C.; Da-violante, Georges; Blech, Stefan; Schulz, Simone I.; Cuyckens, Filip; Nguyen, Mai Anh; Scarfe, Graeme 分享 收藏
Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3) Dekkers, Sebastian; Comez, Dehan; Karsai, Noemi; Arimont-Segura, Marta; Canals, Meritxell; Caspar, Birgit; de Graaf, Chris; Kilpatrick, Laura E.; Leurs, Rob; Kellam, Barrie; Hill, Stephen J.; Briddon, Stephen J.; Stocks, Michael J. 分享 收藏
Alchemical Free Energy Calculations on Membrane-Associated Proteins 膜相关蛋白的炼化自由能计算 Papadourakis, Michail; Sinenka, Hryhory; Matricon, Pierre; Henin, Jerome; Brannigan, Grace; Perez-Benito, Laura; Pande, Vineet; van Vlijmen, Herman; de Graaf, Chris; Deflorian, Francesca; Tresadern, Gary; Cecchini, Marco; Cournia, Zoe 分享 收藏
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The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders Poulter, Simon; Austin, Nigel; Armstrong, Rachel; Barnes, Matt; Bucknell, Sarah Joanne; Higueruelo, Alicia; Banjaree, Joydeep; Mead, Andy; Mould, Richard; MacSweeney, Cliona; O'Brien, M. Alistair; Stott, Lisa Alice; Watson, Stephen P. 分享 收藏
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Poster Abstract Black, S. W.; Steinfeld, T.; Gibson, K.; Osborne, G.; Christopher, J. A.; Cooke, R.; Lefker, B.; Ott, G. R.; Accardi, M. A.; Hartman, D. S. 分享 收藏
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode Southall, Stacey M.; Banerjee, Joydeep; Brown, Jason; Butkovic, Kristina; Cansfield, Andrew D.; Cansfield, Julie E.; Congreve, Miles S.; Cseke, Gabriella; Deflorian, Francesca; Hunjadi, Martina Petrovic; Hutinec, Antun; Inturi, Trinadh Kumar; Rupcic, Renata; Saxty, Gordon; Watson, Stephen P. 分享 收藏
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A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor Griffith, David A.; Edmonds, David J.; Fortin, Jean-Philippe; Kalgutkar, Amit S.; Kuzmiski, J. Brent; Loria, Paula M.; Saxena, Aditi R.; Bagley, Scott W.; Buckeridge, Clare; Curto, John M.; Derksen, David R.; Dias, Joao M.; Griffor, Matthew C.; Han, Seungil; Jackson, V. Margaret; Landis, Margaret S.; Lettiere, Daniel; Limberakis, Chris; Liu, Yuhang; Mathiowetz, Alan M.; Patel, Jayesh C.; Piotrowski, David W.; Price, David A.; Ruggeri, Roger B.; Tess, David A. 分享 收藏
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Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes Cansfield, Andrew D.; Ator, Mark A.; Banerjee, Joydeep; Bestwick, Michael; Bortolato, Andrea; Brown, Giles A.; Brown, Jason; Butkovic, Kristina; Cansfield, Julie E.; Christopher, John A.; Congreve, Miles; Cseke, Gabriella; Deflorian, Francesca; Dugan, Benjamin; Hunjadi, Martina Petrovic; Hutinec, Antun; Inturi, Trinadh Kumar; Landek, Goran; Mason, Jonathan; O'Brien, Alistair; Ott, Gregory R.; Rupcic, Renata; Saxty, Gordon; Southall, Stacey M.; Zadravec, Rahela; Watson, Stephen P. 分享 收藏
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease 选择性毒蕈碱M1受体激动剂HTL0018318在轻中度阿尔茨海默病患者中的安全性和初步药效学1b/2a期多中心研究 Nathan, Pradeep. J. J.; Millais, S. Babli; Godwood, Alex; Dewit, Odile; Cross, David. M. M.; Liptrot, Janet; Ruparelia, Bharat; Jones, Stephen Paul; Bakker, Geor; Maruff, Paul. T. T.; Light, Gregory. A. A.; Brown, Alastair J. H.; Weir, Malcolm Peter; Congreve, Miles; Tasker, Tim 分享 收藏
The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation Winfield, Ian; Barkan, Kerry; Routledge, Sarah; Robertson, Nathan J.; Harris, Matthew; Jazayeri, Ali; Simms, John; Reynolds, Christopher A.; Poyner, David R.; Ladds, Graham 分享 收藏
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