未登录Metastatic tropism of molecularly defined clear-cell renal cell carcinoma clusters分子定义的透明细胞肾细胞癌亚群转移趋向性
Haddad, Gaelle; Guo, Junyu; Xi, Yin; Albayrak, Emin; Huseni, Mahrukh; Hamidi, Habib; Banchereau, Romain; Kadel, Edward; Dubey, Sarita; Carter, Corey; Kapur, Payal; Brugarolas, James; Pedrosa, Ivan .png)
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收藏TWO-YEAR EFFECTIVENESS, DURABILITY AND SAFETY OF FARICIMAB IN EYES WITH DIABETIC MACULAR OEDEMA: RESULTS FROM THE UK FARWIDE-DMO STUDYfaricimab在糖尿病黄斑水肿眼中的两年有效性与持久性及安全性：UK FARWIDE-DMO研究的结果Peto, T.; Kiire, C.; Reynolds, R.; Sivaprasad, S.; Bailey, C.; Downey, L.; Pearce, I.; Chi, G. C.; Darnell, A.; Dayal, P. 分享 收藏 The Federation of American Societies for Experimental Biology (FASEB) Gen AI Taskforce Recommendations美国实验生物学学会联合会（FASEB）生成式人工智能工作组建议Hernandez, Mark; Calvaresi, Emilia; Chauhan, Chavi; Damico, Hannah; Henderson, Darla P.; Karner, Courtney; Lorenz, Robin G.; Madak-Erdogan, Zeynep; Yost, Joseph H.; Matasci, Naim 分享 收藏 INJECTION FREQUENCY, LOADING DOSE COMPLETION, AND 12-MONTH OUTCOMES OF ANTI-VEGF TREATMENT IN DIABETIC MACULAR OEDEMA抗VEGF治疗在糖尿病黄斑水肿中的注射频率、负荷剂量完成情况及12个月结局Peto, T.; Chen, X.; Ghanchi, F.; Menon, G.; Talks, S. j.; Fulcher, C.; Yang, Q.; Lu, H.; Machavaram, H.; Chi, G. c. 分享 收藏 Clinicopathologic Analyses of 34 Cases of High-Grade Serous-Like Carcinoma (HG-SL-Ca) of the Breast34例高分级浆液样乳腺癌（HG-SL-Ca）的临床病理分析Haw, Yulin; Krings, Gregor; Hsiao, Wen-Yu; Zhan, Haiying; Hou, Yanjun; Zhang, Gloria; Zhang, Huina; Wei, Shi; Yang, Wei; Lae, Marick; Post, Miriam D.; Liu, Yi; Shamir, Eliah R.; Rosa, Marilin; Siziopikou, Kalliopi; Schnitt, Stuart; Chen, Yunn-Yi; Li, Xiaoxian 分享 收藏 Tracer kinetic modeling of a 14 kDa anti-CD8 PET tracer (2C8v144) for in vivo estimation of CD8 expression in tissue and blood, binding affinity, and total body receptor occupancy14 kDa抗CD8 PET示踪剂（2C8v144）的示踪剂动力学建模：用于体内评估组织中CD8表达、血液中结合亲和力及全身受体占有率Port, Ruediger E.; Boswell, C. Andrew; Ogasawara, Annie; Gill, Herman; Marik, Jan; Tarantal, Alice F.; Berg, Eric; Williams, Simon P.; Ferl, Gregory Z. 分享 收藏 Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation模板驱动的SCFFBXO42支架调节PP2A降解Coassolo, Sebastien; Michaelian, Nairie; Maculins, Timurs; Azumaya, Caleigh M.; Cheung, Tommy K.; Yin, Jianping; Zilberleyb, Inna; Pahuja, Kanika Bajaj; Garner, Thomas; Lau, Ted; Mau, Davis; Grimmer, Matthew; Fortin, Jean-Philippe; Costa, Mike; Dimitrova, Yoana N.; Rose, Christopher M.; Hsu, Peter L.; Yauch, Robert L. 分享 收藏 Efficacy and Safety of Obinutuzumab in Active Systemic Lupus ErythematosusFurie, Richard A.; Dall'era, Maria; Vital, Edward M.; Garg, Jay P.; Irazoque Palazuelos, Fedra; Zuta Santillan, Adolfina E.; Ravelo-Hernandez, Jorge; Santiago, Mittermayer B.; Zazueta Montiel, Beatriz; Botha, Stella; Leszczynski, Piotr; de Souza, Viviane Angelina; Sicsik, Sandra A.; Bellatin, Luis; Naidoo, Asokan; Amoura, Zahir; D'Dgostino, Maria Antonietta; Kumar, Sunil; Workeneh, Biruh; Rae, Julie; Mao, Huiyan A.; Erblang, Felix; Meier, Oliver; Maller, Justine C.; Askanase, Anca D. 分享 收藏 Characterization of an anti-STEAP1 T-cell dependent bispecific antibody for the treatment of prostate cancer and associated toxicity in cynomolgus monkeys抗STEAP1 T细胞依赖性双特异性抗体在前列腺癌治疗中的应用及其在食蟹猴中的相关性毒性表征Tonkin, Elizabeth G.; Lepherd, Michelle; Davies, John; Gampa, Gautham; Hotzel, Isidro; Koeppen, Hartmut; Liu, Wenyu; Melnikov, Fjodor; Niu, Xiang; Nickles, Dorothee; Romero-Lopez, Monica; Shao, Lily; Totpal, Klara; Schaefer, Gabriele 分享 收藏 The BaeSR two-component system activates bamK, a paralog of the essential β-barrel foldase bamA, in Klebsiella pneumoniae鲍氏不动杆菌中BaeSR双组分系统激活bamK（bamA同源基因），bamA是必需的β桶状折叠酶Storek, Kelly M.; Reeder, Janina; Sun, Dawei; Yan, Donghong; Murchison, Austin K.; Xu, Min; Skippington, Elizabeth; Rutherford, Steven T. 分享 收藏 Modulation of VHL binding affinity improves selectivity of PROTACs targeting BRM (SMARCA2) over BRG1 (SMARCA4)调节VHL结合亲和力可提高靶向BRM（SMARCA2）相对于BRG1（SMARCA4）的PROTACs的选择性Berlin, Michael; Cantley, Jennifer; Broccatelli, Fabio; Cao, Lin; Chen, Huifen; Cheung, Tommy K.; Crew, Andrew P.; DiNicola, Dean; Dong, Hanqing; Grimmer, Matthew; Hamman, Brian D.; Harbin, Alicia; He, Mingtao; Hu, Xiuxian; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Liu, Xiangjia; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Snyder, Lawrence B.; Staben, Leanna R.; Wang, Gan; Wang, Jing; Ye, Xiaofen; Yauch, Robert L.; Dragovich, Peter S. 分享 收藏 One-year Real-world Outcomes With Faricimab in Neovascular Age-related Macular Degeneration使用Faricimab治疗新生血管性年龄相关性黄斑变性的一年真实世界结果Tabano, David C.; Ali, Ferhina S.; Borkar, Durga S.; Leng, Theodore; Ahmed, Ayesha; Ko, Stella; Myrick, Alayna; Zwick, Erin; Downey, Amanda; Barteselli, Giulio; Singh, Rishi P. 分享 收藏 Prognostic pan-cancer and single-cancer models: A large-scale analysis using a real-world clinico-genomic database基于真实世界临床基因组学数据库的大规模分析：泛癌种和单癌种预后模型McGough, Sarah F.; Lyalina, Svetlana; Incerti, Devin; Huang, Yunru; Tyanova, Stefka; Mace, Kieran; Harbron, Chris; Copping, Ryan; Narasimhan, Balasubramanian; Tibshirani, Robert 分享 收藏 分享 收藏 2025 White Paper on Recent Issues in Bioanalysis: What is the Future of Bioanalytical LIMS? AI/ML Integration in Bioanalysis; Tear Sample Collection; Radiolabeled Mass Balance Studies; Chiral Assays; Bioanalysis of Antibody-Oligonucleotide & Bicycle Drug Conjugates (PART 1A-Recommendations on Mass Spectrometry Assays, Chromatography, Sample Preparation and Regulated Bioanalysis Sampling, Validating, Analyzing & Reporting PART 1B-Regulatory Agencies' Input on Regulated Bioanalysis/BMV)2025年生物分析热点问题白皮书：生物分析实验室信息管理系统（LIMS）的未来是什么？人工智能/机器学习在生物分析中的应用；泪液样本采集；放射性标记质量平衡研究；手性分析；抗体-寡核苷酸与自行车药物偶联物的生物分析（第一部分A：关于质谱分析、色谱法、样品制备和受监管生物分析的采样、验证、分析与报告的建议；第一部分B：监管机构对受监管生物分析/桥接方法验证的反馈）Wojcik, John; Qian, Mark; Rosenbaum, Anton I.; Maes, Estelle; Xue, Yongjun; Kochansky, Christopher; Boer, Jason; Chen, Linzhi; Descloux, Sandrine; Garofolo, Fabio; Johnson, Jay; Kaur, Surinder; Lassman, Michael; Mcgregor, Jessica; O'callaghan, Lisa; Sikorski, Timothy; Wan, Katty; Wang, Shunhai; Zheng, Naiyu; Zhang, Guodong; Hoover, Michael; Wang, Jian; Yuan, Long; Ji, Qin; Jones, Barry; Boyanapalli, Ramakrishna; Chen, Jian; Dobson, Christine; Dong, Linlin; Ferrari, Luca; Fu, Yunlin; Gong, Chao; Ivanova, Dany; Li, Jing; Licea-Perez, Hermes; Liu, Aihua; Tang, Xiaonan; Tao, Lin; Tweed, Joseph; Eddy, John; Francis, Jennifer; Kavetska, Olga; Araya, Marcela; Foley, Timothy; Andisik, Matthew; Belfast, Mary; Borbridge, Lisa; Cho, Seongeun (julia); Colligan, Liliana; Dasgupta, Arindam; Edmison, Anna; Fandozzi, Christine; Galliccia, Fabrizio; Kim, Yeoun Jin; Lu, Yang; Massip, Anne-Marie; Shakleya, Diaa; Tampal, Nilufer; Neto, Joao Tavares; Thomas, Justina; Wang, Jin; Wang, Linna; Wang, Ying; Whale, Emma; Wiberg, Megan; Yang, Li 分享 收藏 An Industry Perspective on Key Considerations for the ICH S13 Guidance: Nonclinical Safety Evaluations of Oligonucleotide-Based Therapeutics从行业视角探讨ICH S13指导原则的关键考虑因素：寡核苷酸基治疗药物的非临床安全性评价Sisler, Jennifer D.; Andersson, Patrik; Brown, Alan; Harbison, Carole; Irrechukwu, Onyi; Lightfoot, Helen; Maes, Michael; Mukherjee, Sucheta; Parry, Joel D.; Schumacher, Justin; Westlind Johnsson, Anna; Yang, Yi; Harper Jr, Tod A. 分享 收藏 Assessment and Control of Host Cell Proteins in Biologics: Survey of Industry Practices and a Vision for Harmonization生物制剂中宿主细胞蛋白的评估和控制: 行业实践调查和协调愿景Graham, Jessica; Anand, Sathanandam S.; Bercu, Joel; Besenhofer, Lauren; de Zafra, Christina; Feng, Yu; Glowienke, Susanne; Hillegass, Jedd; Hutchinson, Richard; Jolly, Robert; Masuda-herrera, Melisa; Nicholas, Tyler; Olszova, Daniela; Schmitz, Matthew; Semmelmann, Florian; Tien, Eric 分享 收藏 分享 收藏 分享 收藏 Downregulation of Cyclin Kinase Inhibitors p16INK4a and p27 in Conjunctival Melanomas结膜黑色素瘤中周期蛋白激酶抑制剂p16INK4a和p27的下调Sarrasin, Emerentienne; Lalys, Elea; Nardou, Katya; Celik, Elifnaz; Quinodoz, Mathieu; Schalenbourg, Ann; Riggi, Nicolo; Rivolta, Carlo; Berger, Adeline; Moulin, Alexandre 分享 收藏 
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