未登录 Route Design, Process Development, and Manufacture of XL495: An Atropisomeric PKMYT1 Inhibitor XL495的合成路线设计、工艺开发与制造：一种阿托普异构体PKMYT1抑制剂 Zhu, Jiang; Geng, Xiaoyu; Li, Haoshang; Hu, Baoqiang; Zhang, Qiliang; Zhang, Rong; Jiang, Faming; Liao, Xiaoming; Martinelli, Michael J. 分享 收藏
2025 White Paper on Recent Issues in Bioanalysis: What is the Future of Bioanalytical LIMS? AI/ML Integration in Bioanalysis; Tear Sample Collection; Radiolabeled Mass Balance Studies; Chiral Assays; Bioanalysis of Antibody-Oligonucleotide & Bicycle Drug Conjugates (PART 1A-Recommendations on Mass Spectrometry Assays, Chromatography, Sample Preparation and Regulated Bioanalysis Sampling, Validating, Analyzing & Reporting PART 1B-Regulatory Agencies' Input on Regulated Bioanalysis/BMV) 2025年生物分析热点问题白皮书：生物分析实验室信息管理系统（LIMS）的未来是什么？人工智能/机器学习在生物分析中的应用；泪液样本采集；放射性标记质量平衡研究；手性分析；抗体-寡核苷酸与自行车药物偶联物的生物分析（第一部分A：关于质谱分析、色谱法、样品制备和受监管生物分析的采样、验证、分析与报告的建议；第一部分B：监管机构对受监管生物分析/桥接方法验证的反馈） Wojcik, John; Qian, Mark; Rosenbaum, Anton I.; Maes, Estelle; Xue, Yongjun; Kochansky, Christopher; Boer, Jason; Chen, Linzhi; Descloux, Sandrine; Garofolo, Fabio; Johnson, Jay; Kaur, Surinder; Lassman, Michael; Mcgregor, Jessica; O'callaghan, Lisa; Sikorski, Timothy; Wan, Katty; Wang, Shunhai; Zheng, Naiyu; Zhang, Guodong; Hoover, Michael; Wang, Jian; Yuan, Long; Ji, Qin; Jones, Barry; Boyanapalli, Ramakrishna; Chen, Jian; Dobson, Christine; Dong, Linlin; Ferrari, Luca; Fu, Yunlin; Gong, Chao; Ivanova, Dany; Li, Jing; Licea-Perez, Hermes; Liu, Aihua; Tang, Xiaonan; Tao, Lin; Tweed, Joseph; Eddy, John; Francis, Jennifer; Kavetska, Olga; Araya, Marcela; Foley, Timothy; Andisik, Matthew; Belfast, Mary; Borbridge, Lisa; Cho, Seongeun (julia); Colligan, Liliana; Dasgupta, Arindam; Edmison, Anna; Fandozzi, Christine; Galliccia, Fabrizio; Kim, Yeoun Jin; Lu, Yang; Massip, Anne-Marie; Shakleya, Diaa; Tampal, Nilufer; Neto, Joao Tavares; Thomas, Justina; Wang, Jin; Wang, Linna; Wang, Ying; Whale, Emma; Wiberg, Megan; Yang, Li 分享 收藏
Oncology pharmacist survey: Understanding task value and professional satisfaction 肿瘤科药师调查：理解任务价值与职业满意度 Benitez, Lydia L.; Signorelli, Jessie; Adler, Kristin; Cimino, Sarah; Darling, Julianne; Dotson, Emily; Goodner, Joshua A.; Harris, Christy; McDevitt, Rachel L.; Rasor, Brendan; Schroader, Bridgette Kanz; Sirek, Marie; Vogel, Vishnuprabha; Wolff, Alexandra S.; Griffin, Shawn P. 分享 收藏
Discovery of Potent, Selective and Efficacious Aminopyrazole Inhibitors of PLK4 发现强效、选择性及高效的氨基吡唑类PLK4抑制剂 Jeong, Joon Won; Chang, Trevor; Murray, Jeremy M.; Gonciarz, Ryan L.; Salvant, Justin M.; St. Amant, Andre H.; Bhattarai, Sanjay; Chang, Jae H.; Chang, Jo-Ting; Gwinn, Dana M.; Kochansky, Christopher; Matsuura, Rhea; Mok, Leo; Munoz, Nina M.; Raub, Andrew G.; Shaya, David; Wang, Ziqiang; Xu, Wei; Yang, Kai S.; Finlay, Heather J.; Sherer, Brian A. 分享 收藏
Final results of the phase 3 COSMIC-313 study comparing first-line cabozantinib plus nivolumab and ipilimumab with nivolumab plus ipilimumab in patients with advanced renal-cell carcinoma III期COSMIC-313研究的最终结果：比较卡博赞替尼联合纳武利尤单抗和伊匹木单抗与纳武利尤单抗联合伊匹木单抗在晚期肾细胞癌患者中的一线治疗。 Albiges, Laurence; Motzer, Robert; Aguirre, Sergio Arnoldo Trevino; Kanesvaran, Ravindran; Centkowski, Piotr; Reimers, Melissa A.; Sade, Juan Pablo; Pouessel, Damien; Biscaldi, Elisa; Esteban, Emilio; Angel, Jose; Arija, Arranz; Tykodi, Scott; Ma, Haijun; Zhou, Lei; Losio, Maximiliano van Kooten; Simmons, Andrew; Braun, David; Choueri, Toni; Powles, Thomas 分享 收藏
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Developing biomarkers and methods of risk stratification: Consensus statements from the International Kidney Cancer Symposium North America 2024 Think Tank 开发生物标志物和风险分层方法：国际肾癌研讨会北美2024年思辨研讨会的共识声明 Shapiro, Daniel D.; Abel, Edwin Jason; Albiges, Laurence; Battle, Dena; Berg, Stephanie A.; Campbell, Matthew T.; Cella, David; Coleman, Katie; Garmezy, Benjamin; Geynisman, Daniel M.; Hall, Tasha; Henske, Elizabeth P.; Jonasch, Eric; Karam, Jose A.; La Rosa, Salvatore; Leibovich, Bradley C.; Maranchie, Jodi K.; Master, Viraj A.; Maughan, Benjamin L.; Mcgregor, Bradley A.; Msaouel, Pavlos; Pal, Sumanta K.; Perez, Jose; Plimack, Elizabeth R.; Psutka, Sarah P.; Riaz, Irbaz B.; Rini, Brian I.; Shuch, Brian; Simon, Marie Celeste; Singer, Eric A.; Smith, Andrew; Staehler, Michael; Tang, Chad; Tannir, Nizar M.; Vaishampayan, Ulka; Voss, Martin H.; Zakharia, Yousef; Zhang, Qing; Zhang, Tian; Carlo, Maria I. 分享 收藏
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STELLAR-304: a phase III study of zanzalintinib (XL092) plus nivolumab in advanced non-clear cell renal cell carcinoma STELLAR-304: zanzalintinib (XL092) 联合nivolumab治疗晚期非透明细胞肾细胞癌的III期研究 Pal, Sumanta K.; Powles, Thomas; Kanesvaran, Ravindran; Molina-Cerrillo, Javier; Feldman, Darren R.; Barata, Pedro; Liu, Mohan; Bhatt, Aarohi; Wang, Zhong; Nandoskar, Prachi; Suarez, Cristina 分享 收藏
Preclinical Characterization of XB002, an Anti-Tissue Factor Antibody-Drug Conjugate for the Treatment of Solid Tumors Kantak, Seema; Faggioni, Raffaella; Cai, Allen G.; Bhatti, Maryam M.; Li, Jing; Vainshtein, Inna; Cheng, Jackie; Mendelsohn, Brian A.; Gaudreault, Jacques; Migone, Thi-Sau; Theunissen, Jan-Willem 分享 收藏
Plain language summary of quality of life in CheckMate 9ER: Cabozantinib plus nivolumab in advanced renal cell carcinoma CheckMate 9ER患者生活质量的简明语言总结: 卡博替尼联合纳武单抗治疗晚期肾细胞癌 Cella, David; Motzer, Robert J.; Suarez, Cristina; Blum, Steven I.; Ejzykowicz, Flavia; Hamilton, Melissa; Wallace, Joel F.; Simsek, Burcin; Zhang, Joshua; Ivanescu, Cristina; Choueiri, Toni K.; Apolo, Andrea B. 分享 收藏
Cabozantinib Plus Atezolizumab or Cabozantinib Alone in Patients With Advanced NSCLC Previously Treated With an Immune Checkpoint Inhibitor: Results From the Phase 1b COSMIC-021 Study 卡博替尼联合阿特珠单抗或单用卡博替尼治疗先前接受免疫检查点抑制剂治疗的晚期NSCLC患者: 1b COSMIC-021期研究的结果 Neal, Joel W.; Santoro, Armando; Gonzalez-Cao, Maria; Lim, Farah Louise; Fang, Bruno; Gentzler, Ryan D.; Goldschmidt, Jerome; Khrizman, Polina; Proto, Claudia; Patel, Shiven; Puri, Sonam; V. Liu, Stephen; Massarelli, Erminia; Williamson, Denise; Schwickart, Martin; Scheffold, Christian; Andrianova, Svetlana; Felip, Enriqueta 分享 收藏
Investigation of cabozantinib and zanzalintinib differentiation via in vitro kinase profiling and in vivo tissue and tumor distribution 通过体外激酶谱分析以及体内组织和肿瘤分布研究卡博替尼和赞扎替尼的分化 Chang, J.; Haroldsen, P.; Standeven, A. M.; Belmont, L.; Kumar, A. R.; Chang, J. T.; Okazaki, C.; Nghima-Tahiri, R.; Cortez, O.; Lai, J.; Wu, R.; Leong, K.; Polley, A.; Mahaney, P. E.; Aftab, D. T. 分享 收藏
Neutralizing Antibody Sample Testing and Report Harmonization (vol 26, 80, 2024) Jani, Darshana; Gunsior, Michele; Marsden, Robin; Cowan, Kyra J.; Irvin, Susan C.; Hay, Laura Schild; Ward, Bethany; Armstrong, Luke; Azadeh, Mitra; Cao, Liching; Carmean, Rebecca; Delcarpini, Jason; Dholakiya, Sanjay L.; Hays, Amanda; Hosback, Sarah; Hu, Zheng; Kulagina, Nadia; Kumar, Seema; Lai, Ching Ha; Lichtfuss, Marit; Liu, Hsing-Yin; Liu, Susana; Mozaffari, Reza; Pan, Luying; Pennucci, Jason; Poupart, Marie-Eve; Saini, Gurleen; Snoeck, Veerle; Storey, Kristine; Turner, Amy; Vainshtein, Inna; Verthelyi, Daniela; Wala, Iwona; Yang, Lili; Yang, Lin 分享 收藏
Neutralizing Antibody Sample Testing and Report Harmonization Jani, Darshana; Gunsior, Michele; Marsden, Robin; Cowan, Kyra J.; Irvin, Susan C.; Hay, Laura Schild; Ward, Bethany; Armstrong, Luke; Azadeh, Mitra; Cao, Liching; Carmean, Rebecca; DelCarpini, Jason; Dholakiya, Sanjay L.; Hays, Amanda; Hosback, Sarah; Hu, Zheng; Kulagina, Nadia; Kumar, Seema; Lai, Ching Ha; Lichtfuss, Marit; Liu, Hsing-Yin; Liu, Susana; Mozaffari, Reza; Pan, Luying; Pennucci, Jason; Poupart, Marie-Eve; Saini, Gurleen; Snoeck, Veerle; Storey, Kristine; Turner, Amy; Vainshtein, Inna; Verthelyi, Daniela; Wala, Iwona; Yang, Lili; Yang, Lin 分享 收藏
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AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Selective Antibody-Drug Conjugate Synthesis Matsuda, Yutaka; Shikida, Natsuki; Hatada, Noriko; Yamada, Kei; Seki, Takuya; Nakahara, Yuichi; Endo, Yuta; Shimbo, Kazutaka; Takahashi, Kazutoshi; Nakayama, Akira; Mendelsohn, Brian A.; Fujii, Tomohiro; Okuzumi, Tatsuya; Hirasawa, Shigeo 分享 收藏
Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312): final results of a randomised phase 3 study 卡博替尼联合阿特珠单抗与索拉非尼治疗晚期肝细胞癌 (COSMIC-312): 一项随机3期研究的最终结果 Yau, Thomas; Kaseb, Ahmed; Cheng, Ann-Lii; Qin, Shukui; Zhu, Andrew X.; Chan, Stephen L.; Melkadze, Tamar; Sukeepaisarnjaroen, Wattana; Breder, Valery; Verset, Gontran; Gane, Edward; Borbath, Ivan; Rangel, Jose David Gomez; Ryoo, Baek-Yeol; Makharadze, Tamta; Merle, Philippe; Benzaghou, Fawzi; Milwee, Steven; Wang, Zhong; Curran, Dominic; Kelley, Robin Kate; Rimassa, Lorenza 分享 收藏
Increased Progression-Free Survival with Cabozantinib Versus Placebo in Patients with Radioiodine-RefractoryDifferentiated Thyroid Cancer Irrespective of Prior Vascular Endothelial Growth Factor Receptor-Targeted Therapy and Tumor Histology: A Subgroup Analysis of the COSMIC-311 Study Capdevila, Jaume; Krajewska, Jolanta; Hernando, Jorge; Robinson, Bruce; Sherman, Steven I.; Jarzab, Barbara; Lin, Chia-Chi; Vaisman, Fernanda; Hoff, Ana O.; Hitre, Erika; Bowles, Daniel W.; Williamson, Denise; Levytskyy, Roman; Oliver, Jennifer; Keam, Bhumsuk; Brose, Marcia S. 分享 收藏
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