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I

Ionis Pharmaceuticals Inc.

学者数771
论文数481
被引数1
关联论文 (473)
发表时间
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Neurodegenerative NMNAT2 Deficiency Promotes APP Processing in a SARM1-Dependent Manner神经退行性NMNAT2缺乏以SARM1依赖性方式促进APP加工
errCells
IF5.2
err2026-06-17
err0
errOAAI
errAndrea Enriquez; Sen Yang; Karen Ling; Paymaan Jafar-Nejad; Hui-Chen Lu
err分享
err收藏
TGFβ activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver diseaseTGFβ活性稳定ACC1以增加代谢性肝病中的从头脂质合成
errMolecular Metabolism
IF6.6
err2026-06-01
err0
errOAAI
errBrent Mayfield; Yoko Yagashita; Jinku Kang; Changyu Zhu; Stefania Mira; Timothy J. Kendall; Qiuyan Sun; Maria E. Meincke; Domenick Raphael; Meng Li; Shuxuan Chen; Harrison Cullen; Stryder M. Meadows; Luke E. Berchowitz; Michele Carrer; Jonathan A. Fallowfield; Robert F. Schwabe; Luca Valenti; Utpal B. Pajvani
err分享
err收藏
Enhanced splicing modulation by NMA-modified antisense oligonucleotidesNMA修饰的反义寡核苷酸增强剪接调控
errNucleic Acids Research
IF13.1
err2026-05-21
err0
errOAAI
errKaren Ling; Thazha P Prakash; Jinghua Yu; Michaela Jackson; Seung J Chun; Gemma Bachmann; Noah Post; Sarah Greenlee; Armand Soriano; John L Hunyara; Daniel A Norris; Paymaan Jafar-nejad; Eric E Swayze; C Frank Bennett; Frank Rigo
err分享
err收藏
Comparative Efficacy and Safety of Olezarsen Versus Plozasiran for Familial Chylomicronemia Syndrome: A Matching-Adjusted Indirect Comparison奥列扎森与普洛扎森治疗家族性乳糜微粒血症综合征的疗效和安全性的比较：一项匹配调整间接比较研究
errJournal of Clinical Lipidology
IF4.6
err2026-05-07
err0
errOAAI
errAsia Sikora Kessler; Paul Serafini; Divya Pushkarna; Mir-Masoud Pourrahmat; Seth J. Baum; Sotirios Tsimikas; Montserrat Vera Llonch
err分享
err收藏
LncRNA-splicing factor condensates regulate hypoxia-responsive pre-mRNA processing near nuclear speckles长链非编码RNA-剪接因子凝聚体调控缺氧响应的pre-mRNA加工，其位置靠近核斑。
errMolecular Cell
IF16.6
err2026-03-19
err0
PREAI
errYou Jin Song; Min Kyung Shinn; Sushant Bangru; Yu Wang; Qinyu Sun; Qinyu Hao; Pankaj Chaturvedi; Susan M. Freier; Pablo Perez-Pinera; Erik R. Nelson; Andrew S. Belmont; Mitchell Guttman; Supriya G. Prasanth; Auinash Kalsotra; Rohit V. Pappu; Kannanganattu V. Prasanth
err分享
err收藏
Impact of AGT rs5050(T>G) variants on associations between estradiol and angiotensinogen levels: Multi-Ethnic Study of Atherosclerosis (MESA)AGT rs5050(T>G)变异对雌二醇与血管紧张素原水平关联性的影响：动脉粥样硬化多种族研究（MESA）
errPLoS One
IF2.6
err2025-12-31
err0
PREAI
errLidani, Karita C. F.; Trainor, Patrick J.; Tomar, Shubham; Michos, Erin D.; Morgan, Erin S.; Rotter, Jerome I.; Guo, Xiuqing; Tsimikas, Sotirios; Defilippis, Andrew P.
err分享
err收藏
Temporal Patterns of Triglyceride Testing and Test Results among Adults with Severe or Extreme Hypertriglyceridemia in US Clinical Practice美国临床实践中，严重或极重度高甘油三酯血症成人患者的甘油三酯检测时间模式及检测结果
errAmerican Journal of Preventive Cardiology
IF5.9
err2025-11-20
err0
errOAAI
errAsia Sikora Kessler; Seth J. Baum; Emily Kutrieb; Montserrat Vera Llonch; Hongsheng Wu; Derek Weycker; Jonathan L. Respress; Daniel E. Soffer
err分享
err收藏
Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia长效APOC3 siRNA的发现：用于治疗高甘油三酯血症患者
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-11-11
err0
PREAI
errPrakash, Thazha P.; Mullick, Adam E.; Riney, Stan; Yu, Jinghua; Nikan, Mehran; Quirk, Clare; Crutchfield, Amanda; Damle, Sagar S.; Klein, Stephanie; Swayze, Eric E.
err分享
err收藏
Considerations for Microbiological Control Strategy during Oligonucleotide Drug Substance Manufacturing寡核苷酸药物物质制造过程中的微生物控制策略考量
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2025-11-01
err0
PREAI
errAllen, Deborah; Arts, Rick; Belin, Gamze; Borna, Mandana; Coffin, Chris; Drinkwater, Sophie; Jehle, Peter; Johnson, Joyce; Nuydens, Anja; Olbrich, Martin; Ortiz, Aura R.; Ozdemir, Mahir; Quinn, Andrew; Seyberth, Tobias; Smith, Peter D.; Tremmel, Sandra; Venkatram, Bharath; Willis, Jonathan
err分享
err收藏
Accurate Mass Differences of High Molecular Weight Unknown Compounds from Resolved Isotopic Distributions: Oligonucleotide Impurities高分子量未知化合物的精确质量差异来自解析的同位素分布：寡核苷酸杂质
errANALYTICAL CHEMISTRY
IF6.7
err2025-11-01
err0
PREAI
errRoussis, Stilianos G.
err分享
err收藏
A Modeling Investigation of the CYP1A Drug Interactions of Riluzole利鲁唑CYP1A药物相互作用的建模研究
errCTS-CLINICAL AND TRANSLATIONAL SCIENCE
IF2.8
err2025-09-16
err0
errOAAI
errMalik, Paul; Mian, Paola; Andrews, Jinsy; Rosebraugh, Matthew; Ajroud-Driss, Senda
err分享
err收藏
In PLN-R14del mice, SR structure restoration, rather than calcium cycling, is the dominant effector of PLN-ASO treatment在PLN-R14del小鼠中，SR结构恢复而非钙循环是PLN-ASO治疗的主要效应器。
errCARDIOVASCULAR RESEARCH
IF13.3
err2025-09-01
err1
errOAAI
errSun, Liu; Eijgenraam, Tim R.; Amilon, Carl; Janzen, David; Hansson, Kenny M.; Kubli, Dieter A.; Spater, Daniela; Mullick, Adam E.; van der Meer, Peter; Teixeira, Vivian Oliveira Nunes; Sillje, Herman H. W.
err分享
err收藏
Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile单烷基膦酸酯修饰的siRNA骨架在种子区域增强了特异性和治疗谱
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-08-12
err0
PREAI
errNikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W. Brad; Watt, Andrew T.; Migawa, Michael T.; Swayze, Eric E.; Prakash, Thazha P.
err分享
err收藏
Hepatocyte KCTD17-mediated SERPINA3 inhibition determines liver fibrosis in metabolic dysfunction-associated steatohepatitis肝细胞KCTD17介导的SERPINA3抑制决定代谢功能障碍相关脂肪性肝炎中的肝纤维化
errExperimental & Molecular Medicine
IF12.9
err2025-08-01
err0
errOAAI
errYelin Jeong; Ah-Reum Oh; Young Hoon Jung; Kyung Hee Jung; Seongju Lee; Michele Carrer; Sang Bae Lee; Luca Valenti; Utpal B. Pajvani; KyeongJin Kim
err分享
err收藏
Rates of acute pancreatitis and cardiovascular events among adults with severe or extreme hypertriglyceridemia in US clinical practice美国临床实践中，成人重度或极重度高甘油三酯血症患者急性胰腺炎和心血管事件的发生率。
errLipids in Health and Disease
IF4.2
err2025-07-30
err0
PREAI
errAsia Sikora Kessler; Seth J. Baum; Emily Kutrieb; Montserrat Vera Llonch; Alex Lonshteyn; Derek Weycker; Daniel E. Soffer
err分享
err收藏
Effect of Olezarsen on Lipoprotein-Associated ApoC-III Levels in Patients with Familial Chylomicronemia Syndrome奥列扎森（Olezarsen）对家族性乳糜微粒血症综合征患者脂蛋白相关载脂蛋白C-III水平的影响
errAtherosclerosis
IF5.7
err2025-07-21
err0
PREAI
errXiaohong Yang; Veronica J. Alexander; Shuting Xia; Sotirios Tsimikas
err分享
err收藏
Antisense oligonucleotide therapy for patients with Friedreich’s ataxia carrying the c.165+5G>C splicing mutation携带c.165+5G>C剪接突变的弗里德赖希共济失调患者反义寡核苷酸治疗
errMolecular Therapy Nucleic Acids
IF6.1
err2025-07-01
err0
errOAAI
errPouiré Yameogo; Selina Aguilar; Thazha P. Prakash; Frank Rigo; David R. Lynch; Jill S. Napierala; Marek Napierala
err分享
err收藏
Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation两种BRCA2 DNA结合域在DNA损伤修复和复制叉保护中的不同作用
errCELL REPORTS
IF6.9
err2025-05-01
err0
errOAAI
errNeal, Francisco E.; Li, Wenjing; Uhrig, Mollie E.; Katz, Jeffrey N.; Syed, Shahrez; Sharma, Neelam; Dutta, Arijit; Burma, Sandeep; Hromas, Robert; Mazin, Alexander, V; Dray, Eloise; Libich, David S.; Olsen, Shaun K.; Wasmuth, Elizabeth, V; Zhao, Weixing; Sorensen, Claus S.; Wiese, Claudia; Kwon, Youngho; Sung, Patrick
err分享
err收藏
The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune responseHNRNPA1异构体对基因表达的不同影响及其与dsRNA介导的先天免疫反应的相关性
errSCIENTIFIC REPORTS
IF3.9
err2025-05-01
err0
errOAAI
errDeshaies, Jade-Emmanuelle; Triassi, Valerie; Lacombe, Andreanne; Gagne, Myriam; Ling, Karen; Ghosh, Asmita; Labrecque, Marjorie; Rigo, Frank; Jafar-nejad, Paymaan; Tetreault, Martine; Velde, Christine Vande
err分享
err收藏
Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease靶向糖原合成酶1的反义寡核苷酸在小鼠庞贝病模型中的骨骼肌效应
errCLINICAL AND TRANSLATIONAL MEDICINE
IF6.8
err2025-04-23
err0
errOAAI
errWeiss, Lan; Carrer, Michele; Shmara, Alyaa; Martin, Angela; Yin, Hong; Pal, Pallabi; Cheng, Cheng; Ta, Lac; Boock, Victoria; Fazeli, Yasamin; Chang, Mindy; Paguio, Marvin; Lee, Jonathan; Yu, Howard; Weiss, John; Grossman, Tamar R.; Raben, Nina; Jafar-Nejad, Paymaan; Kimonis, Virginia
err分享
err收藏