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罗

罗海彬 (Hai‐Bin Luo)

Hainan University

45H指数
278论文数
9.0K被引数
收录论文 134
发表时间
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Structure-Based Optimization of Imidazopyridine Derivatives as Selective and Orally Bioavailable Phosphodiesterase 10A Inhibitors with Reduced Blood–Brain Barrier Penetration for the Treatment of Idiopathic Pulmonary Fibrosis基于结构的咪唑吡啶衍生物优化，作为选择性且口服生物利用度高的磷酸二酯酶10A抑制剂，具有降低血脑屏障穿透性，用于特发性肺纤维化的治疗
errJournal of Medicinal Chemistry
IF6.8
err2025-11-21
err0
PREAI
errFengcai Zhang; Han Yuan; Siqi Yao; Dongjing Yang; Jiafei Wu; Jianwen Chen; Quan Wang; Yi-You Huang; Hai-Bin Luo; Lei Guo
err分享
err收藏
Artificial Intelligence-Driven Discovery of Pyrazolo[1,5-a]pyrimidine Derivatives as Novel Phosphodiesterase 4 Inhibitors for Treating Idiopathic Pulmonary Fibrosis人工智能驱动的吡唑并[1,5-a]嘧啶衍生物作为新型磷酸二酯酶4抑制剂用于治疗特发性肺纤维化
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-11-01
err0
PREAI
errLi, Zheng; Huan, Wanting; Liu, Xingfu; Zhang, Kai; Wang, Xue; Huang, Yiyou; Zhou, Qian; Huang, Shuheng; Sang, Zhipei; Luo, Hai-Bin
err分享
err收藏
PDE5 inhibitor LW1646 improves kidney fibrosis by alleviating ER stress and mitochondrial calcium overloadPDE5抑制剂LW1646通过缓解内质网应激和线粒体钙过载改善肾脏纤维化
errNephrology Dialysis Transplantation
IF5.6
err2025-10-01
err0
errOAAI
errWang, Minghui; Xu, Long; Zhao, Xiaoduo; Wu, Deyan; Liu, Qinghua; Li, Chunling; Luo, Hai-Bin; Wang, Weidong
err分享
err收藏
Discovery of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of Alzheimer's disease: An artificial intelligence-driven synergized strategyα- Garciniaone 衍生物作为新型PDE4抑制剂用于治疗阿尔茨海默病：一种人工智能驱动的协同策略
errChinese Chemical Letters
IF8.9
err2025-05-16
err0
PREAI
errZhi-Pei Sang; Teng Xue; Qian-Ru Xing; Qi-Yao Zhang; Hong-Song Chen; Xue Wang; Fu-Rong Zhang; Wen-Ling Fu; Wu Dong; Shu-Heng Huang; Yi-You Huang; Hai-Bin Luo
err分享
err收藏
Fraxin Alleviates Atherosclerosis by Inhibiting Oxidative Stress and Inflammatory Responses via the TLR4/PI3K/Akt PathwayFraxin 通过抑制氧化应激和炎症反应，经由 TLR4/PI3K/Akt 通路缓解动脉粥样硬化。
errCURRENT ISSUES IN MOLECULAR BIOLOGY
IF3
err2025-04-27
err0
errOAAI
errWang, Yaru; Wei, Bailing; Leng, Mingyang; He, Jiali; Zhao, Yicheng; Xia, Haohao; Luo, Haibin; Bai, Xue
err分享
err收藏
Plasma metabolites-based drug design: Discovery of novel and highly selective phosphodiesterase 5 inhibitors基于血浆代谢物的药物设计：新型高选择性磷酸二酯酶5抑制剂的发现
errChinese Chemical Letters
IF8.9
err2025-04-22
err0
PREAI
errDeyan Wu; Qingjiang Ma; Yanquan Chen; Guofeng Yang; Fengcai Zhang; Meiyan Jiang; Xue Wang; Xingfu Liu; Qian Zhou; Yi-You Huang; Zhe Li; Hai-Bin Luo
err分享
err收藏
Hydroxychavicol derivatives from Piper betle Linn. as natural PDE4 inhibitors with anti-inflammatory effectsPiper betle Linn.来源的羟基香豆素衍生物作为具有抗炎作用的天然PDE4抑制剂
errBIOORGANIC CHEMISTRY
IF4.7
err2025-04-01
err0
PREAI
errOu, Jiazhi; Zhong, Fang; Huang, Peiluo; Zhang, Yan; Xie, Shenghong; Wu, Peng; Li, Junyi; Qiu, Haihang; Wang, Chunying; Huang, Yiyou; Zhou, Qian; Cheng, Zhongbin; Luo, Hai-Bin
err分享
err收藏
Discovery of amentoflavone as a natural PDE4 inhibitor with anti-fibrotic effects发现amentoflavone作为具有抗纤维化作用的天然PDE4抑制剂
errCHINESE CHEMICAL LETTERS
IF8.9
err2025-04-01
err1
PREAI
errChen, Zhexin; Shi, Yuqing; Zhong, Fang; Zhang, Kai; Zhang, Furong; Xie, Shenghong; Cheng, Zhongbin; Zhou, Qian; Huang, Yi-You; Luo, Hai-Bin
err分享
err收藏
Divide-and-Conquer ABFE: Improving Free Energy Calculations by Enhancing Water Sampling分治ABFE：通过增强水采样来改进自由能计算
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2025-03-24
err0
PREAI
errLiu, Runduo; Yao, Yufen; Huang, Wanyi; Zhong, Yilin; Luo, Hai-Bin
err分享
err收藏
Psychological consistency network characteristics and influencing factors in patients after percutaneous coronary intervention treatment
errworld psychiatry
IF3.4
err2025-03-19
err0
PREAI
errLi, Yue; Wang, Liang-Hong; Zeng, Huan; Zhao, Yan; Lu, Yao-Qiong; Zhang, Tian-Ying; Luo, Hai-Bin; Tang, Feng
err分享
err收藏
Structure-Based Optimization of Moracin M as Potent and Selective PDE4 Inhibitors with Antipsoriasis Effects基于结构的Moracin M优化作为具有抗银屑病作用的强效且选择性PDE4抑制剂
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-03-11
err0
PREAI
errZhang, Furong; Zheng, Tiansheng; Wang, Xue; Chen, Yu; Zhang, Feng; Liu, Xingfu; Wang, Sen; Yang, Guofeng; Xie, Shenghong; Wu, Qi; Xu, Chao; Zhou, Qian; Wu, Deyan; Luo, Hai-Bin
err分享
err收藏
3D-EDiffMG: 3D equivariant diffusion-driven molecular generation to accelerate drug discovery3D-EDiffMG：一种基于3D等变扩散驱动的分子生成方法，用于加速药物发现
errJournal of Pharmaceutical Analysis
IF8.9
err2025-03-05
err0
errOAAI
errChao Xu; Runduo Liu; Yufen Yao; Wanyi Huang; Zhe Li; Hai-Bin Luo
err分享
err收藏
Response surface optimization of coal tar-based porous carbon and its supercapacitor performance analysis
errELECTROCHIMICA ACTA
IF5.6
err2025-02-01
err0
PREAI
errWu, Peng; Xu, Xinyuan; Xue, Yuanmeng; Dou, Qiang; Luo, Haibin; Zhou, Chunru; Li, Wencheng; Lv, Yuting
err分享
err收藏
Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline表没食子儿茶素-3-没食子酸酯抑制由槟榔碱诱导的口腔黏膜下纤维化的胶原蛋白积聚。
errFRONTIERS IN PHARMACOLOGY
IF4.8
err2025-01-31
err0
errOAAI
errGao, Ge; Lin, Caipeng; Li, Ruibo; Xie, Xi; Luo, Hai-Bin
err分享
err收藏
Inhalable Carbonyl Sulfide Donor-Hybridized Selective Phosphodiesterase 10A Inhibitor for Treating Idiopathic Pulmonary Fibrosis by Inhibiting Tumor Growth Factor-β Signaling and Activating the cAMP/Protein Kinase A/cAMP Response Element-Binding Protein (CREB)/p53 Axis吸入性羰基硫供体杂化选择性磷酸二酯酶10A抑制剂，通过抑制肿瘤生长因子-β信号通路并激活cAMP/蛋白激酶A/cAMP反应元件结合蛋白(CREB)/p53轴，用于治疗特发性肺纤维化
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2024-12-28
err0
PREAI
errWang, Q; Liu, XY; Yuan, H; Zhang, FC; Wu, JF; Yang, DJ; Qian, J; Huang, YY; Chai, GH; Luo, HB; Guo, L
err分享
err收藏
Platycladus orientalis (L.) Franco demonstrates effective anti-psoriasis effects by inhibiting PDE4 with favorable safety profiles侧柏（Platycladus orientalis (L.) Franco）通过抑制PDE4表现出有效的抗银屑病作用，并具有有利的 safety profiles（安全特征）。
errChinese Chemical Letters
IF8.9
err2024-12-25
err0
PREAI
errQing Zhang; Ling Sun; Lingyu Wu; Xue Wang; Liru Chen; Youyou Chen; Yuhang Liu; Wenhui Gu; Donglei Shi; Wenwen Liu; Jian Li; Yi-You Huang; Baoli Li; Hai-Bin Luo
err分享
err收藏
A Bait-and-Hook Hydrogel for Net Tumor Cells to Enhance Chemotherapy and Mitigate Metastatic Dissemination
errPHARMACEUTICS
IF5.5
err2024-11-25
err0
errOAAI
errChen, Cailian; Liu, Jinying; Zhang, Hongbo; Zhang, Hongrui; Liang, Yanhui; Ye, Qilian; Shen, Wei; Luo, Haibin; Guo, Ling
err分享
err收藏
Cross-Generational Exposure to Low-Density Polyethylene Microplastics Induced Hyperactive Responses in Eisenia fetida Offsprings
errENVIRONMENTAL SCIENCE & TECHNOLOGY
IF11.3
err2024-11-18
err0
PREAI
errZhao, Yuanyuan; Jia, Huiting; Deng, Hui; Ge, Chengjun; Luo, Haibin; Zhang, Ying
err分享
err收藏
Discovery of Selective PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects by Targeting the Metal Pocket
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-15
err0
PREAI
errJiang, Mei-Yan; Zhang, Chen; Huang, Qing-Hua; Feng, Ling-Ling; Yang, Yi-Yi; Zhou, Qian; Luo, Hai-Bin; Wu, Yinuo
err分享
err收藏
Combination therapy with GalNAc-siRNA drugs targeting both PCSK9 and APOC3 resulted in enhanced lipid lowering in mice
errEUROPEAN HEART JOURNAL
IF35.6
err2024-10-28
err0
PREAI
errLuo, H.; Zheng, S.; Cao, H.; Singh, A.; Tong, C.; Zhang, H.; Liang, Z.; Gronros, J.; Wikstrom, J.; Gao, S.; Gan, L.
err分享
err收藏

研究方向

药物设计新方法PDE靶向药物
合作学者
合作期刊
C
Christian Drosten
H 指数: 136 · 论文数: 778
王军 封面图
王军 (Jun Wang)
H 指数: 122 · 论文数: 1.6K
张
张丽 (Li Zhang)
H 指数: 112 · 论文数: 4.1K
李
李亚平 (Yaping Li)
H 指数: 102 · 论文数: 1.1K
蒋
蒋华良 (Hualiang Jiang)
H 指数: 101 · 论文数: 983
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