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D

Duncan Sproul

University of Edinburgh
H指数:29
被引数:5,010

个人简介

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工作经历

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荣誉奖项

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Replication-associated mechanisms contribute to an increased CpG > TpG mutation burden in mismatch repair-deficient cancers

与复制相关的机制导致错配修复缺陷型癌症中CpG > TpG突变负担增加。

Genome Medicine
IF11.2
2025-08-270
PRE
Joseph C. Ward; Ignacio Soriano; Steve Thorn; Juan Fernández-Tajes; Kitty Sherwood; Güler Gül; Joost Scheffers; Anna Frangou; Ben Kinnersley; Ioannis Kafetzopoulos; Duncan Sproul; Sara Galavotti; Claire Palles; Andreas J. Gruber; David N. Church; Ian Tomlinson
DNMT3B PWWP mutations cause hypermethylation of heterochromatin
EMBO REPORTS
IF6.2
2024-01-302
OA
Taglini, Francesca; Kafetzopoulos, Ioannis; Rolls, Willow; Musialik, Kamila Irena; Lee, Heng Yang; Zhang, Yujie; Marenda, Mattia; Kerr, Lyndsay; Finan, Hannah; Rubio-Ramon, Cristina; Gautier, Philippe; Wapenaar, Hannah; Kumar, Dhananjay; Davidson-Smith, Hazel; Wills, Jimi; Murphy, Laura; Wheeler, Ann; Wilson, Marcus; Sproul, Duncan
Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair

由DNA修复缺陷引起的孟德尔癌症综合征家族中的种系从头突变

NATURE COMMUNICATIONS
IF15.7
2023-06-196
OAAI
Sherwood, Kitty; Ward, Joseph C.; Soriano, Ignacio; Martin, Lynn; Campbell, Archie; Rahbari, Raheleh; Kafetzopoulos, Ioannis; Sproul, Duncan; Green, Andrew; Sampson, Julian R.; Donaldson, Alan; Ong, Kai-Ren; Heinimann, Karl; Nielsen, Maartje; Thomas, Huw; Latchford, Andrew; Palles, Claire; Tomlinson, Ian
cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing

由于组蛋白前mRNA加工的先天性错误，cGAS介导的I型干扰素的诱导

NATURE GENETICS
IF31.8
2020-11-23121
OAAI
Uggenti, Carolina; Lepelley, Alice; Depp, Marine; Badrock, Andrew P.; Rodero, Mathieu P.; El-Daher, Marie-Therese; Rice, Gillian I.; Dhir, Somdutta; Wheeler, Ann P.; Dhir, Ashish; Albawardi, Waad; Fremond, Marie-Louise; Seabra, Luis; Doig, Jennifer; Blair, Natalie; Martin-Niclos, Maria Jose; Della Mina, Erika; Rubio-Roldan, Alejandro; Garcia-Perez, Jose L.; Sproul, Duncan; Rehwinkel, Jan; Hertzog, Jonny; Boland-Auge, Anne; Olaso, Robert; Deleuze, Jean-Francois; Baruteau, Julien; Brochard, Karine; Buckley, Jonathan; Cavallera, Vanessa; Cereda, Cristina; De Waele, Liesbeth M. H.; Dobbie, Angus; Doummar, Diane; Elmslie, Frances; Koch-Hogrebe, Margarete; Kumar, Ram; Lamb, Kate; Livingston, John H.; Majumdar, Anirban; Lorenco, Charles Marques; Orcesi, Simona; Peudenier, Sylviane; Rostasy, Kevin; Salmon, Caroline A.; Scott, Christiaan; Tonduti, Davide; Touati, Guy; Valente, Marialuisa; van der Linden, Helio, Jr.; Van Esch, Hilde; Vermelle, Marie; Webb, Kate; Jackson, Andrew P.; Reijns, Martin A. M.; Gilbert, Nick; Crow, Yanick J.
An epigenetic predictor of death captures multi-modal measures of brain health
MOLECULAR PSYCHIATRY
IF10.1
2019-12-0375
OAAI
Hillary, Robert F.; Stevenson, Anna J.; Cox, Simon R.; McCartney, Daniel L.; Harris, Sarah E.; Seeboth, Anne; Higham, Jon; Sproul, Duncan; Taylor, Adele M.; Redmond, Paul; Corley, Janie; Pattie, Alison; Hernandez, Maria Del C. Valdes; Munoz-Maniega, Susana; Bastin, Mark E.; Wardlaw, Joanna M.; Horvath, Steve; Ritchie, Craig W.; Spires-Jones, Tara L.; McIntosh, Andrew M.; Evans, Kathryn L.; Deary, Ian J.; Marioni, Riccardo E.
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation (vol 10, 1383, 2019)
NATURE COMMUNICATIONS
IF15.7
2019-05-011
OAAI
Zeng, Yanni; Amador, Carmen; Xia, Charley; Marioni, Riccardo; Sproul, Duncan; Walker, Rosie M.; Morris, Stewart W.; Bretherick, Andrew; Canela-Xandri, Oriol; Boutin, Thibaud S.; Clark, David W.; Campbell, Archie; Rawlik, Konrad; Hayward, Caroline; Nagy, Reka; Tenesa, Albert; Porteous, David J.; Wilson, James F.; Deary, Ian J.; Evans, Kathryn L.; McIntosh, Andrew M.; Navarro, Pau; Haley, Chris S.
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
NATURE COMMUNICATIONS
IF15.7
2019-03-2721
OAAI
Zeng, Yanni; Amador, Carmen; Xia, Charley; Marioni, Riccardo; Sproul, Duncan; Walker, Rosie M.; Morris, Stewart W.; Bretherick, Andrew; Canela-Xandri, Oriol; Boutin, Thibaud S.; Clark, David W.; Campbell, Archie; Rawlik, Konrad; Hayward, Caroline; Nagy, Reka; Tenesa, Albert; Porteous, David J.; Wilson, James F.; Deary, Ian J.; Evans, Kathryn L.; McIntosh, Andrew M.; Navarro, Pau; Haley, Chris S.
Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions
NATURE GENETICS
IF31.8
2018-11-26116
OAAI
Heyn, Patricia; Logan, Clare V.; Fluteau, Adeline; Challis, Rachel C.; Auchynnikava, Tatsiana; Martin, Carol-Anne; Marsh, Joseph A.; Taglini, Francesca; Kilanowski, Fiona; Parry, David A.; Cormier-Daire, Valerie; Fong, Chin-To; Gibson, Kate; Hwa, Vivian; Ibanez, Lourdes; Robertson, Stephen P.; Sebastiani, Giorgia; Rappsilber, Juri; Allshire, Robin C.; Reijns, Martin A. M.; Dauber, Andrew; Sproul, Duncan; Jackson, Andrew P.

研究方向

暂未获取到该数据
R
Richard R. Meehan
H 指数:62论文数:203被引数:1.2万
I
Ioannis Kafetzopoulos
H 指数:5论文数:20被引数:126
I
Ian J. Deary
H 指数:200论文数:2,412被引数:17.2万
D
David J. Harrison
H 指数:74论文数:944被引数:2.3万
A
Archie Campbell
H 指数:77论文数:510被引数:2.7万
R
Riccardo E. Marioni
H 指数:93论文数:528被引数:4.2万
A
Andrew M. McIntosh
H 指数:142论文数:1,244被引数:11.5万
W
Wendy A. Bickmore
H 指数:80论文数:330被引数:2.4万
K
Kathryn L. Evans
H 指数:53论文数:424被引数:1.2万
J
Jonathan Higham
H 指数:21论文数:72被引数:1,425