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R

Richard R. Meehan

University of Edinburgh
H指数:62
被引数:1.2万

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Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549-586. doi: 10.1080/10408444.2025.2513332

致编辑函:关于综述文章的评论——山田T、科恩SM、莱克BG. 激活性常驻雄烷受体(CAR)和过氧化物增殖激活受体α(PPARα)诱导啮齿动物肝脏肿瘤形成的机制与人类癌症风险无关:一项更新的批判性评估. 批评性毒理学评论. 2025;55(5):549-586. doi: 10.1080/10408444.2025.2513332

2026-01-010
PRE
The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals

强效的人类CAR激动剂CITCO是人体化组成型雄烷受体小鼠中的非遗传毒性肝肿瘤促进剂,但不是野生型动物中的。

2025-03-050
OA
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis
2021-02-01118
OAAI
Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop
2017-12-01103
OAAI