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H

Hannes Mikula

Institute of Applied Synthetic Chemistry
H指数:29
被引数:3,177

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Iontronic click-to-release enables electrically controlled delivery of drugs and biomolecules beyond charge and size limitations

离子tronics点击释放技术实现了超越电荷和尺寸限制的电控药物和生物分子递送

Nature Communications
IF15.7
2026-03-310
OAAI
Sebastian Hecko; Marle E. J. Vleugels; Christian Bayer; Donghak Byun; Moa E. Hörberg; Nikolaus Poremba; Rassen Boukraa; Patrick Keppel; Andreas Löffler; Walter Kuba; Helena Saarela Unemo; Iwona Bernacka-Wojcik; Theresia Arbring Sjöström; Magnus Berggren; Daniel T. Simon; Rainer Schindl; Linda Waldherr; Hannes Mikula; Johannes Bintinger
trans-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity

反式-环辛烯-笼化的IL-1β免疫细胞因子构建体与未修饰的纳米抗体连接，实现了基于点击-释放策略的细胞因子活性控制

RSC Chem. Biol.
IF3.1
2025-08-060
OA
Amber Barendrecht ‡; Heleen H. C. Peeters ‡; Diana Torres-García ‡; M. Thierry Shema; Alexi J. C. Sarris; Shimrit David; Göktuğ Aba; Camille M. Le Gall; Martin Wilkovitsch; Martijn Verdoes; Hannes Mikula; Mark A. Travis; Sander I. van Kasteren
Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes

将芳基四嗪转化为生物正交剪刀，用于反式环辛烯的系统裂解

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2024-11-061
OA
Wilkovitsch, Martin; Kuba, Walter; Keppel, Patrick; Sohr, Barbara; Loeffler, Andreas; Kronister, Stefan; del Castillo, Andres Fernandez; Goldeck, Marion; Dzijak, Rastislav; Rahm, Michal; Vrabel, Milan; Svatunek, Dennis; Carlson, Jonathan C. T.; Mikula, Hannes
Sulfonated Hydroxyaryl-Tetrazines with Increased pKa for Accelerated Bioorthogonal Click-to-Release Reactions in Cells

具有增加的pKa的磺化羟基芳基四嗪可加速细胞中的生物正交点击释放反应

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2024-10-310
OA
Rahm, Michal; Keppel, Patrick; Slachtova, Veronika; Dzijak, Rastislav; Dracinsky, Martin; Bellova, Simona; Reyes-Gutierrez, Paul E.; Stepanova, Sille; Raffler, Jakob; Tloustova, Eva; Mertlikova-Kaiserova, Helena; Mikula, Hannes; Vrabel, Milan
Pretargeted imaging beyond the blood-brain barrier
RSC MEDICINAL CHEMISTRY
IF3.6
2023-01-0116
OAAI
Shalgunov, Vladimir; van den Broek, Sara Lopes; Andersen, Ida Vang; Vazquez, Rocio Garcia; Raval, Nakul Ravi; Palner, Mikael; Mori, Yuki; Schafer, Gabriela; Herrmann, Barbara; Mikula, Hannes; Beschorner, Natalie; Nedergaard, Maiken; Syvanen, Stina; Barz, Matthias; Knudsen, Gitte Moos; Battisti, Umberto Maria; Herth, Matthias Manfred
Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy
SCIENCE ADVANCES
IF12.5
2022-04-2910
OAAI
Ng, Thomas S. C.; Hu, Huiyu; Kronister, Stefan; Lee, Chanseo; Li, Ran; Gerosa, Luca; Stopka, Sylwia A.; Burgenske, Danielle M.; Khurana, Ishaan; Regan, Michael S.; Vallabhaneni, Sreeram; Putta, Niharika; Scott, Ella; Matvey, Dylan; Giobbie-Hurder, Anita; Kohler, Rainer H.; Sarkaria, Jann N.; Parangi, Sareh; Sorger, Peter K.; Agar, Nathalie Y. R.; Jacene, Heather A.; Sullivan, Ryan J.; Buchbinder, Elizabeth; Mikula, Hannes; Weissleder, Ralph; Miller, Miles A.

研究方向

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D
Dennis Svatunek
H 指数:22论文数:130被引数:1,777
R
Ralph Weissleder
H 指数:200论文数:1,603被引数:17.1万
J
Johannes Fröhlich
H 指数:30论文数:305被引数:3,426
R
Rainer H. Köhler
H 指数:50论文数:185被引数:1.4万
J
Jonathan Carlson
H 指数:24论文数:135被引数:4,857
B
Barbara Sohr
H 指数:9论文数:23被引数:316
P
Patrick Keppel
H 指数:4论文数:22被引数:65
M
Matthias M. Herth
H 指数:30论文数:257被引数:3,255
C
Christoph Denk
H 指数:12论文数:36被引数:490
M
Martin Wilkovitsch
H 指数:10论文数:39被引数:490