Wei‐Shuo Fang - Publications, H-index & Citations

Wei‐Shuo Fang

chinese academy of medical sciences and peking union medical college

26H指数

110论文数

1.8K被引数

收录论文 33

发表时间

Discovery of 7-Ether Substituted Homoisoflavonoids as Selective FXR Modulators Attenuating MASH via the FXR and AMPK Pathways 7-醚取代的异黄酮类化合物的发现：作为选择性FXR调节剂，通过FXR和AMPK通路减轻MASH

European Journal of Medicinal Chemistry

IF5.9

2026-04-06

PREAI

Guoning Zhang; Wenqiang Jia; Xinyue Zhou; Shuaishuai Niu; Na Wang; Shaorong Wang; Min Wang; Yihang Hu; Na Zhang; Yi Huan; Hua Sun; Jinsong Liu; Hongwei He; Wei-Shuo Fang

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-11-01

PREAI

Ma, Yuntao; Josa-Prado, Fernando; Essif, Jacob Nathaniel; Liu, Shuqi; Li, Shuo; Lucena-Agell, Daniel; Chan, Peter YW.; Goossens, Kenneth; Hortiguela, Rafael; Matesanz, Ruth; Wang, Yingjie; Gago, Federico; Wang, Hongbo; Risinger, April; Diaz, J. Fernando; Fang, Wei-Shuo

Structure Optimization of 12β-O-?-Glutamyl Oleanolic Acid Derivatives Resulting in Potent FXR Antagonist/Modulator for NASH Therapy

PHARMACEUTICALS

IF4.8

2023-05-17

OAAI

Ma, Hao; Bao, Yunyang; Niu, Shuaishuai; Wang, Shaorong; Li, Yiming; He, Hongwei; Zhang, Na; Fang, Weishuo

Structural insight into the stabilization of microtubules by taxanes 紫杉烷类化合物对微管稳定的结构见解

ELIFE

IF0

2023-03-06

OAAI

Prota, Andrea E.; Lucena-Agell, Daniel; Ma, Yuntao; Estevez-Gallego, Juan; Li, Shuo; Bargsten, Katja; Josa-Prado, Fernando; Altmann, Karl-Heinz; Gaillard, Natacha; Kamimura, Shinji; Muhlethaler, Tobias; Gago, Federico; Oliva, Maria A.; Steinmetz, Michel O.; Fang, Wei-Shuo; Diaz, J. Fernando

Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis

CHEMMEDCHEM

IF3.4

2022-04-11

PREAI

Niu, Shuaishuai; Zhang, Guoning; Wang, Na; Lv, Guangyao; Liu, Jinsong; Wang, Hongbo; Fang, Wei-Shuo

A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1's Expression and H2O2-Induced Cytotoxicity in SH-SY5Y Cells

NEUROCHEMICAL RESEARCH

IF3.8

2020-06-18

PREAI

Cheng, Chen; Zheng, Nan; Sun, Deyang; Fang, Weishuo; Zheng, Lingling; Song, Weihong; Huang, Jian

Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties

MOLECULES

IF4.6

2019-12-26

OAAI

Sun, De-Yang; Cheng, Chen; Moschke, Katrin; Huang, Jian; Fang, Wei-Shuo

Taxanes convert regions of perturbed microtubule growth into rescue sites

NATURE MATERIALS

IF38.5

2019-12-09

OAAI

Rai, Ankit; Liu, Tianyang; Glauser, Simon; Katrukha, Eugene A.; Estevez-Gallego, Juan; Rodriguez-Garcia, Ruddi; Fang, Wei-Shuo; Diaz, J. Fernando; Steinmetz, Michel O.; Altmann, Karl-Heinz; Kapitein, Lukas C.; Moores, Carolyn A.; Akhmanova, Anna

Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids

MOLECULES

IF4.6

2019-06-08

OAAI

Zhao, Yu; Wang, Tian-En; Mills, Alberto; Gago, Federico; Fang, Wei-Shuo

A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

JOURNAL OF NATURAL PRODUCTS

IF3.6

2018-01-23

PREAI

Ma, Yun-Tao; Yang, Yanting; Cai, Pei; Sun, De-Yang; Sanchez-Murcia, Pedro A.; Zhang, Xiao-Ying; Jia, Wen-Qiang; Lei, Lei; Guo, Mengqi; Gago, Federico; Wang, Hongbo; Fang, Wei-Shuo

Potent and water-soluble C3′ modified docetaxel analogs by enthalpic driven optimization

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-01-01

PREAI

Fang, Weishuo; Wang, Hongbo; Gago, Federico

Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2017-09-01

OAAI

Tang, Yong; Rodriguez-Salarichs, Javier; Zhao, Yu; Cai, Pei; Estevez-Gallego, Juan; Balaguer-Perez, Francisco; Redondo Horcajo, Mariano; Lucena-Agell, Daniel; Barasoain, Isabel; Fernando Diaz, J.; Fang, Wei-Shuo

Design, synthesis and metabolic regulation effect of farnesoid X receptor (FXR) antagonistic benzoxepin-5-ones

CHINESE CHEMICAL LETTERS

IF8.9

2017-07-01

PREAI

Zhang, Guo-Ning; Huan, Yi; Wang, Xing; Sun, Su-Juan; Shen, Zhu-Fang; Fang, Wei-Shuo

Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods

MOLECULES

IF4.6

2017-04-26

OAAI

Wang, Shao-Rong; Xu, Tingting; Deng, Kai; Wong, Chi-Wai; Liu, Jinsong; Fang, Wei-Shuo

Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2017-03-01

OAAI

Zhang, Guoning; Liu, Shuainan; Tan, Wenjuan; Verma, Ruchi; Chen, Yuan; Sun, Deyang; Huan, Yi; Jiang, Qian; Wang, Xing; Wang, Na; Xu, Yang; Wong, Chiwai; Shen, Zhufang; Deng, Ruitang; Liu, Jinsong; Zhang, Yanqiao; Fang, Weishuo

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

ACTA PHARMACEUTICA SINICA B

IF14.6

2017-01-01

OAAI

Lv, Guangyao; Sun, Dengjun; Zhang, Jingwen; Xie, Xiaoxia; Wu, Xiaoqiong; Fang, Weishuo; Tian, Jingwei; Yan, Chunhong; Wang, Hongbo; Fu, Fenghua

Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer

INTERNATIONAL JOURNAL OF NANOMEDICINE

IF6.5

2016-10-01

OAAI

Chen, Li-qing; Huang, Wei; Gao, Zhong-gao; Fang, Wei-shuo; Jin, Ming-ji

Restoration of Microtubule Interaction and Cytotoxicity in D-seco Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups

ORGANIC LETTERS

IF5

2015-12-09

PREAI

Wang, Shao-Rong; Yang, Chun-Gang; Sanchez-Murcia, Pedro A.; Snyder, James P.; Yan, Ning; Saez-Calvo, Gonzalo; Diaz, Jose Fernando; Gago, Federico; Fang, Wei-Shuo

High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells

CANCER LETTERS

IF10.1

2015-11-01

OAAI

Pera, Benet; Calvo-Vidal, M. Nieves; Ambati, Srikanth; Jordi, Michel; Kahn, Alissa; Diaz, J. Fernando; Fang, Weishuo; Altmann, Karl-Heinz; Cerchietti, Leandro; Moore, Malcolm A. S.

C-seco taxanes with 7, 9-linkages exhibit better activity in drug-resistant tumor cells

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Tang, Yong; Cai, Pei; Rodriguez-Salarisch, Javier; Fernando Diaz, J.; Fang, Weishuo

研究方向