Kevin M. Maloney - Publications, H-index & Citations

Kevin M. Maloney

Process Research and Development

32H指数

106论文数

3.6K被引数

收录论文 50

发表时间

Discovery of a potent sGC stimulator with once-daily dosing potential for the treatment of hypertension 发现一种具有每日一次给药潜力的强效sGC刺激剂，用于治疗高血压

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

IF2.2

2026-07-01

PREAI

Raghavan, Subharekha; Brockunier, Linda; Guo, Jian; Rosauer, Keith; Smith, Cameron; Yang, Qifeng; Shepherd, Cherrie; Yang, Liming; Pai, Lee-Yuh; Metzger, Joseph; Pereira, Antonio; Salituro, Gino; Xu, Shiyao Sherrie; Johnson, Timothy; Maloney, Kevin; Mortko, Christopher; Roy, Sophie; Parmee, Emma

Reagent for the Chemoselective Reduction of Carboxylic Acids to Aldehydes 用于选择性地将羧酸还原为醛类的试剂

Organic Letters

IF5

2025-10-23

PREAI

Ethan Fung; Kevin M. Maloney; Patrick S. Fier

Development of a Biocatalytic Aerobic Oxidation for the Manufacturing Route to Islatravir

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-08-14

PREAI

Shaw, Megan H.; Fryszkowska, Anna; Alvizo, Oscar; Attadgie, Ilana; Borra-Garske, Margie; Devine, Paul N.; Duan, Da; Grosser, Shane T.; Forstater, Jacob H.; Hughes, Gregory J.; Maloney, Kevin M.; Margelefsky, Eric L.; Mattern, Keith A.; Miller, Margaret T.; Nawrat, Christopher C.; Nazor, Jovana; Orth, Peter; Ouimet, Claire M.; Robaire, Sandra A.; Ruccolo, Serge; Schwalm, Erica L.; Verma, Deeptak; Xiao, Li; Zhang, Victoria

Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2024-02-19

PREAI

Cheung-Lee, Wai Ling; Kolev, Joshua N.; Mcintosh, John A.; Gil, Agnieszka A.; Pan, Weilan; Xiao, Li; Velasquez, Juan E.; Gangam, Rekha; Winston, Matthew S.; Li, Shasha; Abe, Kotoe; Alwedi, Embarek; Dance, Zachary E. X.; Fan, Haiyang; Hiraga, Kaori; Kim, Jungchul; Kosjek, Birgit; Le, Diane N.; Marzijarani, Nastaran Salehi; Mattern, Keith; Mcmullen, Jonathan P.; Narsimhan, Karthik; Vikram, Ajit; Wang, Wei; Yan, Jia-Xuan; Yang, Rong-Sheng; Zhang, Victoria; Zhong, Wendy; Dirocco, Daniel A.; Morris, William J.; Murphy, Grant S.; Maloney, Kevin M.

Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib 使用动态流动平台将分批固定化转氨酶过程转化为填充床反应器，以合成内姆他布替尼中间体

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2023-12-15

PREAI

Di Maso, Michael J.; Kuethe, Jeffrey T.; Narsimhan, Karthik; Burris, Matthew; Chung, Cheol K.; DiBenedetto, Michael; Forstater, Jacob H.; Grosser, Shane T.; Kuhl, Nadine; Levesque, Francois; Maguire, Anne; Maloney, Kevin M.; McMullen, Jonathan P.; Prier, Christopher K.; Qi, Ji; Rivera, Nelo R.; Wang, Zhixun; Wyvratt, Brian M.; Zewge, Daniel

Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib 通过固定化生物催化对绿色溶剂进行胺化以合成Nemtabrutinib

ACS CATALYSIS

IF13.1

2023-05-26

OAAI

Prier, Christopher K.; Camacho Soto, Karla; Forstater, Jacob H.; Kuhl, Nadine; Kuethe, Jeffrey T.; Cheung-Lee, Wai Ling; Di Maso, Michael J.; Eberle, Claire M.; Grosser, Shane T.; Ho, Hsing-, I; Hoyt, Erik; Maguire, Anne; Maloney, Kevin M.; Makarewicz, Amanda; McMullen, Jonathan P.; Moore, Jeffrey C.; Murphy, Grant S.; Narsimhan, Karthik; Pan, Weilan; Rivera, Nelo R.; Saha-Shah, Anumita; Thaisrivongs, David A.; Verma, Deeptak; Wyatt, Adeya; Zewge, Daniel

Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2022-07-01

PREAI

Bottecchia, Cecilia; Lehnherr, Dan; Levesque, Francois; Reibarkh, Mikhail; Ji, Yining; Rodrigues, Vailankanni L.; Wang, Heather; Lam, Yu-hong; Vickery, Thomas P.; Armstrong, Brittany M.; Mattern, Keith A.; Stone, Kevin; Wismer, Michael K.; Singh, Andrew N.; Regalado, Erik L.; Maloney, Kevin M.; Strotman, Neil A.

Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2022-04-18

OAAI

Sherer, Edward C.; Bagchi, Ansuman; Kosjek, Birgit; Maloney, Kevin M.; Peng, Zhengwei; Robaire, Sandra A.; Sheridan, Robert P.; Metwally, Essam; Campeau, Louis-Charles

Designing for sustainability with biocatalytic and chemoenzymatic cascade processes 通过生物催化和化学酶级联过程设计可持续性

CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY

IF9.4

2022-04-01

PREAI

An, Chihui; Maloney, Kevin M.

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

ACS CENTRAL SCIENCE

IF10.4

2021-10-29

109

OAAI

McIntosh, John A.; Benkovics, Tamas; Silverman, Steven M.; Huffman, Mark A.; Kong, Jongrock; Maligres, Peter E.; Itoh, Tetsuji; Yang, Hao; Verma, Deeptak; Pan, Weilan; Ho, Hsing-, I; Vroom, Jonathan; Knight, Anders M.; Hurtak, Jessica A.; Klapars, Artis; Fryszkowska, Anna; Morris, William J.; Strotman, Neil A.; Murphy, Grant S.; Maloney, Kevin M.; Fier, Patrick S.

The application of modern reactions in large-scale synthesis

NATURE REVIEWS CHEMISTRY

IF51.7

2021-06-22

PREAI

Lovato, Kaitlyn; Fier, Patrick S.; Maloney, Kevin M.

Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2021-02-09

PREAI

Mohan, Anne E.; DiBenedetto, Michael; Alwedi, Embarek; Ang, Yee Swan; Sihombing, Muhammad Sofian Bin Asi; Chang, Hsieh Yao D.; Cote, Aaron; Desmond, Richard; Diaz-Santana, Anthony; Khong, Eric; Lee, Ivan H.; Liu, Wenjun; Maloney, Kevin M.; Mattern, Keith; Pridgen, Christopher; Ren, Hong; Sirk, Kevin; Sirota, Eric; Spencer, Glenn; Tao, Beata; Whittington, Michael; Yang, Cuixian; Zhang, Si-Wei

Synthesis of Isotopically Labeled Anti-HIV Nucleoside Islatravir through a One-Pot Biocatalytic Cascade Reaction

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-12-23

PREAI

Ren, Sumei; Huffman, Mark A.; Whittaker, Aaron M.; Yang, Hao; Nawrat, Christopher C.; Waterhouse, David J.; Maloney, Kevin M.; Strotman, Neil A.

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation-Cyclization as a Flow-Batch Process Leads to Significant Improvements in Process Mass Intensity (PMI) and CO Generated versus the Batch-Batch Process

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-11-05

PREAI

Otte, Douglas A. L.; Basu, Kallol; Jellett, Lisa; Whittington, Michael; Spencer, Glenn; Burris, Matthew; Corcoran, Emily B.; Stone, Kevin; Nappi, Jarod; Arvary, Rebecca A.; Donoghue, David; Ren, Hong; Maloney, Kevin M.; Naber, John R.

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-10-23

PREAI

Maloney, Kevin M.; Zhang, Si-Wei; Mohan, Anne E.; Lee, Alfred Y.; Larpent, Patrick; Ren, Hong; Humphrey, Guy R.; Desmond, Richard; DiBenedetto, Michael; Liu, Wenjun; Lee, Ivan H.; Sirota, Eric; Di Maso, Michael J.; Alwedi, Embarek; Song, Siqing; Chang, Hsieh Yao D.

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation-Cyclization Sequence to the Diaminopyrimidine Core

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-10-20

PREAI

Basu, Kallol; Lehnherr, Dan; Martin, Gary E.; Desmond, Richard A.; Lam, Yu-hong; Peng, Feng; Chung, John Y. L.; Arvary, Rebecca A.; Zompa, Michael A.; Zhang, Si-Wei; Liu, Jinchu; Dance, Zachary E. X.; Larpent, Patrick; Cohen, Ryan D.; Guzman, Francisco J.; Rogus, Nicholas J.; Di Maso, Michael J.; Ren, Hong; Maloney, Kevin M.

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-10-20

PREAI

Di Maso, Michael J.; Ren, Hong; Zhang, Si-Wei; Liu, Wenjun; Desmond, Richard; Alwedi, Embarek; Narsimhan, Karthik; Kalinin, Alexei; Larpent, Patrick; Lee, Alfred Y.; Ren, Sumei; Maloney, Kevin M.

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-10-16

PREAI

Peng, Feng; Humphrey, Guy R.; Maloney, Kevin M.; Lehnherr, Dan; Weisel, Mark; Levesque, Francois; Naber, John R.; Brunskill, Andrew P. J.; Larpent, Patrick; Zhang, Si-Wei; Lee, Alfred Y.; Arvary, Rebecca A.; Lee, Claire H.; Bishara, Daniel; Narsimhan, Karthik; Sirota, Eric; Whittington, Michael

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-10-16

PREAI

Ren, Hong; Maloney, Kevin M.; Basu, Kallol; Di Maso, Michael J.; Humphrey, Guy R.; Peng, Feng; Desmond, Richard; Otte, Douglas A. L.; Alwedi, Embarek; Liu, Wenjun; Zhang, Si-Wei; Song, Siqing; Arvary, Rebecca A.; Zompa, Michael A.; Lehnherr, Dan; Martin, Gary E.; Chang, Hsieh Yao D.; Mohan, Anne E.; Guzman, Francisco J.; Jellett, Lisa; Lee, Alfred Y.; Spencer, Glenn; Fisher, Elizabeth S.; Naber, John R.; Gao, Hong; Lohani, Sachin; Ruck, Rebecca T.; Campeau, Louis-Charles

Five-Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2020-10-01

PREAI

Patel, Niki R.; Huffman, Mark A.; Wang, Xiao; Ding, Bangwei; McLaughlin, Mark; Newman, Justin A.; Andreani, Teresa; Maloney, Kevin M.; Johnson, Heather C.; Whittaker, Aaron M.

研究方向