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Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge Lawson, Catherine L.; Kryshtafovych, Andriy; Pintilie, Grigore D.; Burley, Stephen K.; Cerny, Jiri; Chen, Vincent B.; Emsley, Paul; Gobbi, Alberto; Joachimiak, Andrzej; Noreng, Sigrid; Prisant, Michael G.; Read, Randy J.; Richardson, Jane S.; Rohou, Alexis L.; Schneider, Bohdan; Sellers, Benjamin D.; Shao, Chenghua; Sourial, Elizabeth; Williams, Chris I.; Williams, Christopher J.; Yang, Ying; Abbaraju, Venkat; Afonine, Pavel V.; Baker, Matthew L.; Bond, Paul S.; Blundell, Tom L.; Burnley, Tom; Campbell, Arthur; Cao, Renzhi; Cheng, Jianlin; Chojnowski, Grzegorz; Cowtan, K. D.; DiMaio, Frank; Esmaeeli, Reza; Giri, Nabin; Grubmueller, Helmut; Hoh, Soon Wen; Hou, Jie; Hryc, Corey F.; Hunte, Carola; Igaev, Maxim; Joseph, Agnel P.; Kao, Wei-Chun; Kihara, Daisuke; Kumar, Dilip; Lang, Lijun; Lin, Sean; Subramaniya, Sai R. Maddhuri Venkata; Mittal, Sumit; Mondal, Arup; Moriarty, Nigel W.; Muenks, Andrew; Murshudov, Garib N.; Nicholls, Robert A.; Olek, Mateusz; Palmer, Colin M.; Perez, Alberto; Pohjolainen, Emmi; Pothula, Karunakar R.; Rowley, Christopher N.; Sarkar, Daipayan; Schaefer, Luisa U.; Schlicksup, Christopher J.; Schroeder, Gunnar F.; Shekhar, Mrinal; Si, Dong; Singharoy, Abhishek; Sobolev, Oleg V.; Terashi, Genki; Vaiana, Andrea C.; Vedithi, Sundeep C.; Verburgt, Jacob; Wang, Xiao; Warshamanage, Rangana; Winn, Martyn D.; Weyand, Simone; Yamashita, Keitaro; Zhao, Minglei; Schmid, Michael F.; Berman, Helen M.; Chiu, Wah 分享 收藏
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Adapting Ferritin, a Naturally Occurring Protein Cage, to Modulate Intrinsic Agonism of OX40 Shatz-Binder, Whitney; Azumaya, Caleigh M.; Leonard, Brandon; Vuong, Ivan; Sudhamsu, Jawahar; Rohou, Alexis; Liu, Peter; Sandoval, Wendy; Bol, Karenna; Izadi, Saeed; Holder, Patrick G.; Blanchette, Craig; Perozzo, Remo; Kelley, Robert F.; Kalia, Yogeshvar 分享 收藏
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Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors Kschonsak, Marc; Jao, Christine C.; Arthur, Christopher P.; Rohou, Alexis L.; Bergeron, Philippe; Ortwine, Daniel F.; McKerrall, Steven J.; Hackos, David H.; Deng, Lunbin; Chen, Jun; Li, Tianbo; Dragovich, Peter S.; Volgraf, Matthew; Wright, Matthew R.; Payandeh, Jian; Ciferri, Claudio; Tellis, John C. 分享 收藏
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration Gerhardy, Stefan; Ultsch, Mark; Tang, Wanjian; Green, Evan; Holden, Jeffrey K.; Li, Wei; Estevez, Alberto; Arthur, Chris; Tom, Irene; Rohou, Alexis; Kirchhofer, Daniel 分享 收藏
Structural basis for HCMV Pentamer receptor recognition and antibody neutralization HCMV五聚体受体识别和抗体中和的结构基础 Kschonsak, Marc; Johnson, Matthew C.; Schelling, Rachel; Green, Evan M.; Rouge, Lionel; Ho, Hoangdung; Patel, Nidhi; Kilic, Cem; Kraft, Edward; Arthur, Christopher P.; Rohou, Alexis L.; Comps-Agrar, Laetitia; Martinez-Martin, Nadia; Perez, Laurent; Payandeh, Jian; Ciferri, Claudio 分享 收藏
Discovery of a dual pathway aggregation mechanism for a therapeutic constrained peptide Chen, Tao; Tang, Shijia; Hecht, Elizabeth S.; Yen, Chun-Wan; Andersen, Nisana; Chin, Steven; Cadang, Lance; Roper, Brian; Estevez, Alberto; Rohou, Alexis; Chang, Debby; Dai, Lu; Liu, Peter; Al-Sayah, Mohammad; Nagapudi, Karthik; Lin, Fiona; Famili, Amin; Hu, Chloe; Kuhn, Robert; Stella, Cinzia; Crittenden, Christopher M.; Gruenhagen, Jason A.; Venkatramani, Cadapakam; Hannoush, Rami N.; Leung, Dennis; Vandlen, Richard; Yehl, Peter 分享 收藏
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy Terrett, Jack A.; Chen, Huifen; Shore, Daniel G.; Villemure, Elisia; Larouche-Gauthier, Robin; Dery, Martin; Beaumier, Francis; Constantineau-Forget, Lea; Grand-Maitre, Chantal; Lepissier, Luce; Ciblat, Stephane; Sturino, Claudio; Chen, Yong; Hu, Baihua; Lu, Aijun; Wang, Yunli; Cridland, Andrew P.; Ward, Stuart, I; Hackos, David H.; Reese, Rebecca M.; Shields, Shannon D.; Chen, Jun; Balestrini, Alessia; Riol-Blanco, Lorena; Lee, Wyne P.; Liu, John; Suto, Eric; Wu, Xiumin; Zhang, Juan; Ly, Justin Q.; La, Hank; Johnson, Kevin; Baumgardner, Matt; Chou, Kang-Jye; Rohou, Alexis; Rouge, Lionel; Safina, Brian S.; Magnuson, Steven; Volgraf, Matthew 分享 收藏
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment Balestrini, Alessia; Joseph, Victory; Dourado, Michelle; Reese, Rebecca M.; Shields, Shannon D.; Rouge, Lionel; Bravo, Daniel D.; Chernov-Rogan, Tania; Austin, Cary D.; Chen, Huifen; Wang, Lan; Villemure, Elisia; Shore, Daniel G. M.; Verma, Vishal A.; Hu, Baihua; Chen, Yong; Leong, Laurie; Bjornson, Chris; Hotel, Kathy; Gogineni, Alvin; Lee, Wyne P.; Suto, Eric; Wu, Xiumin; Liu, John; Zhang, Juan; Gandham, Vineela; Wang, Jianyong; Payandeh, Jian; Ciferri, Claudio; Estevez, Alberto; Arthur, Christopher P.; Kortmann, Jens; Wong, Ryan L.; Heredia, Jose E.; Doerr, Jonas; Jung, Min; Vander Heiden, Jason A.; Roose-Girma, Merone; Tam, Lucinda; Barck, Kai H.; Carano, Richard A. D.; Ding, Han Ting; Brillantes, Bobby; Tam, Christine; Yang, Xiaoying; Gao, Simon S.; Ly, Justin Q.; Liu, Liling; Chen, Liuxi; Liederer, Bianca M.; Lin, Joseph H.; Magnuson, Steven; Chen, Jun; Hackos, David H.; Elstrott, Justin; Rohou, Alexis; Safina, Brian S.; Volgraf, Matthew; Bauer, Rebecca N.; Riol-Blanco, Lorena 分享 收藏
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A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel Liu, Chang; Reese, Rebecca; Vu, Simon; Rouge, Lionel; Shields, Shannon D.; Kakiuchi-Kiyota, Satoko; Chen, Huifen; Johnson, Kevin; Shi, Yu Patrick; Chernov-Rogan, Tania; Greiner, Demi Maria Zabala; Kohli, Pawan Bir; Hackos, David; Brillantes, Bobby; Tam, Christine; Li, Tianbo; Wang, Jianyong; Safina, Brian; Magnuson, Steve; Volgraf, Matthew; Payandeh, Jian; Zheng, Jie; Rohou, Alexis; Chen, Jun 分享 收藏
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Structural Basis of Nav1.7 Inhibition by the Tarantula Toxin Protoxin-II Xu, Hui; Li, Tianbo; Rohou, Alexis; Arthur, Christopher; Tzakoniati, Foteini; Wong, Evera; Estevez, Alberto; Kugel, Christine; Franke, Yvonne; Chen, Jun; Ciferri, Claudio; Hackos, David; Koth, Christopher; Payandeh, Jian 分享 收藏
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