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Alan S.L. Wong

University of Hong Kong

18H指数
70论文数
1.3K被引数
收录论文 27
发表时间
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AI identifies interactions in CRISPR complexes to improve specificity of DNA editingAI识别CRISPR复合物中的相互作用以改善DNA编辑的特异性
errNature
IF48.5
err2026-07-22
err0
PREAI
errHoi Yee Chu; Alan S. L. Wong
err分享
err收藏
Rapid customization of base editors via machine learning-powered combinatorial mutagenesis基于机器学习驱动的组合诱变实现碱基编辑器的快速定制
errMolecular Cell
IF16.6
err2026-04-16
err0
PREAI
errJiaxing Peng; Don C.T. Chan; Hoi Yee Chu; John H.C. Fong; Yin Kau Lam; Maggie S.H. Cheung; Wing Leung; Gigi C.G. Choi; Alan S.L. Wong
err分享
err收藏
Droplet-based single-cell pairing for high-throughput interaction mapping of antigen-receptor combinations基于液滴的单细胞配对，用于高通量抗原-受体组合的相互作用图谱绘制
errScience Advances
IF12.5
err2025-12-12
err0
errOAAI
errLang Nan; Tianjiao Mao; Charles W. F. Chan; Bei Wang; Ziyu Han; Gigi C. G. Choi; Xueyong Wei; Alan S. L. Wong; Ho Cheung Shum
err分享
err收藏
A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer一种联合肠道神经元-胃肿瘤类器官揭示了胃癌的代谢易损性
errCell Stem Cell
IF20.4
err2025-09-02
err0
errOAAI
errBecky K.C. Chan; Chu Zhang; Chi Him Poon; Marie H.Y. Lee; Hoi Yee Chu; Bei Wang; Sin-Guang Chen; Helen H.N. Yan; Suet Yi Leung; Alan S.L. Wong
err分享
err收藏
Drosophila Nhe2 overexpression induces autophagic cell death
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2024-07-01
err1
PREAI
errPeralta, Jobelle; DuPriest, Blake; Orozco, Daniel; Pacheco, Juan Reyna; Martins, Laura; Soriano, Rachel Ann; Wong, Alan; Wong, Ramy; Grillo-Hill, Bree
err分享
err收藏
Accurate top protein variant discovery via low-N pick-and-validate machine learning
errCELL SYSTEMS
IF7.7
err2024-02-01
err2
PREAI
errChu, Hoi Yee; Fong, John H. C.; Thean, Dawn G. L.; Zhou, Peng; Fung, Frederic K. C.; Huang, Yuanhua; Wong, Alan S. L.
err分享
err收藏
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2 (Nov, 10.1038/s41551-023-01140-z, 2023)
errNATURE BIOMEDICAL ENGINEERING
IF26.6
err2024-01-24
err0
errOAAI
errChan, Charles W. F.; Wang, Bei; Nan, Lang; Huang, Xiner; Mao, Tianjiao; Chu, Hoi Yee; Luo, Cuiting; Chu, Hin; Choi, Gigi C. G.; Shum, Ho Cheung; Wong, Alan S. L.
err分享
err收藏
Discovery of regulatory motifs in 5' untranslated regions using interpretable multi-task learning models使用可解释的多任务学习模型在5' 未翻译区域中发现调控基序
errCELL SYSTEMS
IF7.7
err2023-12-01
err3
PREAI
errZheng, Weizhong; Fong, John H. C.; Wan, Yuk Kei; Chu, Athena H. Y.; Huang, Yuanhua; Wong, Alan S. L.; Ho, Joshua W. K.
err分享
err收藏
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2
errNATURE BIOMEDICAL ENGINEERING
IF26.6
err2023-11-23
err3
errOAAI
errChan, Charles W. F.; Wang, Bei; Nan, Lang; Huang, Xiner; Mao, Tianjiao; Chu, Hoi Yee; Luo, Cuiting; Chu, Hin; Choi, Gigi C. G.; Shum, Anderson H. C.; Wong, Alan S. L.
err分享
err收藏
Parallel engineering and activity profiling of a base editor system
errCELL SYSTEMS
IF7.7
err2023-05-01
err2
errOAAI
errJohn, H. C.; Chu, Hoi Yee; Zhou, Peng; Wong, Alan S. L.
err分享
err收藏
CRISPR screening in cancer stem cells
errESSAYS IN BIOCHEMISTRY
IF5.7
err2022-09-16
err2
PREAI
errWang, Bei; Wong, Alan S. L.
err分享
err收藏
Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities机器学习耦合的组合诱变实现了CRISPR-Cas9基因组编辑器活动的资源高效工程
errNATURE COMMUNICATIONS
IF15.7
err2022-04-25
err17
errOAAI
errThean, Dawn G. L.; Chu, Hoi Yee; Fong, John H. C.; Chan, Becky K. C.; Zhou, Peng; Kwok, Cynthia C. S.; Chan, Yee Man; Mak, Silvia Y. L.; Choi, Gigi C. G.; Ho, Joshua W. K.; Zheng, Zongli; Wong, Alan S. L.
err分享
err收藏
High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-01-21
err11
errOAAI
errYuen, Chaya T. L.; Thean, Dawn G. L.; Chan, Becky K. C.; Zhou, Peng; Kwok, Cynthia C. S.; Chu, Hoi Yee; Cheung, Maggie S. H.; Wang, Bei; Chan, Yee Man; Mak, Silvia Y. L.; Leung, Anskar Y.; Choi, Gigi C. G.; Zheng, Zongli; Wong, Alan S. L.
err分享
err收藏
A Combinatorial CRISPR-Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment
errCANCER RESEARCH
IF16.6
err2021-12-15
err17
errOAAI
errXu, Feng; Tong, Man; Tong, Cindy S. W.; Chan, Becky K. C.; Chu, Hoi Yee; Wong, Tin Lok; Fong, John H. C.; Cheung, Maggie S. H.; Mak, Kylie Hin-Man; Pardeshi, Lakhansing; Huang, Yuanhua; Wong, Koon Ho; Choi, Gigi C. G.; Ma, Stephanie; Wong, Alan S. L.
err分享
err收藏
High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies
errNATURE COMMUNICATIONS
IF15.7
err2021-07-06
err69
errOAAI
errCao, Jicong; Novoa, Eva Maria; Zhang, Zhizhuo; Chen, William C. W.; Liu, Dianbo; Choi, Gigi C. G.; Wong, Alan S. L.; Wehrspaun, Claudia; Kellis, Manolis; Lu, Timothy K.
err分享
err收藏
Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose- Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells
errSTEM CELL REPORTS
IF5.1
err2020-11-01
err34
errOAAI
errLi, Xisheng; Yang, Kevin Y.; Chan, Vicken W.; Leung, Kam Tong; Zhang, Xiao-Bing; Wong, Alan S.; Chong, Charing C. N.; Wang, Chi Chiu; Ku, Manching; Lui, Kathy O.
err分享
err收藏
A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets
errCELL REPORTS
IF6.9
err2020-08-01
err31
PREAI
errZhou, Peng; Chan, Becky K. C.; Wan, Yuk Kei; Yuen, Chaya T. L.; Choi, Gigi C. G.; Li, Xinran; Tong, Cindy S. W.; Zhong, Sophia S. W.; Sun, Jieran; Bao, Yufan; Mak, Silvia Y. L.; Chow, Maggie Z. Y.; Khaw, Jien Vei; Leung, Suet Yi; Zheng, Zongli; Cheung, Lydia W. T.; Tan, Kaeling; Wong, Koon Ho; Chan, H. Y. Edwin; Wong, Alan S. L.
err分享
err收藏
Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 (vol 16, pg 722, 2019)
errNATURE METHODS
IF32.1
err2019-07-23
err0
errOAAI
errChoi, Gigi C. G.; Zhou, Peng; Yuen, Chaya T. L.; Chan, Becky K. C.; Xu, Feng; Bao, Siyu; Chu, Hoi Yee; Thean, Dawn; Tan, Kaeling; Wong, Koon Ho; Zheng, Zongli; Wong, Alan S. L.
err分享
err收藏
Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9
errNATURE METHODS
IF32.1
err2019-07-15
err52
PREAI
errChoi, Gigi C. G.; Zhou, Peng; Yuen, Chaya T. L.; Chan, Becky K. C.; Xu, Feng; Bao, Siyu; Chu, Hoi Yee; Thean, Dawn; Tan, Kaeling; Wong, Koon Ho; Zheng, Zongli; Wong, Alan S. L.
err分享
err收藏
High-throughput screening of therapeutic combinations against ovarian cancer
errCANCER RESEARCH
IF16.6
err2019-07-01
err0
PREAI
errZhou, Peng; Wong, Alan S.
err分享
err收藏

研究方向

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