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Alex K. Shalek

Broad Institute of Harvard and MIT
H指数:81
被引数:4.8万

个人简介

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荣誉奖项

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Intratumoral T cell activation kills tumors regardless of T cell specificity

肿瘤内T细胞激活可杀死肿瘤，与T细胞特异性无关

Nature Immunology
IF27.6
2026-09-080
PRE
Olivia C. Ghirardelli Smith; Tyler T. Dao; Noah V. Gavil; Stephen D. O’Flanagan; Adam J. Rubin; Son Nguyen; Matthew B. Watowich; Nuo Liu; Eyob Weyu; Clare F. Quarnstrom; Andrew G. Soerens; Vineet Joag; Pamela C. Rosato; Matthew F. Krummel; Melissa A. Geller; Jeffrey S. Miller; Alessio Giubellino; Vaiva Vezys; Alex K. Shalek; David Masopust
Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones

生酮饮食通过脂质而非酮体介导肠道肿瘤发生

Nature
IF48.5
2026-07-150
PRE
Jessica E. S. Shay; Fangtao Chi; Constantine N. Tzouanas; Shixun Han; Xiao Zhang; Johanna Ten Hoeve; Kevin J. Williams; Seda Neptun; Tolga Sever; Isabela Fuentes; Sangeeta N. Bhatia; Gizem Calibasi-Kocal; Matthew G. Vander Heiden; Alex K. Shalek; Ömer H. Yilmaz
Aging disrupts spatiotemporal coordination in the cycling murine ovary

衰老破坏了循环小鼠卵巢中的时空协调

Nature Aging
IF19.4
2026-06-170
OAAI
Tammy C. T. Lan; Alison Kochersberger; Ruth Raichur; Sophia Szady; Hien Tran; Radiana Simeonova; Ashley Helmuth; Andrew Minagar; Maria José Orozco Fuentes; Vipin Kumar; Giovanni Marrero; Irving Barrera; Sarah Mangiameli; Alex K. Shalek; Pardis C. Sabeti; Fei Chen; David S. Fischer; Jennifer L. Garrison; Hattie Chung
The Single Cell Notebooks for inclusive and accessible training in single-cell and spatial omics

单细胞笔记本电脑，用于单细胞和空间组学的包容性和可访问性培训

Nature Genetics
IF29
2026-05-050
PRE
Adolfo Rojas-Hidalgo; Raúl Arias-Carrasco; Joyce Karoline Silva; Erick Armingol; Sebastián Urquiza-Zurich; Bruno Vinagre; Cesar A. Prada-Medina; Sergio Triana; Daniela D. Russo; Diego Pérez-Stuardo; Emiliano Vicencio; Gerardo Muñoz; Cristóvão Antunes de Lanna; Leandro Santos; Gabriela Rapozo; Natalia Tavares; Andrés Moreno-Estrada; John Randell; Patricia Severino; Ricardo Khouri; Orr Ashenberg; Alex K. Shalek; Mariana Boroni; Yesid Cuesta-Astroz; Benilton S. Carvalho; Vinicius Maracaja-Coutinho
Understanding tumor-immune-stromal dynamics driving response and resistance to immune checkpoint blockade in melanoma
JOURNAL OF IMMUNOLOGY
IF3.4
2025-11-010
PRE
Tarantino, Giuseppe; He, Yiwen; Solanky, Priyanka; Cui, Xinyu; Pfaff, Kathleen; Thorner, Aaron R.; Blosser, Timothy; Boblitt, Elliot; Frangieh, Allison; Aprati, Tyler; Zhang, Boyang; Chen, Jiajia; Faulkner, Hannah Mae; Lawless, Aleigha; Manos, Michael; Helvie, Karla; Sharova, Tatyana; Frederick, Dennie; Krishna, Sachi; Mangum, Chanell; Abbondanza, Domenic; Mccann, Cai; Johnson, Bruce; Shalek, Alex K.; Van Allen, Eliezer; Zhuang, Xiaowei; Sullivan, Ryan; Engelhardt, Barbara; Farhi, Sami; Rodig, Scott; Hodi, F. Stephen; Boland, Genevieve M.; Liu, David
Single-cell profiling reveals a role for tuberculosis-induced myofibroblasts in the immunopathology of infected lungs
JOURNAL OF IMMUNOLOGY
IF3.4
2025-11-010
PRE
Liu, Nuo; Mbano, Ian Maheti; Wardsworth, Marc; Chambers, Mark; Mpotje, Thabo; Asowata, Osaretin; Nyquist, Sarah; Nargan, Kievershen; Ramsuran, Duran; Karim, Farina; Hughes, Travis; Bromley, Joshua; Krause, Robert; Tezera, Liku; Reichmann, Michaela; Keanne, Sharie; Ganchua, C.; Kloverpris, Henrik; Dullabh, Kaylesh; Madansein, Rajhmun; Triana, Sergio; Steyn, Adrie; Berger, Bonnie; Marakalala, Mohlopheni; Fortune, Sarah; Flynn, Joanne L.; Elkington, Paul T.; Shalek, Alex K.; Leslie, Alasdair
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes

利用转录组学进行主动学习框架识别疾病表型调节因子

Science
IF45.8
2025-10-230
PRE
Benjamin DeMeo; Charlotte Nesbitt; Samuel A. Miller; Daniel B. Burkhardt; Inna Lipchina; Doris Fu; Peter Holderrieth; David Kim; Sergey Kolchenko; Artur Szalata; Ishan Gupta; Christine Kerr; Thomas Pfefer; Raziel Rojas-Rodriguez; Sunil Kuppassani; Laurens Kruidenier; Parul B. Doshi; Mahdi Zamanighomi; James J. Collins; Alex K. Shalek; Fabian J. Theis; Mauricio Cortes
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV

CD8+ T细胞的免疫代谢缺陷会破坏HIV感染者肠道屏障的完整性

Cell
IF42.5
2025-09-110
OAAI
Upasana Das Adhikari; Leah M. Froehle; Alexandra N. Pipkin; Heeva Baharlou; Alice H. Linder; Palak Shah; Amanda Hussey; Qiming Zhang; Sarah Nyquist; Saleh Khwaled; Fangtao Chi; Swagata Goswami; Sabhyata Sedhain; Salina Hussain; Thomas J. Diefenbach; Benjamin J. Read; Byungji Kim; Darrell Irvine; Osaretin Asowata; Mark Ladinsky; Pamela Bjorkman; Fusi Madela; Shakeel Kader; Alex K. Shalek; Musie Ghebremichael; Henrik Kloverpris; Alison E. Ringel; Ömer H. Yilmaz; Douglas S. Kwon
A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

单核和空间转录组图谱揭示了COVID-19患者肝脏中的拓扑结构、功能及再生性器官损伤

GENOME BIOLOGY
IF9.4
2025-03-142
OA
Pita-Juarez, Yered; Karagkouni, Dimitra; Kalavros, Nikolaos; Melms, Johannes C.; Niezen, Sebastian; Delorey, Toni M.; Essene, Adam L.; Brook, Olga R.; Pant, Deepti; Skelton-Badlani, Disha; Naderi, Pourya; Huang, Pinzhu; Pan, Liuliu; Hether, Tyler; Andrews, Tallulah S.; Ziegler, Carly G. K.; Reeves, Jason; Myloserdnyy, Andriy; Chen, Rachel; Nam, Andy; Phelan, Stefan; Liang, Yan; Gregory, Mark; He, Shanshan; Patrick, Michael; Rane, Tushar; Wardhani, Aster; Amin, Amit Dipak; Biermann, Jana; Hibshoosh, Hanina; Veregge, Molly; Kramer, Zachary; Jacobs, Christopher; Yalcin, Yusuf; Phillips, Devan; Slyper, Michal; Subramanian, Ayshwarya; Ashenberg, Orr; Bloom-Ackermann, Zohar; Tran, Victoria M.; Gomez, James; Sturm, Alexander; Zhang, Shuting; Fleming, Stephen J.; Warren, Sarah; Beechem, Joseph; Hung, Deborah; Babadi, Mehrtash; Padera Jr, Robert F.; Macparland, Sonya A.; Bader, Gary D.; Imad, Nasser; Solomon, Isaac H.; Miller, Eric; Riedel, Stefan; Porter, Caroline B. M.; Villani, Alexandra-Chloe; Tsai, Linus T. -Y.; Hide, Winston; Szabo, Gyongyi; Hecht, Jonathan; Rozenblatt-Rosen, Orit; Shalek, Alex K.; Izar, Benjamin; Popov, Yury V.; Jiang, Z. Gordon; Vlachos, Ioannis S.
scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria

scRNA-seq揭示儿童无并发症疟疾中单核细胞通过NFkB表现出升高的干扰素反应和TNF-α信号。

EXPERIMENTAL BIOLOGY AND MEDICINE
IF2.7
2025-01-030
OA
Morang'a, Collins M.; Drake, Riley S.; Miao, Vincent N.; Nyakoe, Nancy K.; Amuzu, Dominic S. Y.; Appiah, Vincent; Aniweh, Yaw; Bediako, Yaw; Bah, Saikou Y.; Shalek, Alex K.; Awandare, Gordon A.; Amenga-Etego, Lucas

研究方向

暂未获取到该数据
J
José Ordovás-Montañés
H 指数:38论文数:126被引数:1.3万
M
Marc H. Wadsworth
H 指数:29论文数:86被引数:1.5万
S
Samuel W. Kazer
H 指数:22论文数:70被引数:1.0万
A
Aviv Regev
H 指数:208论文数:999被引数:22.6万
T
Travis K. Hughes
H 指数:25论文数:92被引数:7,921
S
Sarah K. Nyquist
H 指数:18论文数:62被引数:8,330
P
Peter Winter
H 指数:52论文数:240被引数:1.1万
B
Bonnie Berger
H 指数:85论文数:518被引数:3.4万
R
Riley S. Drake
H 指数:10论文数:36被引数:868
S
Sanjay M. Prakadan
H 指数:11论文数:105被引数:6,218