E.F. Pai - Publications, H-index & Citations

E.F. Pai

university of toronto

62H指数

388论文数

1.7W被引数

收录论文 72

发表时间

Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-09-01

OAAI

Sekine, Mai; Okamoto, Ken; Pai, Emil F.; Nagata, Koji; Ichida, Kimiyoshi; Hille, Russ; Nishino, Takeshi

Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison

SCIENCE ADVANCES

IF12.5

2021-03-19

OAAI

Mehrabi, P.; Buecker, R.; Bourenkov, G.; Ginn, H. M.; von Stetten, D.; Mueller-Werkmeister, H. M.; Kuo, A.; Morizumi, T.; Eger, B. T.; Ou, W-L; Oghbaey, S.; Sarracini, A.; Besaw, J. E.; Pare-Labrosse, O.; Meier, S.; Schikora, H.; Tellkamp, F.; Marx, A.; Sherrell, D. A.; Axford, D.; Owen, R. L.; Ernst, O. P.; Pai, E. F.; Schulz, E. C.; Miller, R. J. D.

Development of Antibiotics That Dysregulate the Neisserial ClpP Protease 开发调节奈瑟氏菌ClpP蛋白酶的抗生素

ACS INFECTIOUS DISEASES

IF3.8

2020-11-25

OAAI

Binepal, Gursonika; Mabanglo, Mark F.; Goodreid, Jordan D.; Leung, Elisa; Barghash, Marim M.; Wong, Keith S.; Lin, Funing; Cossette, Michele; Bansagi, Jazmin; Song, Boxi; Serrao, Vitor Hugo Balasco; Pai, Emil F.; Batey, Robert A.; Gray-Owen, Scott D.; Houry, Walid A.

ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores ClpP蛋白酶激活是由入口孔处静电相互作用网络的重组引起的

COMMUNICATIONS BIOLOGY

IF5.1

2019-11-13

OAAI

Mabanglo, Mark F.; Leung, Elisa; Vahidi, Siavash; Seraphim, Thiago, V; Eger, Bryan T.; Bryson, Steve; Bhandari, Vaibhav; Zhou, Jin Lin; Mao, Yu-Qian; Rizzolo, Kamran; Barghash, Marim M.; Goodreid, Jordan D.; Phanse, Sadhna; Babu, Mohan; Barbosa, Leandro R. S.; Ramos, Carlos H., I; Batey, Robert A.; Kay, Lewis E.; Pai, Emil F.; Houry, Walid A.

Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2019-08-13

PREAI

De Gasparo, Raoul; Halgas, Ondrej; Harangozo, Dora; Kaiser, Marcel; Pai, Emil F.; Krauth-Siegel, R. Luise; Diederich, Francois

Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Ishizawa, Jo; Zarabi, Sarah F.; Davis, R. Eric; Halgas, Ondrej; Nii, Takenobu; Jitkova, Yulia; Zhao, Ran; St-Germain, Jonathan; Heese, Lauren E.; Egan, Grace; Ruvolo, Vivian R.; Barghout, Samir H.; Nishida, Yuki; Hurren, Rose; Ma, Wencai; Gronda, Marcela; Link, Todd; Wong, Keith; Mabanglo, Mark; Kojima, Kensuke; Borthakur, Gautam; MacLean, Neil; Ma, John Man Chun; Leber, Andrew B.; Minden, Mark D.; Houry, Walid; Kantarjian, Hagop; Stogniew, Martin; Raught, Brian; Pai, Emil F.; Schimmer, Aaron D.; Andreeff, Michael

Substrate-Based Allosteric Regulation of a Homodimeric Enzyme

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2019-06-12

PREAI

Mehrabi, Pedram; Di Pietrantonio, Christopher; Kim, Tae Hun; Sljoka, Adnan; Taverner, Keith; Ing, Christopher; Kruglyak, Natasha; Pomes, Regis; Pai, Emil F.; Prosser, R. Scott

The hit-and-return system enables efficient time-resolved serial synchrotron crystallography

NATURE METHODS

IF32.1

2018-10-30

OAAI

Schulz, Eike C.; Mehrabi, Pedram; Mueller-Werkmeister, Henrike M.; Tellkamp, Friedjof; Jha, Ajay; Stuart, William; Persch, Elke; De Gasparo, Raoul; Diederich, Francois; Pai, Emil F.; Miller, R. J. Dwayne

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities 人gm-csf自身抗体抑制gm-csf的机制提示了新的治疗机会

MABS

IF7.3

2018-07-03

OAAI

Dhagat, Urmi; Hercus, Timothy R.; Broughton, Sophie E.; Nero, Tracy L.; Shing, Karen S. Cheung Tung; Barry, Emma F.; Thomson, Christy A.; Bryson, Steve; Pai, Emil F.; McClure, Barbara J.; Schrader, John W.; Lopez, Angel F.; Parker, Michael W.

Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia 选择性小分子UBA1抑制剂TAK-243在急性髓系白血病中的临床前评估

LEUKEMIA

IF13.4

2018-06-08

PREAI

Barghout, Samir H.; Patel, Parasvi S.; Wang, Xiaoming; Xu, G. Wei; Kavanagh, Simon; Halgas, Ondrej; Zarabi, Sara F.; Gronda, Marcela; Hurren, Rose; Jeyaraju, Danny, V; MacLean, Neil; Brennan, Shawn; Hyer, Marc L.; Berger, Allison; Traore, Tary; Milhollen, Michael; Smith, Adam C.; Minden, Mark D.; Pai, Emil F.; Hakem, Razq; Schimmer, Aaron D.

The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling

SCIENTIFIC REPORTS

IF3.9

2018-06-05

OAAI

Ghodrati, Farinaz; Mehrabian, Mohadeseh; Williams, Declan; Halgas, Ondrej; Bourkas, Matthew E. C.; Watts, Joel C.; Pai, Emil F.; Schmitt-Ulms, Gerold

Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma

CHEMMEDCHEM

IF3.4

2018-04-06

OAAI

De Gasparo, Raoul; Brodbeck-Persch, Elke; Bryson, Steve; Hentzen, Nina B.; Kaiser, Marcel; Pai, Emil F.; Krauth-Siegel, R. Luise; Diederich, Francois

Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation

JOURNAL OF IMMUNOLOGY

IF3.4

2016-06-01

PREAI

Bryson, Steve; Thomson, Christy A.; Risnes, Louise F.; Dasgupta, Somnath; Smith, Kenneth; Schrader, John W.; Pai, Emil F.

Data publication with the structural biology data grid supports live analysis

NATURE COMMUNICATIONS

IF15.7

2016-03-07

105

OAAI

Meyer, Peter A.; Socias, Stephanie; Key, Jason; Ransey, Elizabeth; Tjon, Emily C.; Buschiazzo, Alejandro; Lei, Ming; Botka, Chris; Withrow, James; Neau, David; Rajashankar, Kanagalaghatta; Anderson, Karen S.; Baxter, Richard H.; Blacklow, Stephen C.; Boggon, Titus J.; Bonvin, Alexandre M. J. J.; Borek, Dominika; Brett, Tom J.; Caflisch, Amedeo; Chang, Chung-I; Chazin, Walter J.; Corbett, Kevin D.; Cosgrove, Michael S.; Crosson, Sean; Dhe-Paganon, Sirano; Di Cera, Enrico; Drennan, Catherine L.; Eck, Michael J.; Eichman, Brandt F.; Fan, Qing R.; Ferre-D'Amare, Adrian R.; Fromme, J. Christopher; Garcia, K. Christopher; Gaudet, Rachelle; Gong, Peng; Harrison, Stephen C.; Heldwein, Ekaterina E.; Jia, Zongchao; Keenan, Robert J.; Kruse, Andrew C.; Kvansakul, Marc; McLellan, Jason S.; Modis, Yorgo; Nam, Yunsun; Otwinowski, Zbyszek; Pai, Emil F.; Barbosa Pereira, Pedro Jose; Petosa, Carlo; Raman, S.; Rapoport, Tom A.; Roll-Mecak, Antonina; Rosen, Michael K.; Rudenko, Gabby; Schlessinger, Joseph; Schwartz, Thomas U.; Shamoo, Yousif; Sondermann, Holger; Tao, Yizhi J.; Tolia, Niraj H.; Tsodikov, Oleg V.; Westover, Kenneth D.; Wu, Hao; Foster, Ian; Fraser, James S.; Maia, Filipe R. N. C.; Gonen, Tamir; Kirchhausen, Tom; Diederichs, Kay; Crosas, Merce; Sliz, Piotr

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity 具有增强的抗菌活性的有效环状酰基酯肽类似物的开发和表征

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-01-12

PREAI

Goodreid, Jordan D.; Janetzko, John; Maria, John P. Santa, Jr.; Wong, Keith S.; Leung, Elisa; Eger, Bryan T.; Bryson, Steve; Pai, Emil F.; Gray-Owen, Scott D.; Walker, Suzanne; Houry, Walid A.; Batey, Robert A.

Orotidine Monophosphate Decarboxylase - A Fascinating Workhorse Enzyme with Therapeutic Potential

JOURNAL OF GENETICS AND GENOMICS

IF7.1

2015-05-01

PREAI

Fujihashi, Masahiro; Mnpotra, Jagjeet S.; Mishra, Ram Kumar; Pai, Emil F.; Kotra, Lakshmi P.

The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase C端肽在黄嘌呤脱氢酶和黄嘌呤氧化酶之间的过渡过程中在中间形式的形成中起作用

FEBS JOURNAL

IF4.2

2015-04-13

OAAI

Nishino, Tomoko; Okamoto, Ken; Kawaguchi, Yuko; Matsumura, Tomohiro; Eger, Bryan T.; Pai, Emil F.; Nishino, Takeshi

A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Yip, Kenneth W.; Zhang, Zhan; Sakemura-Nakatsugawa, Noriko; Huang, Jui-Wen; Yue, Shijun; Jitkova, Yulia; To, Terence; Pai, Emil; Schimmer, Aaron; Lovell, Jonathan; Sessler, Jonathan; Liu, Fei-Fei

Binding to Large Enzyme Pockets: Small-Molecule Inhibitors of Trypanothione Reductase

CHEMMEDCHEM

IF3.4

2014-04-30

PREAI

Persch, Elke; Bryson, Steve; Todoroff, Nickolay K.; Eberle, Christian; Thelemann, Jonas; Dirdjaja, Natalie; Kaiser, Marcel; Weber, Maria; Derbani, Hassan; Brun, Reto; Schneider, Gisbert; Pai, Emil F.; Krauth-Siegel, R. Luise; Diederich, Francois

Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope IMPLICATIONS FOR ANTIBODY RECOGNITION MECHANISM AND IMMUNOGEN DESIGN

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-03-01

OAAI

Serrano, Soraya; Araujo, Aitziber; Apellaniz, Beatriz; Bryson, Steve; Carravilla, Pablo; de la Arada, Igor; Huarte, Nerea; Rujas, Edurne; Pai, Emil F.; Arrondo, Jose L. R.; Domene, Carmen; Angeles Jimenez, Maria; Nieva, Jose L.

研究方向