未登录 Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures Genomics 2 Proteins portal: 用于将遗传筛选输出与蛋白质序列和结构联系起来的资源和发现工具 Kwon, Seulki; Safer, Jordan; Nguyen, Duyen T.; Hoksza, David; May, Patrick; Arbesfeld, Jeremy A.; Rubin, Alan F.; Campbell, Arthur J.; Burgin, Alex; Iqbal, Sumaiya 分享 收藏
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge Lawson, Catherine L.; Kryshtafovych, Andriy; Pintilie, Grigore D.; Burley, Stephen K.; Cerny, Jiri; Chen, Vincent B.; Emsley, Paul; Gobbi, Alberto; Joachimiak, Andrzej; Noreng, Sigrid; Prisant, Michael G.; Read, Randy J.; Richardson, Jane S.; Rohou, Alexis L.; Schneider, Bohdan; Sellers, Benjamin D.; Shao, Chenghua; Sourial, Elizabeth; Williams, Chris I.; Williams, Christopher J.; Yang, Ying; Abbaraju, Venkat; Afonine, Pavel V.; Baker, Matthew L.; Bond, Paul S.; Blundell, Tom L.; Burnley, Tom; Campbell, Arthur; Cao, Renzhi; Cheng, Jianlin; Chojnowski, Grzegorz; Cowtan, K. D.; DiMaio, Frank; Esmaeeli, Reza; Giri, Nabin; Grubmueller, Helmut; Hoh, Soon Wen; Hou, Jie; Hryc, Corey F.; Hunte, Carola; Igaev, Maxim; Joseph, Agnel P.; Kao, Wei-Chun; Kihara, Daisuke; Kumar, Dilip; Lang, Lijun; Lin, Sean; Subramaniya, Sai R. Maddhuri Venkata; Mittal, Sumit; Mondal, Arup; Moriarty, Nigel W.; Muenks, Andrew; Murshudov, Garib N.; Nicholls, Robert A.; Olek, Mateusz; Palmer, Colin M.; Perez, Alberto; Pohjolainen, Emmi; Pothula, Karunakar R.; Rowley, Christopher N.; Sarkar, Daipayan; Schaefer, Luisa U.; Schlicksup, Christopher J.; Schroeder, Gunnar F.; Shekhar, Mrinal; Si, Dong; Singharoy, Abhishek; Sobolev, Oleg V.; Terashi, Genki; Vaiana, Andrea C.; Vedithi, Sundeep C.; Verburgt, Jacob; Wang, Xiao; Warshamanage, Rangana; Winn, Martyn D.; Weyand, Simone; Yamashita, Keitaro; Zhao, Minglei; Schmid, Michael F.; Berman, Helen M.; Chiu, Wah 分享 收藏
A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging Placzek, Michael S.; Wilton, Daniel K.; Weiwer, Michel; Manter, Mariah A.; Reid, Sarah E.; Meyer, Christopher J.; Campbell, Arthur J.; Bajrami, Besnik; Bigot, Antoine; Bricault, Sarah; Fayet, Agathe; Frouin, Arnaud; Gergits, Frederick; Gupta, Mehak; Jiang, Wei; Melanson, Michelle; Romano, Chiara D.; Riley, Misha M.; Wang, Jessica M.; Wey, Hsiao-Ying; Wagner, Florence F.; Stevens, Beth; Hooker, Jacob M. 分享 收藏
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Delineation of functionally essential protein regions for 242 neurodevelopmental genes Iqbal, Sumaiya; Bruenger, Tobias; Perez-Palma, Eduardo; Macnee, Marie; Brunklaus, Andreas; Daly, Mark J.; Campbell, Arthur J.; Hoksza, David; May, Patrick; Lal, Dennis 分享 收藏
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state Miller, Peter G.; Sathappa, Murugappan; Moroco, Jamie A.; Jiang, Wei; Qian, Yue; Iqbal, Sumaiya; Guo, Qi; Giacomelli, Andrew O.; Shaw, Subrata; Vernier, Camille; Bajrami, Besnik; Yang, Xiaoping; Raffier, Cerise; Sperling, Adam S.; Gibson, Christopher J.; Kahn, Josephine; Jin, Cyrus; Ranaghan, Matthew; Caliman, Alisha; Brousseau, Merissa; Fischer, Eric S.; Lintner, Robert; Piccioni, Federica; Campbell, Arthur J.; Root, David E.; Garvie, Colin W.; Ebert, Benjamin L. 分享 收藏
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Structural mapping of GABRB3 variants reveals genotype-phenotype correlations Johannesen, Katrine M.; Iqbal, Sumaiya; Guazzi, Milena; Mohammadi, Nazanin A.; Perez-Palma, Eduardo; Schaefer, Elise; De Saint Martin, Anne; Abiwarde, Marie Therese; McTague, Amy; Pons, Roser; Piton, Amelie; Kurian, Manju A.; Ambegaonkar, Gautam; Firth, Helen; Sanchis-Juan, Alba; Deprez, Marie; Jansen, Katrien; De Waele, Liesbeth; Briltra, Eva H.; Verbeek, Nienke E.; van Kempen, Marjan; Fazeli, Walid; Striano, Pasquale; Zara, Federico; Visser, Gerhard; Braakman, Hilde M. H.; Haeusler, Martin; Elbracht, Miriam; Vaher, Ulvi; Smol, Thomas; Lemke, Johannes R.; Platzer, Konrad; Kennedy, Joanna; Klein, Karl Martin; Au, Ping Yee Billie; Smyth, Kimberly; Kaplan, Julie; Thomas, Morgan; Dewenter, Malin K.; Dinopoulos, Argirios; Campbell, Arthur J.; Lal, Dennis; Lederer, Damien; Liao, Vivian W. Y.; Ahring, Philip K.; Moller, Rikke S.; Gardella, Elena 分享 收藏
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction McKinney, David C.; McMillan, Brian J.; Ranaghan, Matthew; Moroco, Jamie A.; Brousseau, Merissa; Mullin-Bernstein, Zachary; O'Keefe, Meghan; McCarren, Patrick; Mesleh, Michael F.; Mulvaney, Kathleen M.; Robinson, Foxy; Singh, Ritu; Bajrami, Besnik; Wagner, Florence F.; Hilgraf, Robert; Drysdale, Martin J.; Campbell, Arthur J.; Skepner, Adam; Timm, David E.; Porter, Dale; Kaushik, Virendar K.; Sellers, William R.; Ianari, Alessandra 分享 收藏
Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants Iqbal, Sumaiya; Perez-Palma, Eduardo; Jespersen, Jakob B.; May, Patrick; Hoksza, David; Heyne, Henrike O.; Ahmed, Shehab S.; Rifat, Zaara T.; Rahman, M. Sohel; Lage, Kasper; Palotie, Aarno; Cottrell, Jeffrey R.; Wagner, Florence F.; Daly, Mark J.; Campbell, Arthur J.; Lal, Dennis 分享 收藏
Current knowledge of SLC6A1-related neurodevelopmental disorders SLC6A1-related神经发育障碍的当前知识 Goodspeed, Kimberly; Perez-Palma, Eduardo; Iqbal, Sumaiya; Cooper, Dominique; Scimemi, Annalisa; Johannesen, Katrine M.; Stefanski, Arthur; Demarest, Scott; Helbig, Katherine L.; Kang, Jingqiong; Shaffo, Frances C.; Prentice, Brandon; Brownstein, Catherine A.; Lim, Byungchan; Helbig, Ingo; De Los Reyes, Emily; McKnight, Dianalee; Crunelli, Vincenzo; Campbell, Arthur J.; Moller, Rikke S.; Freed, Amber; Lal, Dennis 分享 收藏
Multimodal small-molecule screening for human prion protein binders Reidenbach, Andrew G.; Mesleh, Michael F.; Casalena, Dominick; Vallabh, Sonia M.; Dahlin, Jayme L.; Leed, Alison J.; Chan, Alix I.; Usanov, Dmitry L.; Yehl, Jenna B.; Lemke, Christopher T.; Campbell, Arthur J.; Shah, Rishi N.; Shrestha, Om K.; Sacher, Joshua R.; Rangel, Victor L.; Moroco, Jamie A.; Sathappa, Murugappan; Nonato, Maria Cristina; Nguyen, Kong T.; Wright, S. Kirk; Liu, David R.; Wagner, Florence F.; Kaushik, Virendar K.; Auld, Douglas S.; Schreiber, Stuart L.; Minikel, Eric Vallabh 分享 收藏
MISCAST: MIssense variant to protein StruCture Analysis web SuiTe Iqbal, Sumaiya; Hoksza, David; Perez-Palma, Eduardo; May, Patrick; Jespersen, Jakob B.; Ahmed, Shehab S.; Rifat, Zaara T.; Heyne, Henrike O.; Rahman, M. Sohel; Cottrell, Jeffrey R.; Wagner, Florence F.; Daly, Mark J.; Campbell, Arthur J.; Lal, Dennis 分享 收藏
Biological concepts in human sodium channel epilepsies and their relevance in clinical practice Brunklaus, Andreas; Du, Juanjiangmeng; Steckler, Felix; Ghanty, Ismael I.; Johannesen, Katrine M.; Fenger, Christina Duhring; Schorge, Stephanie; Baez-Nieto, David; Wang, Hao-Ran; Allen, Andrew; Pan, Jen Q.; Lerche, Holger; Heyne, Henrike; Symonds, Joseph D.; Zuberi, Sameer M.; Sanders, Stephan; Sheidley, Beth R.; Craiu, Dana; Olson, Heather E.; Weckhuysen, Sarah; DeJonge, Peter; Helbig, Ingo; Van Esch, Hilde; Busa, Tiffany; Milh, Matthieu; Isidor, Bertrand; Depienne, Christel; Poduri, Annapurna; Campbell, Arthur J.; Dimidschstein, Jordane; Moller, Rikke S.; Lal, Dennis 分享 收藏
Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation RNA解旋酶DDX6中罕见的从头错义变异会导致智力障碍和畸形特征，并导致P体缺陷和RNA失调 Balak, Chris; Benard, Marianne; Schaefer, Elise; Iqbal, Sumaiya; Ramsey, Keri; Ernoult-Lange, Michele; Mattioli, Francesca; Llaci, Lorida; Geoffroy, Veronique; Courel, Maite; Naymik, Marcus; Bachman, Kristine K.; Pfundt, Rolph; Rump, Patrick; ter Beest, Johanna; Wentzensen, Ingrid M.; Monaghan, Kristin G.; McWalter, Kirsty; Richholt, Ryan; Le Bechec, Antony; Jepsen, Wayne; De Both, Matt; Belnap, Newell; Boland, Anne; Piras, Ignazio S.; Deleuze, Jean-Francois; Szelinger, Szabolcs; Dollfus, Helene; Chelly, Jamel; Muller, Jean; Campbell, Arthur; Lal, Dennis; Rangasamy, Sampathkumar; Mandel, Jean-Louis; Narayanan, Vinodh; Huentelman, Matt; Weil, Dominique; Piton, Amelie 分享 收藏
Functional Interpretation of Single Amino Acid Substitutions in 1,330 Disease-Associated Genes Iqbal, Sumaiya; Jespersen, Jakob Berg; Perez-Palma, Eduardo; May, Patrick; Palotie, Aarno; Cottrell, Jeffrey R.; Wagner, Florence F.; Daly, Mark J.; Campbell, Arthur J.; Lal, Dennis 分享 收藏
Exploiting an Asp-Glu switch in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia 利用糖原合酶激酶3中的asp-glu开关设计用于急性髓细胞性白血病的旁系同源物选择性抑制剂 Wagner, Florence F.; Benajiba, Lina; Campbell, Arthur J.; Weiwer, Michel; Sacher, Joshua R.; Gale, Jennifer P.; Ross, Linda; Puissant, Alexandre; Alexe, Gabriela; Conway, Amy; Back, Morgan; Pikman, Yana; Galinsky, Ilene; DeAngelo, Daniel J.; Stone, Richard M.; Kaya, Taner; Shi, Xi; Robers, Matthew B.; Machleidt, Thomas; Wilkinson, Jennifer; Hermine, Olivier; Kung, Andrew; Stein, Adam J.; Lakshminarasimhan, Damodharan; Hemann, Michael T.; Scolnick, Edward; Zhang, Yan-Ling; Pan, Jen Q.; Stegmaier, Kimberly; Holson, Edward B. 分享 收藏
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment Weiwer, Michel; Xu, Qihong; Gale, Jennifer P.; Lewis, Michael; Campbell, Arthur J.; Schroeder, Frederick A.; van de Bittner, Genevieve C.; Walk, Michelle; Amaya, Aldo; Su, Ping; Dordevic, Luka; Sacher, Joshua R.; Skepner, Adam; Fei, David; Dennehy, Kelly; Nguyen, Shannon; Faloon, Patrick W.; Perez, Jose; Cottrell, Jeffrey R.; Liu, Fang; Palmer, Michelle; Pan, Jen Q.; Hooker, Jacob M.; Zhang, Yan-Ling; Scolnick, Edward; Wagner, Florence F.; Holson, Edward B. 分享 收藏
HDAC6 Brain Mapping with [18F] Bavarostat Enabled by a RuMediated Deoxyfluorination Strebl, Martin G.; Campbell, Arthur J.; Zhao, Wen-Ning; Schroeder, Frederick A.; Riley, Misha M.; Chindavong, Peter S.; Morin, Thomas M.; Haggarty, Stephen J.; Wagner, Florence F.; Ritter, Tobias; Hooker, Jacob M. 分享 收藏
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors Wagner, Florence F.; Weiwer, Michel; Steinbacher, Stefan; Schomburg, Adrian; Reinemer, Peter; Gale, Jennifer P.; Campbell, Arthur J.; Fisher, Stewart L.; Zhao, Wen-Ning; Reis, Surya A.; Hennig, Krista M.; Thomas, Meryl; Muller, Peter; Jefson, Martin R.; Fass, Daniel M.; Haggarty, Stephen J.; Zhang, Yan-Ling; Holson, Edward B. 分享 收藏
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