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Feixiong Cheng 封面图

Feixiong Cheng

cleveland clinic邮箱:chengf@ccf.org
H指数:92
被引数:5.8万

个人简介

A computational biologist with expertise in analyzing, visualizing, and mining data from real world (e.g., electronic health records, and health care claims) and experiments that profile the molecular state of human cells and tissues by interactomics, transcriptomics, genomics, proteomics, and metabolomics for personalized drug discovery and precise patient care. The primary goal of the scholar's lab is to combine tools from genomics, network medicine, bioinformatics, computational biology, chemical biology, and experimental pharmacology and systems biology assays (e.g., single cell sequencing and iPS-derived cardiomyocytes), to address the challenging questions toward understanding of various human complex diseases (e.g., cardio-oncology, pulmonary vascular diseases, and cancer), which could have a major impact in identifying novel real-world data-driven diagnostic biomarkers and therapeutic targets for precision medicine.

教育背景

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工作经历

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荣誉奖项

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A single-nucleus multiome map of the human cerebellum with Alzheimer’s disease and related dementias

单核多组学图谱揭示阿尔茨海默病及相关痴呆症下的人脑小脑

Nature Communications
IF15.7
2026-10-140
OAAI
Yayan Feng; Xin Chen; Wenqiang Song; Xiaoyu Yang; Lijun Dou; Borna Bonakdarpour; Pouya Jamshidi; Rudolph J. Castellani; Qinwen Mao; Xiaona Chu; Hongyu Gao; Yunlong Liu; Jielin Xu; Yuan Hou; William Martin; Peter T. Nelson; James B. Leverenz; Ming Hu; Yang E. Li; Andrew A. Pieper; Jeffrey Cummings; Margaret E. Flanagan; Feixiong Cheng
Alzheimer’s disease target and drug discovery by leveraging multiomics and electronic health data

阿尔茨海默病靶点与药物发现：利用多组学和电子健康数据

Nature Neuroscience
IF20
2026-10-080
OA
Yuan Hou; Yichen Li; Pengyue Zhang; Noah Lorincz-Comi; Dhruv Gohel; Fan Fan; Yunguang Qiu; Jun Yang; Xin Chen; Wenqiang Song; Xiaoyu Yang; Zhibing Tan; Zhigang Liu; Xing Fang; Isabela Rivera Paz; William Martin; Yayan Feng; Yadi Zhou; Jielin Xu; Lijun Dou; Jane Border; Huawei Zhang; Jena’ N. Mazique; Sung Hee Hwang; Richard J. Roman; Tousi Babak; Lynn Bekris; Ehud Karavani; Michael Danziger; Michal Rosen-Zvi; Jonathan L. Haines; Haiyuan Yu; Bruce D. Hammock; James B. Leverenz; Andrew A. Pieper; Jeffrey Cummings; Feixiong Cheng
Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

脑脊液与血浆的关联性将分析物与阿尔茨海默病风险老年人群的认知衰退联系起来

Annals of Clinical and Translational Neurology
IF3.9
2026-09-180
OAAI
Jagan A. Pillai; Audrey Zhu; Chunxuan Ma; Ming Wang; Yifan Yang; Lynn M. Bekris; Maria Khrestian; Frank P. DiFilippo; Mikhail Nasrallah; Aaron Burberry; James B. Leverenz; Yuan Hou; Feixiong Cheng; Stephen M. Rao
Role of Muscarinic Receptor Signaling Processes in Specific Aspects of Morphine-Induced Respiratory Depression in Rats

Getsy, P.M.; May, W.J.; Baby, S.M.; Coffee, G.A.; Qiu, Y.; Cheng, F.; Bates, J.N.; Lewis, S.J. 阿片类药物诱导的呼吸抑制中胆碱能受体信号转导过程在特定方面的作用。 Pharmaceuticals, 2026; under review. [CrossRef]

Pharmaceuticals
IF4.8
2026-08-140
OA
Paulina M. Getsy; Walter J. May; Santhosh M. Baby; Gregory A. Coffee; Yunguang Qiu; Feixiong Cheng; James N. Bates; Stephen J. Lewis
GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells

GABA信号激活通过髓源性抑制细胞驱动雌性小鼠胶质母细胞瘤的进展

Nature Cancer
IF28.5
2026-06-230
OAAI
Asmita Pathak; Palavalasa Sravya; Bruno Colon; Erika Ciervo; Yadi Zhou; Oriana Y. Teran Pumar; Brandon Emanuel León; Jonathan Mitchell; Pedro Henrique Assenza Tavares Coroa; Beatriz Mateo-Victoriano; Andrew J. Scott; Durga Prasad Gannamedi; Harrison K. A. Wong; Li Zhang; Juyeun Lee; Kristen Kay; Efe Karaca; Diana H. Chin; Haleh Amirian; Irem Karaman; Preyasha Shrestha; Katelyn Sellick; Danielle Dean; Daniel Bilbao Cortes; Jashodeep Datta; Scott M. Welford; Maria Clara Franco; Kiran Kurmi; Ashish H. Shah; Feixiong Cheng; Justin D. Lathia; Priyamvada Rai; David B. Lombard; Costas A. Lyssiotis; Dionysios C. Watson; Michele Ceccarelli; Daniel R. Wahl; Defne Bayik
Analyses of GWAS and Sub-Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

全基因组关联研究（GWAS）和亚阈值位点的分析揭示了精神分裂症遗传风险下树突发育和形态功能障碍的发现。

Advanced Science
IF14.1
2025-08-290
OAAI
Rui Chen; Benjamin Siciliano; Quan Wang; Chongchong Xu; Qiang Wei; Hai Yang; James S Sutcliffe; Yi Jiang; Ying Ji; Chunyu Liu; Feixiong Cheng; Edwin H Cook; Nancy J Cox; Xue Zhong; Zhexing Wen; Bingshan Li
Single-microglia transcriptomic transition network-based prediction and real-world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease
ALZHEIMERS & DEMENTIA
IF11.1
2024-12-060
PRE
Xu, Jielin; Song, Wenqiang; Xu, Zhenxing; Danziger, Michael M.; Karavani, Ehud; Zang, Chengxi; Chen, Xin; Li, Yichen; Paz, Isabela M. Rivera; Gohel, Dhruv; Su, Chang; Zhou, Yadi; Hou, Yuan; Shimoni, Yishai; Pieper, Andrew A.; Hu, Jianying; Wang, Fei; Rosen-Zvi, Michal; Leverenz, James B.; Cummings, Jeffrey; Cheng, Feixiong
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
NEURON
IF15
2024-12-010
OAAI
Carling, Gillian K.; Fan, Li; Foxe, Nessa R.; Norman, Kendra; Wong, Man Ying; Zhu, Daphne; Corona, Carlo; Razzoli, Agnese; Yu, Fangmin; Yarahmady, Allan; Ye, Pearly; Chen, Hao; Huang, Yige; Amin, Sadaf; Sereda, Rebecca; Lopez-Lee, Chloe; Zacharioudakis, Emmanouil; Chen, Xiaoying; Xu, Jielin; Cheng, Feixiong; Gavathiotis, Evripidis; Cuervo, Ana Maria; Holtzman, David M.; Mok, Sue-Ann; Sinha, Subhash C.; Sidoli, Simone; Ratan, Rajiv R.; Luo, Wenjie; Gong, Shiaoching; Gan, Li

研究方向

Cardio-Oncologypulmonary vascular diseasescancerpersonalized drug discoveryprecision medicine
Y
Yadi Zhou
H 指数:36论文数:128被引数:9,879
唐赟 封面图
唐赟
H 指数:54论文数:483被引数:1.5万
A
Andrew A. Pieper
H 指数:50论文数:222被引数:9,262
Y
Yuan Hou
H 指数:23论文数:97被引数:4,877
J
Jeffrey L. Cummings
H 指数:176论文数:1,522被引数:16.9万
卢伟强 封面图
卢伟强
H 指数:35论文数:124被引数:4,922
Z
Zhongming Zhao
H 指数:86论文数:1,076被引数:3.6万
方
方坚松
H 指数:38论文数:186被引数:5,029
C
Charis Eng
H 指数:139论文数:1,220被引数:7.4万
李卫华 封面图
李卫华
H 指数:53论文数:323被引数:1.4万