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J

Jonathan D. Tyzack

european molecular biology laboratory (embl)

17H指数
36论文数
1.6K被引数
收录论文 19
发表时间
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ANNalog: generation of MedChem-similar moleculesANNalog: 生成类药物化学分子
errJournal of Cheminformatics
IF5.7
err2026-04-15
err0
errOAAI
errWei Dai; Jonathan D. Tyzack; Arianna Fornili; Chris de Graaf; Noel M. O’Boyle
err分享
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Large-scale annotation of biochemically relevant pockets and tunnels in cognate enzyme-ligand complexes同源酶-配体复合物中生化相关口袋和隧道的大规模注释
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2024-10-15
err0
errOAAI
errVavra, O.; Tyzack, J.; Haddadi, F.; Stourac, J.; Damborsky, J.; Mazurenko, S.; Thornton, J. M.; Bednar, D.
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EzMechanism: an automated tool to propose catalytic mechanisms of enzyme reactionsEz机制: 提出酶反应催化机制的自动化工具
errNATURE METHODS
IF32.1
err2023-09-21
err4
errOAAI
errRibeiro, Antonio J. M.; Riziotis, Ioannis G.; Tyzack, Jonathan D.; Borkakoti, Neera; Thornton, Janet M.
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GRaSP-web: a machine learning strategy to predict binding sites based on residue neighborhood graphsGrasb-web: 一种基于残基邻域图预测结合位点的机器学习策略
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-05-07
err10
errOAAI
errSantana, Charles A.; Izidoro, Sandro C.; De Melo-Minardi, Raquel C.; Tyzack, Jonathan D.; Ribeiro, Antonio J. M.; Pires, Douglas E., V; Thornton, Janet M.; Silveira, Sabrina de A.
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The Enzyme Portal: an integrative tool for enzyme information and analysis酶门户: 酶信息和分析的综合工具
errFEBS JOURNAL
IF4.2
err2021-09-03
err5
errOAAI
errZaru, Rossana; Onwubiko, Joseph; Ribeiro, Antonio J. M.; Cochrane, Keeva; Tyzack, Jonathan D.; Muthukrishnan, Venkatesh; Pravda, Lukas; Thornton, Janet M.; O'Donovan, Claire; Velanker, Sameer; Orchard, Sandra; Leach, Andrew; Martin, Maria J.
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A global analysis of function and conservation of catalytic residues in enzymes
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2020-01-01
err90
errOAAI
errRibeiro, Antonio J. M.; Tyzack, Jonathan D.; Borkakoti, Neera; Holliday, Gemma L.; Thornton, Janet M.
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Identifying pseudoenzymes using functional annotation. How loss of function correlates with mutations in the catalytic site
errFEBS JOURNAL
IF4.2
err2019-12-05
err18
errOAAI
errRibeiro, Antonio J. M.; Tyzack, Jonathan D.; Borkakoti, Neera; Thornton, Janet M.
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Exploring Chemical Biosynthetic Design Space with Transform-MinER
errACS SYNTHETIC BIOLOGY
IF3.9
err2019-10-24
err12
errOAAI
errTyzack, Jonathan D.; Ribeiro, Antonio J. M.; Borkakoti, Neera; Thornton, Janet M.
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PDBe-KB: a community-driven resource for structural and functional annotations
errNUCLEIC ACIDS RESEARCH
IF13.1
err2019-10-04
err75
errOAAI
errVaradi, Mihaly; Bcrrisford, John; Deshpande, Mandar; Nair, Sreenath S.; Gutmanas, Aleksandras; Armstrong, David; Pravda, Lukas; Al-Lazikani, Bissan; Anyango, Stephen; Barton, Geoffrey J.; Berka, Karel; Blundell, Tom; Borkakoti, Neera; Dana, Jose; Das, Sayoni; Dey, Sucharita; Di Micco, Patrizio; Fraternali, Franca; Gibson, Toby; Helmer-Citterich, Manuela; Hoksza, David; Huang, Liang-Chin; Jain, Rishabh; Jubb, Harry; Kannas, Christos; Kannan, Natarajan; Koca, Jaroslav; Krivak, Radoslav; Kumar, Manjeet; Levy, Emmanuel D.; Madeira, F.; Madhusudhan, M. S.; Martell, Henry J.; MacGowan, Stuart; McGreig, Jake E.; Mir, Saqib; Mukhopadhyay, Abhik; Parca, Luca; Paysan-Lafosse, Typhaine; Radusky, Leandro; Ribeiro, Antonio; Serrano, Luis; Sillitoe, Ian; Singh, Gulzar; Skoda, Petr; Svobodova, Radka; Tyzack, Jonathan; Valencia, Alfonso; Fernandez, Eloy Villasclaras; Vranken, Wim; Wass, Mark; Thornton, Janet; Sternberg, Michael; Orengo, Christine; Velankar, Sameer
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Computational methods and tools to predict cytochrome P450 metabolism for drug discovery
errCHEMICAL BIOLOGY & DRUG DESIGN
IF3.3
err2019-01-15
err133
errOAAI
errTyzack, Jonathan D.; Kirchmair, Johannes
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Can the inhibition of cytochrome P450 in aquatic invertebrates due to azole fungicides be estimated with in silico and in vitro models and extrapolated between species?
errAQUATIC TOXICOLOGY
IF4.3
err2018-08-01
err13
errOAAI
errGottardi, Michele; Tyzack, Jonathan D.; Bender, Andreas; Cedergreen, Nina
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WhichP450: a multi-class categorical model to predict the major metabolising CYP450 isoform for a compound
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2018-02-20
err51
PREAI
errHunt, Peter A.; Segall, Matthew D.; Tyzack, Jonathan D.
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Understanding enzyme function evolution from a computational perspective
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2017-12-01
err34
errOAAI
errTyzack, Jonathan D.; Furnham, Nicholas; Sillitoe, Ian; Orengo, Christine M.; Thornton, Janet M.
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Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites
errNUCLEIC ACIDS RESEARCH
IF13.1
err2017-11-02
err148
errOAAI
errRibeiro, Antonio J. M.; Holliday, Gemma L.; Furnham, Nicholas; Tyzack, Jonathan D.; Ferris, Katherine; Thornton, Janet M.
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Predicting Regioselectivity and Lability of Cytochrome P450 Metabolism Using Quantum Mechanical Simulations
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2016-10-26
err38
PREAI
errTyzack, Jonathan D.; Hunt, Peter A.; Segall, Matthew D.
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Cytochrome P450 site of metabolism prediction from 2D topological fingerprints using GPU accelerated probabilistic classifiers
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2014-05-27
err30
errOAAI
errTyzack, Jonathan D.; Mussa, Hamse Y.; Williamson, Mark J.; Kirchmair, Johannes; Glen, Robert C.
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FAst MEtabolizer (FAME): A Rapid and Accurate Predictor of Sites of Metabolism in Multiple Species by Endogenous Enzymes
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2013-11-12
err46
PREAI
errKirchmair, Johannes; Williamson, Mark J.; Afzal, Avid M.; Tyzack, Jonathan D.; Choy, Alison P. K.; Howlett, Andrew; Rydberg, Patrik; Glen, Robert C.
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Prediction of Cytochrome P450 Xenobiotic Metabolism: Tethered Docking and Reactivity Derived from Ligand Molecular Orbital Analysis
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2013-05-24
err45
PREAI
errTyzack, Jonathan D.; Williamson, Mark J.; Torella, Rubben; Glen, Robert C.
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Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2012-02-17
err240
errOAAI
errKirchmair, Johannes; Williamson, Mark J.; Tyzack, Jonathan D.; Tan, Lu; Bond, Peter J.; Bender, Andreas; Glen, Robert C.
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研究方向

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合作学者
合作期刊
J
Janet M. Thornton
H 指数: 135 · 论文数: 784
A
Alfonso Valencia
H 指数: 127 · 论文数: 866
T
Tom L. Blundell
H 指数: 112 · 论文数: 736
M
Michael J.E. Sternberg
H 指数: 100 · 论文数: 502
T
Toby J. Gibson
H 指数: 85 · 论文数: 232
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