未登录 A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin Qiu, Deyun; Pei, Jinxin V.; Rosling, James E. O.; Thathy, Vandana; Li, Dongdi; Xue, Yi; Tanner, John D.; Penington, Jocelyn Sietsma; Aw, Yi Tong Vincent; Aw, Jessica Yi Han; Xu, Guoyue; Tripathi, Abhai K.; Gnadig, Nina F.; Yeo, Tomas; Fairhurst, Kate J.; Stokes, Barbara H.; Murithi, James M.; Kumpornsin, Krittikorn; Hasemer, Heath; Dennis, Adelaide S. M.; Ridgway, Melanie C.; Schmitt, Esther K.; Straimer, Judith; Papenfuss, Anthony T.; Lee, Marcus C. S.; Corry, Ben; Sinnis, Photini; Fidock, David A.; van Dooren, Giel G.; Kirk, Kiaran; Lehane, Adele M. 分享 收藏
An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials Tse, Edwin G.; Aithani, Laksh; Anderson, Mark; Cardoso-Silva, Jonathan; Cincilla, Giovanni; Conduit, Gareth J.; Galushka, Mykola; Guan, Davy; Hallyburton, Irene; Irwin, Benedict W. J.; Kirk, Kiaran; Lehane, Adele M.; Lindblom, Julia C. R.; Lui, Raymond; Matthews, Slade; McCulloch, James; Motion, Alice; Ng, Ho Leung; Oeren, Mario; Robertson, Murray N.; Spadavecchio, Vito; Tatsis, Vasileios A.; van Hoorn, Willem P.; Wade, Alexander D.; Whitehead, Thomas M.; Willis, Paul; Todd, Matthew H. 分享 收藏
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A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4 恶性疟原虫生长的4-氰基-3-甲基异喹啉抑制剂靶向钠外排泵PfATP4 Gilson, Paul R.; Kumarasingha, Rasika; Thompson, Jennifer; Zhang, Xinxin; Sietsma Penington, Jocelyn; Kalhor, Robabeh; Bullen, Hayley E.; Lehane, Adele M.; Dans, Madeline G.; de Koning-Ward, Tania F.; Holien, Jessica K.; Soares da Costa, Tatiana P.; Hulett, Mark D.; Buskes, Melissa J.; Crabb, Brendan S.; Kirk, Kiaran; Papenfuss, Anthony T.; Cowman, Alan F.; Abbott, Belinda M. 分享 收藏
Characterization of the ATP4 ion pump in Toxoplasma gondii Lehane, Adele M.; Dennis, Adelaide S. M.; Bray, Katherine O.; Li, Dongdi; Rajendran, Esther; McCoy, James M.; McArthur, Hillary M.; Winterberg, Markus; Rahimi, Farid; Tonkin, Christopher J.; Kirk, Kiaran; van Dooren, Giel G. 分享 收藏
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Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites Rajendran, Esther; Hapuarachchi, Sanduni V.; Miller, Catherine M.; Fairweather, Stephen J.; Cai, Yeping; Smith, Nicholas C.; Cockburn, Ian A.; Broer, Stefan; Kirk, Kiaran; van Dooren, Giel G. 分享 收藏
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Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase Hewitt, Stephen Nakazawa; Dranow, David M.; Horst, Benjamin G.; Abendroth, Jan A.; Forte, Barbara; Hallyburton, Irene; Jansen, Chimed; Baragana, Beatriz; Choi, Ryan; Rivas, Kasey L.; Hulverson, Matthew A.; Dumais, Mitchell; Edwards, Thomas E.; Lorimer, Donald D.; Fairlamb, Alan H.; Gray, David W.; Read, Kevin D.; Lehane, Adele M.; Kirk, Kiaran; Myler, Peter J.; Wernimont, Amy; Walpole, Chris; Stacy, Robin; Barrett, Lynn K.; Gilbert, Ian H.; Van Voorhis, Wesley C. 分享 收藏
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles 开源药物发现: 源自Tres Cantos芳基吡咯的高效抗疟化合物 Williamson, Alice E.; Ylioja, Paul M.; Robertson, Murray N.; Antonova-Koch, Yevgeniya; Avery, Vicky; Baell, Jonathan B.; Batchu, Harikrishna; Batra, Sanjay; Burrows, Jeremy N.; Bhattacharyya, Soumya; Calderon, Felix; Charman, Susan A.; Clark, Julie; Crespo, Benigno; Dean, Matin; Debbert, Stefan L.; Delves, Michael; Dennis, Adelaide S. M.; Deroose, Frederik; Duffy, Sandra; Fletcher, Sabine; Giaever, Guri; Hallyburton, Irene; Gamo, Francisco-Javier; Gebbia, Marinella; Guy, R. Kiplin; Hungerford, Zoe; Kirk, Kiaran; Lafuente-Monasterio, Maria J.; Lee, Anna; Meister, Stephan; Nislow, Corey; Overington, John P.; Papadatos, George; Patiny, Luc; Pham, James; Ralph, Stuart A.; Ruecker, Andrea; Ryan, Eileen; Southan, Christopher; Srivastava, Kumkum; Swain, Chris; Tarnowski, Matthew J.; Thomson, Patrick; Turner, Peter; Wallace, Iain M.; Wells, Timothy N. C.; White, Karen; White, Laura; Willis, Paul; Winzeler, Elizabeth A.; Wittlin, Sergio; Todd, Matthew H. 分享 收藏
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Van Voorhis, Wesley C.; Adams, John H.; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H.; Alano, Pietro; Alday, Aintzane; Resto, Yesmalie Aleman; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T.; Avery, Simon V.; Avery, Vicky M.; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Juergen; Boucher, Lauren E.; Boyom, Fabrice F.; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R.; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Cassera, Maria Belen; Cheng, Ken Chih-Chien; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L.; Colon-Lopez, Daisy D.; Corbett, Yolanda; Crowther, Gregory J.; Cowan, Noemi; D'Alessandro, Sarah; Le Dang, Na; Delves, Michael; DeRisi, Joseph L.; Du, Alan Y.; Duffy, Sandra; El-Sayed, Shimaa Abd El-Salam; Ferdig, Michael T.; Robledo, Jose A. Fernandez; Fidock, David A.; Florent, Isabelle; Fokou, Patrick V. T.; Galstian, Ani; Javier Gamo, Francisco; Gokool, Suzanne; Gold, Ben; Golub, Todd; Goldgof, Gregory M.; Guha, Rajarshi; Guiguemde, W. Armand; Gural, Nil; Guy, R. Kiplin; Hansen, Michael A. E.; Hanson, Kirsten K.; Hemphill, Andrew; van Huijsduijnen, Rob Hooft; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B.; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A.; Jadhav, Ajit; Jensen, Amornrat Naranuntarat; Jensen, Laran T.; Jiang, Rays H. Y.; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P.; Kyle, Dennis E.; Jose Lafuente, Maria; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M.; Li, Fengwu; Little, David; Liu, Liqiong; Llinas, Manuel; Loza, Maria I.; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R.; March, Sandra; McGowan, Sheena; Vera, Iset Medina; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N.; Misra, Raj N.; Moon, Seunghyun; Moore, John P.; Rodrigues da Costa, Francielly Morais; Mueller, Joachim; Muriana, Arantza; Hewitt, Stephen Nakazawa; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K.; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Ngoc Pham; Prats, Sarah; Plouffe, David M.; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J.; Rice, Christopher A.; Rizk, Mohamed Abdo; Ruecker, Andrea; St Onge, Robert; Ferreira, Rafaela Salgado; Samra, Jasmeet; Robinett, Natalie G.; Schlecht, Ulrich; Schmitt, Marjorie; Villela, Filipe Silva; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A.; Soldati, Thierry; Spitzmueller, Andreas; Stamm, Serge Maximilian; Sullivan, David J.; Sullivan, William; Suresh, Sundari; Suzuki, Brian M.; Suzuki, Yo; Swamidass, S. Joshua; Taramelli, Donatella; Tchokouaha, Lauve R. Y.; Theron, Anjo; Thomas, David; Tonissen, Kathryn F.; Townson, Simon; Tripathi, Abhai K.; Trofimov, Valentin; Udenze, Kenneth O.; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M.; Phat Voong Vinh; Hoan Vu; Watanabe, Nao-aki; Weatherby, Kate; White, Pamela M.; Wilks, Andrew F.; Winzeler, Elizabeth A.; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul H. A.; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoit; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A. 分享 收藏
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