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H

Hans E. Purkey

genentech, inc.
H指数:30
被引数:3,158

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Large-Scale Collaborative Assessment of Binding Free Energy Calculations for Drug Discovery Using OpenFE

利用OpenFE进行药物发现中结合自由能计算的大规模协作评估

Journal of Chemical Information and Modeling
IF5.3
2026-05-210
PRE
Hannah M. Baumann; Joshua T. Horton; Michael M. Henry; Alyssa Travitz; Benjamin Ries; Richard J. Gowers; David W. H. Swenson; Iván Pulido; Dominic Rufa; David L. Dotson; Nupur Bansal; Joseph P. Bluck; Howard Broughton; Kira A. Campbell; Lili Cao; Benedikt Frieg; Vytautas Gapsys; Hendrik Göddeke; Marco Klähn; Sirish Kaushik Lakkaraju; Stephanie M. Linker; Thomas Löhr; Aniket Magarkar; Sergio Pérez-Conesa; Hans E. Purkey; Hayk Saribekyan; Jenke Scheen; Christina E. M. Schindler; Thomas Steinbrecher; Chaya D. Stern; Patricia Suriana; William C. Swope; Gary Tresadern; Lev Tsidilkovski; Binqing Wei; Alexander H. Williams; Yao Wu; Ivy Zhang; John D. Chodera; James R. B. Eastwood; David L. Mobley; Irfan Alibay
Discovery and Optimization of a Potent; Efficacious; and Brain-Penetrant Inhibitor of KRAS G12C

发现和优化一种强效、高效且能穿透血脑屏障的KRAS G12C抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-03-020
PRE
Matthew L. Landry; Sushant Malhotra; Maureen Beresini; Connie Chan; Emily Chan; Cecile C. de la Cruz; Nicholas F. Endres; Marie Evangelista; Amy Gustafson; Dennis Hu; Thomas Hunsaker; Peter Hsu; Yevgeniy Izrayelit; Hank La; Pablo Saenz-Lopez Larrocha; Qihui Lian; Mark Merchant; Jialin Mao; Rana Mroue; Angela Oh; Emile Plise; Cheng Shao; Michael Siu; John C. Tran; Yanguang Wang; Weiru Wang; Binqing Wei; Susan Wong; Chun-Wan Yen; Yuhui Zhou; Hans E. Purkey; Timothy P. Heffron; Laurent Salphati
Discovery and Characterization of Divarasib (GDC-6036); a Potent Covalent Inhibitor of KRAS G12C

Divarasib (GDC-6036)的发现与表征：一种强效的KRAS G12C共价抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-03-020
PRE
Nicholas F. Endres; Steven Do; Rana Mroue; Jack A. Terrett; Matt Saabye; Angela Oh; Thomas Hunsaker; Emily Chan; John C. Tran; Lan K. Nguyen; Qihui Lian; Taylur P. Ma; Thomas Garner; Luca Gerosa; Maureen Beresini; Aaron Boudreau; Sarah M. Bronner; Patrick Cyr; Noriko Ishisoko; Yevgeniy Izrayelit; Fan Jiang; Terry Kellar; Hank La; Sharada Labadie; Matthew Lardy; Liling Liu; Wendy Liu; Sarah Miller; Joachim Rudolph; Emile Plise; Benjamin D. Sellers; Cheng Shao; Weiru Wang; Yanguang Wang; Wentao Wei; Susan Wong; Christine Yu; Kebing Yu; Po-Wai Yuen; Richard Zang; Chenghong Zhang; Yuhui Zhou; Xiaoyu Zhu; John G. Quinn; Xin Ye; James R. Kiefer; Jialin Mao; Marie Evangelista; Mark Merchant; Matthew L. Landry; Sushant Malhotra; Hans E. Purkey
Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry
ANALYTICAL CHEMISTRY
IF6.7
2023-03-064
PRE
Tran, John C.; Hunsaker, Thomas; Bell, Christina; Ma, Taylur P.; Chan, Emily; Larrocha, Pablo Saenz-Lopez; Homyk, Kelsey; Liu, Liling; La, Hank; Mao, Jialin; de la Cruz, Cecile C.; Yu, Kebing; Beresini, Maureen; Forrest, William F.; Xiao, Yang; Jang, Anne; Samus, Natalia; Stesco, Nicholas Dupuis; Mentinova, Marija; Parent, Stephane; Pottiez, Gwenael; Schirm, Michael; Purkey, Hans E.; Liu, Yichin; Merchant, Mark
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-12-0145
PRE
Hanan, Emily J.; Braun, Marie-Gabrielle; Heald, Robert A.; MacLeod, Calum; Chan, Connie; Clausen, Saundra; Edgar, Kyle A.; Eigenbrot, Charles; Elliott, Richard; Endres, Nicholas; Friedman, Lori S.; Gogol, Emily; Gu, Xiao-Hui; Thibodeau, Rebecca Hong; Jackson, Philip S.; Kiefer, James R.; Knight, Jamie D.; Nannini, Michelle; Narukulla, Raman; Pace, Amanda; Pang, Jodie; Purkey, Hans E.; Salphati, Laurent; Sampath, Deepak; Schmidt, Stephen; Sideris, Steve; Song, Kyung; Sujatha-Bhaskar, Swathi; Ultsch, Mark; Wallweber, Heidi; Xin, Jianfeng; Yeap, SiewKuen; Young, Amy; Zhong, Yu; Staben, Steven T.
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors
NATURE BIOTECHNOLOGY
IF41.7
2022-01-067
OA
Davies, Christopher W.; Oh, Angela J.; Mroue, Rana; Steffek, Micah; Bruning, John M.; Xiao, Yang; Feng, Siyu; Jayakar, Sangeeta; Chan, Emily; Arumugam, Vidhyalakshmi; Uribe, Sean Carlo; Drummond, Jake; Frommlet, Alexandra; Lu, Cheng; Franke, Yvonne; Merchant, Mark; Koeppen, Hartmut; Quinn, John G.; Malhotra, Sushant; Do, Steve; Gazzard, Lewis; Purkey, Hans E.; Rudolph, Joachim; Mulvihill, Melinda M.; Koerber, James T.; Wang, Weiru; Evangelista, Marie
Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

通过抑制脂多糖转运蛋白MsbA破坏革兰氏阴性细菌外膜生物合成

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2018-11-0153
OAAI
Alexander, Mary Kate; Miu, Anh; Oh, Angela; Reichelt, Mike; Ho, Hoangdung; Chalouni, Cecile; Labadie, Sharada; Wang, Lan; Liang, Jun; Nickerson, Nicholas N.; Hu, Huiyong; Yu, Lan; Du, Miaofen; Yang, Donghong; Park, Summer; Kim, Janice; Xu, Min; Sellers, Benjamin D.; Purkey, Hans E.; Skelton, Nicholas J.; Koehler, Michael F. T.; Payandeh, Tian; Verma, Vishal; Xu, Yiming; Koth, Christopher M.; Nishiyama, Mireille
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-09-1232
PREAI
Chan, Bryan K.; Hanan, Emily J.; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Emily; Chen, Yuan; Clausen, Saundra; Dela Vega, Trisha; Dotson, Jennafer; Eigenbrot, Charles; Elliott, Richard L.; Heald, Robert A.; Jackson, Philip S.; Knight, Jamie D.; La, Hank; Lainchbury, Michael D.; Malek, Shiva; Purkey, Hans E.; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen M.; Sideris, Steve; Shao, Lily; Wang, Shumei; Yeap, Siew Kuen; Yen, Ivana; Yu, Christine; Heffron, Timothy P.
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2016-09-0650
OAAI
Purkey, Hans E.; Robarge, Kirk; Chen, Jinhua; Chen, Zhongguo; Corson, Laura B.; Ding, Charles Z.; DiPasquale, Antonio G.; Dragovich, Peter S.; Eigenbrot, Charles; Evangelista, Marie; Fauber, Benjamin P.; Gao, Zhenting; Ge, Hongxiu; Hitz, Anna; Ho, Qunh; Labadie, Sharada S.; Lai, Kwong Wah; Liu, Wenfeng; Liu, Yajing; Li, Chiho; Ma, Shuguang; Malek, Shiva; O'Brien, Thomas; Pang, Jodie; Peterson, David; Salphati, Laurent; Sideris, Steve; Ultsch, Mark; Wei, BinQing; Yen, Ivana; Yue, Qin; Zhang, Huihui; Zhou, Aihe
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition
NATURE CHEMICAL BIOLOGY
IF13.7
2016-08-01189
PREAI
Boudreau, Aaron; Purkey, Hans E.; Hitz, Anna; Robarge, Kirk; Peterson, David; Labadie, Sharada; Kwong, Mandy; Hong, Rebecca; Gao, Min; Del Nagro, Christopher; Pusapati, Raju; Ma, Shuguang; Salphati, Laurent; Pang, Jodie; Zhou, Aihe; Lai, Tommy; Li, Yingjie; Chen, Zhongguo; Wei, Binqing; Yen, Ivana; Sideris, Steve; McCleland, Mark; Firestein, Ron; Corson, Laura; Vanderbilt, Alex; Williams, Simon; Daemen, Anneleen; Belvin, Marcia; Eigenbrot, Charles; Jackson, Peter K.; Malek, Shiva; Hatzivassiliou, Georgia; Sampath, Deepak; Evangelista, Marie; O'Brien, Thomas
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study (vol 58, pg 8877, 2015)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-03-110
OAAI
Heald, Robert; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Bryan; Chan, Emily; Chen, Yuan; Clausen, Saundra; -Fernandez, Belen Dominguez; Eigenbrot, Charles; Elliott, Richard; Hanan, Emily J.; Jackson, Philip; Knight, Jamie; La, Hank; Lainchbury, Michael; Malek, Shiva; Mann, Sam; Merchant, Mark; Mortara, Kyle; Purkey, Hans; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen; Sideris, Steve; Shao, Lily; Wang, Shumei; Yeap, Kuen; Yen, Ivana; Yu, Christine; Heffron, Timothy P.
Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2015-12-2137
OAAI
Bryan, Marian C.; Burdick, Daniel J.; Chan, Bryan K.; Chen, Yuan; Clausen, Saundra; Dotson, Jennafer; Eigenbrot, Charles; Elliott, Richard; Hanan, Emily J.; Heald, Robert; Jackson, Philip; La, Hank; Lainchbury, Michael; Malek, Shiva; Mann, Sam E.; Purkey, Hans E.; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen; Sideris, Steve; Wang, Shumei; Yen, Ivana; Yu, Christine; Heffron, Timothy P.
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-11-1252
PREAI
Heald, Robert; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Bryan; Chan, Emily; Chen, Yuan; Clausen, Saundra; Dominguez-Fernandez, Belen; Eigenbrot, Charles; Elliott, Richard; Hanan, Emily J.; Jackson, Philip; Knight, Jamie; La, Hank; Lainchbury, Michael; Malek, Shiva; Mann, Sam; Merchant, Mark; Mortara, Kyle; Purkey, Hans; Schaefee, Gabriele; Schmidt, Stephen; Seward, Eileen; Sideris, Steve; Shao, Lily; Wang, Shumei; Yeap, Kuen; Yen, Ivana; Yu, Christine; Heffron, Timothy P.
8-Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-11-2617
PREAI
Thomas, Allen A.; Hunt, Kevin W.; Newhouse, Brad; Watts, Ryan J.; Liu, Xingrong; Vigers, Guy; Smith, Darin; Rhodes, Susan P.; Brown, Karin D.; Otten, Jennifer N.; Burkard, Michael; Cox, April A.; Do, Mary K. Geck; Dutcher, Darrin; Rana, Sumeet; DeLisle, Robert K.; Regal, Kelly; Wright, Albion D.; Groneberg, Robert; Liao, Jiangpeng; Scearce-Levie, Kimberly; Siu, Michael; Purkey, Hans E.; Lyssikatos, Joseph P.
Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-11-2072
OAAI
Hanan, Emily J.; Eigenbrot, Charles; Bryan, Marian C.; Burdick, Daniel J.; Chan, Bryan K.; Chen, Yuan; Dotson, Jennafer; Heald, Robert A.; Jackson, Philip S.; La, Hank; Lainchbury, Michael D.; Malek, Shiva; Purkey, Hans E.; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen M.; Sideris, Steve; Tam, Christine; Wang, Shumei; Yeap, Siew Kuen; Yen, Ivana; Yin, Jianping; Yu, Christine; Zilberleyb, Inna; Heffron, Timothy P.

研究方向

暂未获取到该数据
C
Charles Eigenbrot
H 指数:61论文数:242被引数:1.6万
M
Marie Evangelista
H 指数:35论文数:169被引数:1.0万
S
Steve Sideris
H 指数:30论文数:97被引数:4,476
H
Hank La
H 指数:25论文数:128被引数:2,280
S
Shiva Malek
H 指数:36论文数:216被引数:7,411
C
Christine Yu
H 指数:24论文数:43被引数:3,078
T
Timothy P. Heffron
H 指数:29论文数:155被引数:2,620
I
Ivana Yen
H 指数:21论文数:84被引数:3,326
R
Robert A. Heald
H 指数:26论文数:93被引数:2,647
E
Emily J. Hanan
H 指数:21论文数:58被引数:1,249